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Information on EC 2.4.1.148 - acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
for references in articles please use BRENDA:EC2.4.1.148
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EC Tree 2 Transferases
2.4 Glycosyltransferases
2.4.1 Hexosyltransferases
2.4.1.148 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
IUBMB Comments
cf. EC 2.4.1.102 (β-1,3-galactosyl-O-glycosyl-glycoprotein β-1,6-N-acetylglucosaminyltransferase), EC 2.4.1.146 (β-1,3-galactosyl-O-glycosyl-glycoprotein β-1,3-N-acetylglucosaminyltransferase) and EC 2.4.1.147 (acetylgalactosaminyl-O-glycosyl-glycoprotein β-1,3-N-acetylglucosaminyltransferase).
The enzyme appears in viruses and cellular organisms
Reaction Schemes
showSynonyms
c2gnt-2, leukocyte-type core 2 beta1,6-n-acetylglucosaminyltransferase, core 2 beta 1,6 n-acetylglucosaminyltransferase, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-mucin beta(1-->6)-, B
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C2GnT
c2GnT-M
C2GnT2
core 2 N-acetylglucosaminyltransferase-M
core 4 beta6-GalNAc-transferase
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core 6beta-GalNAc-transferase B
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O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV
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uridine diphosphoacetylglucosamine-mucin beta(1-->6)-acetylglucosaminyltransferase B
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additional information
additional information
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the enzyme belongs to the mucin beta6-N-acetylglucosaminyltransferase family
additional information
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the enzyme is a member of the beta-1,6-N-acetylglucosaminyltransferase gene family
additional information
core 2 beta6-GalNAc-transferase, EC 2.4.1.102, exists in 2 types, type L and type M, the latter shows an additional core 4 beta6-GalNAc transferase activity
additional information
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core 2 beta6-GalNAc-transferase, EC 2.4.1.102, exists in 2 types, type L and type M, the latter shows an additional core 4 beta6-GalNAc transferase activity
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->6)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-N-acetyl-D-galactosaminyl-R
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->6)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-N-acetyl-D-galactosaminyl-R
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UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->6)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-N-acetyl-D-galactosaminyl-R
the cystine pair pattern influences the substrate specificity of the enzyme, comparison to the enzyme from mouse
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hexosyl group transfer
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PATHWAY SOURCE
PATHWAYS
MetaCyc
mucin core 3 and core 4 O-glycosylation
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SYSTEMATIC NAME
IUBMB Comments
UDP-N-acetyl-D-glucosamine:N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-D-galactosaminyl-R 6-beta-N-acetyl-D-glucosaminyltransferase
cf. EC 2.4.1.102 (beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase), EC 2.4.1.146 (beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase) and EC 2.4.1.147 (acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase).
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CAS REGISTRY NUMBER
COMMENTARY
87927-98-8
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95978-15-7
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-N-acetyl-alpha-D-glucosamine + N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-Ser/Thr
UDP + N-acetyl-beta-D-glucosaminyl-(1->6)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-N-acetyl-alpha-D-galactosaminyl-Ser/Thr
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Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + blood group i oligosaccharide
UDP + N-acetyl-beta-D-glucosaminyl-1,6-blood group i oligosaccharide
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Substrates: I branching activity
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-benzyl
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-p-nitrophenol
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-p-nitrophenol
Substrates: recombinant chimeric soluble enzyme
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-phenyl
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-phenyl
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-R
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-4-nitrophenyl
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-galactosaminyl-4-nitrophenyl
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Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-galactosaminyl-R
UDP-N-acetyl-D-glucosamine + core 1 oligosaccharide
UDP + core 2 oligosaccharide
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Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + core 1 oligosaccharide
UDP + core 2 oligosaccharide
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Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + core 1 oligosaccharide
UDP + core 2 oligosaccharide
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Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + core 3 oligosaccharide
UDP + core 4 oligosaccharide
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Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + core 3 oligosaccharide
UDP + core 4 oligosaccharide
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Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + core 3 oligosaccharide
UDP + core 4 oligosaccharide
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-benzyl
