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Information on EC 2.4.1.122 - N-acetylgalactosaminide beta-1,3-galactosyltransferase
for references in articles please use BRENDA:EC2.4.1.122
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EC Tree 2 Transferases
2.4 Glycosyltransferases
2.4.1 Hexosyltransferases
2.4.1.122 N-acetylgalactosaminide beta-1,3-galactosyltransferase
IUBMB Comments
The eukaryotic enzyme can act on non-reducing O-serine-linked N-acetylgalactosamine residues in mucin glycoproteins, forming the T antigen. The bacterial enzyme, found in some pathogenic strains, is involved in biosynthesis of the O-antigen repeating unit.
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
- 2.4.1.122
-
galactosylation
- glycosyltransferases
- oligosaccharide
- n-acetylglucosamine
- apparatus
- milk
-
sialyltransferase
- alpha-lactalbumin
- glcnac
- o-glycans
- lectin
- epitope
-
o-glycosylation
- glycolipids
-
o-linked
-
sialylated
-
sialic
-
fucosyltransferase
- ganglioside
- glycoconjugates
- glycopeptides
- agglutinin
-
trans-golgi
-
n-acetylglucosaminyltransferase
-
cisterna
- 5'-nucleotidase
-
xenotransplantation
- lactosylceramide
-
n-acetylgalactosaminyltransferase
- n-acetyllactosamine
- iga1
- glycosphingolipids
-
fucosylated
-
hyperacute
-
alpha1,3
- gm2
-
3hgalactose
- trisaccharide
-
submaxillary
- glucosylceramide
-
anti-gal
- pellucida
-
cmp-sialic
- ovomucoid
- galactans
-
xenoantigens
-
mannosyltransferase
-
1-4glcnac
-
golgi-enriched
-
xylosyltransferase
- medicine
- diagnostics
Reaction Schemes
showSynonyms
galactosyltransferase, c1galt1, t-synthase, beta-galactosyltransferase, c1galt, core 1 synthase, dc1galt1, core 1 beta3-gal-t, ce-t-synthase, core 1 beta3-gal-transferase, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
C1GalT
C1GALT1
core 1 beta1,3-galactosyltransferase
core 1 beta3-Gal-T
core 1 beta3-Gal-transferase
core 1 UDP-alpha-galactose (UDP-Gal):GalNAca1-Ser/Thr beta1,3-galactosyltransferase
-
EC 2.4.1.307
-
-
formerly
-
galactosyltransferase, uridine diphosphogalactose-mucin beta-(1-3)-
-
-
-
-
glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
UniProt
O-glycan core 1 UDPgalactose:N-acetyl-alpha-galactosaminyl-R beta3-galactosyltransferase
T-synthase
UDP-Gal:glycoprotein-N-acetylgalactosamine-1,3-galactosyltransferase
-
UDP-Gal:N-acetylgalactosaminide mucin:beta1,3-galactosyltransferase
uridine diphosphogalactose-mucin beta-(1-3)-galactosyltransferase
-
-
-
-
WbnJ
O-glycan core 1 UDPgalactose:N-acetyl-alpha-galactosaminyl-R beta3-galactosyltransferase
-
-
O-glycan core 1 UDPgalactose:N-acetyl-alpha-galactosaminyl-R beta3-galactosyltransferase
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
charge-charge interactions between enzyme and substrate
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UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
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-
-
-
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
the non-reducing O-serine-linked N-acetylgalactosamine residues in mucin glycoproteins can act as acceptors
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hexosyl group transfer
hexosyl group transfer
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
MetaCyc
Escherichia coli serotype O:127 O antigen biosynthesis, Escherichia coli serotype O:86 O antigen biosynthesis, mucin core 1 and core 2 O-glycosylation, Salmonella enterica serotype O:13 O antigen biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
UDP-alpha-D-galactose:N-acetyl-alpha-D-galactosaminyl-R beta-1,3-galactosyltransferase (configuration-inverting)
The eukaryotic enzyme can act on non-reducing O-serine-linked N-acetylgalactosamine residues in mucin glycoproteins, forming the T antigen. The bacterial enzyme, found in some pathogenic strains, is involved in biosynthesis of the O-antigen repeating unit.
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CAS REGISTRY NUMBER
COMMENTARY
97089-61-7
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-alpha-D-galactose + alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol
UDP + beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol
UDP-alpha-D-galactose + Galbeta1-3GalNAcalpha1-4-nitrophenol
?
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
UDP-galactose + A-P-(N-acetyl-D-galactosaminyl)T-S-S-A
UDP + A-P-(beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl)T-S-S-A
-
Substrates: synthetic peptide
Products: -
Products: -
?
UDP-galactose + A-P-(N-acetyl-D-galactosaminyl)T-S-S-S
UDP + A-P-(beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl)T-S-S-S
-
Substrates: synthetic peptide
Products: -
Products: -
?
UDP-galactose + Ac-GHA-(GalNAcalpha1-)TSLPVTG-NH2
UDP + Ac-GHA-(Galbeta1-3GalNAcalpha1-)TSLPVTG-NH2
Substrates: pH 7.0, 0.2 mM, 750% activity in H292-cells, 550% activity in A549 cells relative to 1-O-benzyl-N-acetyl-D-galactosamine
Products: -
Products: -
?
