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Information on EC 2.4.1.129 - peptidoglycan glycosyltransferase
for references in articles please use BRENDA:EC2.4.1.129
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transferred to Ec 2.4.99.28, peptidoglycan glycosyltransferase
EC Tree 2 Transferases
2.4 Glycosyltransferases
2.4.1 Hexosyltransferases
2.4.1.129 peptidoglycan glycosyltransferase
IUBMB Comments
The enzyme also works when the lysine residue is replaced by meso-2,6-diaminoheptanedioate (meso-2,6-diaminopimelate, A2pm) combined with adjacent residues through its L-centre, as it is in Gram-negative and some Gram-positive organisms. The undecaprenol involved is ditrans,octacis-undecaprenol (for definitions, click here). Involved in the synthesis of cell-wall peptidoglycan.
Synonyms
pbp2a, pbp2b, penicillin binding protein, gtase, penicillin-binding protein 3, penicillin-binding protein 2, pbp 2b, pbp 1a, pbp 2x, spoiid, more
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PATHWAY SOURCE 
PATHWAYS
BRENDA
MetaCyc
peptidoglycan biosynthesis I (meso-diaminopimelate containing), peptidoglycan biosynthesis II (staphylococci), peptidoglycan biosynthesis III (mycobacteria), peptidoglycan biosynthesis IV (Enterococcus faecium), peptidoglycan biosynthesis V (beta-lactam resistance), peptidoglycan maturation (meso-diaminopimelate containing)
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abscess
PBP-2 Negative Methicillin Resistant Staphylococcus schleiferi Bacteremia from a Prostate Abscess: An Unusual Occurrence.
Adenocarcinoma
Gamma glutamyl transpeptidase in colon cancer induced by 1,2-dimethylhydrazine.
Arthritis
Tissue-specific galactosyltransferase abnormalities in an experimental model of rheumatoid arthritis.
Arthritis, Rheumatoid
Tissue-specific galactosyltransferase abnormalities in an experimental model of rheumatoid arthritis.
Bacteremia
Identification of a patient with Streptococcus pneumoniae bacteremia and meningitis by the polymerase chain reaction (PCR).
Bacteremia
PBP-2 Negative Methicillin Resistant Staphylococcus schleiferi Bacteremia from a Prostate Abscess: An Unusual Occurrence.
Blister
The gastroprotective potential of silibinin against Helicobacter pylori infection and gastric tumor cells.
Carcinogenesis
Glutathione and gamma glutamyl transpeptidase in rat liver during chemical carcinogenesis.
Carcinoma, Hepatocellular
Glutathione and gamma glutamyl transpeptidase in rat liver during chemical carcinogenesis.
Colonic Neoplasms
Gamma glutamyl transpeptidase in colon cancer induced by 1,2-dimethylhydrazine.
Communicable Diseases
Alterations of pbp1a, pbp2b, and pbp2x in Streptococcus pneumoniae isolates from children with otolaryngological infectious disease in the Sapporo district of Japan.
Communicable Diseases
Computational studies of bacterial resistance to ?-lactam antibiotics: mechanism of covalent inhibition of the penicillin-binding protein 2a (PBP2a).
Cystic Fibrosis
Penicillin binding protein 3 is a common adaptive target among Pseudomonas aeruginosa isolates from adult cystic fibrosis patients treated with ?-lactams.
Cystitis
Morphological studies of Escherichia coli in the urine of patients with acute simple cystitis treated with aztreonam.
Dental Caries
Oral passive immunization against dental caries in rats by use of hen egg yolk antibodies specific for cell-associated glucosyltransferase of Streptococcus mutans.
Empyema
Identifying pneumococci in parapneumonic pleural effusion: Is there a role for culture-independent methods?
Gastritis, Atrophic
Prevalence of atrophic gastritis in southwest China and predictive strength of serum gastrin-17: A cross-sectional study (SIGES).
Hypersensitivity
The highly conserved serine threonine kinase StkP of Streptococcus pneumoniae contributes to penicillin susceptibility independently from genes encoding penicillin-binding proteins.
Infections
Bacteremia due to Staphylococcus aureus with reduced susceptibility to vancomycin.
Infections
Binding of ceftaroline to penicillin-binding proteins of Staphylococcus aureus and Streptococcus pneumoniae.
Infections
Clinical isolates of Staphylococcus intermedius masquerading as methicillin-resistant Staphylococcus aureus.
Infections
Computer aided screening and evaluation of herbal therapeutics against MRSA infections.
Infections
Crystal structures of penicillin-binding protein 2 from penicillin-susceptible and -resistant strains of Neisseria gonorrhoeae reveal an unexpectedly subtle mechanism for antibiotic resistance.
Infections
Determinants of plasma pepsinogen levels in a population at high risk for stomach cancer in Venezuela.
Infections
Expression of the Escherichia coli cell division gene sep cloned in a lambda Charon phage.
Infections
Identification of the Putative Specific Pathogenic Genes of Porphyromonas gingivalis with Type II Fimbriae.
Infections
Improved Performance of a Rapid Immunochromatographic Assay for the Detection of PBP2a in non-Staphylococcus aureus Staphylococcal Species.
Infections
Integrating a Rapid Diagnostic Test and Antimicrobial Stewardship: Optimizing Discharge Antibiotics in Skin and Soft Tissue Infections.
Infections
LB11058, a new cephalosporin with high penicillin-binding protein 2a affinity and activity in experimental endocarditis due to homogeneously methicillin-resistant Staphylococcus aureus.
Infections
Old Drugs To Treat Resistant Bugs: Methicillin-Resistant Staphylococcus aureus Isolates with mecC Are Susceptible to a Combination of Penicillin and Clavulanic Acid.
Infections
Pepsinogen-II 100 bp ins/del gene polymorphism and its elevated circulating levels are associated with gastric cancer, particularly with Helicobacter pylori infection and intestinal metaplasia.
Infections
Quercetin 3-O-rutinoside mediated inhibition of PBP2a: computational and experimental evidence to its anti-MRSA activity.
Infections
Recombinant PBP2a as a vaccine candidate against methicillin-resistant Staphylococcus aureus: Immunogenicity and protectivity.
Infections
Relationship Between Different Resistance Mechanisms and Virulence in Acinetobacter baumannii.
Infections
Respiratory syncytial virus increases the virulence of Streptococcus pneumoniae by binding to penicillin binding protein 1a. A new paradigm in respiratory infection.
Infections
Single dose 1 g ceftriaxone for urogenital and pharyngeal infection caused by Neisseria gonorrhoeae.
Infections
Structural analysis of avibactam-mediated activation of the bla and mec divergons in methicillin-resistant Staphylococcus aureus.
Infections
The Molecular Epidemiology and Antimicrobial Resistance of Neisseria gonorrhoeae in Australia: A Nationwide Cross-Sectional Study, 2012.
Infections
The role of integrase/recombinase xerD and monofunctional biosynthesis peptidoglycan transglycosylase genes in the pathogenicity of Brucella abortus infection in vitro and in vivo.
Infections
Transcriptomic data for analyzing global gene expression patterns in Methicillin-resistance Staphylococcus aureus in response to spermine and oxacillin stress.
Meningitis
Identification of a patient with Streptococcus pneumoniae bacteremia and meningitis by the polymerase chain reaction (PCR).
Meningitis
Molecular epidemiology survey of penicillin-susceptible and -resistant Streptococcus pneumoniae recovered from patients with meningitis in France.
Neoplasms
Mechanisms of the Epithelial-Mesenchymal Transition and Tumor Microenvironment in Helicobacter pylori-Induced Gastric Cancer.
Neoplasms
Small molecule inhibitors of peptidoglycan synthesis targeting the lipid II precursor.
Otitis
[Molecular epidemiology of pneumococci with decreased susceptibility to penicillin isolated in a Parisian pediatric hospital]
Otitis Media
Antimicrobial resistance in Haemophilus influenzae isolated from the nasopharynx among Japanese children with acute otitis media.
Otitis Media
Antimicrobial resistance of Haemophilus influenzae isolated from the nasopharynx of Japanese children with acute otitis media.
Otitis Media
Diverse mutations in the ftsI gene in ampicillin-resistant Haemophilus influenzae isolates from pediatric patients with acute otitis media.
Otitis Media
High Prevalence of Streptococcus pneumoniae with Mutations in pbp1a, pbp2x, and pbp2b Genes of Penicillin-Binding Proteins in the Nasopharynx in Children in Japan.
Otitis Media
Nasopharyngeal carriage of drug-resistant Streptococcus pneumoniae in children with acute otitis media evaluated by polymerase chain reaction-based genotyping of penicillin-binding proteins.