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Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-benzyl
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Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-benzyl
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Substrates: no activity
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-benzyl
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Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-benzyl
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Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-benzyl
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-benzyl
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-phenyl
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-phenyl
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Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-phenyl
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-phenyl
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-phenyl
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-phenyl
-
Substrates: no activity
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-phenyl
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-phenyl
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-phenyl
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-phenyl
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-phenyl
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-phenyl
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-phenyl
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-phenyl
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-R
-
Substrates: involved in mucin oligosaccharide biosynthesis
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-R
-
Substrates: involved in mucin oligosaccharide biosynthesis
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-R
-
Substrates: involved in mucin oligosaccharide biosynthesis
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-R
-
Substrates: involved in mucin oligosaccharide biosynthesis
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-R
-
Substrates: involved in mucin oligosaccharide biosynthesis
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-R
-
Substrates: involved in mucin oligosaccharide biosynthesis
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
Substrates: enzyme shows both core 2 beta6-GalNAc-transferase activity, EC 2.4.1.102, and core 4 beta6-GalNAc-transferase activity, EC 2.4.1.148, and is termed a type M core 2 beta6-GalNAc-transferase
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
Substrates: i.e. core 3
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
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Substrates: R: polypeptide derived from mucin
Products: i.e. core 4
Products: i.e. core 4
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
-
Substrates: i.e. core 3
Products: i.e. core 4
Products: i.e. core 4
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
-
Substrates: R is not H
Products: i.e. core 4
Products: i.e. core 4
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
-
Substrates: R: polypeptide derived from mucin
Products: i.e. core 4
Products: i.e. core 4
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
-
Substrates: i.e. core 3
Products: i.e. core 4
Products: i.e. core 4
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
-
Substrates: R is not H
Products: i.e. core 4
Products: i.e. core 4
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
-
Substrates: i.e. core 3
Products: i.e. core 4
Products: i.e. core 4
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
-
Substrates: very low activity, recombinant L-type core 2 beta6-N-acetylglucosaminyltransferase, EC 2.4.1.102, also shows minor core 4 beta6-GalNAc-transferase activity
Products: i.e. core 4
Products: i.e. core 4
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
-
Substrates: R: polypeptide derived from mucin
Products: i.e. core 4
Products: i.e. core 4
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
-
Substrates: i.e. core 3
Products: i.e. core 4
Products: i.e. core 4
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
-
Substrates: R is not H
Products: i.e. core 4
Products: i.e. core 4
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
-
Substrates: R: polypeptide derived from mucin
Products: i.e. core 4
Products: i.e. core 4
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
-
Substrates: i.e. core 3
Products: i.e. core 4
Products: i.e. core 4
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
-
Substrates: R is not H
Products: i.e. core 4
Products: i.e. core 4
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
-
Substrates: R: polypeptide derived from mucin
Products: i.e. core 4
Products: i.e. core 4
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
-
Substrates: i.e. core 3
Products: i.e. core 4
Products: i.e. core 4
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
-
Substrates: R is not H
Products: i.e. core 4
Products: i.e. core 4
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
-
Substrates: R: polypeptide derived from mucin
Products: i.e. core 4
Products: i.e. core 4
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
-
Substrates: i.e. core 3
Products: i.e. core 4
Products: i.e. core 4
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-alpha-galactosaminyl-R
-
Substrates: R is not H
Products: i.e. core 4
Products: i.e. core 4
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-galactosaminyl-R
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-galactosaminyl-R
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-galactosaminyl-R
-
Substrates: -
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme catalyzes the formation of all mucin beta1,6-N-acetylglucosaminides, including core 2, core 4, and blood group I structures
Products: -
Products: -
?
additional information
?
