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Information on EC 2.4.1.253 - baicalein 7-O-glucuronosyltransferase
for references in articles please use BRENDA:EC2.4.1.253
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EC Tree 2 Transferases
2.4 Glycosyltransferases
2.4.1 Hexosyltransferases
2.4.1.253 baicalein 7-O-glucuronosyltransferase
IUBMB Comments
The enzyme is specific for UDP-D-glucuronate as a sugar donor and flavones with substitution ortho- to the 7-OH group such as baicalein (6-OH), scutellarein (6-OH) and wogonin (8-OMe).
The expected taxonomic range for this enzyme is: Scutellaria baicalensis
- 2.4.1.253
-
scutellariae
- baicalensis
- flavonoids
- baicalin
- georgi
- wogonin
- catalase
showSynonyms
ubgat, udp-glucuronate baicalein 7-o-glucuronosyltransferase, baicalein 7-o-glucuronosyltransferase, udp-glucuronate:baicalein 7-o-glucuronosyltransferase, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
UBGAT
UDP-glucuronate baicalein 7-O-glucuronosyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
UDP-D-glucuronate + baicalein = UDP + baicalin
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
MetaCyc
baicalein metabolism, wogonin metabolism
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SYSTEMATIC NAME
IUBMB Comments
UDP-D-glucuronate:5,6,7-trihydroxyflavone 7-O-glucuronosyltransferase
The enzyme is specific for UDP-D-glucuronate as a sugar donor and flavones with substitution ortho- to the 7-OH group such as baicalein (6-OH), scutellarein (6-OH) and wogonin (8-OMe).
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-D-glucuronate + 4',5,6,7-tetrahydroxyflavone
UDP + 4',5,6,7-tetrahydroxyflavone 7-O-beta-D-glucuronate
UDP-D-glucuronate + 5,6,7-trihydroxyflavone
UDP + 5,6,7-trihydroxyflavone-7-O-beta-D-glucuronate
UDP-D-glucuronate + 5,7-dihydroxy-8-methoxyflavone
UDP + 5,7-dihydroxy-8-methoxyflavone-7-O-beta-D-glucuronate
UDP-glucuronate + baicalein
UDP + baicalin
-
Substrates: -
Products: -
Products: -
?
UDP-D-glucuronate + 4',5,6,7-tetrahydroxyflavone
UDP + 4',5,6,7-tetrahydroxyflavone 7-O-beta-D-glucuronate
-
Substrates: i.e. 5,6,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one, i.e. scutellarein. The enzyme is specific to UDP-glucuronic acid as a sugar donor and flavones with substitution ortho- to the 7-OH group such as baicalein (6-OH), scutellarein (6-OH) and wogonin (8-OMe)
Products: i.e. scutellarein 7-O-glucuronide
Products: i.e. scutellarein 7-O-glucuronide
?
UDP-D-glucuronate + 4',5,6,7-tetrahydroxyflavone
UDP + 4',5,6,7-tetrahydroxyflavone 7-O-beta-D-glucuronate
-
Substrates: i.e. 5,6,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one, i.e. scutellarein. The enzyme is specific to UDP-glucuronic acid as a sugar donor and flavones with substitution ortho- to the 7-OH group such as baicalein (6-OH), scutellarein (6-OH) and wogonin (8-OMe)
Products: i.e. scutellarein 7-O-glucuronide
Products: i.e. scutellarein 7-O-glucuronide
?
UDP-D-glucuronate + 5,6,7-trihydroxyflavone
UDP + 5,6,7-trihydroxyflavone-7-O-beta-D-glucuronate
-
Substrates: i.e. 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one, i.e. baicalein. The enzyme is specific to UDP-glucuronic acid as a sugar donor and flavones with substitution ortho- to the 7-OH group such as baicalein (6-OH), scutellarein (6-OH) and wogonin (8-OMe)
Products: i.e. 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid, i.e. baicalein 7-O-glucuronide
Products: i.e. 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid, i.e. baicalein 7-O-glucuronide
?
UDP-D-glucuronate + 5,6,7-trihydroxyflavone
UDP + 5,6,7-trihydroxyflavone-7-O-beta-D-glucuronate
-
Substrates: i.e. 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one, i.e. baicalein. The enzyme is specific to UDP-glucuronic acid as a sugar donor and flavones with substitution ortho- to the 7-OH group such as baicalein (6-OH), scutellarein (6-OH) and wogonin (8-OMe)
Products: i.e. 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid, i.e. baicalein 7-O-glucuronide. Identification and quantitation of the enzyme reaction products are carried out by reversed phase-HPLC
Products: i.e. 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid, i.e. baicalein 7-O-glucuronide. Identification and quantitation of the enzyme reaction products are carried out by reversed phase-HPLC
?
