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[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-threonine
[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-3-O-ubiquitinyl-L-threonine
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[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [F-box protein FBXW7]-L-threonine
[E2 ubiquitin-conjugating enzyme]-L-cysteine + [F-box protein FBXW7]-3-O-ubiquitinyl-L-threonine
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[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [RCR-type E3 ubiquitin transferase]-L-cysteine
[E2 ubiquitin-conjugating enzyme]-L-cysteine + [RCR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine
[RCR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-threonine
[RCR-type E3 ubiquitin transferase]-L-cysteine + [acceptor protein]-3-O-ubiquitinyl-L-threonine
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[RCR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine + [F-box protein FBXW7]-L-threonine
[RCR-type E3 ubiquitin transferase]-L-cysteine + [F-box protein FBXW7]-3-O-ubiquitinyl-L-threonine
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additional information
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[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [RCR-type E3 ubiquitin transferase]-L-cysteine
[E2 ubiquitin-conjugating enzyme]-L-cysteine + [RCR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine
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[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [RCR-type E3 ubiquitin transferase]-L-cysteine
[E2 ubiquitin-conjugating enzyme]-L-cysteine + [RCR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine
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additional information
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MYCBP2 contains two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates. It shows esterification activity and intrinsic selectivity for threonine over serine
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additional information
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MYCBP2 contains two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates. It shows esterification activity and intrinsic selectivity for threonine over serine
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additional information
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F-box protein FBXW7 protein levels markedly decline during extended mitotic arrest. F-box/SPRY domain-containing protein FBXO45 binds to a conserved acidic N-terminal motif of FBXW7 specifically under a prolonged delay in mitosis, leading to ubiquitylation and subsequent proteasomal degradation of FBXW7 by the FBXO45-MYCBP2 E3 ubiquitin ligase
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[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-threonine
[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-3-O-ubiquitinyl-L-threonine
-
-
-
?
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [RCR-type E3 ubiquitin transferase]-L-cysteine
[E2 ubiquitin-conjugating enzyme]-L-cysteine + [RCR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine
-
-
-
?
[RCR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-threonine
[RCR-type E3 ubiquitin transferase]-L-cysteine + [acceptor protein]-3-O-ubiquitinyl-L-threonine
-
-
-
?
additional information
?
-
additional information
?
-
MYCBP2 contains two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates. It shows esterification activity and intrinsic selectivity for threonine over serine
-
-
?
additional information
?
-
-
MYCBP2 contains two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates. It shows esterification activity and intrinsic selectivity for threonine over serine
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Colonic Neoplasms
Epigenetically regulated miR-1247 functions as a novel tumour suppressor via MYCBP2 in methylator colon cancers.
Hyperalgesia
MYCBP2 Is a Guanosine Exchange Factor for Ran Protein and Determines Its Localization in Neurons of Dorsal Root Ganglia.
Hyperalgesia
The ubiquitin ligase MYCBP2 regulates transient receptor potential vanilloid receptor 1 (TRPV1) internalization through inhibition of p38 MAPK signaling.
Infections
A Chimeric Pneumovirus Fusion Protein Carrying Neutralizing Epitopes of Both MPV and RSV.
Melanoma
miR-92a-3p and MYCBP2 are involved in MS-275-induced and c-myc-mediated TRAIL-sensitivity in melanoma cells.
Neoplasms
Epigenetically regulated miR-1247 functions as a novel tumour suppressor via MYCBP2 in methylator colon cancers.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Clinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros dysfunction in adult acute lymphoblastic leukemia.
Prostatic Neoplasms
MiR-1247-5p is overexpressed in castration resistant prostate cancer and targets MYCBP2.
Virus Diseases
A Chimeric Pneumovirus Fusion Protein Carrying Neutralizing Epitopes of Both MPV and RSV.