-
-
Substrates: substrate specificities of wild-type and mutant enzyme, overview
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme is not essential for virus replication in vitro, but contributes to posttranslational modifications of structural proteins
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme is involved in the mucin biosynthesis
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme is involved in the glycosylation process of oviductal proteins, O-glycanbiosynthetic pathway overview
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-N-acetyl-alpha-D-glucosamine + N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-Ser/Thr
UDP + N-acetyl-beta-D-glucosaminyl-(1->6)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-N-acetyl-alpha-D-galactosaminyl-Ser/Thr
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + core 1 oligosaccharide
UDP + core 2 oligosaccharide
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + core 3 oligosaccharide
UDP + core 4 oligosaccharide
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-R
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-galactosaminyl-R
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-R
-
Substrates: involved in mucin oligosaccharide biosynthesis
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-R
-
Substrates: involved in mucin oligosaccharide biosynthesis
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-R
-
Substrates: involved in mucin oligosaccharide biosynthesis
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-R
-
Substrates: involved in mucin oligosaccharide biosynthesis
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-R
-
Substrates: involved in mucin oligosaccharide biosynthesis
Products: -
Products: -
?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-alpha-D-galactosaminyl-R
-
Substrates: involved in mucin oligosaccharide biosynthesis
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme catalyzes the formation of all mucin beta1,6-N-acetylglucosaminides, including core 2, core 4, and blood group I structures
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme is involved in the mucin biosynthesis
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme is involved in the glycosylation process of oviductal proteins, O-glycanbiosynthetic pathway overview
Products: -
Products: -
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
interleukin-4
-
synergistic with retinoic acid in activating the core 4 N-acetylglucosaminyltransferase activity
-
retinoic acid
-
upregulation of enzyme expression, synergistic with interleukin-4 in activating the core 4 N-acetylglucosaminyltransferase activity
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
2.8
UDP-N-acetyl-D-glucosamine
-
mutant enzyme C217S, in 50 mM Tris (pH 7.5), at 37°C
0.6
N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-alpha-benzyl
-
colon
1.8
N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-alpha-benzyl
-
stomach
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
0.00016
0.00026
-
enzyme activity in oviduct homogenate, substrate core 1 oligosaccharide, also including C2GnT1 activity
0.00016
-
enzyme activity in oviduct homogenate, substrate core 3 oligosaccharide
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6.5
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
37
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
isoform C2GnT2 is highly expressed mainly in the stomach and the colon
brenda
-
isoform C2GnT3 is highly expressed mainly in the small intestine, liver and spleen
brenda
-
enzyme activity is regulated during estrous cycle, overview
brenda
-
the enzyme forms complexes with NMIIA in Panc1-bC2GnT-M (c-Myc) cells
brenda
-
isoform C2GnT3 is highly expressed mainly in the small intestine, liver and spleen
brenda
additional information
-
isoform C2GnT3 is highly expressed mainly in the small intestine, liver and spleen
brenda
-
isoform C2GnT2 is highly expressed mainly in the stomach and the colon
brenda
additional information
-
isoform C2GnT1 is widely expressed in most tissues
brenda
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
-
the triple knockout mice lack the ability to synthesize all three known isoforms of core 2 beta1,6-N-acetylglucosaminyltransferase. This multiple deficiency causes a complete absence of core 2 O-glycans in the colon
physiological function
physiological function
-
enzyme expressing tumor are more resistant to natural killer cell cytotoxicity than tumor cells with reduced enzyme expression
physiological function
-
the enzyme synthesizes all three beta6GlcNAc branch structures found in secreted mucins
Show AA Sequence and Transmembrane Helices (862 entries)
Please use the AA Sequence and Transmembrane Helices Search for a specific query.
Please use the AA Sequence and Transmembrane Helices Search for a specific query.
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
the enzyme possesses 9 cysteine residues, 8 of which forming disulfide bonds, Cys113 remains free, determination in the recombinant enzyme, overview
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POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
mutant enzyme C217S in complex with UDP, hanging drop vapor diffusion method, using 24% (w/v) polyethylene glycol 4000, 0.1 M glycine (pH 9.0) and 0.6 M LiCl
-
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
C217S
-
the mutant is not oxidatively inactivated, and its kinetic parameters are very similar to those of the native enzyme
additional information
-
construction of an enzyme-deletion mutant strain, the deletion does not alter the virus replication in vitro
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant enzyme from CHO cell culture medium by nickel affinity chromatography
-
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
functional expression in CHO cells, soluble chimeric enzyme form shows core 4 6beta-GalNAc transferase activity, DNA and amino acid sequence determination
phylogenetic analysis, the gene Bo17, encoding the enzyme, is acquired from an ancestor of the African buffalo 1.5 million years ago
-
stable expression of the enzyme, lacking the cytoplasmic tail and the transmembrane domain, in CHO cells, secretion of the fully active recombinant enzyme to the culture medium
-
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
medicine
-
the expression of the enzyme in bladder tumors positively correlates with tumor progression
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schachter, H.; Brockhausen, I.; Hull, E.
High-performance liquid chromatography assays for N-acetylglucosaminyltransferases involved in N- and O-glycan synthesis
Methods Enzymol.
179
351-397
1989
Canis lupus familiaris, Homo sapiens, Ovis aries, Platyrrhini, Rattus norvegicus, Sus scrofa
brenda
Brockhausen, I.; Rachaman, E.S.; Matta, K.L.; Schachter, H.
The separation by liquid chromatography (under elevated pressure) of phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides. Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis
Carbohydr. Res.
120
3-16
1983
Rattus norvegicus
brenda
Brockhausen, I.; Matta, K.L.; Orr, J.; Schachter, H.
