Reference on EC 2.3.2.B14 - L,D-transpeptidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Magnet, S.; Bellais, S.; Dubost, L.; Fourgeaud, M.; Mainardi, J.L.; Petit-Frere, S.; Marie, A.; Mengin-Lecreulx, D.; Arthur, M.; Gutmann, L.
Identification of the L,D-transpeptidases responsible for attachment of the Braun lipoprotein to Escherichia coli peptidoglycan
J. Bacteriol.
189
3927-3931
2007
Enterococcus faecium
Magnet, S.; Arbeloa, A.; Mainardi, J.L.; Hugonnet, J.E.; Fourgeaud, M.; Dubost, L.; Marie, A.; Delfosse, V.; Mayer, C.; Rice, L.B.; Arthur, M.
Specificity of L,D-transpeptidases from Gram-positive bacteria producing different peptidoglycan chemotypes
J. Biol. Chem.
282
13151-13159
2007
Bacillus subtilis, Bacillus subtilis 168, Enterococcus faecalis, Enterococcus faecalis JH2-2, Enterococcus faecium, Enterococcus faecium M512
Biarrotte-Sorin, S.; Hugonnet, J.E.; Delfosse, V.; Mainardi, J.L.; Gutmann, L.; Arthur, M.; Mayer, C.
Crystal structure of a novel beta-lactam-insensitive peptidoglycan transpeptidase
J. Mol. Biol.
359
533-538
2006
Enterococcus faecium
Dubee, V.; Arthur, M.; Fief, H.; Triboulet, S.; Mainardi, J.L.; Gutmann, L.; Sollogoub, M.; Rice, L.B.; Etheve-Quelquejeu, M.; Hugonnet, J.E.
Kinetic analysis of Enterococcus faecium L,D-transpeptidase inactivation by carbapenems
Antimicrob. Agents Chemother.
56
3409-3412
2012
Enterococcus faecium, Enterococcus faecium M512
Dubee, V.; Triboulet, S.; Mainardi, J.L.; Etheve-Quelquejeu, M.; Gutmann, L.; Marie, A.; Dubost, L.; Hugonnet, J.E.; Arthur, M.
Inactivation of Mycobacterium tuberculosis L,D-transpeptidase LdtMt1 by carbapenems and cephalosporins
Antimicrob. Agents Chemother.
56
4189-4195
2012
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Lavollay, M.; Fourgeaud, M.; Herrmann, J.L.; Dubost, L.; Marie, A.; Gutmann, L.; Arthur, M.; Mainardi, J.L.
The peptidoglycan of Mycobacterium abscessus is predominantly cross-linked by L,D-transpeptidases
J. Bacteriol.
193
778-782
2011
Mycobacteroides abscessus, Mycobacteroides abscessus CIP104536T
Gupta, R.; Lavollay, M.; Mainardi, J.L.; Arthur, M.; Bishai, W.R.; Lamichhane, G.
The Mycobacterium tuberculosis protein LdtMt2 is a nonclassical transpeptidase required for virulence and resistance to amoxicillin
Nat. Med.
16
466-469
2010
Mycobacterium tuberculosis, Mycobacterium tuberculosis CDC 1551
Nolan, S.T.; Lamichhane, G.
Protective efficacy of BCG overexpressing an L,D-transpeptidase against M. tuberculosis infection
PLoS ONE
5
e13773
2010
Mycobacterium tuberculosis variant bovis, Mycobacterium tuberculosis variant bovis BCG Copenhagen
Erdemli, S.B.; Gupta, R.; Bishai, W.R.; Lamichhane, G.; Amzel, L.M.; Bianchet, M.A.
Targeting the cell wall of Mycobacterium tuberculosis: structure and mechanism of L,D-transpeptidase 2
Structure
20
2103-2115
2012
Mycobacterium tuberculosis (O53223), Mycobacterium tuberculosis
Gokulan, K.; Khare, S.; Cerniglia, C.E.; Foley, S.L.; Varughese, K.I.
Structure and inhibitor specificity of L,D-transpeptidase (LdtMt2) from Mycobacterium tuberculosis and antibiotic resistance calcium binding promotes dimer formation
AAPS J.
