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Information on EC 2.3.3.9 - malate synthase

for references in articles please use BRENDA:EC2.3.3.9

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IUBMB Comments

The enzyme catalyses the irreversible condensation of acetyl-CoA with glyoxylate to form (S)-malate. Among other functions, the enzyme participates in the glyoxylate cycle, a modified version of the TCA cycle that bypasses steps that lead to a loss of CO2.

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

Synonyms
malate synthase, malate synthase g, glyoxylate cycle enzyme, malate synthetase, malate synthase a, malate synthase 1, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
chitin deacetylation, crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered), D-xylose degradation IV, glycolate and glyoxylate degradation II, glyoxylate cycle, L-arabinose degradation IV