Reference on EC 2.3.2.23 - E2 ubiquitin-conjugating enzyme
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hatfield, P.M.; Gosink, M.M.; Carpenter, T.B.; Vierstra, R.D.
The ubiquitin-activating enzyme (E1) gene family in Arabidopsis thaliana
Plant J.
11
213-226
1997
Arabidopsis thaliana, Arabidopsis thaliana (P92974)
Tokgoez, Z.; Bohnsack, R.N.; Haas, A.L.
Pleiotropic effects of ATP*Mg2+ binding in the catalytic cycle of ubiquitin-activating enzyme
J. Biol. Chem.
281
14729-14737
2006
Homo sapiens
Pelzer, C.; Kassner, I.; Matentzoglu, K.; Singh, R.K.; Wollscheid, H.P.; Scheffner, M.; Schmidtke, G.; Groettrup, M.
UBE1L2, a novel E1 enzyme specific for ubiquitin
J. Biol. Chem.
282
23010-23014
2007
Homo sapiens (P62837), Homo sapiens
Xu, Z.; Kohli, E.; Devlin, K.I.; Bold, M.; Nix, J.C.; Misra, S.
Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes
BMC Struct. Biol.
8
26
2008
Danio rerio (Q6PC58)
Zheng, M.; Liu, J.; Yang, Z.; Gu, X.; Li, F.; Lou, T.; Ji, C.; Mao, Y.
Expression, purification and characterization of human ubiquitin-activating enzyme, UBE1
Mol. Biol. Rep.
37
1413-1419
2010
Homo sapiens
Plafker, K.S.; Nguyen, L.; Barneche, M.; Mirza, S.; Crawford, D.; Plafker, S.M.
The ubiquitin-conjugating enzyme UbcM2 can regulate the stability and activity of the antioxidant transcription factor Nrf2
J. Biol. Chem.
285
23064-23074
2010
Homo sapiens
Yokota, N.; Harada, Y.; Sawada, H.
Identification of testis-specific ubiquitin-conjugating enzyme in the ascidian Ciona intestinalis
Mol. Reprod. Dev.
77
640-647
2010
Ciona intestinalis
Li, D.F.; Feng, L.; Hou, Y.J.; Liu, W.
The expression, purification and crystallization of a ubiquitin-conjugating enzyme E2 from Agrocybe aegerita underscore the impactof His-tag location on recombinant protein properties
Acta Crystallogr. Sect. F
69
153-157
2013
Cyclocybe aegerita
van Wijk, S.J.; Timmers, H.T.
The family of ubiquitin-conjugating enzymes (E2s):deciding between life and death of proteins
FASEB J.
24
981-93
2010
Homo sapiens
David, Y.; Ziv, T.; Admon, A.; Navon, A.
The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines
J. Biol. Chem.
285
8595-8604
2010
Homo sapiens
Scaglione, K.M.; Basrur, V.; Ashraf, N.S.; Konen, J.R.; Elenitoba-Johnson, K.S.; Todi, S.V.; Paulson, H.L.
The ubiquitin-conjugating enzyme (E2) Ube2w ubiquitinates the N terminus of substrates
J. Biol. Chem.
288
18784-18788
2013
Homo sapiens
Carvalho, A.F.; Pinto, M.P.; Grou, C.P.; Vitorino, R.; Domingues, P.; Yamao, F.; Sa-Miranda, C.; Azevedo, J.E.
High-yield expression in Escherichia coli and purification ofmouse ubiquitin-activating enzyme E1
Mol. Biotechnol.
51
254-261
2012
Mus musculus (Q9Z1K5)
Tokgoez, Z.; Siepmann, T.J.; Streich, F.; Kumar, B.; Klein, J.M.; Haas, A.L.
E1-E2 interactions in ubiquitin and Nedd8 ligation pathways
J. Biol. Chem.
287
311-321
2012
Homo sapiens (P22314), Homo sapiens (Q8TBC4)
Wee, K.E.; Lai, Z.; Auger, K.R.; Ma, J.; Horiuchi, K.Y.; Dowling, R.L.; Dougherty, C.S.; Corman, J.I.; Wynn, R.; Copeland, R.A.
Steady-state kinetic analysis of human ubiquitin-activating enzyme (E1) using a fluorescently labeled ubiquitin substrate
J. Protein Chem.
19
489-498
2000
Homo sapiens (P62837)
Unver, T.; Turktas, M.; Budak, H.
