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Disease on EC 2.3.2.B8 - E2:E3 ubiquitin transferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
UBCH5 Family Members Differentially Impact Stabilization of Mutant p53 via RNF128 Iso1 During Barrett's Progression to Esophageal Adenocarcinoma.
Amyotrophic Lateral Sclerosis
Both ubiquitin ligases FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated.
Angelman Syndrome
Subcellular organization of UBE3A in neurons.
Tissue-specific variation of Ube3a protein expression in rodents and in a mouse model of Angelman syndrome.
Zn-binding AZUL domain of human ubiquitin protein ligase Ube3A.
Autoimmune Diseases
A sesquiterpene lactone from a medicinal herb inhibits proinflammatory activity of TNF-? by inhibiting ubiquitin-conjugating enzyme UbcH5.
E3 ubiquitin-protein ligase TRIM21-mediated lysine capture by UBE2E1 reveals substrate-targeting mode of a ubiquitin-conjugating E2.
Brain Injuries
A Combined Proteomics and Bioinformatics Approach Reveals Novel Signaling Pathways and Molecular Targets After Intracerebral Hemorrhage.
Brain Ischemia
Circular RNA circ_HECTD1 regulates cell injury after cerebral infarction by miR-27a-3p/FSTL1 axis.
Breast Neoplasms
Aberrant recombination and repair during immunoglobulin class switching in BRCA1-deficient human B cells.
Drug mechanism-of-action discovery through the integration of pharmacological and CRISPR screens.
KSP inhibitor SB743921 inhibits growth and induces apoptosis of breast cancer cells by regulating p53, Bcl-2, and DTL.
Carcinogenesis
Constitutional Translocation Breakpoint Mapping by Genome-wide Paired-end Sequencing Identifies HACE1 as a Putative Wilms Tumor Susceptibility Gene.
HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.
NEDD4 promotes cell growth and migration via PTEN/PI3K/AKT signaling in hepatocellular carcinoma.
Carcinoma, Lobular
Aberrations of Chromosomes 1 and 16 in Breast Cancer: A Framework for Cooperation of Transcriptionally Dysregulated Genes.
Cholangiocarcinoma
XIAP Antagonist Embelin Inhibited Proliferation of Cholangiocarcinoma Cells.
Colitis, Ulcerative
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Dementia
Identification of prefrontal cortex protein alterations in Alzheimer's disease.
Dyskinesias
L-DOPA impairs proteasome activity in parkinsonism through D1 dopamine receptor.
Esophageal Achalasia
Autophagy-related 16-like 1 is influenced by human herpes virus 1-encoded microRNAs in biopsy samples from the lower esophageal sphincter muscle during per-oral endoscopic myotomy for esophageal achalasia.
Fanconi Anemia
Aberrant recombination and repair during immunoglobulin class switching in BRCA1-deficient human B cells.
Glioma
Ectopic expression of E3 ubiquitin-protein ligase 2 in glioma and enhances resistance to apoptosis through activating nuclear factor ?-light-chain-enhancer of B cells.
Herpes Simplex
Comparative proteomics identifies Schlafen 5 (SLFN5) as a herpes simplex virus restriction factor that suppresses viral transcription.
Infections
Comparative proteomics identifies Schlafen 5 (SLFN5) as a herpes simplex virus restriction factor that suppresses viral transcription.
HACE1, an E3 ubiquitin-protein ligase, Mitigates Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Infection Induced Oxidative Stress by Promoting Nrf2 Activity.
Insulin Resistance
Cbl Proto-Oncogene B (CBLB) c.197A>T Mutation Induces Mild Metabolic Dysfunction in Partial Type I Multiple Symmetric Lipomatosis (MSL).
Intellectual Disability
Erratum to: Haploinsufficiency of the E3 ubiquitin-protein ligase gene TRIP12 causes intellectual disability with or without autism spectrum disorders, speech delay, and dysmorphic features.
Haploinsufficiency of the E3 ubiquitin-protein ligase gene TRIP12 causes intellectual disability with or without autism spectrum disorders, speech delay, and dysmorphic features.
Language Development Disorders
Erratum to: Haploinsufficiency of the E3 ubiquitin-protein ligase gene TRIP12 causes intellectual disability with or without autism spectrum disorders, speech delay, and dysmorphic features.
Haploinsufficiency of the E3 ubiquitin-protein ligase gene TRIP12 causes intellectual disability with or without autism spectrum disorders, speech delay, and dysmorphic features.
Liver Cirrhosis
[Effects of bone morphogenetic protein-7 therapy on E3 ubiquitin ligase expression in mouse liver with experimentally induced fibrosis].
Liver Diseases
Overexpression of ring finger protein 20 inhibits the progression of liver fibrosis via mediation of histone H2B lysine 120 ubiquitination.
Lung Neoplasms
Effects of RING-SH2Grb², a Chimeric Protein Containing the E3 Ligase Domain of Cbl, on the EGFR Pathway.
Lymphoma
E3 ubiquitin ligase Cbl-b in innate and adaptive immunity.
Effects of RING-SH2Grb², a Chimeric Protein Containing the E3 Ligase Domain of Cbl, on the EGFR Pathway.
The anergy induction of M3 muscarinic acetylcholine receptor-reactive CD4+ T cells suppresses experimental sialadenitis-like Sjögren's syndrome.
The E3 Ubiquitin Ligase Cbl-b Predicts Favorable Prognosis in Breast Cancer.
Motor Neuron Disease
Both ubiquitin ligases FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated.
Mouth Neoplasms
Molecular docking data of E3 ubiquitin-protein ligase WWP1 with compounds from a medicinal plant Justicia adhatoda L.
