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(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-xylose 1-phosphate
alpha-D-xylose-(1,4-alpha-D-glucosyl)n + phosphate
-
Substrates: polysaccharide substrate is starch, very low activity
Products: -
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
(maltodextrin)n + phosphate
(maltodextrin)n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
?
(maltodextrin)n-1 + alpha-D-glucose 1-phosphate
(maltodextrin)n + phosphate
-
Substrates: maltodextrin phosphorylase is involved in the utilization of maltodextrins
Products: -
r
(maltodextrin)n-1 + glucose 1-phosphate
(maltodextrin)n + phosphate
(maltooligosaccaride)n-1 + alpha-D-glucose 1-phosphate
(maltooligosaccharide)n + phosphate
alpha-D-glucan + alpha-D-glucose 1-phosphate
glycogen + phosphate
alpha-D-glucose-1-phosphate + maltohexaose
amylose + phosphate
-
Substrates: -
Products: in presence of lipids, spontaneous formation and precipitation of amylose-lipid complexes. Presence of lipid also leads to lower amylose degrees of polymerization. Lipid chain length defines degree of amylose polymerization, which increases in the order myristic acid, glyceryl monostearate, stearic acid and docosanoic acid. Thermal stability of complexes increases in the same manner
?
amylopectin + alpha-D-glucose 1-phosphate
amylopectin + phosphate
Substrates: -
Products: -
?
amylopectin + glucose 1-phosphate
amylopectin + phosphate
amylopectin + phosphate
amylopectin + D-glucose-1-phosphate
amylose + glucose 1-phosphate
amylose + phosphate
amylose + phosphate
amylose + D-glucose-1-phosphate
amylose + phosphate
amylose + glucose 1-phosphate
debranched amylopectin + glucose 1-phosphate
debranched amylopectin + phosphate
-
Substrates: most effective primer glucan for chloroplastic enzyme
Products: -
r
dextrin + alpha-D-glucose 1-phosphate
dextrin + phosphate
dextrin DP11 + phosphate
dextrin DP10 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
?
dextrin DP13 + alpha-D-glucose 1-phosphate
dextrin DP14 + phosphate
dextrin DP14 + phosphate
dextrin DP13 + alpha-D-glucose 1-phosphate
dextrin DP18 + alpha-D-glucose 1-phosphate
dextrin DP19 + phosphate
-
Substrates: prolongation of the dextrin molecule with one glucose monomer
Products: -
r
dextrin DP19 + phosphate
dextrin DP18 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
dextrin DP3 + alpha-D-glucose 1-phosphate
dextrin DP4 + phosphate
-
Substrates: prolongation of the dextrin molecule with one glucose monomer
Products: -
r
dextrin DP4 + phosphate
dextrin DP3 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
dextrin DP9 + phosphate
dextrin DP8 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
?
glycogen + alpha-D-glucose 1-phosphate
glycogen + phosphate
glycogen + glucose 1-phosphate
glycogen + phosphate
glycogen + phosphate
? + alpha-D-glucose 1-phosphate
Substrates: -
Products: -
r
glycogen + phosphate
alpha-D-glucan + alpha-D-glucose 1-phosphate
glycogen + phosphate
alpha-D-glucose 1-phosphate + ?
-
Substrates: -
Products: -
?
glycogen + phosphate
glycogen + alpha-D-glucose 1-phosphate
glycogen + phosphate
glycogen + glucose 1-phosphate
glycogen DP14 + phosphate
glycogen DP13 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
granulose + glucose 1-phosphate
granulose + phosphate
-
Substrates: -
Products: -
?
maltodecaheptaose + phosphate
maltodecahexaose + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
maltodecaose + alpha-D-glucose 1-phosphate
? + phosphate
-
Substrates: low activity
Products: -
r
maltodextrin + phosphate
? + alpha-D-glucose 1-phosphate
Substrates: -
Products: -
r
maltoheptadecaose + glucose 1-phosphate
maltooctadecaose + phosphate
-
Substrates: -
Products: -
r
maltoheptaose + alpha-D-glucose 1-phosphate
maltooctaose + phosphate
maltoheptaose + glucose 1-phosphate
maltooctaose + phosphate
maltoheptaose + phosphate
maltohexaose + alpha-D-glucose 1-phosphate
maltohexaose + alpha-D-glucose 1-phosphate
maltoheptaose + phosphate
maltohexaose + arsenate
maltopentaose + glucose 1-arsenate
-
Substrates: -
Products: -
?
maltohexaose + glucose 1-phosphate
maltoheptaose + phosphate
maltohexaose + phosphate
maltopentaose + alpha-D-glucose 1-phosphate
maltononaose + alpha-D-glucose 1-phosphate
maltodecaose + phosphate
-
Substrates: low activity
Products: -
r
maltooctaose + alpha-D-glucose 1-phosphate
maltononaose + phosphate
-
Substrates: low activity
Products: -
r
maltooctaose + glucose 1-phosphate
maltononaose + phosphate
maltopentaose + alpha-D-glucose 1-phosphate
maltohexaose + phosphate
maltopentaose + glucose 1-phosphate
maltohexaose + phosphate
maltopentaose + phosphate
?
Substrates: -
Products: -
?
maltopentaose + phosphate
maltotetraose + alpha-D-glucose 1-phosphate
maltose + alpha-D-glucose 1-phosphate
?
-
Substrates: -
Products: -
?
maltose + alpha-D-glucose 1-phosphate
maltotriose + phosphate
maltotetraose + 2-amino-2-deoxy-alpha-D-glucopyranosyl 1-phosphate
GlcNAc-alpha-(1->4)-Glc-alpha-(1->4)-Glc-alpha-(1->4)-Glc-alpha-(1->4)-Glcalpha + phosphate
-
Substrates: -
Products: alpha-glucosamine is positioned at the non-reducing end of the oligosaccharide
?
maltotetraose + alpha-D-glucose 1-phosphate
maltopentaose + phosphate
maltotetraose + D-glucose-1-phosphate
maltopentaose + phosphate
-
Substrates: -
Products: -
?
maltotetraose + glucose 1-phosphate
maltopentaose + phosphate
maltotetraose + phosphate
maltotriose + alpha-D-glucose 1-phosphate
maltotriose + alpha-D-glucose 1-phosphate
maltotetraose + phosphate
maltotriose + glucose 1-phosphate
maltotetraose + phosphate
maltotriose + phosphate
maltobiose + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
maltotriose + phosphate
maltose + alpha-D-glucose 1-phosphate
pyridylamino-maltohexaose + alpha-D-glucose 1-phosphate
pyridylamino-maltoheptaose + phosphate
Substrates: -
Products: -
r
soluble heteroglycan + alpha-D-glucose 1-phosphate
? + phosphate
-
Substrates: substrate is a soluble heteroppolysaccharide containing a high percentage of arabinogalactan-like linkages but also minor components, namely glucosyl, mannosyl, rhamnosyl, and fucosyl residues, and is isolated from pea leaf cytosol, 3 different variants, overview
Products: -
?
soluble starch + alpha-D-glucose 1-phosphate
?
Voandzeia subterranea
-
Substrates: -
Products: -
?
soluble starch + phosphate
?
-
Substrates: -
Products: -
?
soluble starch + phosphate
? + alpha-D-glucose 1-phosphate
Substrates: -
Products: -
r
starch + alpha-D-glucose 1-phosphate
starch + phosphate
starch + glucose 1-phosphate
starch + phosphate
starch + phosphate
? + alpha-D-glucose 1-phosphate
Substrates: -
Products: -
r
starch + phosphate
starch + D-glucose 1-phosphate
Substrates: -
Products: -
?
starch + phosphate
starch + D-glucose-1-phosphate
starch DP24 + phosphate
starch DP23 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
additional information
?
-
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
-
Substrates: polysaccharide substrate is glycogen
Products: -
?
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
-
Substrates: polysaccharide substrate is bovine liver glycogen
Products: -
?
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
Substrates: polysaccharide substrate is glycogen, mobilization of glucose 1-phosphate as readily useable energy source
Products: -
r
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
Substrates: polysaccharide substrates are glycogen and starch, phosphorolysis is the preferred reaction
Products: -
r
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
-
Substrates: polysaccharide substrates are starch and glycogen, phosphorolysis is the preferred reaction, maltotetraose is the smallest substrate accepted
Products: -
r
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
Substrates: polysaccharide substrate is glycogen
Products: -
r
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
-
Substrates: polysaccharide substrate is glycogen, first step in glycogen breakdown removing one glucose at a time
Products: -
r
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
-
Substrates: polysaccharide substrate is glycogen, phosphorolysis is the preferred reaction
Products: -
r
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
-
Substrates: polysaccharide substrate is starch, phosphorolysis is the physiologic reaction of the starch degrading enzyme
Products: -
r
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
-
Substrates: polysaccharide substrates are soluble starch and Zulkowsky soluble starch, amylopectin, glycogen, and dextrin, amyylopectin is the best substrate
Products: -
r
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
-
Substrates: polysaccharide substrate is glycogen
Products: -
?
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
Substrates: the cytosolic isozyme is involved in the processing of incoming carbohydrate during rapid tissue growth, plastidic isozyme is associated with transitory leaf starch metabolism and with the initiation of seed endosperm reserve starch accumulation, but it plays no role in the degradation of the reserve starch
Products: -
r
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
Substrates: the cytosolic isozyme utilizes amylopectin, amylose, soluble starch, and glycogen as polysaccharide substrates, while the plastidic isozyme prefers starch
Products: -
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
-
Substrates: -
Products: -
?