UDP-D-glucuronate + 5,6,7-trihydroxyflavone
UDP + 5,6,7-trihydroxyflavone-7-O-beta-D-glucuronate
-
Substrates: i.e. 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one, i.e. baicalein. The enzyme is specific to UDP-glucuronic acid as a sugar donor and flavones with substitution ortho- to the 7-OH group such as baicalein (6-OH), scutellarein (6-OH) and wogonin (8-OMe)
Products: i.e. 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid, i.e. baicalein 7-O-glucuronide
Products: i.e. 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid, i.e. baicalein 7-O-glucuronide
?
UDP-D-glucuronate + 5,6,7-trihydroxyflavone
UDP + 5,6,7-trihydroxyflavone-7-O-beta-D-glucuronate
-
Substrates: i.e. 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one, i.e. baicalein. The enzyme is specific to UDP-glucuronic acid as a sugar donor and flavones with substitution ortho- to the 7-OH group such as baicalein (6-OH), scutellarein (6-OH) and wogonin (8-OMe)
Products: i.e. 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid, i.e. baicalein 7-O-glucuronide. Identification and quantitation of the enzyme reaction products are carried out by reversed phase-HPLC
Products: i.e. 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid, i.e. baicalein 7-O-glucuronide. Identification and quantitation of the enzyme reaction products are carried out by reversed phase-HPLC
?
UDP-D-glucuronate + 5,7-dihydroxy-8-methoxyflavone
UDP + 5,7-dihydroxy-8-methoxyflavone-7-O-beta-D-glucuronate
-
Substrates: i.e. 5,7-dihydroxy-8-methoxy-2-phenylchromen-4-one, i.e. wogonin. The enzyme is specific to UDP-glucuronic acid as a sugar donor and flavones with substitution ortho- to the 7-OH group such as baicalein (6-OH), scutellarein (6-OH) and wogonin (8-OMe)
Products: i.e wogonin 7-O-glucuronide
Products: i.e wogonin 7-O-glucuronide
?
UDP-D-glucuronate + 5,7-dihydroxy-8-methoxyflavone
UDP + 5,7-dihydroxy-8-methoxyflavone-7-O-beta-D-glucuronate
-
Substrates: i.e. 5,7-dihydroxy-8-methoxy-2-phenylchromen-4-one, i.e. wogonin. The enzyme is specific to UDP-glucuronic acid as a sugar donor and flavones with substitution ortho- to the 7-OH group such as baicalein (6-OH), scutellarein (6-OH) and wogonin (8-OMe)
Products: i.e wogonin 7-O-glucuronide
Products: i.e wogonin 7-O-glucuronide
?
UDP-D-glucuronate + baicalein
UDP + baicalin
Substrates: -
Products: -
Products: -
?
UDP-D-glucuronate + baicalein
UDP + baicalin
Substrates: -
Products: -
Products: -
?
additional information
?
-
-
Substrates: flavonoids lacking a substitution at the position ortho- to the 7-OH (chrysin, apigenin, luteolin, quercetin, formononetin and daidzein) do not serve as substrates
Products: -
Products: -
?
additional information
?
-
-
Substrates: flavonoids lacking a substitution at the position ortho- to the 7-OH (chrysin, apigenin, luteolin, quercetin, formononetin and daidzein) do not serve as substrates
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-D-glucuronate + 5,6,7-trihydroxyflavone
UDP + 5,6,7-trihydroxyflavone-7-O-beta-D-glucuronate
UDP-glucuronate + baicalein
UDP + baicalin
-
Substrates: -
Products: -
Products: -
?
UDP-D-glucuronate + 5,6,7-trihydroxyflavone
UDP + 5,6,7-trihydroxyflavone-7-O-beta-D-glucuronate
-
Substrates: i.e. 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one, i.e. baicalein. The enzyme is specific to UDP-glucuronic acid as a sugar donor and flavones with substitution ortho- to the 7-OH group such as baicalein (6-OH), scutellarein (6-OH) and wogonin (8-OMe)
Products: i.e. 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid, i.e. baicalein 7-O-glucuronide
Products: i.e. 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid, i.e. baicalein 7-O-glucuronide
?
