Reference on EC 2.4.1.135 - galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Helting, T.; Roden, L.
Biosynthesis of chondroitin sulfate. II. Glucuronosyl transfer in the formation of the carbohydrate-protein linkage region
J. Biol. Chem.
244
2799-2805
1969
Gallus gallus
Helting, T.
Biosynthesis of heparin. Solubilization and partial purification of uridine diphosphate glucuronic acid: acceptor glucuronosyltransferase from mouse mastocytoma
J. Biol. Chem.
247
4327-4332
1972
Mus musculus
Pedersen, L.C.; Darden, T.A.; Negishi, M.
Crystal structure of beta 1,3-glucuronyltransferase I in complex with active donor substrate UDP-GlcUA
J. Biol. Chem.
277
21869-21873
2002
Homo sapiens
Tone, Y.; Kitagawa, H.; Imiya, K.; Oka, S.; Kawasaki, T.; Sugahara, K.
Characterization of recombinant human glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans
FEBS Lett.
459
415-420
1999
Homo sapiens
Pedersen, L.C.; Tsuchida, K.; Kitagawa, H.; Sugahara, K.; Darden, T.A.; Negishi, M.
Heparan/chondroitin sulfate biosynthesis. Structure and mechanism of human glucuronyltransferase I
J. Biol. Chem.
275
34580-34585
2000
Homo sapiens
Ouzzine, M.; Gulberti, S.; Netter, P.; Magdalou, J.; Fournel-Gigleux, S.
Structure/function of the human Ga1beta1,3-glucuronosyltransferase. Dimerization and functional activity are mediated by two crucial cysteine residues
J. Biol. Chem.
275
28254-28260
2000
Homo sapiens
Kitagawa, H.; Tone, Y.; Tamura, J.; Neumann, K.W.; Ogawa, T.; Oka, S.; Kawasaki, T.; Sugahara, K.
Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans
J. Biol. Chem.
273
6615-6618
1998
Homo sapiens (O94766), Homo sapiens
Bai, X.; Wei, G.; Sinha, A.; Esko, J.D.
Chinese hamster ovary cell mutants defective in glycosaminoglycan assembly and glucuronosyltransferase I
J. Biol. Chem.
274
13017-13024
1999
Cricetulus griseus
Negishi, M.; Dong, J.; Darden, T.A.; Pedersen, L.G.; Pedersen, L.C.
Glucosaminylglycan biosynthesis: what we can learn from the X-ray crystal structures of glycosyltransferases GlcAT1 and EXTL2
Biochem. Biophys. Res. Commun.
303
393-398
2003
Homo sapiens
Kitagawa, H.; Taoka, M.; Tone, Y.; Sugahara, K.
Human glycosaminoglycan glucuronyltransferase I gene and a related processed pseudogene: genomic structure, chromosomal mapping and characterization
Biochem. J.
358
539-546
2001
Homo sapiens (Q9P2W7), Homo sapiens
Wei, G.; Bai, X.; Sarkar, A.K.; Esko, J.D.
Formation of HNK-1 determinants and the glycosaminoglycan tetrasaccharide linkage region by UDP-GlcUA:galactose beta1,3-glucuronosyltransferases
J. Biol. Chem.
274
7857-7864
1999
Cricetulus griseus (Q9WU47), Cricetulus griseus
Ouzzine, M.; Gulberti, S.; Levoin, N.; Netter, P.; Magdalou, J.; Fournel-Gigleux, S.
The donor substrate specificity of the human beta1,3-glucuronosyltransferase I toward UDP-glucuronic acid is determined by two crucial histidine and arginine residues
J. Biol. Chem.
277
25439-25445
2002
Homo sapiens (Q9P2W7), Homo sapiens
Gulberti, S.; Fournel-Gigleux, S.; Mulliert, G.; Aubry, A.; Netter, P.; Magdalou, J.; Ouzzine, M.
The functional glycosyltransferase signature sequence of the human beta 1,3-glucuronosyltransferase is a XDD motif
J. Biol. Chem.
278
32219-32226
2003
Homo sapiens (Q9P2W7), Homo sapiens
Wei, G.; Bai, X.; Esko, J.D.