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
-
Substrates: -
Products: -
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
-
Substrates: -
Products: -
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
-
Substrates: maltodextrin phosphorylase, preferred substrate
Products: -
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
-
Substrates: preferred substrate
Products: -
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
-
Substrates: not phosphorylase B
Products: -
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
-
Substrates: less effective than starch, amylose or glycogen
Products: -
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
-
Substrates: achrodextrin
Products: -
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
-
Substrates: -
Products: -
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
-
Substrates: corn dextrin, phosphorolysis at 85% the rate of glycogen phosphorolysis
Products: -
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
-
Substrates: corn dextrin, phosphorolysis at 85% the rate of glycogen phosphorolysis
Products: -
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
-
Substrates: -
Products: -
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
-
Substrates: -
Products: -
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
-
Substrates: best substrate
Products: -
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
-
Substrates: preferred substrate
Products: -
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
-
Substrates: corn dextrin
Products: -
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
-
Substrates: -
Products: -
r
(maltodextrin)n-1 + glucose 1-phosphate
(maltodextrin)n + phosphate
-
Substrates: phosphorolysis activity ceases when maltodextrins are degraded to maltotetraose
Products: -
r
(maltodextrin)n-1 + glucose 1-phosphate
(maltodextrin)n + phosphate
-
Substrates: glucosylation at 96% the rate of maltoheptaose glucosylation
Products: -
r
(maltodextrin)n-1 + glucose 1-phosphate
(maltodextrin)n + phosphate
-
Substrates: minimum chain length requirement for efficient activity: 5 glucose units per maltodextrin molecule
Products: -
r
(maltodextrin)n-1 + glucose 1-phosphate
(maltodextrin)n + phosphate
-
Substrates: minimum chain length requirement for efficient activity: 4 glucose units per maltodextrin molecule
Products: -
r
(maltodextrin)n-1 + glucose 1-phosphate
(maltodextrin)n + phosphate
-
Substrates: maltodextrin with up to 11 glucose units
Products: -
r
(maltodextrin)n-1 + glucose 1-phosphate
(maltodextrin)n + phosphate
-
Substrates: minimum chain length requirement for efficient activity: 5 glucose units per maltodextrin molecule
Products: -
r
(maltodextrin)n-1 + glucose 1-phosphate
(maltodextrin)n + phosphate
-
Substrates: minimum chain length requirement for efficient activity: 4 glucose units per maltodextrin molecule
Products: -
r
(maltodextrin)n-1 + glucose 1-phosphate
(maltodextrin)n + phosphate
-
Substrates: -
Products: -
?
(maltodextrin)n-1 + glucose 1-phosphate
(maltodextrin)n + phosphate
-
Substrates: -
Products: -
r
(maltooligosaccaride)n-1 + alpha-D-glucose 1-phosphate
(maltooligosaccharide)n + phosphate
Substrates: -
Products: -
r
(maltooligosaccaride)n-1 + alpha-D-glucose 1-phosphate
(maltooligosaccharide)n + phosphate
Substrates: preferred substrate
Products: -
r
alpha-D-glucan + alpha-D-glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
r
alpha-D-glucan + alpha-D-glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
r
alpha-D-glucan + alpha-D-glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
r
alpha-D-glucan + alpha-D-glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
r
amylopectin + glucose 1-phosphate
amylopectin + phosphate
-
Substrates: best substrate
Products: -
r
amylopectin + glucose 1-phosphate
amylopectin + phosphate
-
Substrates: potato amylopectin
Products: -
r
amylopectin + glucose 1-phosphate
amylopectin + phosphate
-
Substrates: -
Products: -
r
amylopectin + glucose 1-phosphate
amylopectin + phosphate
-
Substrates: preferred substrate
Products: -
r
amylopectin + glucose 1-phosphate
amylopectin + phosphate
-
Substrates: -
Products: -
r
amylopectin + glucose 1-phosphate
amylopectin + phosphate
-
Substrates: -
Products: -
r
amylopectin + glucose 1-phosphate
amylopectin + phosphate
-
Substrates: glucosylation at 23% the rate of maltoheptaose glucosylation
Products: -
r
amylopectin + glucose 1-phosphate
amylopectin + phosphate
-
Substrates: waxy maize amylopectin
Products: -
r
amylopectin + glucose 1-phosphate
amylopectin + phosphate
-
Substrates: less effective than starch, amylose or glycogen
Products: -
r
amylopectin + glucose 1-phosphate
amylopectin + phosphate
-
Substrates: -
Products: -
r
amylopectin + glucose 1-phosphate
amylopectin + phosphate
-
Substrates: potato amylopectin
Products: -
r
amylopectin + glucose 1-phosphate
amylopectin + phosphate
-
Substrates: waxy rice or pea cotyledon
Products: -
?
amylopectin + glucose 1-phosphate
amylopectin + phosphate
-
Substrates: -
Products: -
r
amylopectin + glucose 1-phosphate
amylopectin + phosphate
-
Substrates: effective primer
Products: -
r
amylopectin + glucose 1-phosphate
amylopectin + phosphate
-
Substrates: -
Products: -
?
amylopectin + glucose 1-phosphate
amylopectin + phosphate
-
Substrates: -
Products: -
r
amylopectin + glucose 1-phosphate
amylopectin + phosphate
-
Substrates: best substrate
Products: -
?
amylopectin + phosphate
amylopectin + D-glucose-1-phosphate
-
Substrates: -
Products: -
?
amylopectin + phosphate
amylopectin + D-glucose-1-phosphate
-
Substrates: -
Products: -
?
amylopectin + phosphate
amylopectin + D-glucose-1-phosphate
-
Substrates: -
Products: -
?
amylopectin + phosphate
amylopectin + D-glucose-1-phosphate
Substrates: -
Products: -
r
amylose + glucose 1-phosphate
amylose + phosphate
-
Substrates: -
Products: -
?
amylose + glucose 1-phosphate
amylose + phosphate
-
Substrates: glucosylation at 7% the rate of maltoheptaose glucosylation
Products: -
?
amylose + glucose 1-phosphate
amylose + phosphate
-
Substrates: best substrate
Products: -
?
amylose + glucose 1-phosphate
amylose + phosphate
-
Substrates: -
Products: -
?
amylose + glucose 1-phosphate
amylose + phosphate
-
Substrates: effective primer
Products: -
r
amylose + glucose 1-phosphate
amylose + phosphate
-
Substrates: potato amylose
Products: -
r
amylose + glucose 1-phosphate
amylose + phosphate
-
Substrates: -
Products: -
r
amylose + phosphate
amylose + D-glucose-1-phosphate
-
Substrates: -
Products: -
?
amylose + phosphate
amylose + D-glucose-1-phosphate
-
Substrates: -
Products: -
?
amylose + phosphate
amylose + glucose 1-phosphate
-
Substrates: -
Products: -
?
amylose + phosphate
amylose + glucose 1-phosphate
-
Substrates: pea cotyledon amylose
Products: -
?
amylose + phosphate
amylose + glucose 1-phosphate
-
Substrates: arsenate can replace phosphate
Products: -
?
dextrin + alpha-D-glucose 1-phosphate
dextrin + phosphate
Substrates: -
Products: -
?
dextrin + alpha-D-glucose 1-phosphate
dextrin + phosphate
-
Substrates: -
Products: -
?
dextrin DP13 + alpha-D-glucose 1-phosphate
dextrin DP14 + phosphate
-
Substrates: prolongation of the dextrin molecule with one glucose monomer
Products: -
r
dextrin DP13 + alpha-D-glucose 1-phosphate
dextrin DP14 + phosphate
-
Substrates: prolongation of the dextrin molecule with one glucose monomer
Products: -
r
dextrin DP14 + phosphate
dextrin DP13 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
dextrin DP14 + phosphate
dextrin DP13 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
glycogen + alpha-D-glucose 1-phosphate
glycogen + phosphate
Substrates: -
Products: -
?
glycogen + alpha-D-glucose 1-phosphate
glycogen + phosphate
Substrates: -
Products: -
r
glycogen + alpha-D-glucose 1-phosphate
glycogen + phosphate
-
Substrates: enzyme catalyzes the initial degradation of glycogen
Products: -
?
glycogen + alpha-D-glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
?
glycogen + alpha-D-glucose 1-phosphate
glycogen + phosphate
Substrates: 75% of the activity with maltose, 64% of the activity with maltoheptaose
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: rabbit liver glycogen
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: glycogen from oyster
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: glycogen from: rabbit liver
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
?
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: rabbit liver glycogen
Products: -
?
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: glycogen from: oyster
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: preferred substrate of glycogen phosphorylase
Products: -
?
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
Indocibium guttattam
-
Substrates: -
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
?
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: glycogen from: rabbit liver
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: glucosylation at 14.4% the rate of maltoheptaose glucosylation
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: best substrate
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: not phosphorylase B
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: glycogen from oyster
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: glycogen from shell fish
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
?
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
Substrates: -
Products: -
?
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
?
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: glycogen from oyster
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: yeast or rabbit enzyme
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: glycogen from oyster
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: endogenous glycogen
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: glycogen from: rabbit liver
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: best substrate
Products: -
?
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: best substrate
Products: -
?
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: glycogen from oyster
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: glycogen from Streptococcus salivarius
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: glycogen from oyster
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: glycogen from Streptococcus salivarius
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: rabbit liver glycogen
Products: -
?
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: phytoglycogen
Products: -
?
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
?
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: favoured reaction
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: glycogen from oyster
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: yeast or rabbit enzyme
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: favoured reaction
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
?
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: glycogen from: rabbit liver
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
?
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: about half as effective as dextrin
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: glycogen from oyster
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: glycogen from: oyster
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
?
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
?