In planta evidence for the involvement of a ubiquitin conjugating enzyme (UBI E2 Clade) in negative regulation of disease resistance
Plant Mol. Biol. Rep.
31
323-334
2013
Nicotiana benthamiana, Arabidopsis thaliana (P42745)
-
Wang, J.; Taherbhoy, A.M.; Hunt, H.W.; Seyedin, S.N.; Miller, D.W., Miller, D.J.; Huang, D.T.; Schulman, B.A.
Crystal structure of UBA2ufd-Ubc9: Insights into E1-E2 interactions in Sumo pathways
PLoS ONE
1
e15805
2010
Saccharomyces cerevisiae (P50623), Saccharomyces cerevisiae
Chung, E.; Cho, C.W.; So, H.A.; Kang, J.S.; Chung, Y.S.; Lee, J.H.
Overexpression of VrUBC1, a mung bean E2 Ubiquitin-conjugating enzyme, enhances osmotic stress tolerance in Arabidopsis
PLoS One
8
e66056
2013
Vigna radiata (D2D3G0)
Tatham, M.; Kim, S.; Yu, B.; Jaffray, E.; Song, J.; Zheng, J.; Rodriguez, M.; Hay, R.; Chen, Y.
Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation
Biochemistry
42
9959-9969
2003
Homo sapiens (P63279)
Nguyen, L.; Plafker, K.S.; Starnes, A.; Cook, M.; Klevit, R.E.; Plafker, S.M.
The ubiquitin-conjugating enzyme, UbcM2, is restricted to monoubiquitylation by a two-fold mechanism that involves backside residues of E2 and Lys48 of ubiquitin
Biochemistry
53
4004-4014
2014
Homo sapiens (Q969T4)
Horikoshi, Y.; Habu, T.; Matsumoto, T.
An E2 enzyme Ubc11 is required for ubiquitination of Slp1/Cdc20 and spindle checkpoint silencing in fission yeast
Cell Cycle
12
961-971
2013
Schizosaccharomyces pombe (O00103), Schizosaccharomyces pombe, Schizosaccharomyces pombe 972 (O00103)
Wang, R.; Kaul, Z.; Ambardekar, C.; Yamamoto, T.G.; Kavdia, K.; Kodali, K.; High, A.A.; Kitagawa, R.
HECT-E3 ligase ETC-1 regulates securin and cyclin B1 cytoplasmic abundance to promote timely anaphase during meiosis in C. elegans
Development
140
2149-2159
2013
Caenorhabditis elegans (Q21633), Caenorhabditis elegans
Aichem, A.; Catone, N.; Groettrup, M.
Investigations into the auto-FAT10ylation of the bispecific E2 conjugating enzyme UBA6-specific E2 enzyme 1
FEBS J.
281
1848-1859
2014
Homo sapiens (Q9H832)
Zulkifle, N.
Systematic yeast two-hybrid analysis of human E2 ubiquitin-conjugating enzyme and deubiquitin (DUB) protein interactions
Int. J. Biol. Chem.
7
1-14
2013
Homo sapiens
-
Yokota, K.; Shibata, H.; Kurihara, I.; Kobayashi, S.; Suda, N.; Murai-Takeda, A.; Saito, I.; Kitagawa, H.; Kato, S.; Saruta, T.; Itoh, H.
Coactivation of the N-terminal transactivation of mineralocorticoid receptor by Ubc9
J. Biol. Chem.
282
1998-2010
2007
Homo sapiens
Park, Y.; Yoon, S.K.; Yoon, J.B.
The HECT domain of TRIP12 ubiquitinates substrates of the ubiquitin fusion degradation pathway
J. Biol. Chem.
284
1540-1549
2009
Homo sapiens (P51668)
Koenig, P.A.; Nicholls, P.K.; Schmidt, F.I.; Hagiwara, M.; Maruyama, T.; Frydman, G.H.; Watson, N.; Page, D.C.; Ploegh, H.L.
The E2 ubiquitin-conjugating enzyme UBE2J1 is required for spermiogenesis in mice
J. Biol. Chem.
289
34490-34502
2014
Mus musculus (Q9JJZ4)
Wang, Y.; Kim, S.M.; Trnka, M.J.; Liu, Y.; Burlingame, A.L.; Correia, M.A.
