Reference on EC 2.4.1.221 - peptide-O-fucosyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hofsteenge, J.; Huwiler, K.G.; Bacik B.; Hess, D.; Lawler, J.; Mosher, D.F.; Peter-Katalinic, J.
C-mannosylation and o-fuxosylation of the thrombospondin type 1 module
J. Biol. Chem.
276
6485-6498
2001
Homo sapiens
Wang, Y.; Lee, G.F.; Kelley, R.F.; Spellman, M.W.
Identification of a GDP-L-fucose:polypeptide fucosyltransferase and enzymic addition of O-linked fucose to EGF domains
Glycobiology
6
837-842
1996
Cricetulus griseus, Rattus norvegicus
ang, Y.; Shao, L.; Shi, S.; Harris, R.J.; Spellman, M.W.; Stanley, P.; Haltiwanger, R.S.
Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase
J. Biol. Chem.
276
40338-40345
2001
Candida elegans, Drosophila melanogaster, Mus musculus (Q91ZW2), Mus musculus, Homo sapiens (Q9H488), Homo sapiens
Wang, Y.; Spellman, M.W.
Purification and characterization of a GDP-fucose:polypeptide fucosyltransferase from Chinese hamster ovary cells
J. Biol. Chem.
273
8112-8118
1998
Cricetulus griseus
Okajima, T.; Xu, A.; Irvine, K.D.
Modulation of notch-ligand binding by protein O-fucosyltransferase 1 and fringe
J. Biol. Chem.
278
42340-42345
2003
Drosophila melanogaster
Luo, Y.; Haltiwanger, R.S.
O-fucosylation of notch occurs in the endoplasmic reticulum
J. Biol. Chem.
280
11289-11294
2005
Homo sapiens
Shi, S.; Stanley, P.
Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways
Proc. Natl. Acad. Sci. USA
100
5234-5239
2003
Mus musculus
Okajima, T.; Xu, A.; Lei, L.; Irvine, K.D.
Chaperone activity of protein O-fucosyltransferase 1 promotes notch receptor folding
Science
307
1599-1603
2005
Drosophila melanogaster
Sasamura, T.; Sasaki, N.; Miyashita, F.; Nakao, S.; Ishikawa, H.O.; Ito, M.; Kitagawa, M.; Harigaya, K.; Spana, E.; Bilder, D.; Perrimon, N.; Matsuno, K.
neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions
Development
130
4785-4795
2003
Drosophila melanogaster (Q9V6X7)
Speer, N.J.; Tang, S.J.; Miller, T.; Chiang, T.C.
Coherent electronic fringe structure in incommensurate silver-silicon quantum wells
Science
314
804-806
2006
Drosophila sp. (in: flies)
Okajima, T.; Reddy, B.; Matsuda, T.; Irvine, K.D.
Contributions of chaperone and glycosyltransferase activities of O-fucosyltransferase 1 to Notch signaling
BMC Biol.
6
1-10
2008
Drosophila melanogaster
Sasamura, T.; Ishikawa, H.O.; Sasaki, N.; Higashi, S.; Kanai, M.; Nakao, S.; Ayukawa, T.; Aigaki, T.; Noda, K.; Miyoshi, E.; Taniguchi, N.; Matsuno, K.
The O-fucosyltransferase O-fut1 is an extracellular component that is essential for the constitutive endocytic trafficking of Notch in Drosophila
Development
134
1347-1356
2007
Drosophila melanogaster
Sasaki, N.; Sasamura, T.; Ishikawa, H.O.; Kanai, M.; Ueda, R.; Saigo, K.; Matsuno, K.
Polarized exocytosis and transcytosis of Notch during its apical localization in Drosophila epithelial cells
Genes Cells
12
89-103
2007
Drosophila melanogaster
Chigira, Y.; Oka, T.; Okajima, T.; Jigami, Y.
Engineering of a mammalian O-glycosylation pathway in the yeast Saccharomyces cerevisiae: production of O-fucosylated epidermal growth factor domains
Glycobiology
18
303-314
2008
Homo sapiens
Kim, M.L.; Chandrasekharan, K.; Glass, M.; Shi, S.; Stahl, M.C.; Kaspar, B.; Stanley, P.; Martin, P.T.
O-fucosylation of muscle agrin determines its ability to cluster acetylcholine receptors
Mol. Cell. Neurosci.
39
452-464
2008
Mus musculus
Okamura, Y.; Saga, Y.
Notch signaling is required for the maintenance of enteric neural crest progenitors
Development
135
3555-3565
2008
Mus musculus
Guilmeau, S.; Flandez, M.; Bancroft, L.; Sellers, R.; Tear, B.; Stanley, P.; Augenlicht, L.
