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The expected taxonomic range for this enzyme is: Escherichia coli
Synonyms hydroxyglutarate synthase, more
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2-hydroxyglutarate glyoxylate-lyase (CoA-propanoylating)
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2-hydroxyglutaratic synthetase
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2-hydroxyglutaric synthetase
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alpha-hydroxyglutarate synthetase
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EC 4.1.3.9
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formerly
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hydroxyglutarate synthase
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synthase, 2-hydroxyglutarate
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propanoyl-CoA + H2O + glyoxylate = 2-hydroxyglutarate + CoA
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propanoyl-CoA:glyoxylate C-propanoyltransferase (thioester-hydrolysing, 2-carboxyethyl-forming)
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propanoyl-CoA + glyoxylate
2-hydroxyglutarate + CoA
propanoyl-CoA + glyoxylate + H2O
2-hydroxyglutarate + CoA
propanoyl-CoA + glyoxylate
2-hydroxyglutarate + CoA
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Substrates: the enzyme is involved in the metabolism of propionate Products: -
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propanoyl-CoA + glyoxylate
2-hydroxyglutarate + CoA
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Substrates: the 2-hydroxyglutarate pathway is metabolically significant during growth of Escherichia coli E-26V on propionate by providing an auxiliary mechanism for the formation of C4 acids Products: -
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propanoyl-CoA + glyoxylate
2-hydroxyglutarate + CoA
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Substrates: the enzyme may play a role in the biosynthesis of cell constituents Products: -
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propanoyl-CoA + glyoxylate
2-hydroxyglutarate + CoA
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Substrates: the 2-hydroxyglutarate pathway is metabolically significant during growth of Escherichia coli E-26V on propionate by providing an auxiliary mechanism for the formation of C4 acids Products: -
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propanoyl-CoA + glyoxylate
2-hydroxyglutarate + CoA
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Substrates: the enzyme may play a role in the biosynthesis of cell constituents Products: -
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propanoyl-CoA + glyoxylate + H2O
2-hydroxyglutarate + CoA
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Substrates: - Products: -
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propanoyl-CoA + glyoxylate + H2O
2-hydroxyglutarate + CoA
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Substrates: - Products: -
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propanoyl-CoA + glyoxylate
2-hydroxyglutarate + CoA
propanoyl-CoA + glyoxylate
2-hydroxyglutarate + CoA
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Substrates: the enzyme is involved in the metabolism of propionate Products: -
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propanoyl-CoA + glyoxylate
2-hydroxyglutarate + CoA
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Substrates: the 2-hydroxyglutarate pathway is metabolically significant during growth of Escherichia coli E-26V on propionate by providing an auxiliary mechanism for the formation of C4 acids Products: -
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propanoyl-CoA + glyoxylate
2-hydroxyglutarate + CoA
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Substrates: the enzyme may play a role in the biosynthesis of cell constituents Products: -
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propanoyl-CoA + glyoxylate
2-hydroxyglutarate + CoA
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Substrates: the 2-hydroxyglutarate pathway is metabolically significant during growth of Escherichia coli E-26V on propionate by providing an auxiliary mechanism for the formation of C4 acids Products: -
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propanoyl-CoA + glyoxylate
2-hydroxyglutarate + CoA
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Substrates: the enzyme may play a role in the biosynthesis of cell constituents Products: -
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additional information
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additional information
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radioactive assay
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E-26
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derivate K2PRP3
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E-26
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mutant E-26V
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no activity in E. coli strain K2
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Highest Expressing Human Cell Lines
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Wegener, W.S.; Reeves, H.C.; Ajl, S.J.
Propionate metabolism. III. Studies on the significance of the alpha-hydroxyglutarate pathway
Arch. Biochem. Biophys.
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62-65
1968
Escherichia coli, Escherichia coli E-26
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Reeves, H.C.; Ajl, S.J.
alpha-Hydroxyglutaric acid synthetase
J. Bacteriol.
84
186-187
1962
Escherichia coli, Escherichia coli E-26
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Wegener, W.S.; Reeves, H.C.; Rabin, R.; Ajl, S.J.
A radioactive assay for malate synthase and other glyoxylate condensing enzymes
Methods Enzymol.
13
362-365
1969
Escherichia coli, Escherichia coli E-26
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Kay, W.W.
Genetic control of the metabolism of propionate by Escherichia coli K12
Biochim. Biophys. Acta
264
508-521
1972
Escherichia coli
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