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: -
Products: -
r
glycogen + glucose 1-phosphate
glycogen + phosphate
-
Substrates: poor substrate
Products: -
?
glycogen + phosphate
alpha-D-glucan + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
glycogen + phosphate
alpha-D-glucan + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
glycogen + phosphate
alpha-D-glucan + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
glycogen + phosphate
alpha-D-glucan + alpha-D-glucose 1-phosphate
Substrates: -
Products: -
r
glycogen + phosphate
glycogen + alpha-D-glucose 1-phosphate
Substrates: -
Products: -
r
glycogen + phosphate
glycogen + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
?
glycogen + phosphate
glycogen + glucose 1-phosphate
-
Substrates: -
Products: -
?
glycogen + phosphate
glycogen + glucose 1-phosphate
Substrates: -
Products: -
?
maltoheptaose + alpha-D-glucose 1-phosphate
maltooctaose + phosphate
Substrates: -
Products: -
r
maltoheptaose + alpha-D-glucose 1-phosphate
maltooctaose + phosphate
-
Substrates: low activity
Products: -
r
maltoheptaose + alpha-D-glucose 1-phosphate
maltooctaose + phosphate
Substrates: 80% of the activity with maltose
Products: -
r
maltoheptaose + alpha-D-glucose 1-phosphate
maltooctaose + phosphate
Substrates: the cytosolic isozyme
Products: -
r
maltoheptaose + glucose 1-phosphate
maltooctaose + phosphate
-
Substrates: -
Products: -
r
maltoheptaose + glucose 1-phosphate
maltooctaose + phosphate
-
Substrates: -
Products: -
r
maltoheptaose + glucose 1-phosphate
maltooctaose + phosphate
-
Substrates: -
Products: -
r
maltoheptaose + glucose 1-phosphate
maltooctaose + phosphate
-
Substrates: best substrate
Products: -
r
maltoheptaose + glucose 1-phosphate
maltooctaose + phosphate
-
Substrates: poor substrate
Products: -
r
maltoheptaose + glucose 1-phosphate
maltooctaose + phosphate
-
Substrates: best substrate
Products: -
r
maltoheptaose + glucose 1-phosphate
maltooctaose + phosphate
-
Substrates: isozyme I
Products: -
r
maltoheptaose + glucose 1-phosphate
maltooctaose + phosphate
-
Substrates: -
Products: -
r
maltoheptaose + phosphate
maltohexaose + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
maltoheptaose + phosphate
maltohexaose + alpha-D-glucose 1-phosphate
Substrates: -
Products: -
r
maltoheptaose + phosphate
maltohexaose + alpha-D-glucose 1-phosphate
Substrates: 35% of the activity with maltoheptaose
Products: -
r
maltoheptaose + phosphate
maltohexaose + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
?
maltoheptaose + phosphate
maltohexaose + alpha-D-glucose 1-phosphate
Substrates: the cytosolic isozyme
Products: -
r
maltohexaose + alpha-D-glucose 1-phosphate
maltoheptaose + phosphate
Substrates: -
Products: -
r
maltohexaose + alpha-D-glucose 1-phosphate
maltoheptaose + phosphate
-
Substrates: -
Products: -
r
maltohexaose + alpha-D-glucose 1-phosphate
maltoheptaose + phosphate
-
Substrates: low activity
Products: -
r
maltohexaose + alpha-D-glucose 1-phosphate
maltoheptaose + phosphate
Substrates: 82% of the activity with maltose
Products: -
r
maltohexaose + glucose 1-phosphate
maltoheptaose + phosphate
-
Substrates: -
Products: -
r
maltohexaose + glucose 1-phosphate
maltoheptaose + phosphate
-
Substrates: -
Products: -
r
maltohexaose + glucose 1-phosphate
maltoheptaose + phosphate
-
Substrates: -
Products: -
r
maltohexaose + glucose 1-phosphate
maltoheptaose + phosphate
-
Substrates: -
Products: -
r
maltohexaose + glucose 1-phosphate
maltoheptaose + phosphate
-
Substrates: -
Products: -
r
maltohexaose + glucose 1-phosphate
maltoheptaose + phosphate
-
Substrates: -
Products: -
r
maltohexaose + phosphate
maltopentaose + alpha-D-glucose 1-phosphate
Substrates: -
Products: -
r
maltohexaose + phosphate
maltopentaose + alpha-D-glucose 1-phosphate
Substrates: 85% of the activity with maltoheptaose
Products: -
r
maltooctaose + glucose 1-phosphate
maltononaose + phosphate
-
Substrates: -
Products: -
r
maltooctaose + glucose 1-phosphate
maltononaose + phosphate
-
Substrates: -
Products: -
r
maltopentaose + alpha-D-glucose 1-phosphate
maltohexaose + phosphate
Substrates: -
Products: -
r
maltopentaose + alpha-D-glucose 1-phosphate
maltohexaose + phosphate
-
Substrates: -
Products: -
r
maltopentaose + alpha-D-glucose 1-phosphate
maltohexaose + phosphate
Substrates: 86% of the activity with maltose
Products: -
r
maltopentaose + glucose 1-phosphate
maltohexaose + phosphate
-
Substrates: -
Products: -
r
maltopentaose + glucose 1-phosphate
maltohexaose + phosphate
-
Substrates: -
Products: -
r
maltopentaose + glucose 1-phosphate
maltohexaose + phosphate
-
Substrates: -
Products: -
r
maltopentaose + glucose 1-phosphate
maltohexaose + phosphate
-
Substrates: -
Products: -
r
maltopentaose + glucose 1-phosphate
maltohexaose + phosphate
-
Substrates: -
Products: -
?
maltopentaose + glucose 1-phosphate
maltohexaose + phosphate
-
Substrates: -
Products: -
r
maltopentaose + glucose 1-phosphate
maltohexaose + phosphate
-
Substrates: cytoplasmic enzyme, glucosylation at the same rate of glucosylation of debranched amylopectin, chloroplastic enzyme, glucosylation at 50% the rate of glucosylation of debranched amylopectin
Products: -
r
maltopentaose + glucose 1-phosphate
maltohexaose + phosphate
-
Substrates: isozyme I
Products: -
r
maltopentaose + glucose 1-phosphate
maltohexaose + phosphate
-
Substrates: -
Products: -
r
maltopentaose + phosphate
maltotetraose + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
maltopentaose + phosphate
maltotetraose + alpha-D-glucose 1-phosphate
Substrates: -
Products: -
r
maltopentaose + phosphate
maltotetraose + alpha-D-glucose 1-phosphate
Substrates: 78% of the activity with maltoheptaose
Products: -
r
maltopentaose + phosphate
maltotetraose + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
?
maltose + alpha-D-glucose 1-phosphate
maltotriose + phosphate
-
Substrates: not phosphorylase B
Products: -
?
maltose + alpha-D-glucose 1-phosphate
maltotriose + phosphate
-
Substrates: less effective than starch, amylose or glycogen
Products: -
?
maltose + alpha-D-glucose 1-phosphate
maltotriose + phosphate
-
Substrates: -
Products: -
?
maltose + alpha-D-glucose 1-phosphate
maltotriose + phosphate
Substrates: -
Products: -
r
maltotetraose + alpha-D-glucose 1-phosphate
maltopentaose + phosphate
Substrates: -
Products: -
r
maltotetraose + alpha-D-glucose 1-phosphate
maltopentaose + phosphate
-
Substrates: -
Products: -
r
maltotetraose + alpha-D-glucose 1-phosphate
maltopentaose + phosphate
Substrates: 90% of the activity with maltose
Products: -
r
maltotetraose + alpha-D-glucose 1-phosphate
maltopentaose + phosphate
Substrates: the cytosolic isozyme
Products: -
r
maltotetraose + glucose 1-phosphate
maltopentaose + phosphate
-
Substrates: best substrate
Products: -
ir
maltotetraose + glucose 1-phosphate
maltopentaose + phosphate
-
Substrates: -
Products: -
ir
maltotetraose + glucose 1-phosphate
maltopentaose + phosphate
-
Substrates: smallest acceptor for synthesis
Products: -
r
maltotetraose + glucose 1-phosphate
maltopentaose + phosphate
-
Substrates: glucosylation at 22% the rate of maltoheptaose glucosylation
Products: -
r
maltotetraose + glucose 1-phosphate
maltopentaose + phosphate
-
Substrates: -
Products: -
ir
maltotetraose + glucose 1-phosphate
maltopentaose + phosphate
-
Substrates: -
Products: -
ir
maltotetraose + glucose 1-phosphate
maltopentaose + phosphate
-
Substrates: -
Products: -
?
maltotetraose + glucose 1-phosphate
maltopentaose + phosphate
-
Substrates: cytoplasmic enzyme: poor substrate
Products: -
r
maltotetraose + glucose 1-phosphate
maltopentaose + phosphate
-
Substrates: -
Products: -
r
maltotetraose + glucose 1-phosphate
maltopentaose + phosphate
-
Substrates: -
Products: -
r
maltotetraose + glucose 1-phosphate
maltopentaose + phosphate
-
Substrates: -
Products: -
ir
maltotetraose + phosphate
maltotriose + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
maltotetraose + phosphate
maltotriose + alpha-D-glucose 1-phosphate
Substrates: -
Products: -
r
maltotetraose + phosphate
maltotriose + alpha-D-glucose 1-phosphate
Substrates: 61% of the activity with maltoheptaose
Products: -
r
maltotetraose + phosphate
maltotriose + alpha-D-glucose 1-phosphate
-
Substrates: 50% of the activity with maltopentaose
Products: -
?
maltotetraose + phosphate
maltotriose + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
maltotriose + alpha-D-glucose 1-phosphate
maltotetraose + phosphate
Substrates: maltotriose is the smallest substrate accepted for the synthetic reaction direction, maltotetraose is the smallest substrate accepted for the phosphorolytic reaction direction
Products: -
r
maltotriose + alpha-D-glucose 1-phosphate
maltotetraose + phosphate
Substrates: 95% of the activity with maltose
Products: -
r
maltotriose + alpha-D-glucose 1-phosphate
maltotetraose + phosphate
-
Substrates: -
Products: -
r
maltotriose + alpha-D-glucose 1-phosphate
maltotetraose + phosphate
-
Substrates: -
Products: -
?
maltotriose + alpha-D-glucose 1-phosphate
maltotetraose + phosphate
-
Substrates: -
Products: -
r
maltotriose + glucose 1-phosphate
maltotetraose + phosphate
-
Substrates: -
Products: -
r
maltotriose + glucose 1-phosphate
maltotetraose + phosphate
-
Substrates: less effective than starch, amylose or glycogen
Products: -
r
maltotriose + glucose 1-phosphate
maltotetraose + phosphate
Substrates: -
Products: -
r
maltotriose + glucose 1-phosphate
maltotetraose + phosphate
-
Substrates: -
Products: -
r
maltotriose + glucose 1-phosphate
maltotetraose + phosphate
-
Substrates: -
Products: -
ir
maltotriose + phosphate
maltose + alpha-D-glucose 1-phosphate
Substrates: -
Products: -
r
maltotriose + phosphate
maltose + alpha-D-glucose 1-phosphate
Substrates: 35% of the activity with maltoheptaose
Products: -
r
starch + alpha-D-glucose 1-phosphate
starch + phosphate
-
Substrates: prolongation of the starch molecule with one glucose monomer
Products: -
r
starch + alpha-D-glucose 1-phosphate
starch + phosphate
-
Substrates: prolongation of the starch molecule with one glucose monomer
Products: -
r
starch + alpha-D-glucose 1-phosphate
starch + phosphate
Substrates: -
Products: -
r
starch + alpha-D-glucose 1-phosphate
starch + phosphate
Substrates: preferred substrate
Products: -
r
starch + alpha-D-glucose 1-phosphate
starch + phosphate
-
Substrates: -
Products: -
?