Temperature-sensitive glycosaminoglycan biosynthesis in a Chinese hamster ovary cell mutant containing a point mutation in glucuronyltransferase I
J. Biol. Chem.
279
5693-5698
2004
Cricetulus griseus
Gulberti, S.; Lattard, V.; Fondeur, M.; Jacquinet, J.C.; Mulliert, G.; Netter, P.; Magdalou, J.; Ouzzine, M.; Fournel-Gigleux, S.
Phosphorylation and sulfation of oligosaccharide substrates critically influence the activity of human beta1,4-galactosyltransferase 7 (GalT-I) and beta1,3-glucuronosyltransferase I (GlcAT-I) involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans
J. Biol. Chem.
280
1417-1425
2005
Homo sapiens (O94766), Homo sapiens
Lattard, V.; Fondeur-Gelinotte, M.; Gulberti, S.; Jacquinet, J.C.; Boudrant, J.; Netter, P.; Magdalou, J.; Ouzzine, M.; Fournel-Gigleux, S.
Purification and characterization of a soluble form of the recombinant human galactose-beta1,3-glucuronosyltransferase I expressed in the yeast Pichia pastoris
Protein Expr. Purif.
47
137-143
2006
Homo sapiens
Fondeur-Gelinotte, M.; Lattard, V.; Oriol, R.; Mollicone, R.; Jacquinet, J.C.; Mulliert, G.; Gulberti, S.; Netter, P.; Magdalou, J.; Ouzzine, M.; Fournel-Gigleux, S.
Phylogenetic and mutational analyses reveal key residues for UDP-glucuronic acid binding and activity of beta1,3-glucuronosyltransferase I (GlcAT-I)
Protein Sci.
15
1667-1678
2006
Homo sapiens
Tone, Y.; Pedersen, L.C.; Yamamoto, T.; Izumikawa, T.; Kitagawa, H.; Nishihara, J.; Tamura, J.; Negishi, M.; Sugahara, K.
2-o-phosphorylation of xylose and 6-o-sulfation of galactose in the protein linkage region of glycosaminoglycans influence the glucuronyltransferase-I activity involved in the linkage region synthesis
J. Biol. Chem.
283
16801-16807
2008
Homo sapiens
Hiyama, A.; Gajghate, S.; Sakai, D.; Mochida, J.; Shapiro, I.M.; Risbud, M.V.
Activation of TonEBP by calcium controls beta1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc
J. Biol. Chem.
284
9824-9834
2009
Rattus norvegicus
Hiyama, A.; Gogate, S.S.; Gajghate, S.; Mochida, J.; Shapiro, I.M.; Risbud, M.V.
BMP-2 and TGFbeta stimulate expression of beta1,3 glucuronosyl transferase-I (GlcAT-I) in nucleus pulposus cells through AP1, TonEBP and Sp1: Role of Map kinases
J. Bone Miner. Res.
25
1179-1190
2010
Rattus norvegicus
Venkatesan, N.; Ouzzine, M.; Kolb, M.; Netter, P.; Ludwig, M.S.
Increased deposition of chondroitin/dermatan sulfate glycosaminoglycan and upregulation of beta1,3-glucuronosyltransferase I in pulmonary fibrosis
Am. J. Physiol. Lung Cell Mol. Physiol.
300
L191-L203
2011
Rattus norvegicus
Gogate, S.S.; Nasser, R.; Shapiro, I.M.; Risbud, M.V.
Hypoxic regulation of beta-1,3-glucuronyltransferase 1 expression in nucleus pulposus cells of the rat intervertebral disc: role of hypoxia-inducible factor proteins
Arthritis Rheum.
63
1950-1960
2011
Rattus norvegicus
Mikami, Y.; Fukushima, A.; Kuwada-Kusunose, T.; Sakurai, T.; Kitano, T.; Komiyama, Y.; Iwase, T.; Komiyama, K.
Whole transcriptome analysis using next-generation sequencing of sterile-cultured Eisenia andrei for immune system research
PLoS ONE
10
e0118587
2015
Eisenia andrei
Itoh, K.; Akimoto, Y.; Kondo, S.; Ichimiya, T.; Aoki, K.; Tiemeyer, M.; Nishihara, S.
Glucuronylated core 1 glycans are required for precise localization of neuromuscular junctions and normal formation of basement membranes on Drosophila muscles
Dev. Biol.
436
108-124
2018
Drosophila melanogaster (M9NE76)
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