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Information on EC 2.3.2.6 - lysine/arginine leucyltransferase

for references in articles please use BRENDA:EC2.3.2.6

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IUBMB Comments

Requires a univalent cation. The enzyme participates in the N-end rule protein degradation pathway in certain bacteria, by attaching the primary destabilizing residue L-leucine to the N-termini of proteins that have an N-terminal L-arginine or L-lysine residue. Once modified, the proteins are recognized by EC 3.4.21.92, the ClpAP/ClpS endopeptidase system. The enzyme also transfers L-phenylalanine in vitro, but this has not been observed in vivo . cf. EC 2.3.2.29, aspartate/glutamate leucyltransferase, and EC 2.3.2.8, arginyltransferase.

The enzyme appears in viruses and cellular organisms
Reaction Schemes
hide
L-leucyl-tRNALeu
+
N-terminal L-lysyl-[protein]
=
tRNALeu
+
N-terminal L-leucyl-L-lysyl-[protein]
+
N-terminal L-lysyl-[protein]
=
+
N-terminal L-leucyl-L-lysyl-[protein]
L-leucyl-tRNALeu
+
N-terminal L-arginyl-[protein]
=
tRNALeu
+
N-terminal L-leucyl-L-arginyl-[protein]
+
N-terminal L-arginyl-[protein]
=
+
N-terminal L-leucyl-L-arginyl-[protein]

Synonyms
l/f-transferase, l/f transferase, leucyl/phenylalanyl-trna-protein transferase, aminoacyl transferase, lf-transferase, leucyl/phenylalanyl-trna protein transferase, l/f-trna-protein transferase, leucyltransferase, leucyl/phenylalanyl trna protein transferase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-leucyl-tRNALeu + N-terminal L-arginyl-[protein] = tRNALeu + N-terminal L-leucyl-L-arginyl-[protein]
show the reaction diagram
(2)
-
-
-
L-leucyl-tRNALeu + N-terminal L-lysyl-[protein] = tRNALeu + N-terminal L-leucyl-L-lysyl-[protein]
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
N-end rule pathway I (prokaryotic)
Highest Expressing Human Cell Lines
Cell Line Links Gene Links