Human liver cytochrome P450 3A4 ubiquitination: molecular recognition by UBC7-gp78 autocrine motility factor receptor and UbcH5a-CHIP-Hsc70-Hsp40 E2-E3 ubiquitin ligase complexes
J. Biol. Chem.
290
3308-3332
2015
Homo sapiens (P62253)
Fiesel, F.; Moussaud-Lamodiere, E.; Ando, M.; Springer, W.
A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently
J. Cell Sci.
127
3488-3504
2014
Homo sapiens
Wen, R.; Wang, S.; Xiang, D.; Venglat, P.; Shi, X.; Zang, Y.; Datla, R.; Xiao, W.; Wang, H.
UBC13, an E2 enzyme for Lys63-linked ubiquitination, functions in root development by affecting auxin signaling and Aux/IAA protein stability
Plant J.
80
424-436
2014
Arabidopsis thaliana (Q94A97)
Cohen, I.; Wiener, R.; Reiss, Y.; Ravid, T.
Distinct activation of an E2 ubiquitin-conjugating enzyme by its cognate E3 ligases
Proc. Natl. Acad. Sci. USA
112
E625-E632
2015
Saccharomyces cerevisiae (Q02159), Saccharomyces cerevisiae
Williams, C.; Van Den Berg, M.; Stanley, W.; Wilmanns, M.; Distel, B.
A disulphide bond in the E2 enzyme Pex4p modulates ubiquitin-conjugating activity
Sci. Rep.
3
2212
2013
Saccharomyces cerevisiae (P29340), Saccharomyces cerevisiae
Arcas, A.; Cases, I.; Rojas, A.
Serine/threonine kinases and E2-ubiquitin conjugating enzymes in Planctomycetes: unexpected findings
Antonie van Leeuwenhoek
104
509-520
2013
Gemmata obscuriglobus, Pirellula staleyi, Pirellula staleyi DSM 6068
Goodman, S.; Petrofes Chapa, R.; Zimmer, W.
Spectrin's chimeric E2/E3 enzymatic activity
Exp. Biol. Med.
240
1039-1049
2015
Homo sapiens
Esparza-Araiza, M.J.; Banuelos-Hernandez, B.; Argueello-Astorga, G.R.; Lara-Avila, J.P.; Goodwin, P.H.; Isordia-Jasso, M.I.; Castillo-Collazo, R.; Rougon-Cardoso, A.; Alpuche-Solis, A.G.
Evaluation of a SUMO E2 conjugating enzyme involved in resistance to Clavibacter michiganensis subsp. michiganensis in Solanum peruvianum, through a tomato mottle virus VIGS assay
Front. Plant Sci.
6
1019
2015
Solanum peruvianum
Gong, M.; Wang, H.; Chen, M.; Bao, D.; Zhu, Q.; Tan, Q.
A newly discovered ubiquitin-conjugating enzyme E2 correlated with the cryogenic autolysis of Volvariella volvacea
Gene
583
58-63
2016
Volvariella volvacea, Volvariella volvacea V23
Qi, C.; Li, D.F.; Feng, L.; Hou, Y.; Sun, H.; Wang, D.C.; Liu, W.
Biochemical and structural characterization of a novel ubiquitin-conjugating enzyme E2 from Agrocybe aegeria reveals Ube2w family-specific properties
Sci. Rep.
5
16056
2015
Cyclocybe aegerita
Imura, Y.; Molho, M.; Chuang, C.; Nagy, P.D.
Cellular Ubc2/Rad6 E2 ubiquitin-conjugating enzyme facilitates tombusvirus replication in yeast and plants
Virology
484
265-275
2015
Arabidopsis thaliana, Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Chakrabarti, K.S.; Li, J.; Das, R.; Byrd, R.A.
Conformational dynamics and allostery in E2 E3 interactions drive ubiquitination gp78 and Ube2g2
Structure
25
794-805
2017
Homo sapiens (P60604)
Hewitt, W.M.; Lountos, G.T.; Zlotkowski, K.; Dahlhauser, S.D.; Saunders, L.B.; Needle, D.; Tropea, J.E.; Zhan, C.; Wei, G.; Ma, B.; Nussinov, R.; Waugh, D.S.; Schneekloth, J.S.