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: -
Products: -
?
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: soluble starch
Products: -
r
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: -
Products: -
?
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: -
Products: -
r
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: -
Products: -
r
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: soluble starch
Products: -
r
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: -
Products: -
?
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: -
Products: -
r
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: soluble starch
Products: -
r
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: best substrate
Products: -
r
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: soluble starch
Products: -
r
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: -
Products: -
r
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: -
Products: -
?
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: soluble starch
Products: -
r
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: poor substrate
Products: -
r
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: soluble starch
Products: -
r
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: phosphorolysis at 31% the rate of glycogen phosphorolysis
Products: -
r
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: phosphorolysis at 31% the rate of glycogen phosphorolysis
Products: -
r
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: best substrate
Products: -
?
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: soluble starch
Products: -
?
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: native chloroplast grains
Products: -
?
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: soluble starch
Products: -
r
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: -
Products: -
?
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: best substrate
Products: -
r
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: soluble starch
Products: -
r
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: potato enzyme
Products: -
r
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: glucosylation at 32% the rate of dextrin glucosylation
Products: -
?
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: -
Products: -
r
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: soluble starch
Products: -
r
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: glucosylation of native starch granules occurs at 82%, isozyme P-1, or 11.5%, isozyme P-2, the rate of soluble starch, phosphorolysis at the same rate as soluble starch
Products: -
r
starch + glucose 1-phosphate
starch + phosphate
-
Substrates: soluble starch
Products: -
r
starch + phosphate
starch + D-glucose-1-phosphate
-
Substrates: -
Products: -
?
starch + phosphate
starch + D-glucose-1-phosphate
-
Substrates: -
Products: -
?
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: ineffective primer: glucose
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: polyglucose primer required
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: key step in cellular differentiation of Dictyostelium discoideum
Products: -
?
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: no activity with glucose 6-phosphate, fructose 6-phosphate, and fructose 1,6-diphosphate
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: strict specificity for glucose 1-phosphate
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: polyglucose primer required
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: pathway in starch
Products: -
?
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: pathway in starch
Products: -
?
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: no activity with Schardinger dextrin and cellulose
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: favoured reaction
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: polyglucose primer required
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: catalyzes incorporation of glucose into alpha-1,4-glucosidic linkage on exterior chains of primer, glycogen synthesis is preferred
Products: -
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[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
Gracilaria sordida
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Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
Gracilaria sordida Harv. W. Nelsen
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Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: the liver enzyme catalyzes the forward reaction
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
Indocibium guttattam
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Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: no activity with pullulan
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: no activity with dextran
Products: -
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[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: no activity with sucrose
Products: -
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[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: no activity with glucose 6-phosphate, fructose 6-phosphate, and fructose 1,6-diphosphate
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: no activity with ribose 5-phosphate
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: strict specificity for glucose 1-phosphate
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: no activity with Schardinger dextrin and cellulose
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: polyglucose primer required
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: glycogen metabolism
Products: -
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[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
488247, 488254, 488257, 488278, 488282, 488283, 488284, 488285, 488287, 718873, 719079, 719265, 719407, 719413 Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
Substrates: bovine liver glycogen, effects of the C-terminal domain on enzyme binding to glycogen, overview
Products: -
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[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
Substrates: usage of four different assay methods
Products: -
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[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: no activity with pullulan
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
Substrates: broad substrate specificity in both the synthesis and degradation of maltooligosaccharides In the synthetic direction of the enzymatic reaction, the lowest oligosaccharide required for the chain elongation is maltose. In the degradative direction the archaeal enzyme can produce D-glucose-1-phosphate from maltotriose or longer maltooligosaccharides including both glycogen and starch
Products: -
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[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: glycogen metabolism
Products: -
?
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: unprimed reaction: lag-phase, product presumably protein-bound glucan
Products: -
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[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: polyglucose primer required
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: polyglucose primer required
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: maltose is the minimum primer for glucan synthesis and maltotriose is the minimum substrate for degradation
Products: -
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[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: glycogen metabolism
Products: -
?
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
Voandzeia subterranea
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: -
Products: -
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
Substrates: polyglucose primer required
Products: -
r
additional information
?
-
-
Substrates: broad substrate specificities for different chain length dextrins and soluble starch, enzyme efficiency on dextrin DP4 is approximately 5fold lower than that on dextrin DP14 although kcat on dextrin DP4 is higher than on dextrin DP14
Products: -
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additional information
?
-
-
Substrates: broad substrate specificities for different chain length dextrins and soluble starch, enzyme efficiency on dextrin DP4 is approximately 5fold lower than that on dextrin DP14 although kcat on dextrin DP4 is higher than on dextrin DP14
Products: -
?
additional information
?
-
-
Substrates: the cell volume affects the activity in hepatocytes, thus the enzyme activity is a function of medium osmolarity, activity is increased in hyperosmotic media, overview
Products: -
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additional information
?
-
Substrates: maltotriose is the smallest substrate accepted for the synthetic reaction direction, maltotetraose is the smallest substrate accepted for the phosphorolytic reaction direction
Products: -
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additional information
?
-
Substrates: enzyme is involved in storage starch synthesis
Products: -
?
additional information
?
-
Substrates: enzyme is involved in storage starch synthesis
Products: -
?
additional information
?
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Substrates: enzyme is involved in storage starch synthesis
Products: -
?
additional information
?
-
-
Substrates: phosphorylase GlgP catalyzes glycogen breakdown and affects glycogen structure by removing glucose units from the polysaccharide outer chains
Products: -
?
additional information
?
-
Substrates: mastoparan binds to the enzyme to negatively regulate sarcoplasmic reticular Ca2+ release in skeletal muscle involving the ryanodine receptor, overview
Products: -
?
additional information
?
-
-
Substrates: mastoparan binds to the enzyme to negatively regulate sarcoplasmic reticular Ca2+ release in skeletal muscle involving the ryanodine receptor, overview
Products: -
?
additional information
?
-
Substrates: the enzyme specifically binds to mastoparan, a wasp venom toxin
Products: -
?
additional information
?
-
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Substrates: the enzyme specifically binds to mastoparan, a wasp venom toxin
Products: -
?
additional information
?
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Substrates: GPa reduces arsenate (As(V)) to the more toxic arsenite (As(III)) in a glutathione (GSH)-dependent fashion
Products: -
?
additional information
?
-
-
Substrates: a maltotetraosyl residue comprising the non-reducing-end of a pyridylaminated maltooligosaccharide is indispensable for the chain-lengthening action of phosphorylase
Products: -
?
additional information
?
-
-
Substrates: the catalytic site binds glucose 1-phosphate, glycogen, glucose, and glucose analogues
Products: -
?
additional information
?
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Substrates: the assay of enzyme activity at micromolar concentration of maltooligosyl-substrate is about 100 times lower than that in conventional enzyme assays using glycogen
Products: -
?
additional information
?
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Substrates: substrate specificity, no or nearly no activity with glucose, maltose, and maltotriose, overview
Products: -
?
additional information
?
-
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Substrates: enzyme is involved in starch degradation during submergence stress in rice plants
Products: -
?
additional information
?
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Substrates: Pho1 not only degrades maltohexaose but also extends them to synthesize longer malto-oligosaccharides, production of a broad spectrum of MOSs (G4-G19) is stimulated both by phosphate and alpha-D-glucose 1-phosphate
Products: -
?
additional information
?
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Substrates: Pho1 not only degrades maltohexaose but also extends them to synthesize longer malto-oligosaccharides, production of a broad spectrum of MOSs (G4-G19) is stimulated both by phosphate and alpha-D-glucose 1-phosphate
Products: -
?
additional information
?
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Substrates: increased enzyme activity increases 5-phosphoribosyl-1-diphosphate availability in hepatocyte cultures and vice versa, glycogenolysis is a major contributor to PRPP generation in liver tissue in the basal state
Products: -
?
additional information
?
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Substrates: the enzyme regulates the association of glycogen synthase with a proteoglycogen substrate in hepatocytes
Products: -
?
additional information
?
-
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Substrates: glycogen phosphorylase is dynamically regulated during and after status in the adult rat, and may have an important role in the pilocarpine model of epilepsy
Products: -
?
additional information
?
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Substrates: glycogen phosphorylase activity is measured in the direction of glycogen degradation (phosphorolysis)
Products: -
?
additional information
?
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Substrates: no substrate in direction of glucose 1-phosphate synthesis: pullulan, maltotriose
Products: -
?
additional information
?
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Substrates: substrate specificity of cytosolic isozyme
Products: -
?
additional information
?