UDP-galactose + Ac-SCSTGHA-(GalNAcalpha1-)TSG-NH2
UDP + Ac-SCSTGHA-(Galbeta-1-3GalNAcalpha1-)TSG-NH2
Substrates: pH 7.0, 0.2 mM, 50% activity in H292-cells, 40% activity in A549 cells relative to 1-O-benzyl-N-acetyl-D-galactosamine
Products: -
Products: -
?
UDP-galactose + Ac-STGHA-(GalNAcalpha1-)TSLPG-NH2
UDP + Ac-STGHA-(Galbeta1-3GalNAcalpha1-)TSLPG-NH2
Substrates: pH 7.0, 0.2 mM, 425% activity in H292-cells, 275% activity in A549 cells relative to 1-O-benzyl-N-acetyl-D-galactosamine
Products: -
Products: -
?
UDP-galactose + Ac-SVS-(GalNAcalpha1-)TGHATSG-NH2
UDP + Ac-SVS-(Galbeta1-3GalNAcalpha1-)TGHATSG-NH2
Substrates: pH 7.0, 0.2 mM, 300% activity in H292-cells, 450% activity in A549 cells relative to 1-O-benzyl-N-acetyl-D-galactosamine
Products: -
Products: -
?
UDP-galactose + Ac-TSSVS-(GalNAcalpha1-)TGHAG-NH2
UDP + Ac-TSSVS-(Galbeta1-3GalNAcalpha1-)TGHAG-NH2
Substrates: pH 7.0, 0.2 mM, 400% activity in H292-cells, 4000% activity in A549 cells relative to 1-O-benzyl-N-acetyl-D-galactosamine
Products: -
Products: -
?
UDP-galactose + asialo bovine submaxillary mucin
UDP + beta-D-galactosyl-1,3-N-acetylgalactosyl-asialo bovine submaxillary mucin
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + asialo ovine submaxillary mucin
UDP + beta-D-galactosyl-1,3-N-acetylgalactosyl-asialo ovine submaxillary mucin
UDP-galactose + asialo-agalacto-alpha1-acid glycoprotein
UDP + galactosyl-beta-1,3-asialo-agalacto-alpha1-acid glycoprotein
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + asialo-agalacto-glycophorin
UDP + beta-D-galactosyl-1,3-N-acetylgalactosyl-asialo-agalacto-glycophorin
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + asialo-mucin of Cowper's gland
UDP + beta-D-galactosyl-1,3-N-acetylgalactosyl-asialo-mucin of Cowper's gland
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + benzyl 2-(acetylamino)-2-deoxy-alpha-D-galactopyranoside
UDP + benzyl 2-(acetylamino)-2-deoxy-3-O-beta-D-galactopyranosyl-alpha-D-galactopyranoside
Substrates: pH 7.0, 2 mM, 100% activity in H292-cells, 100% activity in A549 cells relative to 1-O-benzyl-N-acetyl-D-galactosamine
Products: -
Products: -
?
UDP-galactose + GalNAcalpha1-O-phenyl
?
Substrates: the enzyme is capable of utilizing UDP-Gal as the donor for the transfer of Gal residues to GalNAcalpha-1-O-phenyl and GalNAcalpha1-Ser/Thr for synthesizing core 1 structure Galbeta1-3GalNAcalpha1-R
Products: -
Products: -
?
UDP-galactose + ganglioside Gg3
UDP + galactosyl-beta-1,3-ganglioside Gg3
Substrates: i.e. GalNAcbeta1,4-Galbeta1,4-Glcbeta1-ceramide
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-(1->3)-N-acetyl-D-galactosamine
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
UDP-galactose + N-acetyl-alpha-D-galactosaminyl-benzyl
UDP + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
UDP-galactose + N-acetyl-alpha-D-galactosaminyl-phenyl
UDP + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-phenyl
UDP-galactose + N-acetyl-D-galactosamine
UDP + beta-D-galactosyl-1,3-N-acetyl-D-galactosamine
UDP-galactose + N-acetyl-D-glucosamine
UDP + beta-D-galactosyl-1,3-N-acetyl-D-glucosamine
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + N-acetylgalactosaminide mucin
UDP + beta-D-galactosyl-1,3-N-acetylgalactosaminide mucin
UDP-galactose + N-acetylgalactosaminitol
UDP + beta-D-galactosyl-(1,3)-N-acetylgalactosaminitol
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + p-nitrophenyl-beta-N-acetylgalactosamide
UDP + beta-D-galactosyl-1,3-N-acetylgalactosyl-p-nitrophenyl
UDP-galactose + salivary gland mucin 81 N-acetyl-D-galactosamine
UDP + salivary gland mucin 81 D-galactosyl-1,3-N-acetyl-D-galactosamine
UDP-galactose + TTTV-(GalNAcalpha1-)TPTPTG
UDP + TTTV-(Galbeta1-3GalNAcalpha1-)TPTPTG
Substrates: pH 7.0, 0.2 mM, 50% activity in H292-cells, 90% activity in A549 cells relative to 1-O-benzyl-N-acetyl-D-galactosamine
Products: -
Products: -
?
UDP-galactose + TTTVTP-(GalNAcalpha1-)TPTG
UDP + TTTVTP-(Galbeta1-3GalNAcalpha1-)TPTG
Substrates: pH 7.0, 0.2 mM, 110% activity in H292-cells, 60% activity in A549 cells relative to 1-O-benzyl-N-acetyl-D-galactosamine
Products: -
Products: -
?
UDP-galactose + TTTVTPTP-(GalNAcalpha1-)TG
UDP + TTTVTPTP-(Galbeta1-3GalNAcalpha1-)TG
Substrates: pH 7.0, 0.2 mM, 65% activity in H292-cells, 60% activity in A549 cells relative to 1-O-benzyl-N-acetyl-D-galactosamine
Products: -
Products: -
?
UDP-alpha-D-galactose + alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol
UDP + beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol
Substrates: biosynthesis of the O-polysaccharide is initiated with sequential assembly of repeating units on the cytoplasmic face of the inner membrane by glycosyltransferases WbnH, WbnJ, WbnK and WbnI. The enzyme is involved in the the biosynthesis of the O-polysaccharide repeating unit of Escherichia coli serotype O86
Products: -
Products: -
?
UDP-alpha-D-galactose + alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol
UDP + beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol
Substrates: biosynthesis of the O-polysaccharide is initiated with sequential assembly of repeating units on the cytoplasmic face of the inner membrane by glycosyltransferases WbnH, WbnJ, WbnK and WbnI. The enzyme is involved in the the biosynthesis of the O-polysaccharide repeating unit of Escherichia coli serotype O86
Products: -
Products: -
?
UDP-alpha-D-galactose + alpha-D-GalNAc-OMe
UDP + alpha-D-Gal-(1->3)-alpha-D-GalNAc-OMe
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactose + alpha-D-GalNAc-OMe
UDP + alpha-D-Gal-(1->3)-alpha-D-GalNAc-OMe
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
-
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
-
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
Substrates: -
Products: -
Products: -
?
UDP-galactose + asialo ovine submaxillary mucin
UDP + beta-D-galactosyl-1,3-N-acetylgalactosyl-asialo ovine submaxillary mucin
-
Substrates: best substrate
Products: -
Products: -
?
UDP-galactose + asialo ovine submaxillary mucin
UDP + beta-D-galactosyl-1,3-N-acetylgalactosyl-asialo ovine submaxillary mucin
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + ganglioside GM2
UDP + galactosyl-beta-1,3-ganglioside GM2
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + ganglioside GM2
UDP + galactosyl-beta-1,3-ganglioside GM2
Substrates: i.e. GalNAcbeta1,4-(NeuAcalpha-2,3-)Galbeta1,4-Glcbeta1-ceramide
Products: i.e. ganglioside GM1
Products: i.e. ganglioside GM1
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-(1->3)-N-acetyl-D-galactosamine
Substrates: -
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-(1->3)-N-acetyl-D-galactosamine
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
Substrates: -
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
Substrates: -
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
Substrates: -
Products: i.e. core 1 structure
Products: i.e. core 1 structure
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
Substrates: threonine alpha-D-galactosamine is preferred to serine alpha-D-galactosamine
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
Substrates: high specificity for N-acetylgalactosaminyl residues linked to serine or threonine
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
Substrates: enzyme is important in O-glycan biosynthesis in digestive organs
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
Substrates: linked to serine or threonine of the peptide/protein
Products: i.e. core 1 structure
Products: i.e. core 1 structure
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
Substrates: threonine alpha-D-galactosamine is preferred to serine alpha-D-galactosamine
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
Substrates: Galbeta1,3-GalNAcalpha residues adjacent to Thr(GalNAc) reduces the activity
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
Substrates: substrates with negatively charged amino acids on the N-terminal side are highly efficient substrates
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
Substrates: glycosyl acceptor specificity study
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
Substrates: major control factor in the biosynthesis of O-glycans
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
Substrates: key enzyme in biosynthesis of core 1 O-glycans
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
Substrates: involved in O-glycan biosynthesis
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
Substrates: high specificity for N-acetylgalactosaminyl residues linked to serine or threonine
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
Substrates: most active acceptor: macromolecular mucin glycopeptides with free N-acetylgalactosyl residues linked to polypeptide chain
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
Substrates: glycopeptides with less than 5 amino acids containing terminal N-acetylgalactosaminyl residues
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
Substrates: glycosyl acceptor specificity study
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
Substrates: involved in O-glycan biosynthesis
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
Substrates: the enzyme can O-glycosylate the mucin-like domains of glycoproteins in a site-specific manner dependent on the sort of glycosylation/presence of glycan C-terminal from site of action, a position specific glycosylation pattern results, regulation, overview
Products: -
Products: -
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UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + N-acetyl-alpha-D-galactosaminyl-benzyl
UDP + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + N-acetyl-alpha-D-galactosaminyl-benzyl
UDP + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
-
Substrates: removal or substitution of the 3-OH group or removal of the 4-OH group abolishes enzyme activity, removal or substitution of the 6-OH reduces activity slightly leading to competititve substrates
Products: -
Products: -
?
UDP-galactose + N-acetyl-alpha-D-galactosaminyl-benzyl
UDP + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + N-acetyl-alpha-D-galactosaminyl-phenyl
UDP + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-phenyl
Substrates: -
Products: -
Products: -
?