Insights into the allosteric inhibition of the SUMO E2 enzyme Ubc9
Angew. Chem. Int. Ed. Engl.
55
5703-5707
2016
Homo sapiens (P63279)
Tan, J.M.E.; Cook, E.C.L.; van den Berg, M.; Scheij, S.; Zelcer, N.; Loregger, A.
Differential use of E2 ubiquitin conjugating enzymes for regulated degradation of the rate-limiting enzymes HMGCR and SQLE in cholesterol biosynthesis
Atherosclerosis
281
137-142
2019
Homo sapiens (P60604), Homo sapiens (Q8N2K1), Homo sapiens (Q9Y385), Homo sapiens
Wang, D.; Tian, Y.; Wei, D.; Jing, Y.; Niu, H.; Xie, K.; Song, Y.
DNA damage-induced foci of E2 ubiquitin-conjugating enzyme are detectable upon co-transfection with an interacting E3 ubiquitin ligase
Biochem. Genet.
54
147-157
2016
Homo sapiens (P63146), Homo sapiens (P49459)
Alpi, A.F.; Chaugule, V.; Walden, H.
Mechanism and disease association of E2-conjugating enzymes lessons from UBE2T and UBE2L3
Biochem. J.
473
3401-3419
2016
Homo sapiens (P68036), Homo sapiens (Q9NPD8)
Hsu, S.H.; Chen, S.H.; Kuo, C.C.; Chang, J.Y.
Ubiquitin-conjugating enzyme E2 B regulates the ubiquitination of O6-methylguanine-DNA methyltransferase and BCNU sensitivity in human nasopharyngeal carcinoma cells
Biochem. Pharmacol.
158
327-338
2018
Homo sapiens (P63146), Homo sapiens
Stewart, M.D.; Ritterhoff, T.; Klevit, R.E.; Brzovic, P.S.
E2 enzymes more than just middle men
Cell Res.
26
423-440
2016
Homo sapiens (P60604), Homo sapiens (P68036), Homo sapiens (Q8WVN8), Homo sapiens (Q712K3), Homo sapiens (P49427), Homo sapiens (P63146), Homo sapiens (O00762), Homo sapiens (P62256), Homo sapiens (P61086), Homo sapiens (P61088), Homo sapiens (Q16763), Homo sapiens (Q9NPD8), Homo sapiens (P51668), Homo sapiens (P62837), Homo sapiens (P61077), Homo sapiens (Q13404), Homo sapiens (Q15819), Homo sapiens (P49459), Homo sapiens (P51965), Homo sapiens (Q96LR5), Homo sapiens (Q969T4), Homo sapiens (P62253), Homo sapiens (Q9H832), Homo sapiens (Q8N2K1), Homo sapiens (A1L167), Homo sapiens (Q9Y385), Homo sapiens (Q5JXB2), Homo sapiens (Q7Z7E8), Homo sapiens (Q5VVX9), Homo sapiens (O14933)
Mizushima, N.
The ubiquitin E2 enzyme UBE2QL1 mediates lysophagy
EMBO Rep.
20
e49104
2019
Homo sapiens (A1L167)
Schelpe, J.; Monte, D.; Dewitte, F.; Sixma, T.; Rucktooa, P.
Structure of UBE2Z enzyme provides functional insight into specificity in the FAT10 protein conjugation machinery
J. Biol. Chem.
291
630-639
2016
Homo sapiens (Q9H832)
Lei, L.; Bandola-Simon, J.; Roche, P.A.
Ubiquitin-conjugating enzyme E2 D1 (Ube2D1) mediates lysine-independent ubiquitination of the E3 ubiquitin ligase March-I
J. Biol. Chem.
293
3904-3912
2018
Homo sapiens (P51668)
van de Weijer, M.L.; Schuren, A.B.C.; van den Boomen, D.J.H.; Mulder, A.; Claas, F.H.J.; Lehner, P.J.; Lebbink, R.J.; Wiertz, E.J.H.J.
Multiple E2 ubiquitin-conjugating enzymes regulate human cytomegalovirus US2-mediated immunoreceptor downregulation
J. Cell Sci.
130
2883-2892
2017
Homo sapiens (P60604), Homo sapiens (P61077), Homo sapiens (Q8N2K1), Homo sapiens
Morreale, F.E.; Bortoluzzi, A.; Chaugule, V.K.; Arkinson, C.; Walden, H.; Ciulli, A.