Intestinal deletion of Pofut1 in the mouse inactivates notch signaling and causes enterocolitis
Gastroenterology
135
849-860
2008
Mus musculus
Stanley, P.; Guidos, C.J.
Regulation of Notch signaling during T- and B-cell development by O-fucose glycans
Immunol. Rev.
230
201-215
2009
Cricetulus griseus, Drosophila sp. (in: flies), Mus musculus
Okajima, T.; Matsuura, A.; Matsuda, T.
Biological functions of glycosyltransferase genes involved in O-fucose glycan synthesis
J. Biochem.
144
1-6
2008
Drosophila sp. (in: flies), Mus musculus
Stahl, M.; Uemura, K.; Ge, C.; Shi, S.; Tashima, Y.; Stanley, P.
Roles of Pofut1 and O-fucose in mammalian Notch signaling
J. Biol. Chem.
283
13638-13651
2008
Cricetulus griseus, Mus musculus
Vodovar, N.; Schweisguth, F.
Functions of O-fucosyltransferase in Notch trafficking and signaling: Towards the end of a controversy?
J. Biol.
7
7-7
2008
Drosophila sp. (in: flies)
Okamura, Y.; Saga, Y.
Pofut1 is required for the proper localization of the Notch receptor during mouse development
Mech. Dev.
125
663-673
2008
Mus musculus
Yao, D.; Huang, Y.; Huang, X.; Wang, W.; Yan, Q.; Wei, L.; Xin, W.; Gerson, S.; Stanley, P.; Lowe, J.B.; Zhou, L.
Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions
Blood
117
5652-5662
2011
Mus musculus
Rana, N.A.; Haltiwanger, R.S.
Fringe benefits: functional and structural impacts of O-glycosylation on the extracellular domain of Notch receptors
Curr. Opin. Struct. Biol.
21
583-589
2011
Drosophila melanogaster, Mus musculus
Chen, C.I.; Keusch, J.J.; Klein, D.; Hess, D.; Hofsteenge, J.; Gut, H.
Structure of human POFUT2: insights into thrombospondin type 1 repeat fold and O-fucosylation
EMBO J.
31
3183-3197
2012
Homo sapiens (Q9Y2G5), Homo sapiens
Al-Shareffi, E.; Chaubard, J.L.; Leonhard-Melief, C.; Wang, S.K.; Wong, C.H.; Haltiwanger, R.S.
6-Alkynyl fucose is a bioorthogonal analog for O-fucosylation of epidermal growth factor-like repeats and thrombospondin type-1 repeats by protein O-fucosyltransferases 1 and 2
Glycobiology
23
188-198
2013
Mus musculus
Ishikawa, H.; Ayukawa, T.; Nakayama, M.; Higashi, S.; Kamiyama, S.; Nishihara, S.; Aoki, K.; Ishida, N.; Sanai, Y.; Matsuno, K.
Two pathways for importing GDP-fucose into the endoplasmic reticulum lumen function redundantly in the O-fucosylation of notch in Drosophila
J. Biol. Chem.
285
4122-4129
2010
Drosophila melanogaster
Lira-Navarrete, E.; Valero-Gonzalez, J.; Villanueva, R.; Martinez-Julvez, M.; Tejero, T.; Merino, P.; Panjikar, S.; Hurtado-Guerrero, R.
Structural insights into the mechanism of protein O-fucosylation
PLoS ONE
6
e25365
2011
Caenorhabditis elegans (Q18014)
Ma, L.; Dong, P.; Liu, L.; Gao, Q.; Duan, M.; Zhang, S.; Chen, S.; Xue, R.; Wang, X.
Overexpression of protein O-fucosyltransferase 1 accelerates hepatocellular carcinoma progression via the Notch signaling pathway
Biochem. Biophys. Res. Commun.
473
503-510
2016
Homo sapiens (Q9H488), Homo sapiens
Yokota, S.; Ogawara, K.; Kimura, R.; Shimizu, F.; Baba, T.; Minakawa, Y.; Higo, M.; Kasamatsu, A.; Endo-Sakamoto, Y.; Shiiba, M.; Tanzawa, H.; Uzawa, K.
Protein O-fucosyltransferase 1: a potential diagnostic marker and therapeutic target for human oral cancer
Int. J. Oncol.
43
1864-1870
2013
Homo sapiens (Q9H488), Homo sapiens
Der Vartanian, A.; Audfray, A.; Al Jaam, B.; Janot, M.; Legardinier, S.; Maftah, A.; Germot, A.
Protein O-fucosyltransferase 1 expression impacts myogenic C2C12 cell commitment via the Notch signaling pathway
Mol. Cell. Biol.