20
44
2018
Mycobacterium tuberculosis (I6Y9J2), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (I6Y9J2)
Pidgeon, S.E.; Apostolos, A.J.; Nelson, J.M.; Shaku, M.; Rimal, B.; Islam, M.N.; Crick, D.C.; Kim, S.J.; Pavelka, M.S.; Kana, B.D.; Pires, M.M.
L,D-Transpeptidase specific probe reveals spatial activity of peptidoglycan cross-linking
ACS Chem. Biol.
14
2185-2196
2019
Enterococcus faecium
Zandi, T.A.; Marshburn, R.L.; Stateler, P.K.; Brammer Basta, L.A.
Phylogenetic and biochemical analyses of mycobacterial L,D-transpeptidases reveal a distinct enzyme class that is preferentially acylated by meropenem
ACS Infect. Dis.
5
2047-2054
2019
Mycolicibacterium smegmatis
Libreros-Zuniga, G.A.; Dos Santos Silva, C.; Salgado Ferreira, R.; Dias, M.V.B.
Structural basis for the interaction and processing of beta-lactam antibiotics by L,D-transpeptidase 3 (LdtMt3) from Mycobacterium tuberculosis
ACS Infect. Dis.
5
260-271
2019
Mycobacterium tuberculosis (O06825), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (O06825)
Baldin, S.; Shcherbakova, T.; Svedas, V.
Isolation, purification and characterization of L,D-transpeptidase 2 from Mycobacterium tuberculosis
Acta Naturae
11
23-28
2019
Mycobacterium tuberculosis (I6Y9J2)
Lohans, C.; Chan, H.; Malla, T.; Kumar, K.; Kamps, J.; McArdle, D.; van Groesen, E.; de Munnik, M.; Tooke, C.; Spencer, J.; Paton, R.; Brem, J.; Schofield, C.
Non-hydrolytic beta-lactam antibiotic fragmentation by L,D-transpeptidases and serine beta-lactamase cysteine variants
Angew. Chem. Int. Ed. Engl.
58
1990-1994
2019
Mycobacterium tuberculosis
Kumar, P.; Chauhan, V.; Silva, J.R.A.; Lameira, J.; dAndrea, F.B.; Li, S.G.; Ginell, S.L.; Freundlich, J.S.; Alves, C.N.; Bailey, S.; Cohen, K.A.; Lamichhane, G.
Mycobacterium abscessus L,D-transpeptidases are susceptible to inactivation by carbapenems and cephalosporins but not penicillins
Antimicrob. Agents Chemother.
61
e00866
2017
Mycobacteroides abscessus (B1MDC1), Mycobacteroides abscessus (B1MMQ4), Mycobacteroides abscessus, Mycobacteroides abscessus DSM 44196 (B1MDC1), Mycobacteroides abscessus DSM 44196 (B1MMQ4)
Suetterlin, L.; Edoo, Z.; Hugonnet, J.E.; Mainardi, J.L.; Arthur, M.
Peptidoglycan cross-linking activity of L,D-transpeptidases from Clostridium difficile and inactivation of these enzymes by beta-lactams
Antimicrob. Agents Chemother.
62
e01607
2018
Clostridioides difficile
Wang, X.; Gu, X.; Zhang, C.; Zhao, F.; Deng, K.
Structural and biochemical analyses of the LdtMt2-panipenem adduct provide new insights into the effect of the 1-beta-methyl group on carbapenems
Biochem. Biophys. Res. Commun.
523
6-9
2020
Mycobacterium tuberculosis (I6Y9J2), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 (I6Y9J2)
Bianchet, M.A.; Pan, Y.H.; Basta, L.A.B.; Saavedra, H.; Lloyd, E.P.; Kumar, P.; Mattoo, R.; Townsend, C.A.; Lamichhane, G.
Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase LdtMt2 by biapenem and tebipenem
BMC Biochem.
18
008
2017
Mycobacterium tuberculosis (I6Y9J2), Mycobacterium tuberculosis H37Rv (I6Y9J2)
Coyle, J.F.; Pagliai, F.A.; Zhang, D.; Lorca, G.L.; Gonzalez, C.F.
Purification and partial characterization of LdtP, a cell envelope modifying enzyme in Liberibacter asiaticus
BMC Microbiol.