UDP-galactose + N-acetyl-alpha-D-galactosaminyl-phenyl
UDP + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-phenyl
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + N-acetyl-D-galactosamine
UDP + beta-D-galactosyl-1,3-N-acetyl-D-galactosamine
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + N-acetyl-D-galactosamine
UDP + beta-D-galactosyl-1,3-N-acetyl-D-galactosamine
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + N-acetylgalactosaminide mucin
UDP + beta-D-galactosyl-1,3-N-acetylgalactosaminide mucin
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + N-acetylgalactosaminide mucin
UDP + beta-D-galactosyl-1,3-N-acetylgalactosaminide mucin
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + N-acetylgalactosaminide mucin
UDP + beta-D-galactosyl-1,3-N-acetylgalactosaminide mucin
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + N-acetylgalactosaminide mucin
UDP + beta-D-galactosyl-1,3-N-acetylgalactosaminide mucin
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + N-acetylgalactosaminide mucin
UDP + beta-D-galactosyl-1,3-N-acetylgalactosaminide mucin
-
Substrates: participates in synthesis of the core portion of O-serine- and O-threonine-linked oligosaccharides in respiratory acidic mucins
Products: -
Products: -
?
UDP-galactose + p-nitrophenyl-beta-N-acetylgalactosamide
UDP + beta-D-galactosyl-1,3-N-acetylgalactosyl-p-nitrophenyl
Substrates: -
Products: -
Products: -
?
UDP-galactose + p-nitrophenyl-beta-N-acetylgalactosamide
UDP + beta-D-galactosyl-1,3-N-acetylgalactosyl-p-nitrophenyl
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + salivary gland mucin 81 N-acetyl-D-galactosamine
UDP + salivary gland mucin 81 D-galactosyl-1,3-N-acetyl-D-galactosamine
-
Substrates: glycosylation pattern of the mucin, overview
Products: -
Products: -
?
UDP-galactose + salivary gland mucin 81 N-acetyl-D-galactosamine
UDP + salivary gland mucin 81 D-galactosyl-1,3-N-acetyl-D-galactosamine
-
Substrates: -
Products: -
Products: -
?
additional information
?
-
-
Substrates: the presence of multiple core-1 beta3GalT genes in Drosophila melanogaster suggests an increased complexity of core-1 O-glycan expression, which is possibly related to multiple developmental and physiological functions attributable to this class of glycans
Products: -
Products: -
?
additional information
?
-
Substrates: enzyme elongates O-GalNAc by adding galactose in a beta1,3 linkage
Products: -
Products: -
?
additional information
?
-
Substrates: enzyme elongates O-GalNAc by adding galactose in a beta1,3 linkage
Products: -
Products: -
?
additional information
?
-
Substrates: enzyme elongates O-GalNAc by adding galactose in a beta1,3 linkage
Products: -
Products: -
?
additional information
?
-
Substrates: analysis of glycan structure by mass spectrometry
Products: -
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?
additional information
?
-
-
Substrates: poor substrates are low-molecular weight acceptors, e.g. N-acetylgalactosamine
Products: -
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?
additional information
?
-
-
Substrates: no acceptor substrates: ovalbumin, beta-N-acetyl-D-glucosaminyl-benzyl
Products: -
Products: -
?
additional information
?
-
Substrates: no acceptor substrates: ovalbumin, beta-N-acetyl-D-glucosaminyl-benzyl
Products: -
Products: -
?
additional information
?
-
-
Substrates: elevated preferences for Gly at the +1 position with moderately high preferences for Phe and Tyr in the +3 position relative to the acceptor Thr-O-GalNAc
Products: -
Products: -
?
additional information
?
-
-
Substrates: core 1 synthase specific molecular chaperone is essential for the expression of functional enzyme
Products: -
Products: -
?
additional information
?
-
-
Substrates: poor substrates are low-molecular weight acceptors, e.g. N-acetylgalactosamine
Products: -
Products: -
?
additional information
?
-
-
Substrates: no acceptor substrates: type A and type 0 blood group glycoprotein, ovomucoid, ovalbumin, and fetuin devoid of sialic acid and galactose
Products: -
Products: -
?
additional information
?
-
-
Substrates: terminal alpha-2,6-linked sialic acid residues inhibit the enzyme
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-alpha-D-galactose + alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol
UDP + beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-(1->3)-N-acetyl-D-galactosamine
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
UDP-galactose + N-acetylgalactosaminide mucin
UDP + beta-D-galactosyl-1,3-N-acetylgalactosaminide mucin
-
Substrates: participates in synthesis of the core portion of O-serine- and O-threonine-linked oligosaccharides in respiratory acidic mucins
Products: -
Products: -
?
UDP-galactose + salivary gland mucin 81 N-acetyl-D-galactosamine
UDP + salivary gland mucin 81 D-galactosyl-1,3-N-acetyl-D-galactosamine
-
Substrates: glycosylation pattern of the mucin, overview
Products: -
Products: -
?
UDP-alpha-D-galactose + alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol
UDP + beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol
Substrates: biosynthesis of the O-polysaccharide is initiated with sequential assembly of repeating units on the cytoplasmic face of the inner membrane by glycosyltransferases WbnH, WbnJ, WbnK and WbnI. The enzyme is involved in the the biosynthesis of the O-polysaccharide repeating unit of Escherichia coli serotype O86
Products: -
Products: -
?
UDP-alpha-D-galactose + alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol
UDP + beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol
Substrates: biosynthesis of the O-polysaccharide is initiated with sequential assembly of repeating units on the cytoplasmic face of the inner membrane by glycosyltransferases WbnH, WbnJ, WbnK and WbnI. The enzyme is involved in the the biosynthesis of the O-polysaccharide repeating unit of Escherichia coli serotype O86
Products: -
Products: -
?
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
-
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
-
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
Substrates: -
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-(1->3)-N-acetyl-D-galactosamine
Substrates: -
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-(1->3)-N-acetyl-D-galactosamine
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
Substrates: enzyme is important in O-glycan biosynthesis in digestive organs
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
Substrates: major control factor in the biosynthesis of O-glycans
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
Substrates: key enzyme in biosynthesis of core 1 O-glycans
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
Substrates: involved in O-glycan biosynthesis
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
Substrates: involved in O-glycan biosynthesis
Products: -
Products: -
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
Substrates: the enzyme can O-glycosylate the mucin-like domains of glycoproteins in a site-specific manner dependent on the sort of glycosylation/presence of glycan C-terminal from site of action, a position specific glycosylation pattern results, regulation, overview
Products: -
Products: -
?
additional information
?
-
-
Substrates: the presence of multiple core-1 beta3GalT genes in Drosophila melanogaster suggests an increased complexity of core-1 O-glycan expression, which is possibly related to multiple developmental and physiological functions attributable to this class of glycans
Products: -
Products: -
?
additional information
?
-
Substrates: enzyme elongates O-GalNAc by adding galactose in a beta1,3 linkage
Products: -
Products: -
?
additional information
?
-
Substrates: enzyme elongates O-GalNAc by adding galactose in a beta1,3 linkage
Products: -
Products: -
?
additional information
?
-
Substrates: enzyme elongates O-GalNAc by adding galactose in a beta1,3 linkage
Products: -
Products: -
?
additional information
?
-
-
Substrates: elevated preferences for Gly at the +1 position with moderately high preferences for Phe and Tyr in the +3 position relative to the acceptor Thr-O-GalNAc
Products: -
Products: -
?
additional information
?
-
-
Substrates: core 1 synthase specific molecular chaperone is essential for the expression of functional enzyme
Products: -
Products: -
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mn2+
MnCl2
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
erlotinib
as a C1GALT1 inhibitor it is able to exert anticancer effects by blocking the malignant effects of C1GALT1 in cancer cells
lapatinib
as a C1GALT1 inhibitor it is able to exert anticancer effects by blocking the malignant effects of C1GALT1 in cancer cells
itraconazole
mediates its suppressive effects on malignant phenotypes and EGFR activity by inhibiting C1GALT1 in HNSCC cells. C1GALT1 inhibitor itraconazole can also suppress tumor growth
itraconazole
itraconazole is a C1GALT1 inhibitor that directly binds C1GALT1 and promotes its proteasomal degradation, leading to significant blockade of C1GALT1-mediated effects in HNSCC cells in vitro and in vivo
itraconazole
as a C1GALT1 inhibitor it is able to exert anticancer effects by blocking the malignant effects of C1GALT1 in cancer cells
additional information
homology modeling and docking simulation with potential C1GALT1 inhibitors
-
additional information
-
homology modeling and docking simulation with potential C1GALT1 inhibitors
-
additional information
-
proline on the C-terminal side of the peptide substrate adjacent to Thr(GalNAc) is inhibitory
-
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
lactacystin
-
treatment with 0.01 mM lactacystin results in the increased expression of C1GalT protein
additional information
Cosmc (also known as C1GALT1C1), an endoplasmic reticulum chaperone, is essential for the precise folding and activity of C1GalT1 in mammals. In contrast to mammalian orthologues, Drosophila dC1GalT1 does not require a chaperone such as Cosmc
-
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
5
asialo ovine submaxillary mucin
-
in terms of N-acetylgalactosamine equivalents
-
additional information
additional information
-
kinetic modeling, numerical simulation of in vivo Core 1 glycosylation pattern
-
0.09
asialo-mucin of Cowper's gland
-
calculated on the basis of terminal N-galactosaminyl residues
-
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
0.000168
the extracts of EY13370 third instar larvae have a galactosyltransferase activity of 44% of that of wild-type using para-nitrophenyl-N-acetyl-alpha-galactosaminide as the acceptor
0.0071
-
partially purified enzyme, substrate: N-acetyl-D-galactosaminyl-alpha-benzyl
0.031
-
partially purified enzyme, substrate: A-P-N-acetyl-D-galactosaminyl-T-S-S-A
additional information
additional information
C1GalTA exhibits high activity on Tn and glycopeptide substrates, although it also exhibits weaker activity on glycolipids
additional information
C1GalTA exhibits high activity on Tn and glycopeptide substrates, although it also exhibits weaker activity on glycolipids
additional information
C1GalTA exhibits high activity on Tn and glycopeptide substrates, although it also exhibits weaker activity on glycolipids
additional information