UDP-D-glucuronate + 5,6,7-trihydroxyflavone
UDP + 5,6,7-trihydroxyflavone-7-O-beta-D-glucuronate
-
Substrates: i.e. 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one, i.e. baicalein. The enzyme is specific to UDP-glucuronic acid as a sugar donor and flavones with substitution ortho- to the 7-OH group such as baicalein (6-OH), scutellarein (6-OH) and wogonin (8-OMe)
Products: i.e. 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid, i.e. baicalein 7-O-glucuronide
Products: i.e. 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid, i.e. baicalein 7-O-glucuronide
?
UDP-D-glucuronate + baicalein
UDP + baicalin
Substrates: -
Products: -
Products: -
?
UDP-D-glucuronate + baicalein
UDP + baicalin
Substrates: -
Products: -
Products: -
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
4,4'-diisothiocyanostilbene-2,2'-disulfonic acid
-
0.1 mM, complete inhibition
additional information
-
N-ethylmaleimide has no effect in activity
-
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
additional information
-
Vmax/Km ratio for 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one (i.e. baicalein) is: 4.9 nkat/mg*micromol, Vmax/Km ratio for scutellarein is 2.67 nkat/mg*micromol, Vmax/Km ratio for wogonin is: 1.71 nkat/mg*micromol
-
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pI VALUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
callus tissue derived from the petiole of a sterile young plant
brenda
-
callus tissue derived from the petiole of a sterile young plant
-
brenda
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
enhancement of the flavone contents of Scutellaria baicalensis hairy roots via metabolic engineering using maize Lc and Arabidopsis PAP1 transcription factors
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). UBGAT_SCUBA
441
0
48654
Swiss-Prot
other Location (Reliability: 3)
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
homodimer
homodimer
-
2 * 52000, does not exist or function as monomer, SDS-PAGE
homodimer
-
2 * 52000, does not exist or function as monomer, SDS-PAGE
-
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
23
-
50% of the activity remains after 3 h, 25% of the activity remains after 24 h
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
compared to the control, at the 3 day, 0.000002 mM/l and 0.0002 mM/l H2O2 promotes the expression of UDP-glucuronate baicalein 7-O-glucuronosyltransferase
high temperature of 40°C increases the level of UDP-glucuronate:baicalein 7-O-glucuronosyltransferase transcripts, whereas low temperature does not affect the level of these transcripts compared with their level at 30°C. At 40°C, the expression after 40-days exposure is significantly higher than that after 30 days
compared to the control, at the 3 day, 0.000002 mM/l and 0.0002 mM/l H2O2 promotes the expression of UDP-glucuronate baicalein 7-O-glucuronosyltransferase
compared to the control, at the 3 day, 0.000002 mM/l and 0.0002 mM/l H2O2 promotes the expression of UDP-glucuronate baicalein 7-O-glucuronosyltransferase
-
-
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nagashima, S.; Hirotani, M.; Yoshikawa, T.
Purification and characterization of UDP-glucuronate: baicalein 7-O-glucuronosyltransferase from Scutellaria baicalensis Georgi. cell suspension cultures
Phytochemistry
53
533-538
2000
Scutellaria baicalensis, Scutellaria baicalensis Georgi
brenda
Wang, W.; Chen, J.-k.; Zhou, T.-s.
CHS and UBGAT expression and baicalin accumulation in the roots of Scutellaria baicalensis Georgi during cultivation seasons
Fudan Xuebao Ziran Kexueban
45
674-678
2006
Scutellaria baicalensis
-
brenda
Yuan, Y.; Shuai, L.; Chen, S.; Huang, L.; Qin, S.; Yang, Z.
Flavonoids and antioxidative enzymes in temperature-challenged roots of Scutellaria baicalensis Georgi
Z. Naturforsch. C
67
77-85
2012
Scutellaria baicalensis (Q76MR7), Scutellaria baicalensis
brenda
Qi, S.; Cao, W.; Hua, J.; Zhang, A.; Meng, X.
H2O2 improves quality of radix scutellariae through anti-oxidant effect
Pharmacogn. Mag.
12
84-90
2016
Scutellaria baicalensis (Q76MR7), Scutellaria baicalensis, Scutellaria baicalensis Georgi (Q76MR7)
brenda
Park, C.H.; Xu, H.; Yeo, H.J.; Park, Y.E.; Hwang, G.S.; Park, N.I.; Park, S.U.
Enhancement of the flavone contents of Scutellaria baicalensis hairy roots via metabolic engineering using maize Lc and Arabidopsis PAP1 transcription factors
Metab. Eng.
64
64-73
2021
Scutellaria baicalensis
brenda
EXTERNAL LINKS (specific for EC-Number 2.4.1.253)
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