35
391-405
2015
Mus musculus (Q91ZW2), Mus musculus
Valero-Gonzalez, J.; Leonhard-Melief, C.; Lira-Navarrete, E.; Jimenez-Oses, G.; Hernandez-Ruiz, C.; Pallares, M.C.; Yruela, I.; Vasudevan, D.; Lostao, A.; Corzana, F.; Takeuchi, H.; Haltiwanger, R.S.; Hurtado-Guerrero, R.
A proactive role of water molecules in acceptor recognition by protein O-fucosyltransferase 2
Nat. Chem. Biol.
12
240-246
2016
Caenorhabditis elegans (Q8WR51), Caenorhabditis elegans
Lira-Navarrete, E.; Hurtado-Guerrero, R.
A perspective on structural and mechanistic aspects of protein O-fucosylation
Acta Crystallogr. Sect. F
74
443-450
2018
Caenorhabditis elegans (Q18014), Caenorhabditis elegans (Q8WR51), Mus musculus (Q91ZW2), Homo sapiens (Q9H488), Homo sapiens (Q9Y2G5)
Liu, C.; Liang, X.; Wang, J.; Zheng, Q.; Zhao, Y.; Khan, M.N.; Liu, S.; Yan, Q.
Protein O-fucosyltransferase 1 promotes trophoblast cell proliferation through activation of MAPK and PI3K/Akt signaling athways
Biomed. Pharmacother.
88
95-101
2017
Homo sapiens (Q9H488), Homo sapiens
Holdener, B.C.; Haltiwanger, R.S.
Protein O-fucosylation structure and function
Curr. Opin. Struct. Biol.
56
78-86
2019
Homo sapiens (Q9H488), Homo sapiens (Q9Y2G5)
Sanz, S.; Aquilini, E.; Tweedell, R.E.; Verma, G.; Hamerly, T.; Hritzo, B.; Tripathi, A.; Machado, M.; Churcher, T.S.; Rodrigues, J.A.; Izquierdo, L.; Dinglasan, R.R.
Protein O-fucosyltransferase 2 is not essential for Plasmodium berghei development
Front. Cell. Infect. Microbiol.
9
238
2019
Homo sapiens (Q9H488), Homo sapiens
McMillan, B.J.; Zimmerman, B.; Egan, E.D.; Lofgren, M.; Xu, X.; Hesser, A.; Blacklow, S.C.
Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations
Glycobiology
27
777-786
2017
Homo sapiens (Q9H488), Homo sapiens
Sadeghzadeh, Z.; Khosravi, A.; Jazi, M.S.; Asadi, J.
Upregulation of fucosyltransferase 3, 8 and protein O-fucosyltransferase 1, 2 genes in esophageal cancer stem-like cells (CSLCs)
Glycoconj. J.
37
319-327
2020
Homo sapiens (Q9H488), Homo sapiens (Q9Y2G5)
Khurana, S.; Coffey, M.J.; John, A.; Uboldi, A.D.; Huynh, M.H.; Stewart, R.J.; Carruthers, V.B.; Tonkin, C.J.; Goddard-Borger, E.D.; Scott, N.E.
Protein O-fucosyltransferase 2-mediated O-glycosylation of the adhesin MIC2 is dispensable for Toxoplasma gondii tachyzoite infection
J. Biol. Chem.
294
1541-1553
2019
Toxoplasma gondii (S7WCF5), Toxoplasma gondii, Toxoplasma gondii ATCC 50853 (S7WCF5)
Zentella, R.; Sui, N.; Barnhill, B.; Hsieh, W.; Hu, J.; Shabanowitz, J.; Boyce, M.; Olszewski, N.; Zhou, P.; Hunt, D.; Sun, T.
The Arabidopsis O-fucosyltransferase SPINDLY activates nuclear growth repressor della
Nat. Chem. Biol.
13
479-485
2017
Arabidopsis thaliana (Q96301), Arabidopsis thaliana
Li, Z.; Han, K.; Pak, J.E.; Satkunarajah, M.; Zhou, D.; Rini, J.M.
Recognition of EGF-like domains by the Notch-modifying O-fucosyltransferase POFUT1
Nat. Chem. Biol.
13
757-763
2017
Mus musculus (Q91ZW2), Mus musculus
Lopaticki, S.; Yang, A.S.P.; John, A.; Scott, N.E.; Lingford, J.P.; ONeill, M.T.; Erickson, S.M.; McKenzie, N.C.; Jennison, C.; Whitehead, L.W.; Douglas, D.N.; Kneteman, N.M.; Goddard-Borger, E.D.; Boddey, J.A.
Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts
Nat. Commun.
8
561
2017
Plasmodium falciparum (Q8I360), Plasmodium falciparum
Smith, D.; Harper, J.; Wallace, I.
A potential role for protein O-fucosylation during pollen-pistil interactions
Plant Signal. Behav.
13
e1467687
2018
Arabidopsis thaliana (Q9MA87), Arabidopsis thaliana
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