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Disease on EC 2.3.2.25 - N-terminal E2 ubiquitin-conjugating enzyme

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma of Lung
Expression of UBE2C in lung adenocarcinoma based on database analysis and its clinical significance.
High ubiquitin conjugating enzyme E2 T mRNA expression and its prognostic significance in lung adenocarcinoma: A study based on the TCGA database.
Ubiquitin Conjugating Enzyme E2 H (UBE2H) Is Linked to Poor Outcomes and Metastasis in Lung Adenocarcinoma.
African Swine Fever
A ubiquitin conjugating enzyme encoded by African swine fever virus.
An ARID family protein binds to the African swine fever virus encoded ubiquitin conjugating enzyme, UBCv1.
Alzheimer Disease
A human ubiquitin conjugating enzyme, L-UBC, maps in the Alzheimer's disease locus on chromosome 14q24.3.
Deficiency in the Ubiquitin Conjugating Enzyme UBE2A in Alzheimer's Disease (AD) is Linked to Deficits in a Natural Circular miRNA-7 Sponge (circRNA; ciRS-7).
Autoimmune Diseases
The haplotype of UBE2L3 gene is associated with Hashimoto's thyroiditis in a Chinese Han population.
Breast Neoplasms
Identifying breast cancer subtypes associated modules and biomarkers by integrated bioinformatics analysis.
Inhibition of ubiquitin conjugating enzyme UBE2C reduces proliferation and sensitizes breast cancer cells to radiation, doxorubicin, tamoxifen and letrozole.
Lysine 394 is a novel Rad6B-induced ubiquitination site on beta-catenin.
Prognostic value of ubiquitin E2 UBE2W and its correlation with tumor-infiltrating immune cells in breast cancer.
Stromal cell extracellular vesicular cargo mediated regulation of breast cancer cell metastasis via ubiquitin conjugating enzyme E2 N pathway.
Carcinogenesis
BIR repeat-containing ubiquitin conjugating enzyme (BRUCE) regulation of ?-catenin signaling in the progression of drug-induced hepatic fibrosis and carcinogenesis.
Combined elevation of AURKB and UBE2C predicts severe outcomes and therapy resistance in glioma.
Identification of key candidate genes and pathways in endometrial cancer: Evidence from bioinformatics analysis.
Inhibiting ubiquitin conjugating enzyme E2 N by microRNA-590-3p reduced cell growth of cervical carcinoma.
[Selecting functional siRNA target sites of hUBE2W based on H1-U6 dual promoter RNAi plasmid]
Carcinoma
Inhibiting ubiquitin conjugating enzyme E2 N by microRNA-590-3p reduced cell growth of cervical carcinoma.
Overexpression of UBE2C in esophageal squamous cell carcinoma tissues and molecular analysis.
Carcinoma, Hepatocellular
The ménage à trois of autophagy, lipid droplets and liver disease.
Colitis
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Colitis, Ulcerative
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Crohn Disease
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Endometrial Neoplasms
MLN4924 inhibits cell proliferation by targeting the activated neddylation pathway in endometrial carcinoma.
Esophageal Squamous Cell Carcinoma
Overexpression of UBE2C in esophageal squamous cell carcinoma tissues and molecular analysis.
Fanconi Anemia
UBE2W interacts with FANCL and regulates the monoubiquitination of Fanconi anemia protein FANCD2.
Fatty Liver
The ménage à trois of autophagy, lipid droplets and liver disease.
Glioma
Combined elevation of AURKB and UBE2C predicts severe outcomes and therapy resistance in glioma.
Huntington Disease
The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin.
Hypersensitivity
Loss of ubiquitin E2 Ube2w rescues hypersensitivity of Rnf4 mutant cells to DNA damage.
Infections
PDPK1 regulates autophagosome biogenesis by binding to PIK3C3.
Inflammatory Bowel Diseases
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Leukemia
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
Leukemia, T-Cell
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
Liver Diseases
BIR repeat-containing ubiquitin conjugating enzyme (BRUCE) regulation of ?-catenin signaling in the progression of drug-induced hepatic fibrosis and carcinogenesis.
The ménage à trois of autophagy, lipid droplets and liver disease.
Neoplasm Metastasis
Identification of hub genes associated with esophageal cancer progression using bioinformatics analysis.
Long non-coding RNA UBE2CP3 enhances HCC cell secretion of VEGFA and promotes angiogenesis by activating ERK1/2/HIF-1?/VEGFA signalling in hepatocellular carcinoma.