Mucin synthesis. UDP-GlcNAc:GalNAc-R beta 3-N-acetylglucosaminyltransferase and UDP-GlcNAc:GlcNAc beta 1-3GalNAc-R (GlcNAc to GalNAc) beta 6-N-acetylglucosaminyltransferase from pig and rat colon mucosa
Biochemistry
24
1866-1874
1985
Canis lupus familiaris, Homo sapiens, Ovis aries, Platyrrhini, Rattus norvegicus, Sus scrofa
brenda
Zeng, S.; Dinter, A.; Eisenkratzer, D.; Biselli, M.; Wandrey, C.; Berger, E.G.
Pilot scale expression and purification of soluble protein A tagged beta1,6N-acetylglucosaminyltransferase in CHO cells
Biochem. Biophys. Res. Commun.
237
653-658
1997
Mus musculus
brenda
Vanderplasschen, A.; Markine-Goriaynoff, N.; Lomonte, P.; Suzuki, M.; Hiraoka, N.; Yeh, J.C.; Bureau, F.; Willems, L.; Thiry, E.; Fukuda, M.; Pastoret, P.P.
A multipotential beta-1,6-N-acetylglucosaminyltransferase is encoded by bovine herpesvirus type 4
Proc. Natl. Acad. Sci. USA
97
5756-5761
2000
Bovine gammaherpesvirus 4 (Q9IZK2)
brenda
Beum, P.V.; Basma, H.; Bastola, D.R.; Cheng, P.W.
Mucin biosynthesis: upregulation of core 2 beta 1,6 N-acetylglucosaminyltransferase by retinoic acid and Th2 cytokines in a human airway epithelial cell line
Am. J. Physiol.
288
L116-124
2005
Homo sapiens
brenda
Singh, J.; Khan, G.A.; Kinarsky, L.; Cheng, H.; Wilken, J.; Choi, K.H.; Bedows, E.; Sherman, S.; Cheng, P.W.
Identification of disulfide bonds among the nine core 2 N-acetylglucosaminyltransferase-M cysteines conserved in the mucin beta6-N-acetylglucosaminyltransferase family
J. Biol. Chem.
279
38969-38977
2004
Bos taurus
brenda
McBride, D.S.; Brockhausen, I.; Kan, F.W.K.
Detection of glycosyltransferases in the golden hamster (Mesocricetus auratus) oviduct and evidence for the regulation of O-glycan biosynthesis during the estrous cycle
Biochim. Biophys. Acta
1721
107-115
2005
Mesocricetus auratus
brenda
Markine-Goriaynoff, N.; Gillet, L.; Karlsen, O.A.; Haarr, L.; Minner, F.; Pastoret, P.P.; Fukuda, M.; Vanderplasschen, A.
The core 2 beta-1,6-N-acetylglucosaminyltransferase-M encoded by bovine herpesvirus 4 is not essential for virus replication despite contributing to post-translational modifications of structural proteins
J. Gen. Virol.
85
355-367
2004
Bovine gammaherpesvirus 4
brenda
Ismail, M.N.; Stone, E.L.; Panico, M.; Lee, S.H.; Luu, Y.; Ramirez, K.; Ho, S.B.; Fukuda, M.; Marth, J.D.; Haslam, S.M.; Dell, A.
High-sensitivity O-glycomic analysis of mice deficient in core 2 beta1,6-N-acetylglucosaminyltransferases
Glycobiology
21
82-98
2011
Mus musculus
brenda
Petrosyan, A.; Ali, M.F.; Verma, S.K.; Cheng, H.; Cheng, P.W.
Non-muscle myosin IIA transports a Golgi glycosyltransferase to the endoplasmic reticulum by binding to its cytoplasmic tail
Int. J. Biochem. Cell Biol.
44
1153-1165
2012
Homo sapiens
brenda
Suzuki, Y.; Sutoh, M.; Hatakeyama, S.; Mori, K.; Yamamoto, H.; Koie, T.; Saitoh, H.; Yamaya, K.; Funyu, T.; Habuchi, T.; Arai, Y.; Fukuda, M.; Ohyama, C.; Tsuboi, S.
MUC1 carrying core 2 O-glycans functions as a molecular shield against NK cell attack, promoting bladder tumor metastasis
Int. J. Oncol.
40
1831-1838
2012
Homo sapiens
brenda
Pak, J.E.; Satkunarajah, M.; Seetharaman, J.; Rini, J.M.
Structural and mechanistic characterization of leukocyte-type core 2 ?1,6-N-acetylglucosaminyltransferase: a metal-ion-independent GT-A glycosyltransferase
J. Mol. Biol.
414
798-811
2011
Mus musculus
brenda
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