Periodontal Diseases
Genetic variation of a fimbrial protein from Porphyromonas gingivalis and its distribution in patients with periodontal diseases.
Periodontal Diseases
Immunochemical characterisation and epitope mapping of a novel fimbrial protein (Pg-II fimbria) of Porphyromonas gingivalis.
Periodontitis
Differential virulence and innate immune interactions of type I and II fimbrial genotypes of Porphyromonas gingivalis.
Pneumonia
Molecular analysis of pbp2b in Streptococcus pneumonia isolated from clinical and normal flora samples.
Pneumonia
[Novel gene sequence variants of pbp2b in penicillin-nonsusceptible Streptococcus pneumonia isolates]
Pseudomonas Infections
Cloning, expression and purification of penicillin-binding protein 3 from Pseudomonas aeruginosa CMCC 10104.
Sepsis
Mode of bacterial killing affects the inflammatory response and associated organ dysfunctions in a porcine E. coli intensive care sepsis model.
Sepsis
Novel Immunoprotective Proteins of Streptococcus pneumoniae Identified by Opsonophagocytosis Killing Screen.
Sepsis
Passive immunization against methicillin resistant Staphylococcus aureus recombinant PBP2a in sepsis model of mice: Comparable results with antibiotic therapy.
Shock, Septic
Direct, Specific and Rapid Detection of Staphylococcal Proteins and Exotoxins Using a Multiplex Antibody Microarray.
Soft Tissue Infections
Integrating a Rapid Diagnostic Test and Antimicrobial Stewardship: Optimizing Discharge Antibiotics in Skin and Soft Tissue Infections.
Stomach Neoplasms
Prevalence of atrophic gastritis in southwest China and predictive strength of serum gastrin-17: A cross-sectional study (SIGES).
Tuberculosis
Characterization of a Mycobacterium smegmatis mutant lacking penicillin binding protein 1.
Tuberculosis
Loss of a Class A Penicillin-Binding Protein Alters ?-Lactam Susceptibilities in Mycobacterium tuberculosis.
Tuberculosis
Structural and binding properties of the PASTA domain of PonA2, a key penicillin binding protein from Mycobacterium tuberculosis.
Tuberculosis
Structures of Mycobacterium tuberculosis Penicillin-Binding Protein 3 in Complex with Five ?-Lactam Antibiotics Reveal Mechanism of Inactivation.
Tuberculosis
The Role of the ?5-?11 Loop in the Active-Site Dynamics of Acylated Penicillin-Binding Protein A from Mycobacterium tuberculosis.
Urethritis
Single dose 1 g ceftriaxone for urogenital and pharyngeal infection caused by Neisseria gonorrhoeae.
Uterine Cervicitis
Single dose 1 g ceftriaxone for urogenital and pharyngeal infection caused by Neisseria gonorrhoeae.
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). MGT_STAAW
269
1
31460
Swiss-Prot
Secretory Pathway (Reliability: 1)
PBPB_ECOLI
Escherichia coli (strain K12)
844
1
94293
Swiss-Prot
other Location (Reliability: 3)
Q7CRA4_STRR6
821
1
89481
TrEMBL
-
PBPA_STRR6
719
1
79701
Swiss-Prot
-
MGT_STAAM
269
1
31460
Swiss-Prot
-
C8WPP1_EGGLE
Eggerthella lenta (strain ATCC 25559 / DSM 2243 / CCUG 17323 / JCM 9979 / KCTC 3265 / NCTC 11813 / VPI 0255 / 1899 B)
924
13
97260
TrEMBL
-
C8W9X3_LANP1
Lancefieldella parvula (strain ATCC 33793 / DSM 20469 / CCUG 32760 / JCM 10300 / KCTC 3663 / VPI 0546 / 1246)
574
1
61373
TrEMBL
-
C8W8H7_LANP1
Lancefieldella parvula (strain ATCC 33793 / DSM 20469 / CCUG 32760 / JCM 10300 / KCTC 3663 / VPI 0546 / 1246)
954
13
100455
TrEMBL
-
B1YSR8_BURA4
Burkholderia ambifaria (strain MC40-6)
615
1
66477
TrEMBL
-
Q9HW00_PSEAE
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
399
10
43765
TrEMBL
-
Q5SIX3_THET8
Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
359
8
38662
TrEMBL
other Location (Reliability: 4)
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
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