Stromal cell extracellular vesicular cargo mediated regulation of breast cancer cell metastasis via ubiquitin conjugating enzyme E2 N pathway.
Ubiquitin Conjugating Enzyme E2 H (UBE2H) Is Linked to Poor Outcomes and Metastasis in Lung Adenocarcinoma.
Neoplasms
A Comprehensive Bioinformatics Analysis of UBE2C in Cancers.
BIR repeat-containing ubiquitin conjugating enzyme (BRUCE) regulation of ?-catenin signaling in the progression of drug-induced hepatic fibrosis and carcinogenesis.
Combined elevation of AURKB and UBE2C predicts severe outcomes and therapy resistance in glioma.
High ubiquitin conjugating enzyme E2 T mRNA expression and its prognostic significance in lung adenocarcinoma: A study based on the TCGA database.
Inhibiting ubiquitin conjugating enzyme E2 N by microRNA-590-3p reduced cell growth of cervical carcinoma.
Long non-coding RNA UBE2CP3 enhances HCC cell secretion of VEGFA and promotes angiogenesis by activating ERK1/2/HIF-1?/VEGFA signalling in hepatocellular carcinoma.
Manipulation of the ubiquitin-proteasome pathway in cachexia: pentoxifylline suppresses the activation of 20S and 26S proteasomes in muscles from tumor-bearing rats.
miRNA?101?3p.1 as an independent diagnostic biomarker aggravates chronic obstructive pulmonary disease via activation of the EGFR/PI3K/AKT signaling pathway.
Oncogene UBE2I enhances cellular invasion, migration and proliferation abilities via autophagy-related pathway resulting in poor prognosis in hepatocellular carcinoma.
RAD6 promotes chemoresistance in ovarian cancer.
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Sumoylation of transcription factor ETV1 modulates its oncogenic potential in prostate cancer.
The Positive Correlations between the Expression of Histopathological Ubiquitin-Conjugating Enzyme 2O Staining and Prostate Cancer Advancement.
UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR.
UBE2C is involved in the functions of ECRG4 on esophageal squamous cell carcinoma.
UBE2C mRNA expression controlled by miR-300 and HuR determines its oncogenic role in gastric cancer.
UBE2C promotes the progression of head and neck squamous cell carcinoma.
Ube2S regulates Wnt/?-catenin signaling and promotes the progression of non-small cell lung cancer.
Ubiquitin Conjugating Enzyme E2 H (UBE2H) Is Linked to Poor Outcomes and Metastasis in Lung Adenocarcinoma.
Ubiquitin conjugating enzyme E2 L3 promoted tumor growth of NSCLC through accelerating p27kip1 ubiquitination and degradation.
Uev1A-Ubc13 promotes colorectal cancer metastasis through regulating CXCL1 expression via NF-?B activation.
Non-alcoholic Fatty Liver Disease
The ménage à trois of autophagy, lipid droplets and liver disease.
Osteoarthritis
Ubiquitin conjugating enzyme E2 M promotes apoptosis in osteoarthritis chondrocytes via Wnt/?-catenin signaling.
Ovarian Neoplasms
RAD6 promotes chemoresistance in ovarian cancer.
Parkinson Disease
USP33 deubiquitinates PRKN/parkin and antagonizes its role in mitophagy.
Prostatic Neoplasms
miR-499a inhibits the proliferation and apoptosis of prostate cancer via targeting UBE2V2.
Sumoylation of transcription factor ETV1 modulates its oncogenic potential in prostate cancer.
Retinoblastoma
An ARID family protein binds to the African swine fever virus encoded ubiquitin conjugating enzyme, UBCv1.
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
Sarcoma
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
Using mRNA deep sequencing to analyze differentially expressed genes during Panax notoginseng saponin treatment of ischemic stroke.
Sepsis
Muscle wasting in a rat model of long-lasting sepsis results from the activation of lysosomal, Ca2+ -activated, and ubiquitin-proteasome proteolytic pathways.
Stomach Neoplasms
UBE2C mRNA expression controlled by miR-300 and HuR determines its oncogenic role in gastric cancer.
Triple Negative Breast Neoplasms
Targeting ubiquitin conjugating enzyme UbcH5b by a triterpenoid PC3-15 from Schisandra plants sensitizes triple-negative breast cancer cells to lapatinib.