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Substrates: substrate specificity of cytosolic isozyme
Products: -
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(1S)-1,5-anhydro-D-glucitol-spiro[1.5]-3-(2-naphthyl)-1,4,2-oxathiazole
-
-
(1S)-1,5-anhydro-D-glucitol-spiro[1.5]-3-(4-methoxyphenyl)-1,4,2-oxathiazole
-
-
(2-[[(2,3-dichloro-4H-thieno[3,2-b]pyrrol-5-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)acetic acid
-
-
(2-[[(2-chloro-6H-thieno[2,3-b]pyrrol-5-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)acetic acid
-
-
(2-[[(5-chloro-1H-indol-2-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)acetic acid
-
-
(2-[[(5-chloro-1H-pyrrolo[2,3-c]pyridin-2-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)acetic acid
-
-
(2-[[(5-chloro-6-fluoro-1H-indol-2-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)acetic acid
-
-
(2-[[(5-chloro-7-fluoro-1H-indol-2-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)acetic acid
-
-
(2-[[(5-fluoro-1H-indol-2-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)acetic acid
-
-
(2alpha)-3-hydroxyolean-12-en-28-oic acid
-
-
(2alpha,3beta)-2,3-bis(acetyloxy)olean-12-en-28-oic acid
-
-
(2alpha,3beta)-2,3-bis(butanoyloxy)olean-12-en-28-oic acid
-
-
(2alpha,3beta)-2,3-bis(propanoyloxy)olean-12-en-28-oic acid
-
-
(2beta)-2-hydroxyurs-12-en-28-oic acid
-
-
(2beta)-3-hydroxyolean-12-en-28-oic acid
-
-
(2beta,3alpha)-2,3-dihydroxyolean-12-en-28-oic acid
-
-
(2beta,3alpha)-2,3-dihydroxyurs-12-en-28-oic acid
-
-
(2E,2'E)-N,N'-(oxydiethane-2,1-diyl)bis[3-(3,4-dichlorophenyl)acrylamide]
-
(2E,2'E)-N,N'-(thiodiethane-2,1-diyl)bis[3-(3,4-dichlorophenyl)acrylamide]
-
(2E,2'E)-N,N'-butane-1,4-diylbis[3-(3,4-dichlorophenyl)-acrylamide]
-
(2E,2'E)-N,N'-pentane-1,5-diylbis[3-(3,4-dichlorophenyl)acrylamide]
crystallization data
(2R)-2-cyclohexyl-2-[[(3-[[(2,4,6-trimethylphenyl)carbamoyl]amino]naphthalen-2-yl)carbonyl]amino]propanoic acid
-
potent in vitro inhibition, reduced inhibition of CYP2C9 and good pharmacokinetic properties
(2R,3R,4S,5R,6R)-3,4,5,9-tetrahydroxy-2-hydroxymethyl-7,9-diaza-1-oxa-spiro[4,5]decane-8,10-dione
-
(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-2-hydroxymethyl-7,9-diaza-1-oxa-spiro[4,5]decane-8,10-dione
-
(2S)-2-[[(3-[[(2,4,6-trimethylphenyl)carbamoyl]amino]naphthalen-2-yl)carbonyl]amino]heptanoic acid
-
(2S)-cyclohexyl[[(3-[[(2,4,6-trimethylphenyl)carbamoyl]amino]naphthalen-2-yl)carbonyl]amino]ethanoic acid
-
-
(2S)-cyclopentyl[[(3-[[(2,4,6-trimethylphenyl)carbamoyl]amino]naphthalen-2-yl)carbonyl]amino]ethanoic acid
-
-
(2Z)-2-(hydroxyimino)olean-12-en-28-oic acid
-
-
(2Z)-2-(hydroxyimino)urs-12-en-28-oic acid
-
-
(3beta)-28-[(2-[[2-(acetylamino)ethyl]amino]ethyl)amino]-28-oxoolean-12-en-3-yl acetate
-
-
(3beta)-28-[(3-aminopropyl)amino]-28-oxolup-20(29)-ene-3,23-diyl diacetate
-
-
(3beta)-28-[(6-aminohexyl)amino]-28-oxolup-20(29)-ene-3,23-diyl diacetate
-
-
(3beta)-3-[[(4-[[(phenylacetyl)oxy]methyl]-1H-1,2,3-triazol-1-yl)acetyl]oxy]olean-12-en-28-oic acid
-
-
(3beta)-N-(6-aminohexyl)-3,23-dihydroxylup-20(29)-en-28-amide
-
-
(3beta,12alpha,13xi)-3,12-dihydroxyoleanan-28-oic acid
-
-
(3beta,3'beta)-3,3'-[hexane-1,6-diylbis(1H-1,2,3-triazole-1,4-diylmethanediyloxy)]bisolean-12-en-28-oic acid
-
-
(4aS,6aS,6bR,8aR,14aR,14bR,16bS)-2,2,6a,6b,9,9,14a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,14,14a,14b,15,16b-hexadecahydrochryseno[1,2-g]quinoxaline-4a(2H)-carboxylic acid
-
-
(5R,7R,8R,9S,10R)-7-(hydroxymethyl)-3-(2-naphthyl)-1,6-dioxa-2-azaspiro[4,5]dec-2-ene-8,9,10-triol
-
(5R,7R,8R,9S,10R)-7-(hydroxymethyl)-3-(4-methoxyphenyl)-1,6-dioxa-2-azaspiro[4,5]dec-2-ene-8,9,10-triol
-
(5R,7R,8R,9S,10R)-7-(hydroxymethyl)-3-(4-toluyl)-1,6-dioxa-2-azaspiro[4,5]dec-2-ene-8,9,10-triol
-
(5R,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-6-oxa-1,3-diazaspiro[4.5]decane-2,4-dione
-
-
(5S,7R,8R,9S,10R)-8,9,10-tris(benzyloxy)-7-[(benzyloxy)methyl]-3-(4-methoxyphenyl)-6-oxa-2-thia-1,3-diazaspiro[4.5]decane 2,2-dioxide
-
-
(5S,7R,8R,9S,10R)-8,9,10-tris(benzyloxy)-7-[(benzyloxy)methyl]-3-(naphthalen-2-yl)-6-oxa-2-thia-1,3-diazaspiro[4.5]decane 2,2-dioxide
-
-
(5S,7R,8S,9S,10R)-7-(hydroxymethyl)-3-(4-methoxyphenyl)-6-oxa-2-thia-1,3-diazaspiro[4.5]decane-8,9,10-triol 2,2-dioxide
-
-
(5S,7R,8S,9S,10R)-7-(hydroxymethyl)-3-(5,6,7,8-tetrahydronaphthalen-2-yl)-6-oxa-2-thia-1,3-diazaspiro[4.5]decane-8,9,10-triol 2,2-dioxide
-
-
(5S,7R,8S,9S,10R)-7-(hydroxymethyl)-3-(naphthalen-2-yl)-6-oxa-2-thia-1,3-diazaspiro[4.5]decane-8,9,10-triol 2,2-dioxide
-
-
(5S,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-2-thioxo-6-oxa-1,3-diazaspiro[4.5]decan-4-one
-
-
(5S,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-6-oxa-1,3-diazaspiro[4.5]decane-2,4-dione
-
-
(6aS,6bR,8aR,16aR,16bR,18bS)-2,2,6a,6b,9,9,16a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,16,16a,16b,17,18b-hexadecahydrochryseno[1,2-b]phenazine-4a(2H)-carboxylic acid
-
-
(NH4)2SO4
-
50-300 mM, weak inhibition
1'-(methylsulfonyl)pyrazolo[4,3-b]olean-12-en-28-oic acid
-
-
1'-acetylpyrazolo[4,3-b]olean-12-en-28-oic acid
-
-
1'-propanoylpyrazolo[4,3-b]olean-12-en-28-oic acid
-
-
1,3,5-tris-4'-2''-[3'''-C-(beta-D-glucopyranosyl)-1''',2''',4'''-oxadiazol-5'''-yl]ethyl-1',2',3'-triazol-1'-ylmethylbenzene
-
trivalent inhibitor. The valency of the molecules influences slightly the inhibition of the enzyme whereas the presence of a spacer arm between the core and the pharmacophore moieties does not
1,3,5-tris[3'-C-(beta-D-glucopyranosyl)-1',2',4'-oxadiazol-5'-yl]-benzene
-
trivalent inhibitor. The valency of the molecules influences slightly the inhibition of the enzyme whereas the presence of a spacer arm between the core and the pharmacophore moieties does not
1,4-dideoxy-1,4-imino-D-arabinitol
-
inhibits Pa-catalyzed As(V) reduction, inhibition of As(V) reduction is not influenced by glucose or AMP
1,5-anhydro-2,3,4,6-tetra-O-benzyl-1-methylidene-D-glucitol
-
-
1,5-gluconolactone
-
strong inhibition of muscle isozyme a and b
1-(2-carboxyphenyl)-6-[(2-chloro-4,6-difluorophenyl)amino]-4-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylic acid
1-(2-naphthyl)-3-(2',3',4',6'-tetra-O-benzoyl-beta-D-glucopyranosyl)-1H-1,2,4-triazol-5(4H)-one
-
1-(beta-D-glucopyranosyl)-4-hydroxymethyl-1,2,3-triazole
-
-
1-(beta-D-glucopyranosyl)-4-phenyl-1,2,3-triazole
-
-
1-(beta-D-glucopyranosyl)-5-(hept-1-yn-1-yl)uracil
-
-
1-(beta-D-glucopyranosyl)-5-(pent-1-yn-1-yl)uracil
-
-
1-(beta-D-glucopyranosyl)-5-ethynyluracil
-
cytotoxic effect on Hep-G2 cells
1-(beta-D-glucopyranosyl)-5-iodouracil
-
-
1-deoxy-1-methoxycarbonylamino-beta-D-glucopyranose
-
1-methyl-3-([4-(2-thienylmethyl)phenyl]amino)quinoxalin-2(1H)-one
-
50% inhibition at 0.00011 mM in glycogenolysis assay, no bioavailability in vivo
1-phenyl-3-(2',3',4',6'-tetra-O-benzoyl-beta-D-glucopyranosyl)-1H-1,2,4-triazol-5(4H)-one
-
1-[(2S)-2-([(5-chloro-1H-indol-2-yl)carbonyl]amino)-3-phenylpropanoyl]azetidine-3-carboxylic acid
1-[2-([[(2-chloro-4,5-difluorophenyl)carbonyl]carbamoyl]amino)-4-fluorophenyl]piperidine-4-carboxylic acid
1-[6-(acetyloxy)hexyl] 4-(7-[[(3beta)-3-hydroxy-28-oxoolean-12-en-28-yl]oxy]heptyl) (2R)-2-hydroxybutanedioate
-
-
1-[[(3-[[(2,4,6-trimethylphenyl)carbamoyl]amino]naphthalen-2-yl)carbonyl]amino]cyclodecanecarboxylic acid
-
-
1-[[(3-[[(2,4,6-trimethylphenyl)carbamoyl]amino]naphthalen-2-yl)carbonyl]amino]cyclooctanecarboxylic acid
-
potent in vitro inhibition, reduced inhibition of CYP2C9 and good pharmacokinetic properties
2,2',2''-tris[(2E)-4-hydroxybut-2-en-1-yl] 1,1',1''-(3b,5x,9x,13x,18x)-lup-20(29)-ene-3,23,28-triyl triethanedioate
-
-
2,3,4,6-tetra-O-acetyl-1-O-[(2alpha,3beta)-2,3-dihydroxy-28-oxoolean-12-en-28-yl]-beta-D-glucopyranose
-
-
2,3,4,6-tetra-O-benzyl-1-C-(hydroxymethyl)-alpha-D-glucopyranose
-
-
2,3,4,6-tetra-O-benzyl-1-C-(iodomethyl)-alpha-D-glucopyranose
-
-
2,3,4,6-tetra-O-benzyl-1-C-({[(4-methylphenyl)sulfonyl]oxy}methyl)-alpha-D-glucopyranose
-
-
2,3,4,6-tetra-O-benzyl-1-C-({[2-(1H-indol-3-yl)ethyl]amino}methyl)-alpha-D-glucopyranose
-
-
2,3,4,6-tetra-O-benzyl-1-C-methyl-alpha-D-glucopyranose
-
-
2,3,4,6-tetra-O-benzyl-1-C-[(chlorooxy)methyl]-alpha-D-glucopyranose
-
-
2,3,4,6-tetra-O-benzyl-1-C-[(hydroxyamino)methyl]-alpha-D-glucopyranose
-
-
2,3,4,6-tetra-O-benzyl-1-C-[(naphthalen-2-ylamino)methyl]-alpha-D-glucopyranose
-
-
2,3,4,6-tetra-O-benzyl-1-C-[(pyridin-2-ylamino)methyl]-alpha-D-glucopyranose
-
-
2,3,4,6-tetra-O-benzyl-1-C-{[(4-methoxyphenyl)amino]methyl}-alpha-D-glucopyranose
-
-
2,3-dichloro-N-(1-[(2R)-2,3-dihydroxypropyl]-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.002 microM
2,3-dichloro-N-(1-[3-hydroxy-2-(hydroxymethyl)propyl]-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.038 microM
2,3-dichloro-N-[1-(2-hydroxyethyl)-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl]-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.007 microM
2,3-dihydroisooxazolyl oleanolic acid benzyl ester
-
50% inhibition at 0.0196 mM
2,3-diphosphoglycerate
-
5 mM, 30% inhibition
2,4-dinitrophenol
-
5 mM, 67% inhibition
2-(2-[[(2,3-dichloro-4H-thieno[3,2-b]pyrrol-5-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)-4-methoxybutanoic acid
-
-
2-(phenylamino)ethyl (3beta)-3-hydroxyurs-12-en-28-oate
-
-
2-amino-3,4-dihydroxy-5-methoxybenzoic acid
-
-
2-amino-4-fluoro-5-(1-methyl-1H-imidazol-2-ylsulfanyl)-N-(3-trifluoromethyl-phenyl)-benzamide
simultaneous inhibition of glycogen phosphorylase and activation of glucokinase
2-amino-4-fluoro-N-(3-fluoro-phenyl)-5-(1-methyl-1H-imidazol-2-ylsulfanyl)-benzamide
simultaneous inhibition of glycogen phosphorylase and activation of glucokinase
2-amino-4-fluoro-N-(4-methoxy-phenyl)-5-(1-methyl-1H-imidazol-2-ylsulfanyl)-benzamide
simultaneous inhibition of glycogen phosphorylase and activation of glucokinase
2-amino-N-(3-amino-phenyl)-4-fluoro-5-(1-methyl-1H-imidazol-2-ylsulfanyl)-benzamide
simultaneous inhibition of glycogen phosphorylase and activation of glucokinase
2-amino-N-(3-cyano-phenyl)-4-fluoro-5-(1-methyl-1H-imidazol-2-ylsulfanyl)-benzamide
simultaneous inhibition of glycogen phosphorylase and activation of glucokinase
2-bromoethyl (2beta)-2-hydroxyolean-12-en-28-oate
-
-
2-bromoethyl (3beta)-3-hydroxyurs-12-en-28-oate
-
-
2-chloro-N-((3R)-1-[(2R)-2,3-dihydroxypropyl]-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.040 microM
2-chloro-N-((3R)-1-[(2S)-2,3-dihydroxypropyl]-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.021 microM
2-chloro-N-((3S)-1-[(2R)-2,3-dihydroxypropyl]-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.027 microM
2-chloro-N-((3S)-1-[(2S)-2,3-dihydroxypropyl]-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.012 microM
2-chloro-N-(1-[(2R)-2,3-dihydroxypropyl]-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.029 microM
2-chloro-N-(1-[2-(methylsulfinyl)ethyl]-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.048 microM
2-chloro-N-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.041 microM
2-chloro-N-[1-(2-hydroxybutyl)-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl]-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.044 microM
2-chloro-N-[1-(2-hydroxyethyl)-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl]-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.026 microM
2-chloro-N-[1-(2-methoxyethyl)-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl]-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.05 microM
2-chloro-N-[1-(3-hydroxypropyl)-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl]-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.021 microM
2-chloro-N-[1-(cyanomethyl)-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl]-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.028 microM
2-Cresol
-
5 mM, 67% inhibition
2-ethoxy-2-oxoethyl (2beta)-2-hydroxyolean-12-en-28-oate
-
-
2-ethoxy-2-oxoethyl (2beta,3alpha,5xi,8alpha,9xi,10alpha,14beta,17alpha,18alpha)-2,3-dihydroxyolean-12-en-28-oate
-
50% inhibition at 0.019 mM
2-ethylimidazole
weak inhibition of wild-type activity, inhibition of mutant enzyme H334G
2-hydroxymethenyl oleanonic acid benzyl ester
-
50% inhibition at 0.0063 mM
2-methylimidazole
weak inhibition of wild-type activity
2-O-acetyl-3-oxomaslinic acid benzyl ester
-
50% inhibition at 0.029 mM
2-oxours-12-en-28-oic acid
-
-
2-[(2R)-3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl]-2-hydroxyethyl (1S,2R,4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-10-(acetyloxy)-1,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylate
-
-
2-[(2R)-3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl]-2-hydroxyethyl (4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-10-(acetyloxy)-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylate
-
-
2-[3'-(benzylamino)-2'-oxopyridin-1'(2H)-yl]-N-(3'',4''-dichlorobenzyl)acetamide
-
-
2beta,3alpha-dihydroxyurs-12-en-28-oic acid
-
-
3,5-dinitrobenzoic acid
-
5 mM, 47% inhibition
3-(2',3',4',6'-tetra-O-benzoyl-beta-D-glucopyranosyl)-1H-1,2,4-triazol-5(4H)-one
-
3-(2-[[(2,3-dichloro-4H-thieno[3,2-b]pyrrol-5-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)propanoic acid
-
-
3-(beta-D-glucopyranosyl)-1-(2-naphthyl)-1H-1,2,4-triazol-5(4H)-one
-
3-(beta-D-glucopyranosyl)-1-phenyl-1H-1,2,4-triazol-5(4H)-one
-
3-(beta-D-glucopyranosyl)-1H-1,2,4-triazol-5(4H)-one
-
3-(beta-D-glucopyranosyl)-6-pentyl-2,3-dihydro-furano-[2,3-d]pyrimidin-2-one
-
-
3-(beta-D-glucopyranosyl)-6-propyl-2,3-dihydro-furano-[2,3-d]pyrimidin-2-one
-
-
3-Aminophenol
-
5 mM, 20% inhibition
3-methoxypterolactone
-
-
3-Nitrophenol
-
5 mM, 83% inhibition
3-O-[1-(methyl 6-deoxy-alpha-D-glucopyranosid-6-yl)-1H-1,2,3-triazol-4-yl]methyl 3b-hydroxyolean-12-en-28-oate
inhibitor is predicted to bind at the T-state allosteric site exclusively. The binding position of the oleanolic acid moiety occupies the same location as the T-state allosteric site of asiatic acid in the crystal structure. The newly attached sugar moiety shields the carboxyl group of oleanolic acid from forming the salt bridge with Arg310, and consequently reverses the orientation of the oleanolic acid as well as propelled the sugar moiety to extend more deeply into the alloteric dimer interface. As a result, a new hydrogen-bonding network forms between the sugar hydroxyls and the carboxyl of Asp227 plus the guanidino of Arg193, respectively, enhancing their contribution to the stability of the complex
3-[(2-[[(2,3-dichloro-4H-thieno[3,2-b]pyrrol-5-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)amino]-3-oxopropanoic acid
-
-
3-[(2-[[(2,3-dichloro-4H-thieno[3,2-b]pyrrol-5-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)oxy]propanoic acid
-
-
3-[(4-isoxazolidin-3-ylphenyl)amino]-1-methylquinoxalin-2(1H)-one
-
50% inhibition at 0.00011 mM in glycogenolysis assay, no bioavailability in vivo
4-((E)-azobenzene)-beta-D-glucoside
-
4-((Z)-azobenzene)-beta-D-glucoside
-
4-(2-[[(2,3-dichloro-4H-thieno[3,2-b]pyrrol-5-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)butanoic acid
-
-
4-([[(2-chloro-4,5-difluorophenyl)carbonyl]carbamoyl]amino)-3-(trifluoromethoxy)benzoic acid
4-Cresol
-
5 mM, 67% inhibition
4-hydroxy-3-methoxybenzoic acid
-
-
4-nitrophenol
-
5 mM, 56% inhibition, enhances inhibition by glucose, glucose-6-phosphate and ATP
4-oxo-4-[(pyrazolo[4,3-b]olean-12-en-28-yl)oxy]butanoic acid
-
-
4-S-alpha-D-glucopyranosyl-4-thiomaltotetraose
-
-
4-[(4-methyl-3-oxo-3,4-dihydroquinoxalin-2-yl)amino]-N-(2-thienylmethyl)benzamide
-
50% inhibition at 0.00014 mM in glycogenolysis assay, no bioavailability in vivo
4-[[(2-[[(2,3-dichloro-4H-thieno[3,2-b]pyrrol-5-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)methyl]sulfonyl]butanoic acid
-
-
5-(beta-D-glucopyranosyl)-3-(2-naphthyl)-1,2,4-oxadiazole
-
-
5-(beta-D-glucopyranosyl)-3-(4-methylphenyl)-1,2,4-oxadiazole
-
-
5-chloro-N-(1,3,6,6-tetrafluoro-(R)-5-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl)-1H-indole-2-carboxamide
-
docking study. Hydrophobic residues, such as Phe53, Pro188, and Gly186, around the two aliphatic fluorine atoms suggest that the lipophilic contact among them is an important driver of activity increases. Hydrophobic residues Leu39 and Lys191 are close to one of the aromatic fluorine atoms
5-chloro-N-(1,6,6-trifluoro-5-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl)-1H-indole-2-carboxamide
-
-
5-chloro-N-(1-hydroxy-2,3-dihydro-1H-inden-5-yl)-1H-indole-2-carboxamide
-
-
5-chloro-N-(1-[(2R)-2,3-dihydroxypropyl]-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-1H-indole-2-carboxamide
-
50% inhibition at 0.044 microM
5-chloro-N-(3,6,6-trifluoro-5-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl)-1H-indole-2-carboxamide
-
-
5-chloro-N-(5-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl)-1H-indole-2-carboxamide
-
-
5-chloro-N-(6,6-difluoro-5-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl)-1H-indole-2-carboxamide
-
-
5-chloro-N-[1-(2-hydroxyethyl)-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl]-1H-indole-2-carboxamide
-
50% inhibition at 0.017 microM
5-chloro-N-[2-chloro-4-(1,2-dihydroxyethyl)-phenyl]-1H-indole-2-carboxamide
-
5-chloro-N-[4-(1,2-dihydroxyethyl)-3-(trifluoromethyl)phenyl]-1H-indole-2-carboxamide
-
5-chloro-N-[4-(1,2-dihydroxyethyl)phenyl]-1H-indole-2-carboxamide
5-chloro-N-[4-(2-hydroxyethyl)phenyl]-1H-indole-2-carboxamide
-
5-chloro-N-[5-(1,2-dihydroxyethyl)pyrazin-2-yl]-1H-indole-2-carboxamide
-
5-chloro-N-[5-(1,2-dihydroxyethyl)pyridin-2-yl]-1H-indole-2-carboxamide
-
6-(butylamino)hexyl (3beta)-3-hydroxyolean-12-en-28-oate
-
-
6-aminohexyl (3beta)-3-hydroxyolean-12-en-28-oate
-
-
6-[(4-methylphenyl)amino]hexyl (3beta)-3-hydroxyolean-12-en-28-oate
-
-
6-[4-(methyl 2,3,4-tri-O-benzyl-alpha-D-glucopyranosiduronylmethyl)-1H-1,2,3-triazol-1-yl]hexyl 3beta-hydroxyolean-12-en-28-oate
-
acarbose
-
poor inhibition
acetate
weak inhibition of wild-type activity, no effect on the activity of the H334G mutant
alpha-cyclodextrin
-
mixed-type competitive inhibition, inhibitor is not bound into the enzyme crystal
alpha-cyclodextrin dialdehyde I
-
alpha-cyclodextrin dialdehyde II
-
5 mM, 50% inhibition after 30 min
-
alpha-D-Glucopyranose-1,2-cyclic phosphate
-
competitive vs. glucose 1-phosphate
alpha-D-glucopyranosyl fluoride
alpha-D-glucose
-
physiological inhibitor
alpha-D-glucose 6-phosphate
-
binds at the allosteric site
alpha-D-glucose-1-methylenephosphonate
alpha-D-glucose-methylenephosphonate
-
competitive inhibitor
alpha-methylglucoside
-
-
aniline
-
5 mM, 50% inhibition
Antibodies to skeletal muscle phosphorylase
-
heart enzyme
-
Antiserum of purified phosphorylase
-
-
-
azide
weak inhibition of wild-type activity
baicalein
-
50% inhibition of phosphorylated, active enzyme at 0.0112 mM, 50% inhibition of unphosphorylated, adenosine monophosphate-activated enzyme at 0.0102 mM
BAY U6751
-
inhibits Pa-catalyzed As(V) reduction, glucose enhances inhibitory effect of the inhibitor on As(V) reduction, AMP at high concentration alleviates the inhibition
benzyl (2beta)-2-hydroxyolean-12-en-28-oate
-
-
benzyl (2beta)-2-hydroxyurs-12-en-28-oate
-
-
benzyl (2beta,3alpha)-2,3-dihydroxyolean-12-en-28-oate
-
-
benzyl (2beta,3alpha)-2,3-dihydroxyurs-12-en-28-oate
-
-
benzyl (2beta,5xi,8alpha,9xi,10alpha,14beta,17alpha,18alpha)-2-hydroxy-3-oxoolean-12-en-28-oate
-
50% inhibition at 0.029 mM
benzyl (2Z)-2-(hydroxyimino)olean-12-en-28-oate
-
-
benzyl (2Z)-2-(hydroxyimino)urs-12-en-28-oate
-
-
benzyl (2Z,5xi,8alpha,9xi,10alpha,14beta,17alpha,18alpha)-2-[[(2,4-dichlorobenzyl)oxy]imino]-3-oxoolean-12-en-28-oate
-
50% inhibition at 0.008 mM
benzyl (3beta)-3-[(pyridinium-1-ylacetyl)oxy]olean-12-en-28-oate chloride
-
-
benzyl (3beta)-3-[([4-[(4-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl]phenoxy)methyl]-1H-1,2,3-triazol-1-yl]acetyl)oxy]olean-12-en-28-oate
-
-
benzyl (3beta)-3-[([4-[(dodecanoyloxy)methyl]-1H-1,2,3-triazol-1-yl]acetyl)oxy]olean-12-en-28-oate
-
-
benzyl (3beta)-3-[[(4-[[(phenylacetyl)oxy]methyl]-1H-1,2,3-triazol-1-yl)acetyl]oxy]olean-12-en-28-oate
-
-
benzyl (3beta,12alpha,13xi)-3,12-dihydroxyoleanan-28-oate
-
-
benzyl (3beta,12beta,13xi)-3,12-dihydroxyoleanan-28-oate
-
-
benzyl (5xi,8alpha,9xi,10alpha,14beta,17alpha,18alpha)-2-hydroxy-3-oxooleana-1,12-dien-28-oate
-
50% inhibition at 0.030 mM
benzyl 1'-(2,4-dichlorobenzyl)pyrazolo[4,3-b]olean-12-en-28-oate
-
-
benzyl 1'-(carboxymethyl)pyrazolo[4,3-b]olean-12-en-28-oate
-
-
benzyl 1'-benzylpyrazolo[4,3-b]olean-12-en-28-oate
-
-
benzyl 1'-methylpyrazolo[4,3-b]olean-12-en-28-oate
-
-
benzyl 1'-[(ethoxycarbonyl)methyl]pyrazolo[4,3-b]olean-12-en-28-oate
-
-
benzyl 2-oxoolean-12-en-28-oate
-
-
benzyl 2-oxours-12-en-28-oate
-
-
benzyl 3-O-propargyl-3beta-hydroxyolean-12-en-28-oate
-
benzyl 3beta-(2-(diethylamino)acetoxy)olean-12-en-28-oate
-
-
benzyl 3beta-(2-azidoacetoxy)olean-12-en-28-oate
-
-
benzyl 3beta-(2-chloroacetoxy)olean-12-en-28-oate
-
-
benzyl 3beta-(4-aminobenzoyloxy)olean-12-en-28-oate
-
-
benzyl 3beta-(4-nitrobenzoyloxy)olean-12-en-28-oate
-
-
benzyl pyrazolo[4,3-b]olean-12-en-28-oate
-
-
beta-cyclodextrin
-
mixed-type competitive inhibition, the inhibitor can be accomodated in the glycogen storage site of T-state enzyme, subsite specificity
beta-D-glucopyranosyl 1-(2-cyclopropylamino-2-oxoacetyl)-amide
-
competitive
beta-D-glucopyranosyl 1-(ethoxy(oxo)acetyl)-amide
-
competitive
beta-D-glucopyranosyl 1-(methoxy(oxo)acetyl)-amide
-
competitive
beta-D-glucopyranosyl 1-oxalylamide
-
competitive
beta-D-glucopyranosyl bismethoxyphosphoramidate
weak competitive inhibitor, binds at the catalytic site and induces conformational changes in the vicinity of the site, inhibition mechanism, overview
beta-O-trans-caffeoyl-morolic acid
-
-
bis(6-([(3beta)-3-hydroxy-28-oxoolean-12-en-28-yl]oxy)hexyl) (2R)-2-hydroxybutanedioate
-
-
bredemolic acid
-
allosteric site inhibitor
butyl (2beta)-2-hydroxyolean-12-en-28-oate
-
-
cAMP
-
5 mM, weak inhibition
cyanidin
-
50% inhibition of phosphorylated, active enzyme at 0.003 mM, 50% inhibition of unphosphorylated, adenosine monophosphate-activated enzyme at 0.009 mM
Cyclodextrin-dialdehyde
-
cyclohexaamylose
Gracilaria sordida
-
-
cysteine
-
1 mM, 86% inhibition
D-Fructose 1-phosphate
-
-
D-fructose 6-phosphate
-
strong inhibition
D-gluconic acid 1,5-lactone
-
-
D-glucono-delta-lactone
-
0.05 mM, 90% inhibition of glucan phosphorolysis
D-glucose 6-phosphate
-
-
D-mannose 1-phosphate
-
strong inhibition
delphinidin
-
50% inhibition of phosphorylated, active enzyme at 0.0031 mM, 50% inhibition of unphosphorylated, adenosine monophosphate-activated enzyme at 0.0107 mM
deoxypyridoxine
-
weak inhibition of phosphorylase I, not II
diethyldicarbonate
-
0.84 mM, 50% inhibition
diethyldithiocarbamate
-
1 mM, 94% inhibition
dithiothreitol
-
1 mM, 56% inhibition
DL-phenylalanine
