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IUBMB Comments Involved in the biosynthesis of common antigen in Enterobacteriaceae .
Synonyms
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ManNAcA transferase
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teichuronic acid synthetase
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uridine diphosphoacetylmannosaminuronate-acetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminuronosyltransferase
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UDP-N-acetyl-alpha-D-mannosaminouronate + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = UDP + N-acetyl-beta-D-mannosaminouronyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
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hexosyl group transfer
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MetaCyc
enterobacterial common antigen biosynthesis
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UDP-N-acetyl-beta-D-mannosaminouronate:lipid I N-acetyl-beta-D-mannosaminouronosyltransferase
Involved in the biosynthesis of common antigen in Enterobacteriaceae.
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UDP-N-acetyl-alpha-D-mannosaminuronate + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
UDP + N-acetyl-beta-D-mannosaminuronyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
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Substrates: -
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UDP-N-acetyl-D-mannosaminuronic acid + N-acetyl-D-glucosamine-diphosphorylundecaprenol + 2 H+
UDP + ManNAcA-GlcNAc-diphosphorylundecaprenol + H2O
additional information
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UDP-N-acetyl-D-mannosaminuronic acid + N-acetyl-D-glucosamine-diphosphorylundecaprenol + 2 H+
UDP + ManNAcA-GlcNAc-diphosphorylundecaprenol + H2O
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Substrates: i.e. lipid I
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UDP-N-acetyl-D-mannosaminuronic acid + N-acetyl-D-glucosamine-diphosphorylundecaprenol + 2 H+
UDP + ManNAcA-GlcNAc-diphosphorylundecaprenol + H2O
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Substrates: i.e. lipid I
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UDP-N-acetyl-D-mannosaminuronic acid + N-acetyl-D-glucosamine-diphosphorylundecaprenol + 2 H+
UDP + ManNAcA-GlcNAc-diphosphorylundecaprenol + H2O
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Substrates: i.e. lipid I
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additional information
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Substrates: involved in the biosynthesis of common antigen in Enterobacteriaceae
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additional information
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Substrates: involved in the biosynthesis of common antigen in Enterobacteriaceae
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UDP-N-acetyl-D-mannosaminuronic acid + N-acetyl-D-glucosamine-diphosphorylundecaprenol + 2 H+
UDP + ManNAcA-GlcNAc-diphosphorylundecaprenol + H2O
additional information
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UDP-N-acetyl-D-mannosaminuronic acid + N-acetyl-D-glucosamine-diphosphorylundecaprenol + 2 H+
UDP + ManNAcA-GlcNAc-diphosphorylundecaprenol + H2O
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Substrates: i.e. lipid I
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UDP-N-acetyl-D-mannosaminuronic acid + N-acetyl-D-glucosamine-diphosphorylundecaprenol + 2 H+
UDP + ManNAcA-GlcNAc-diphosphorylundecaprenol + H2O
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Substrates: i.e. lipid I
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UDP-N-acetyl-D-mannosaminuronic acid + N-acetyl-D-glucosamine-diphosphorylundecaprenol + 2 H+
UDP + ManNAcA-GlcNAc-diphosphorylundecaprenol + H2O
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Substrates: i.e. lipid I
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additional information
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Substrates: involved in the biosynthesis of common antigen in Enterobacteriaceae
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additional information
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Substrates: involved in the biosynthesis of common antigen in Enterobacteriaceae
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TUAS embedded in the cell wall, pH 8.2, 25°C
8.7
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TUAS embedded in the vesicle membrane, pH 8.2, 25°C
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F1467, lacking enzyme activity and 21259, wild-type
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PR122
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PR122
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Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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additional information
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the 440 kDa enzyme complex, named teichuronic acid synthetase, TUAS, is an octomer composed of two kinds of glycosyltransferases, glucosyltransferase, and ManNAcA-transferase, which is capable of catalyzing the transfer of disaccharide glycosyl residues containing both glucose and the N-acetylmannosaminuronic acid residues. TUAS is a bifunctional glycosyltransferase capable of transferring both the component sugars, glucose and ManNAcA, for the TUA polymer. The purified TUAS contains carotinoids and lipids. TUAS serves as a multitasking polysaccharide assembling station on the bacterial membrane
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52500
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4 * 54000 + 4 * 52500, TUAS complex, SDS-PAGE
54000
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4 * 54000 + 4 * 52500, TUAS complex, SDS-PAGE
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octamer
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4 * 54000 + 4 * 52500, TUAS complex, SDS-PAGE
additional information
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when the eight subunits disassociate, the protein loses its conformation as well as the catalytic function for TUA biosynthesis
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native TUAS complex partially by fractionation of Thesit-solubilized membrane fraction with ammonium sulfate
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transfection of wild-type enzyme code to mutant
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Barr, K.; Ward, S.; Meier-Dieter, U.; Mayer, H.; Rick, P.D.
Characterization of an Escherichia coli rff mutant defective in transfer of N-acetylmannosaminuronic acid (ManNAcA) from UDP-ManNAcA to a lipid-linked intermediate involved in enterobacterial common antigen synthesis
J. Bacteriol.
170
228-233
1988
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium PR122
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Deng, L.L.; Alexander, A.A.; Lei, S.; Anderson, J.S.
The cell wall teichuronic acid synthetase (TUAS) is an enzyme complex located in the cytoplasmic membrane of Micrococcus luteus
Biochem. Res. Int.
2010
395758
2010
Micrococcus luteus
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