18
201
2018
Candidatus Liberibacter asiaticus (C6XHT0), Candidatus Liberibacter asiaticus, Candidatus Liberibacter asiaticus psy62 (C6XHT0)
Tolufashe, G.; Halder, A.; Ibeji, C.; Lawal, M.; Ntombela, T.; Govender, T.; Maguire, G.; Lamichhane, G.; Kruger, H.; Honarparvar, B.
Inhibition of Mycobacterium tuberculosis L,D-transpeptidase 5 by carbapenems MD and QM/MM mechanistic studies
ChemistrySelect
3
13603-13612
2018
Mycobacterium tuberculosis (A5TZL1)
-
Ibeji, C.U.; Lawal, M.M.; Tolufashe, G.F.; Govender, T.; Naicker, T.; Maguire, G.E.M.; Lamichhane, G.; Kruger, H.G.; Honarparvar, B.
The driving force for the acylation of beta-lactam antibiotics by L,D-transpeptidase 2 quantum mechanics/molecular mechanics (QM/MM) study
Chemphyschem
20
1126-1134
2019
Mycobacterium tuberculosis (I6Y9J2), Mycobacterium tuberculosis ATCC 25618 (I6Y9J2)
Hugonnet, J.E.; Mengin-Lecreulx, D.; Monton, A.; den Blaauwen, T.; Carbonnelle, E.; Veckerle, C.; Brun, Y.V.; van Nieuwenhze, M.; Bouchier, C.; Tu, K.; Rice, L.B.; Arthur, M.
Factors essential for L,D-transpeptidase-mediated peptidoglycan cross-linking and beta-lactam resistance in Escherichia coli
eLife
5
e19469
2016
Escherichia coli (P22525)
Steiner, E.M.; Schneider, G.; Schnell, R.
Binding and processing of beta-lactam antibiotics by the transpeptidase LdtMt2 from Mycobacterium tuberculosis
FEBS J.
284
725-741
2017
Mycobacterium tuberculosis (I6Y9J2), Mycobacterium tuberculosis H37Rv (I6Y9J2)
Ntombela, T.; Fakhar, Z.; Ibeji, C.U.; Govender, T.; Maguire, G.E.M.; Lamichhane, G.; Kruger, H.G.; Honarparvar, B.
Molecular insight on the non-covalent interactions between carbapenems and L,D-transpeptidase 2 from Mycobacterium tuberculosis ONIOM study
J. Comput. Aided Mol. Des.
32
687-701
2018
Mycobacterium tuberculosis (O53223), Mycobacterium tuberculosis CDC 1551 (O53223)
Sabe, V.T.; Tolufashe, G.F.; Ibeji, C.U.; Maseko, S.B.; Govender, T.; Maguire, G.E.M.; Lamichhane, G.; Honarparvar, B.; Kruger, H.G.
Identification of potent L,D-transpeptidase 5 inhibitors for Mycobacterium tuberculosis as potential anti-TB leads virtual screening and molecular dynamics simulations
J. Mol. Model.
25
328
2019
Mycobacterium tuberculosis (P9WKV2), Mycobacterium tuberculosis, Mycobacterium tuberculosis CDC 1551 (P9WKV2)
Caveney, N.A.; Caballero, G.; Voedts, H.; Niciforovic, A.; Worrall, L.J.; Vuckovic, M.; Fonvielle, M.; Hugonnet, J.E.; Arthur, M.; Strynadka, N.C.J.
Structural insight into YcbB-mediated beta-lactam resistance in Escherichia coli
Nat. Commun.
10
1849
2019
Escherichia coli (P22525), Escherichia coli
Ibeji, C.U.; Tolufashe, G.F.; Ntombela, T.; Govender, T.; Maguire, G.E.M.; Lamichhane, G.; Kruger, H.G.; Honarparvar, B.
The catalytic role of water in the binding site of l,d-transpeptidase 2 within acylation mechanism A QM/MM (ONIOM) modelling
Tuberculosis
113
222-230
2018
Mycobacterium tuberculosis (O53223), Mycobacterium tuberculosis, Mycobacterium tuberculosis CDC1551 (O53223)
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