Information on EC 2.3.3.13 - 2-isopropylmalate synthase and Organism(s) Pseudomonas aeruginosa

Reaction Schemes

hideshow

acetyl-CoA

+

3-methyl-2-oxobutanoate

+

H2O

=

(2S)-2-isopropylmalate

+

CoA

+

+

=

+

Synonyms
alpha-isopropylmalate synthase, isopropylmalate synthase, 2-isopropylmalate synthase, mtipms, alpha-ipms, osipms1, rol17, alpha-isopropylmalate synthetase, alpha-ipm synthase, alpha-ipms-14cr, more

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

3-hydroxy-4-methyl-3-carboxy-pentanoate 2-oxo-3-methyl-butanoate lyase (CoA-acetylating)

-

-

-

-

3-hydroxy-4-methyl-3-carboxyvalerate 2-oxo-3-methyl-butyrate lyase (CoA-acetylating)

-

-

-

-

alpha-IPM synthase

-

-

-

-

Alpha-IPM synthetase

-

-

-

-

Alpha-isopropylmalate synthase

-

-

-

-

alpha-isopropylmalate synthase I

-

-

-

-

alpha-isopropylmalate synthase II

-

-

-

-

alpha-isopropylmalate synthetase

-

-

-

-

alpha-isopropylmalic synthetase

-

-

-

-

IPM synthase

-

-

-

-

IPM-synthase

-

-

-

-

IPMS

-

-

-

-

isopropylmalate synthase

-

-

-

-

isopropylmalate synthetase

-

-

-

-

synthase, 2-isopropylmalate

-

-

-

-

synthase, alpha-isopropylmalate

-

-

-

-

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REACTION TYPE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

aldol condensation

-

-

-

-

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PATHWAY SOURCE

PATHWAYS

BRENDA

leucine metabolism

KEGG

Biosynthesis of secondary metabolites, Pyruvate metabolism, Valine, leucine and isoleucine biosynthesis

MetaCyc

3-methylbutanol biosynthesis (engineered), L-leucine biosynthesis

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SYSTEMATIC NAME

IUBMB Comments

acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)

Requires K+.

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CAS REGISTRY NUMBER

COMMENTARY

9030-98-2

-

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

Reversibility
r=reversible
ir=irreversible
?=not specified

2-oxo-3-methylbutanoate + acetyl-CoA + H2O

3-hydroxy-4-methyl-3-carboxypentanoate + CoA

Pseudomonas aeruginosa

-

636533

Substrates: -
Products: -

?

2-oxo-3-methylbutanoate + acetyl-CoA + H2O

?

Pseudomonas aeruginosa

-

636533

Substrates: first enzyme in biosynthesis of L-Leu
Products: -

?

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

2-oxo-3-methylbutanoate + acetyl-CoA + H2O

?

Pseudomonas aeruginosa

-

636533

Substrates: first enzyme in biosynthesis of L-Leu
Products: -

?

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only manually annotated data include textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks include all textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks + FRENDAco-occurrence of enzyme names and organism names (less precise)

ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Pseudomonas aeruginosa

-

636533

-

-

brenda

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UNIPROT

ENTRY NAME

ORGANISM

NO. OF AA

NO. OF TRANSM. HELICES

MOLECULAR WEIGHT[Da]

SOURCE

SEQUENCE

LOCALIZATION PREDICTIONThe reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).

A0A069Q6E5 pBLAST

A0A069Q6E5_PSEAI

Pseudomonas aeruginosa

556

0

61723

TrEMBL

Show Sequence

-

A0A071KXQ1 pBLAST

A0A071KXQ1_PSEAI

Pseudomonas aeruginosa

455

0

50669

TrEMBL

Show Sequence

-

A0A1Y0GQG2 pBLAST

A0A1Y0GQG2_PSEAI

Pseudomonas aeruginosa

592

0

65804

TrEMBL

Show Sequence

-

A0A1Y0GFQ0 pBLAST

A0A1Y0GFQ0_PSEAI

Pseudomonas aeruginosa

455

0

50642

TrEMBL

Show Sequence

-

A0A367MGP3 pBLAST

A0A367MGP3_PSEAI

Pseudomonas aeruginosa

455

0

50614

TrEMBL

Show Sequence

-

A0A367MHI7 pBLAST

A0A367MHI7_PSEAI

Pseudomonas aeruginosa

365

0

40043

TrEMBL

Show Sequence

-

A0A3M5D6D0 pBLAST

A0A3M5D6D0_PSEAI

Pseudomonas aeruginosa

594

0

66000

TrEMBL

Show Sequence

-

A0A5E5QW84 pBLAST

A0A5E5QW84_PSEAI

Pseudomonas aeruginosa

455

0

50699

TrEMBL

Show Sequence

-

A0A643EN89 pBLAST

A0A643EN89_PSEAI

Pseudomonas aeruginosa

592

0

65813

TrEMBL

Show Sequence

other Location (Reliability: 3)

A0A6A9JPL3 pBLAST

A0A6A9JPL3_PSEAI

Pseudomonas aeruginosa

455

0

50656

TrEMBL

Show Sequence

-

A0A6A9K505 pBLAST

A0A6A9K505_PSEAI

Pseudomonas aeruginosa

592

0

65694

TrEMBL

Show Sequence

Secretory Pathway (Reliability: 1)

A0A7M2ZXP4 pBLAST

A0A7M2ZXP4_PSEAI

Pseudomonas aeruginosa

592

0

65808

TrEMBL

Show Sequence

-

A0ABD7K410 pBLAST

A0ABD7K410_PSEAI

Pseudomonas aeruginosa

565

0

62858

TrEMBL

Show Sequence

-

A0ABD7K556 pBLAST

A0ABD7K556_PSEAI

Pseudomonas aeruginosa

556

0

61806

TrEMBL

Show Sequence

other Location (Reliability: 5)

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

636533

Stieglitz, B.I.; Calvo, J.M.

Distribution of the isopropylmalate pathway to leucine among diverse bacteria

J. Bacteriol.

118

935-941

1974

Alcaligenes viscolactis, Bacillus subtilis, Bradyrhizobium japonicum, Cereibacter sphaeroides, Chromatium sp., Chromatium sp. D, Escherichia coli, Escherichia coli B / ATCC 11303, Hydrogenomonas sp., Klebsiella aerogenes, Methylorubrum extorquens, Micrococcus luteus, Micrococcus sp., Paenibacillus polymyxa, Proteus vulgaris, Pseudomonas aeruginosa, Pseudomonas fluorescens, Rhodococcus opacus, Salmonella enterica subsp. enterica serovar Typhimurium

4829932

brenda

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