-
1 mM, 33% inhibition of phosphorylase B
DL-tryptophan
-
1 mM, 41% inhibition of phosphorylase B
EGTA
-
i.e. ethylene glycol bis(beta-aminoethylether)-N,N'-tetraacetic acid, 1 mM, 53% inhibition
epicatechin gallate
-
50% inhibition of phosphorylated, active enzyme at 0.0125 mM, 50% inhibition of unphosphorylated, adenosine monophosphate-activated enzyme at 0.050 mM
epigallocatechin-3-gallate
-
50% inhibition of phosphorylated, active enzyme at 0.0077 mM, 50% inhibition of unphosphorylated, adenosine monophosphate-activated enzyme at 0.0339 mM
ethyl (2beta)-2-hydroxyolean-12-en-28-oate
-
-
formate
5fold reduction of wild-type activity, no effect on the activity of the H334G mutant
FR258900
the inhibitor binds at the allosteric activator site, where the physiological activator AMP binds. The contacts from FR258900 to glycogen phosphorylase are dominated by nonpolar van der Waals interactions with Gln71, Gln72, Phe196, and Val459 (from the symmetry-related subunit), and also by ionic interactions from the carboxylate groups to the three arginine residues (Arg242, Arg309, and Arg310) that form the allosteric phosphate-recognition subsite. The binding of FR258900 to the protein promotes conformational changes that stabilize an inactive T-state quaternary conformation of the enzyme
gamma-cyclodextrin
-
mixed-type competitive inhibition, the inhibitor can be accomodated in the glycogen storage site of T-state enzyme, subsite specificity
glucopyranosylidene spirohydantoin
-
most effective glucose analogue inhibitor for glycogen phosphorylase b
glucopyranosylidene spirothiohydantoin
-
muscle and liver phosphorylase b, strong competitive inhibition vs. phosphate and glycogen
glucose
-
above 5 mM, diminishes GPa-catalyzed As(V) reduction
glucose 2-phosphate
-
weak
guanidine hydrochloride
-
study on kinetics of inactivation and aggregation at 0.7 M guanidine hydrochloride. Osmolytes trimethylamine-N-oxide and betaine exhibit the highest protective efficacy against phosphorylase b inactivation
hexane-1,6-diylbis(1H-1,2,3-triazole-1,4-diylmethanediyl) (3beta,3'beta)-bis(3-hydroxyolean-12-en-28-oate)
-
-
high salt concentration
-
-
-
hydrogencarbonate
-
weak inhibition
imidazole
weak inhibition of wild-type enzyme
iminobis[ethane-2,1-diylimino(3beta)-28-oxoolean-12-ene-28,3-diyl]diacetate
-
-
KCl
-
80 mM, 50% loss of activity, 200 mM, 90% loss of activity
maslinic acid 5-bromopentyl ester
-
50% inhibition at 0.007 mM
maslinic acid-(2-piperidin-1-yl)ethyl ester
-
50% inhibition at 0.031 mM
methyl (2beta)-2-hydroxyolean-12-en-28-oate
-
-
methyl (2S)-[[(2alpha,3beta)-2,3-bis(acetyloxy)-28-oxours-12-en-28-yl]amino](4-hydroxyphenyl)ethanoate
-
-
methyl (2S)-[[(2alpha,3beta)-2,3-bis(acetyloxy)-28-oxours-12-en-28-yl]amino](phenyl)ethanoate
-
-
methyl 6-deoxy-6-[4-([[(3beta)-3-hydroxy-28-oxoolean-12-en-28-yl]oxy]methyl)-1H-1,2,3-triazol-1-yl]-alpha-D-glucopyranoside
-
-
methyl [3-([(2-chloro-6H-thieno[2,3-b]pyrrol-5-yl)carbonyl]amino)-2-oxo-3,4-dihydroquinolin-1(2H)-yl]acetate
-
50% inhibition at 0.084 microM
Mg-ATP
-
reversible by AMP
molybdate
-
5 mM, more than 50% inhibition of glucan phosphorolysis
N-(1-phenyl-1H-1,2,3-triazole-4-carbonyl)-beta-D-glucopyranosylamine
-
N-(3-carboxypropanoyl)-beta-D-glucopyranosylamine
-
-
N-(3-cyano-phenyl)-2-[4-(2-fluoro-phenyl)-piperazin-1-yl]-acetamide
-
N-(3-fluoro-phenyl)-2-[4-(2-fluoro-phenyl)-piperazin-1-yl]-acetamide
-
N-(3-phenyl-1,2-oxazole-5-carbonyl)-beta-D-glucopyranosylamine
-
N-(acetylcarbamoyl)-beta-D-glucopyranosylamine
-
-
N-(azidoacetyl)-beta-D-glucopyranosylamine
-
-
N-(benzoylcarbamoyl)-beta-D-glucopyranosylamine
N-(beta-D-glucopyranosyl)-3-(napht-1-yl)-1,2,4-oxadiazol-5-carboxamide
-
N-(beta-D-glucopyranosyl)-3-phenyl-1,2,4-oxadiazol-5-carboxamide
-
N-(beta-D-glucopyranosyl)-5-(napht-1-yl)-1,3,4-oxadiazole-2-carboxamide
-
N-(beta-D-glucopyranosyl)-5-(naphth-1-yl)-1,2,4-oxadiazol-3-carboxamide
-
N-(beta-D-glucopyranosyl)-5-(naphth-2-yl)-1,3,4-oxadiazole-2-carboxamide
-
N-(beta-D-glucopyranosyl)-5-phenyl-1,2,4-oxadiazol-3-carboxamide
-
N-(beta-D-glucopyranosyl)-5-phenyl-1,3,4-oxadiazole-2-carboxamide
-
N-(dimethoxyphosphoryl)-beta-D-glucopyranosylamine
-
-
N-(naphthalen-2-ylcarbonyl)-beta-D-glucopyranosylamine
-
-
N-(naphthalene-1-carbonyl)-beta-D-glucopyranosylamine
-
N-(naphthalene-2-carbonyl)-beta-D-glucopyranosylamine
-
N-(trifluoroacetyl)-beta-D-glucopyranosylamine
-
-
N-([(2E)-2-[4-(trifluoromethyl)benzylidene]hydrazinyl]carbonothioyl)-beta-D-glucopyranosylamine
-
-
N-([4-[(benzyloxy)carbonyl]benzoyl]carbamoyl)-beta-D-glucopyranosylamine
-
-
N-acetyl-beta-D-glucopyranosylamine
-
-
N-Acetylimidazole
-
glucose 1-phosphate prevents
N-benzoyl-beta-D-glucopyranosylamine
-
N-benzyl-2-[3'-(benzylamino)-2'-oxopyridin-1'(2H)-yl]acetamide
-
-
N-carbamoyl-beta-D-glucopyranosylamine
-
-
N-phenyl-beta-D-glucopyranosylamine
-
-
N-[(2E)-3-(5,6,7,8-tetrahydronaphthalen-2-yl)prop-2-enoyl]-beta-D-glucopyranosylamine
-
N-[(2E)-3-(naphthalen-2-yl)prop-2-enoyl]-beta-D-glucopyranosylamine
-
N-[(2E)-3-([1,1'-biphenyl]-4-yl)prop-2-enoyl]-beta-D-glucopyranosylamine
-
N-[(2E)-3-[4-(propan-2-yl)phenyl]prop-2-enoyl]-beta-D-glucopyranosylamine
-
N-[(2R)-2-methyl-3-[4-(propan-2-yl)phenyl]propanoyl]-beta-D-glucopyranosylamine
-
N-[(3-[[(2,4,6-trimethylphenyl)carbamoyl]amino]naphthalen-2-yl)carbonyl]-L-norleucine
potent in vitro inhibition, low potential for P450 inhibition, and good pharmacokinetic properties
N-[(3S)-3-(4-ethylphenyl)butanoyl]-beta-D-glucopyranosylamine
-
N-[(4-aminobenzoyl)carbamoyl]-beta-D-glucopyranosylamine
-
-
N-[(4-carboxybenzoyl)carbamoyl]-beta-D-glucopyranosylamine
-
-
N-[(4-chlorobenzoyl)carbamoyl]-beta-D-glucopyranosylamine
-
-
N-[(4-hydroxybenzoyl)carbamoyl]-beta-D-glucopyranosylamine
-
-
N-[(4-methoxybenzoyl)carbamoyl]-beta-D-glucopyranosylamine
-
-
N-[(4-methylbenzoyl)carbamoyl]-beta-D-glucopyranosylamine
-
-
N-[(4-nitrobenzoyl)carbamoyl]-beta-D-glucopyranosylamine
-
-
N-[(biphenyl-4-ylcarbonyl)carbamoyl]-beta-D-glucopyranosylamine
-
-
N-[1-(2-amino-2-oxoethyl)-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl]-2-methyl-6H-thieno[2,3-b]pyrrole-5-carboxamide
N-[1-(naphthalen-1-yl)-1H-1,2,3-triazole-4-carbonyl]-beta-D-glucopyranosylamine
-
N-[3-(naphthalen-1-yl)-1,2-oxazole-5-carbonyl]-beta-D-glucopyranosylamine
-
N-[methoxy(oxo)acetyl]-beta-D-glucopyranosylamine
-
-
N-[[(2E)-2-(2-chlorobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
-
N-[[(2E)-2-(2-hydroxybenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
-
N-[[(2E)-2-(2-nitrobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
-
N-[[(2E)-2-(3-bromobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
-
N-[[(2E)-2-(3-chlorobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
-
N-[[(2E)-2-(3-hydroxybenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
-
N-[[(2E)-2-(4-bromobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
-
N-[[(2E)-2-(4-chlorobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
-
N-[[(2E)-2-(4-fluorobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
-
N-[[(2E)-2-(4-hydroxybenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
-
N-[[(2E)-2-(4-methoxybenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
-
N-[[(2E)-2-(4-methylbenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
-
N-[[(2E)-2-(4-nitrobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
-
N-[[(2E)-2-(pyridin-4-ylmethylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
-
N-[[([1,1'-biphenyl]-4-yl)oxy]acetyl]-beta-D-glucopyranosylamine
-
N-[[4-(methoxycarbonyl)benzoyl]carbamoyl]-beta-D-glucopyranosylamine
-
-