Multiple Myeloma
Targeting of the E3 ubiquitin-protein ligase HUWE1 impairs DNA repair capacity and tumor growth in preclinical multiple myeloma models.
Muscular Atrophy
Small Molecular Weight Soybean Protein-Derived Peptides Nutriment Attenuates Rat Burn Injury-Induced Muscle Atrophy by Modulation of Ubiquitin-Proteasome System and Autophagy Signaling Pathway.
Muscular Dystrophies
Caveolin-3: A Causative Process of Chicken Muscular Dystrophy.
Neoplasm Metastasis
Integrative proteomics reveals the role of E3 ubiquitin ligase SYVN1 in hepatocellular carcinoma metastasis.
Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis.
Neoplasms
A HECT E3 ubiquitin-protein ligase with sequence similarity to E6AP does not target p53 for degradation in the softshell clam (Mya arenaria).
Degradation of the proto-oncogene product c-Fos by the ubiquitin proteolytic system in vivo and in vitro: identification and characterization of the conjugating enzymes.
hace1 Influences zebrafish cardiac development via ROS-dependent mechanisms.
HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.
HIF-1alpha and EPAS ubiquitination mediated by the VHL tumour suppressor involves flexibility in the ubiquitination mechanism, similar to other RING E3 ligases.
Identification of CDC20 as an immune infiltration-correlated prognostic biomarker in hepatocellular carcinoma.
Integrative proteomics reveals the role of E3 ubiquitin ligase SYVN1 in hepatocellular carcinoma metastasis.
Interruption of MDM2 signaling augments MDM2-targeted T cell-based antitumor immunotherapy through antigen-presenting machinery.
Loss of H2B monoubiquitination is associated with poor-differentiation and enhanced malignancy of lung adenocarcinoma.
MiR-30 Family Potentially Targeting PI3K-SIAH2 Predicted Interaction Network Represents a Novel Putative Theranostic Panel in Non-small Cell Lung Cancer.
Monoubiquitination is critical for ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 (Otub1) to suppress UbcH5 enzyme and stabilize p53 protein.
NEDD4 promotes cell growth and migration via PTEN/PI3K/AKT signaling in hepatocellular carcinoma.
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53.
Pathogen-associated molecular patterns activate expression of genes involved in cell proliferation, immunity and detoxification in the amebocyte-producing organ of the snail Biomphalaria glabrata.
Stability of the HTLV-1 Antisense-Derived Protein, HBZ, Is Regulated by the E3 Ubiquitin-Protein Ligase, UBR5.
Targeting of the E3 ubiquitin-protein ligase HUWE1 impairs DNA repair capacity and tumor growth in preclinical multiple myeloma models.
The E2 ubiquitin-conjugating enzyme UbcH5c: an emerging target in cancer and immune disorders.
The E3 Ubiquitin Ligase Cbl-b Predicts Favorable Prognosis in Breast Cancer.
The effects of curcumin on proliferation, apoptosis, invasion, and NEDD4 expression in pancreatic cancer.
The tumour suppressor HACE1 controls cell migration by regulating Rac1 degradation.
The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity.
Neuroinflammatory Diseases
MiR-142a-3p and miR-155-5p reduce methamphetamine-induced inflammation: Role of the target protein Peli1.
RNF216 mediates neuronal injury following experimental subarachnoid hemorrhage through the Arc/Arg3.1-AMPAR pathway.
Obesity
Cbl Proto-Oncogene B (CBLB) c.197A>T Mutation Induces Mild Metabolic Dysfunction in Partial Type I Multiple Symmetric Lipomatosis (MSL).
Papilloma
Zn-binding AZUL domain of human ubiquitin protein ligase Ube3A.
Parkinson Disease
Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity.
Both ubiquitin ligases FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated.
Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in ?-synuclein transgenic mice.
Parkin maintains mitochondrial levels of the protective Parkinson's disease-related enzyme 17-? hydroxysteroid dehydrogenase type 10.
Parkin Protects Against Misfolded SOD1 Toxicity by Promoting Its Aggresome Formation and Autophagic Clearance.
PINK1/PARKIN signalling in neurodegeneration and neuroinflammation.
Proteasomal inhibition reduces parkin mRNA in PC12 and SH-SY5Y cells.
Parkinsonian Disorders
14-3-3eta is a novel regulator of parkin ubiquitin ligase.
Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity.
Parkin-deficient mice are not more sensitive to 6-hydroxydopamine or methamphetamine neurotoxicity.
The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.
Ultrastructural localization of parkin in the rat brainstem, thalamus and basal ganglia.
Peste-des-Petits-Ruminants
Quantitative Proteomics Reveals a Novel Role of the E3 Ubiquitin-Protein Ligase FANCL in the Activation of the Innate Immune Response through Regulation of TBK1 Phosphorylation during Peste des Petits Ruminants Virus Infection.
Retinoblastoma
Function of cell-cycle regulators in predicting silent pituitary adenoma progression following surgical resection.
Spinocerebellar Ataxias
Both ubiquitin ligases FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated.
Tauopathies
S-nitrosylation of E3 ubiquitin-protein ligase RNF213 alters non-canonical Wnt/Ca+2 signaling in the P301S mouse model of tauopathy.
Virus Diseases
Quantitative Proteomics Reveals a Novel Role of the E3 Ubiquitin-Protein Ligase FANCL in the Activation of the Innate Immune Response through Regulation of TBK1 Phosphorylation during Peste des Petits Ruminants Virus Infection.
Zn-binding AZUL domain of human ubiquitin protein ligase Ube3A.
Warts
Transcriptome analysis of resistance mechanism to potato wart disease.
Wilms Tumor
Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney.