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IUBMB Comments This enzyme, found in higher vertebrates, modifies tRNAAsp
Synonyms
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GDP-mannose:tRNAAsp-queuosine O-5''-beta-D-mannosyltransferase
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incorrect
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tRNA-queuosine beta-mannosyltransferase
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incorrect
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GDP-alpha-D-mannose + queuosine34 in tRNAAsp = GDP + O-4''-alpha-D-mannosylqueuosine34 in tRNAAsp
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hexosyl group transfer
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GDP-alpha-D-mannose:queuosine34 in tRNAAsp O-4''-alpha-D-mannosyltransferase (configuration-retaining)
This enzyme, found in higher vertebrates, modifies tRNAAsp at the wobble position of the anticodon loop.
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GDP-alpha-D-mannose + queuosine34 in tRNAAsp
GDP + O-4''-alpha-D-mannosylqueuosine34 in tRNAAsp
GDP-alpha-D-mannose + queuosine34 in tRNAAsp
GDP + O-4''-alpha-D-mannosylqueuosine34 in tRNAAsp
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Substrates: strict specificity for E. coli tRNAAsp, transfer with concomitant inversion of anomeric configuration at sugar C-1-carbon, no substrates are tRNATyr, tRNAHis or tRNAAsn
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GDP-alpha-D-mannose + queuosine34 in tRNAAsp
GDP + O-4''-alpha-D-mannosylqueuosine34 in tRNAAsp
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Substrates: -
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GDP-alpha-D-mannose + queuosine34 in tRNAAsp
GDP + O-4''-alpha-D-mannosylqueuosine34 in tRNAAsp
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Substrates: -
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NaCl
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0.1 M NaCl stimulates more than 2fold
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male Donryu
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brenda
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brenda
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brenda
Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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Okada, N.; Nishimura, S.
Enzymatic synthesis of Q nucleoside containing mannose in the anticodon of tRNA: isolation of a novel mannosyltransferase from a cell-free extract of rat liver
Nucleic Acids Res.
4
2931-2937
1977
Rattus norvegicus
brenda
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