-
inactive HPC4-tagged soluble T-synthase regained activity within 5 min after the addition of chaprone 6His-sCosmc, at 37°C
additional information
-
T-synthase may utilize charge-charge interactions to modulate its activity, rejecting basic peptides over neutral and acidic peptide acceptors, T-synthase recognizes specific features of the peptide portion of the substrate, including overall charge and the presence of Gly, Phe, Tyr, and perhaps Pro at specific positions, up to four residues from the site of glycosylation, and indeed may use these features to modulate sites of Core 1 glycosylation
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6.5
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
37
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
expression of C1GALT1 is significantly higher in lung adenocarcinoma tissues than in adjacent non-tumor tissues both at mRNA and protein level
brenda
additional information
during embryogenesis, in late embryos at stage 16
brenda
C1GALT1 expression is upregulated in HNSCC tumors
brenda
-
C1GALT1 expression is upregulated in HNSCC tumors
brenda
additional information
T antigen produced by Drosophila C1GalT1 (dC1GalT1) is expressed in various tissues
brenda
additional information
-
no endogenous activity in Jurkat and LSC, a colorectal cell line, cells
brenda
additional information
no endogenous activity in Jurkat and LSC, a colorectal cell line, cells
brenda
additional information
no endogenous activity in Jurkat and LSC, a colorectal cell line, cells
brenda
additional information
C1GALT1 is overexpressed in various human malignancies
brenda
additional information
-
C1GALT1 is overexpressed in various human malignancies
brenda
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
a specialized extracellular matrix that underlies the epithelium and surrounds other tissues, including muscles, fat, and nerve fibers
brenda
additional information
SLC35A2 deficiency negatively affects Golgi (but not ER) localization of C1GalT1
brenda
transmembrane protein with two putative N-glycosylation sites
brenda
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
drug target
targeting C1GALT1 presents a promising therapeutic strategy for colorectal cancer
malfunction
metabolism
dGlcAT-P (EC 2.4.1.135) genetically interactes with dC1GalT1, and glucuronylated T antigen, rather than unmodified T antigen, contributes to precise localization of NMJ boutons and normal formation of basement membranes on muscles 6/7
physiological function
additional information
malfunction
-
mutations in the chaperone Cosmc, which is encoded by the X-chromosome gene (Xq24) in humans, leads to loss of T-synthase activity and expression of the abnormal Tn (GalNAc1-Ser/Thr) and Sialyl Tn (NeuAc2-3GalNAc1-Ser/Thr) antigens, which are also known as tumor-associated carbohydrate antigens, Tn syndrome is a rare autoimmune disease in which subpopulations of blood cells in all lineages carry an incompletely glycosylated membrane
malfunction
C1GalTA null mutant is lethal, mutant animals exhibit a striking morphogenetic defect in which the ventral nerve cord is greatly elongated and the brain hemispheres are misshapen
malfunction
-
oocyte-specific deletion at the primary follicle stage of T-synthase leads to a sustained increase in fertility mutant females ovulated 30-50% more eggs and has a sustained increase in litter size compared to controls, ovarian weights and follicle numbers are greater in mutants, but follicular apoptosis is not decreased, the number of follicles entering the growing pool is unaltered, but 3-week mutants ovulate fewer eggs, suggesting that increased fertility results from prolonged follicle development, T-synthase mutant ovaries also contain numerous multiple-oocyte follicles that appeared to form by adjacent, predominantly preantral, follicles joining
malfunction
mutant embryos show the loss of T antigens on the CNS and on a subset of hemocytes, 2 mutant lines, EY13370 and KG02976, have a P-element insertion in the CG9520 gene region, although the P-elements are located in the first intron of the gene in both lines, KG02976 homozygotes develop normally whereas some EY13370 homozygotes die during development and escaper homozygous EY13370 adult flies have abnormal legs, the levels of the enzyme transcripts in mutant third instar larvae homozygous for KG02976 or EY13370 are reduced to 60% and 15% of that of wild-type third instar larvae, terminal galactose of T antigen is defective in mutant embryos
malfunction
-
abrogation of the enzyme promotes membrane protein internalization. Disruption of core 1 O-glycosyltransferase activity induces endocytosis and faster accumulation of cell surface proteins in cytoplasmic vesicles and induces clathrin-mediated endocytosis. Enzyme-deficient human corneal keratinocytes display plasma membrane invaginations on the apical surface
malfunction
dC1GalT1 loss in larvae leads to various defects, including a decreased number of circulating hemocytes, hyperdifferentiation of hematopoietic stem cells in lymph glands, malformation of the central nervous system, mislocalization of neuromuscular junction (NMJ) boutons, and ultrastructural abnormalities in NMJs and muscle cells. Mutant larvae show lower expression of glucuronylated T antigen on the muscles and at NMJs. Mislocalization of neuromuscular junction (NMJ) boutons and a partial loss of the basement membrane components collagen IV (Col IV) and nidogen (Ndg) at the muscle 6/7 boundary are observed. Those two phenotypes are correlated and identical to previously described phenotypes in dC1GalT1 mutant larvae
malfunction
C1GALT1 overexpression enhances HNSCC cell viability, migration, and invasion, which can be reversed by erlotinib. Silencing of C1GALT1 suppresses the malignant behavior both in vitro and in vivo. C1GALT1 knockdown decreases the EGFR signaling in SAS, OEC-M1, and FaDu cells. Decreased C1GALT1 causes accumulation of Tn antigens
malfunction
core 1 beta1,3-galactosyltransferase (C1GALT1) expression is upregulated in HNSCC tumors and is associated with adverse clinicopathologic features. Moreover, high C1GALT1 expression predicts poor disease-free and overall survivals. C1GALT1 overexpression enhances HNSCC cell viability, migration, and invasion, which can be reversed by erlotinib. Silencing of C1GALT1 suppresses the malignant behavior both in vitro and in vivo. Blocking O-glycan elongation on epidermal growth factor receptor (EGFR) by C1GALT1 knockdown decreases EGF-EGFR binding affinity and inhibits EGFR signaling, thereby suppressing malignant phenotypes. C1GALT1 knockout also decreases the EGFR signaling in SAS cells as shown in two independent clones. C1GALT1 overexpression in SAS cells increases EGF-induced phosphorylation of EGFR at Y1068. By contrast, C1GALT1 knockdown decreases the EGFR signaling in OEC-M1 and FaDu cells. Decreased C1GALT1 causes accumulation of Tn antigens, which is detected by vicia villosa agglutinin (VVA) lectin
malfunction
the double mutant (DM) mouse generates oocytes lacking complex N- and O-glycans due to oocyte-specific deletion of core 1 beta1,3-galactosyltransferase (C1galt1) and N-acetylglucosaminyltransferase I (Mgat1) and has modified cumulus expansion. Oocyte-specific ablation of C1galt1 and Mgat1 may affect bone morphogenetic protein 15 synthesis or bioactivity, thereby reducing SMAD1/5/8 phosphorylation and hyaluronan production. The genotype of the DM mouse is oocyte-specific. Cumulus-oocyte complexes (COCs) from mice with oocyte-specific deletions of C1galt1 and Mgat1 have abnormal cumulus matrix that is resistant to hyaluronidase treatment
physiological function
-
T-synthase is the key beta3-galactosyltransferase essential for biosynthesis of core 1 O-glycans (Gal beta1-3GalNAc alpha1-Ser/Thr) in animal cell glycoproteins
physiological function
C1GalTA is required for nervous system morphogenesis, C1GalTA is required for laminin O-glycosylation
physiological function
enzyme is responsible for the synthesis and function of T antigen (mucin-type O-glycan) in vivo
physiological function
-
core 1 O-glycosylation is required to maintain transcellular barrier function. Core 1 O-glycans contribute to maintenance of apical barrier function on exposed mucosal surfaces by preventing clathrin-mediated endocytosis
physiological function
the major components of basement membrane are proteins modified by glycans. T antigen (Galbeta1-3GalNAcalpha1-Ser/Thr) is an evolutionary-conserved mucin-type core 1 glycan structure in animals synthesized by core 1 beta1,3-galactosyltrasferase 1 (C1GalT1). T antigen produced by Drosophila C1GalT1 (dC1GalT1) is expressed in various tissues. T antigen formation occurs mainly due to the activity of Drosophila C1GalT1 orthologue
physiological function
core 1 beta1,3-galactosyltransferase (C1GALT1) controls the crucial step of GalNAc-type O-glycosylation and is overexpressed in various human malignancies with a role in head and neck squamous cell carcinoma (HNSCC). Enzyme C1GALT1 seems to promote in vitro disease progression in ovarian cancer. C1GALT1 modifies O-glycans on epidermal growth factor receptor (EGFR). C1GALT1 regulates phosphorylation, EGF-binding affinity, and O-glycosylation of EGFR to enhance malignant phenotypes in HNSCC cells. C1GALT1 regulates EGF-binding affinity of EGFR in HNSCC cells. C1GALT1 transfers galactose to Tn antigen to form T antigen. C1GALT1 is overexpressed in head and neck squamous cell carcinoma (HNSCC) tumors and high C1GALT1 expression predicts poor prognosis
physiological function
core 1 beta1,3-galactosyltransferase (C1GALT1) controls the crucial step of GalNAc-type O-glycosylation. C1GALT1 regulates phosphorylation, EGF-binding affinity, and O-glycosylation of EGFR to enhance malignant phenotypes in HNSCC cells. Itraconazole blocks C1GALT1-mediated malignant phenotypes and EGFR activity, overview. C1GALT1 transfers galactose to Tn antigen to form T antigen
physiological function
T-synthase is required for the generation of complex O-glycans. The O-glycosylation has been implicated in receptor signalling and cell-matrix interactions
physiological function
-
the enzyme is required for synthesis of the core 1 disaccharide (Galbeta1-3-GalNAcalpha1-Ser/Thr) structure of the O-glycan attached to secreted proteins produced in silkworms
physiological function
the enzyme catalyses the transfer of the monosaccharide galactose from UDP-Gal to GalNAc-Ser/Thr, synthesizing the core 1 mucin type O-glycan
physiological function
key glycosyltransferase in glycosylation process and key enzyme in the formation of the core 1 structure on which most complex and branched O-glycans are formed. The enzyme (C1GALT1) has an important role in maintaining normal physiological functions and also participates in the development of tumors. miR-181d-5p and miR-152 negatively regulate C1GALT1 to exert oncogenic effects. Deletion of C1GALT1 triggers spontaneous gastric and duodenal cancers by disrupting the major mucus barrier of the gastrointestinal tract. Loss of C1GALT1 elevates truncated Tn antigen expression, contributing to higher tumorigenic and metastatic potential. C1GALT1 achieves procancer effects by modifying the O-glycans of downstream targets
physiological function
the enzyme (C1GALT1) plays a pivotal role in colorectal cancer development and progression through its involvement in various molecular mechanisms. This enzyme is central to the O-glycosylation process, producing tumor-associated carbohydrate antigens (TACA) like Tn and sTn, which are linked to cancer metastasis and poor prognosis. The interaction between C1GALT1 and core 3 synthase is crucial for the synthesis of core 3 O-glycans, essential for gastrointestinal health and mucosal barrier integrity. Aberrations in this pathway can lead to CRC development