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physiological function
loss of E3 ubiquitin ligase MYCBP2 causes the up-regulation of small GTPase Ran and GTPase-activating protein RanGAP1 in dorsal root ganglia under basal conditions and during inflammatory hyperalgesia. SUMOylated RanGAP1 physically interacts with MYCBP2 and inhibits its E3 ubiquitin ligase activity. Stimulation of neurons induces a RanGAP1-dependent translocation of MYCBP2 to the nucleus. In the nucleus of in dorsal root ganglia neurons MYCBP2 co-localizes with Ran and facilitates through its RCC1-like domain the GDP/GTP exchange of Ran. The nuclear localization of Ran is strongly increased in MYCBP2-deficient dorsal root ganglia
physiological function
loss of MYCBP2 in peripheral sensory neurons inhibits the internalization of transient receptor potential vanilloid receptor 1 (TRPV1) in a p38 MAPK-dependent manner. This prevents desensitization of activity-induced calcium increases and prolongs formalin-induced thermal hyperalgesia
physiological function
Magellan mutant embryos, having a truncated Phr1 protein, motor axons are error prone and wander inefficiently at choice points within embryos. Motor and sensory neurons from Magellan mutants display abnormal morphologies due to a breakdown in the polarized distribution of components that segregate between axons and growth cones. The Magellan phenotype can be reversed by stabilizing microtubules with taxol or inhibiting p38-MAPK activity
physiological function
mice heterozygous for either Mycbp2 or receptor Robo2 are normal, mice double heterozygous for the two genes produce defects in dorsoventral topography in the olfactory bulb. Loss of Mycbp2 function leads to the loss of molecular identity of a subpopulation of olfactory sensory axons that normally express ROBO2. In addition, double heterozygous mice show complete absence of the hippocampal commissure
physiological function
mice with a MYCBP2-deficiency in peripheral sensory neurons show prolonged thermal hyperalgesia. Loss of MYCBP2 constitutively activates p38 MAPK and increases expression of several proteins involved in receptor trafficking. Loss of MYCBP2 inhibits internalization of transient receptor potential vanilloid receptor 1 (TRPV1) and prevents desensitization of capsaicin-induced calcium increases
physiological function
Phr1 E3 ubiquitin ligase is a central component of degeneration program that drives the loss of damaged axons. Loss of Phr1 results in prolonged survival of severed axons both in the peripheral and central nervous systems, as well as preservation of motor and sensory nerve terminals. Phr1 depletion increases the axonal level of the axon survival molecule nicotinamide mononucleotide adenyltransferase 2 (NMNAT2), and NMNAT2 is necessary to mediate Phr1-dependent axon stability
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James, G.; Key, B.; Beverdam, A.
The E3 ubiquitin ligase Mycbp2 genetically interacts with Robo2 to modulate axon guidance in the mouse olfactory system
Brain Struct. Funct.
219
861-874
2014
Mus musculus (Q7TPH6), Mus musculus
brenda
Richter, K.T.; Kschonsak, Y.T.; Vodicska, B.; Hoffmann, I.
FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation
Cell Death Differ.
27
758-772
2019
Homo sapiens (O75592)
brenda
Babetto, E.; Beirowski, B.; Russler, E.; Milbrandt, J.; DiAntonio, A.
The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction
Cell Rep.
3
1422-1429
2013
Mus musculus (Q7TPH6)
brenda
Holland, S.; Scholich, K.
Regulation of neuronal functions by the E3-ubiquitinligase protein associated with MYC (MYCBP2)
Commun. Integr. Biol.
4
513-515
2011
Mus musculus (Q7TPH6)
brenda
Holland, S.; Coste, O.; Zhang, D.D.; Pierre, S.C.; Geisslinger, G.; Scholich, K.
The ubiquitin ligase MYCBP2 regulates transient receptor potential vanilloid receptor 1 (TRPV1) internalization through inhibition of p38 MAPK signaling
J. Biol. Chem.
286
3671-3680
2011
Mus musculus (Q7TPH6)
brenda
Doerr, A.; Pierre, S.; Zhang, D.D.; Henke, M.; Holland, S.; Scholich, K.
MYCBP2 Is a guanosine exchange factor for Ran rrotein and determines its localization in neurons of dorsal root ganglia
J. Biol. Chem.
290
25620-25635
2015
Mus musculus (Q7TPH6)
brenda
Sampathkumar, P.; Ozyurt, S.A.; Miller, S.A.; Bain, K.T.; Rutter, M.E.; Gheyi, T.; Abrams, B.; Wang, Y.; Atwell, S.; Luz, J.G.; Thompson, D.A.; Wasserman, S.R.; Emtage, J.S.; Park, E.C.; Rongo, C.; Jin, Y.; Klemke, R.L.; Sauder, J.M.; Burley, S.K.
Structures of PHR domains from Mus musculus Phr1 (Mycbp2) explain the loss-of-function mutation (Gly1092-->Glu) of the C. elegans ortholog RPM-1
J. Mol. Biol.
397
883-892
2010
Caenorhabditis elegans (Q17551), Caenorhabditis elegans, Mus musculus (Q7TPH6), Mus musculus
brenda
Pao, K.C.; Wood, N.T.; Knebel, A.; Rafie, K.; Stanley, M.; Mabbitt, P.D.; Sundaramoorthy, R.; Hofmann, K.; van Aalten, D.M.F.; Virdee, S.
Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity
Nature
556
381-385
2018
Homo sapiens (O75592), Homo sapiens
brenda
Lewcock, J.; Genoud, N.; Lettieri, K.; Pfaff, S.
The Ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics
Neuron
56
604-620
2007
Mus musculus (Q7TPH6)
brenda
2.3.2.33 RCR-type E3 ubiquitin transferase
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