additional information
C1GALT1 is overexpressed in various human malignancies
additional information
SLC35A2 deficiency reduces protein levels of core 1 beta-1,3-galactosyltransferase 1 (C1GalT1) and its chaperone Cosmc and affects their subcellular localization
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
monomer
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POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
glycoprotein
transmembrane protein with two putative N-glycosylation sites
additional information
additional information
the effect of itraconazole on C1GALT1 protein levels might be through posttranslational modifications, analysis of mechanism by which itraconazole promotes C1GALT1 degradation
additional information
-
the effect of itraconazole on C1GALT1 protein levels might be through posttranslational modifications, analysis of mechanism by which itraconazole promotes C1GALT1 degradation
additional information
itraconazole is a C1GALT1 inhibitor that directly binds C1GALT1 and promotes its proteasomal degradation, leading to significant blockade of C1GALT1-mediated effects in HNSCC cells in vitro and in vivo
additional information
-
itraconazole is a C1GALT1 inhibitor that directly binds C1GALT1 and promotes its proteasomal degradation, leading to significant blockade of C1GALT1-mediated effects in HNSCC cells in vitro and in vivo
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
generation of dC1GalT12.1/+:dGlcAT-PSK6/+ double heterozygous mutants, phenotypes, overview
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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
affinity chromatography on immobilized asialo-bovine submaxillary gland mucin
-
affinity chromatography on Sepharose 4B containing covalently bound mucin substrate
-
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cloning of the C-terminal catalytic domain (amino acids 44-388) of C2GalTA into the vector pMT(1B) and transfected into S2 cells
DNA and amino acid sequence determination
DNA and amino acid sequence determination and analysis, transient functional expression in human 293T cells as wild-type and soluble, i.e. secreted into the medium, epitope-tagged protein, stable functional expression of the soluble epitope-tagged enzyme in CHO-K1 and Lec1-CHO cells
DNA sequence determination, functional expression in human LSC cells
functional expression in Spodoptera frugiperda Sf9cells via baculovirus infection
soluble T-synthase is made by co-expressing N-terminal HPC4 epitope-tagged soluble T-synthase with wild-type full-length Cosmc in Hi-5 insect cells using the Baculovirus system
-
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
C1GalT1 and Cosmc protein levels are decreased in SLC35A2-deficient cells
expression of C1GALT1 is significantly higher in lung adenocarcinoma tissues than in adjacent non-tumor tissues both at mRNA and protein level
real-time RT-PCR analysis shows that C1GALT1 messenger RNA expression is not significantly affected, implying that the effect of itraconazole on C1GALT1 protein levels might be through posttranslational modifications. Itraconazole increases ubiquitinated C1GALT1. C1GALT1 degradation induced by itraconazole is primarily through the proteasomal degradation pathway
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RENATURED/Commentary
ORGANISM
UNIPROT
LITERATURE
the chaperone Cosmc promotes renaturation of denatured T-synthase in vitro, HPC4-tagged soluble T-synthase is denatured in 1 ml of 6 M guanidinium hydrochloride, pH 7.2 for 90 min at room temperature, the sample is diluted 100times in reconstitution buffer (10 mM HEPES, 150 mM NaCl, 12 mM MgCl2, pH 7.8), reconstitution is initiated by the addition of 6His-sCosmc and ATP where the final concentration is 2.27 microM and 5 mM, reaction is incubated for 45 min at room temperature, 6His-sCosmc can cause up to 75% restoration of heat-denatured HPC4-tagged soluble T-synthase activity depending on how long the protein is heat-treated, and that it can restore 30% of activity to HPC4-tagged soluble T-synthase denatured by guanidinium hydrochloride treatment
-
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
diagnostics
medicine
diagnostics
C1GALT1 predicts poor prognosis and is a potential therapeutic target in head and neck cancer
diagnostics
expression of C1GALT1 is significantly higher in lung adenocarcinoma tissues than in adjacent non-tumor tissues both at mRNA and protein level. Elevated C1GALT1 expression in lung adenocarcinoma is associated with an unfavorable prognosis and contributes to increased radioresistance potentially by affecting DNA repair, cell proliferation, cell cycle regulation, and epithelial-mesenchymal transition
diagnostics
the enzyme (C1GALT1) is considered a biomarker and potential therapeutic target for cancer diagnosis and prediction of prognosis
medicine
-
polymorphisms of the C1GALT1 gene are associated with the genetic susceptibility to IgA nephropathy in Chinese population
medicine
C1GALT1 predicts poor prognosis and is a potential therapeutic target in head and neck cancer
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brenda
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brenda
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16
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2006
Caenorhabditis elegans (Q18515), Caenorhabditis elegans
brenda
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366
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Homo sapiens
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18
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