Allosteric targeting of the Fanconi anemia ubiquitin-conjugating enzyme Ube2T by fragment screening
J. Med. Chem.
60
4093-4098
2017
Homo sapiens (Q9NPD8)
Hagiwara, M.; Ling, J.; Koenig, P.A.; Ploegh, H.L.
Posttranscriptional regulation of glycoprotein quality control in the endoplasmic reticulum is controlled by the E2 Ub-conjugating enzyme UBC6e
Mol. Cell
63
753-767
2016
Mus musculus (Q9JJZ4)
Hill, S.; Harrison, J.S.; Lewis, S.M.; Kuhlman, B.; Kleiger, G.
Mechanism of lysine 48 selectivity during polyubiquitin chain formation by the Ube2R1/2 ubiquitin-conjugating enzyme
Mol. Cell. Biol.
36
1720-1732
2016
Homo sapiens (Q712K3), Homo sapiens (P49427)
Williams, K.M.; Qie, S.; Atkison, J.H.; Salazar-Arango, S.; Alan Diehl, J.; Olsen, S.K.
Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34
Nat. Commun.
10
3296
2019
Homo sapiens (P49427), Saccharomyces cerevisiae (P14682), Saccharomyces cerevisiae ATCC 204508 (P14682)
Gao, Y.; Wang, Y.; Xin, H.; Li, S.; Liang, Z.
Involvement of ubiquitin-conjugating enzyme (E2 gene family) in ripening process and response to cold and heat stress of Vitis vinifera
Sci. Rep.
7
13290
2017
Vitis vinifera
Rout, M.K.; Lee, B.L.; Lin, A.; Xiao, W.; Spyracopoulos, L.
Active site gate dynamics modulate the catalytic activity of the ubiquitination enzyme E2-25K
Sci. Rep.
8
7002
2018
Homo sapiens (P61086)
Yu, H.; Xiang, P.; Pan, Q.; Huang, Y.; Xie, N.; Zhu, W.
Ubiquitin-conjugating enzyme E2T is an independent prognostic factor and promotes gastric cancer progression
Tumour Biol.
37
11723-11732
2016
Homo sapiens (Q9NPD8)
Middleton, A.J.; Teyra, J.; Zhu, J.; Sidhu, S.S.; Day, C.L.
Identification of ubiquitin variants that inhibit the E2 ubiquitin conjugating enzyme, Ube2k
ACS Chem. Biol.
16
1745-1756
2021
Homo sapiens (P61086)
Wang, X.; Zhu, Z.
Role of Ubiquitin-conjugating enzyme E2 (UBE2) in two immune-mediated inflammatory skin diseases a mendelian randomization analysis
Arch. Dermatol. Res.
316
249
2024
Homo sapiens, Homo sapiens (P68036)
Kanack, A.; Vittal, V.; Haver, H.; Keppel, T.; Gundry, R.L.; Klevit, R.E.; Scaglione, K.M.
UbcH5 interacts with substrates to participate in lysine selection with the E3 ubiquitin ligase CHIP
Biochemistry
59
2078-2088
2020
Homo sapiens (P51668)
Wang, C.; Zhou, B.; Zhang, Y.; Zeng, L.
Plant ubiquitin E2 enzymes UBC32, UBC33, and UBC34 are involved in ERAD and function in host stress tolerance
BMC Plant Biol.
25
412
2025
Solanum lycopersicum (K4DHV2), Solanum lycopersicum (K4BN65), Solanum lycopersicum (K4C741), Arabidopsis thaliana (Q9LSP7), Arabidopsis thaliana (Q9FK29), Arabidopsis thaliana (Q9SHI7)
Xiang, C.; Yan, H.C.
Ubiquitin conjugating enzyme E2C (UBE2C) may play a dual role involved in the progression of thyroid carcinoma
Cell Death Discov.
8
130
2022
Homo sapiens (O00762)
Welsh, K.A.; Bolhuis, D.L.; Nederstigt, A.E.; Boyer, J.; Temple, B.R.S.; Bonacci, T.; Gu, L.; Ordureau, A.; Harper, J.W.; Steimel, J.P.; Zhang, Q.; Emanuele, M.J.; Harrison, J.S.; Brown, N.G.
Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes
EMBO J.
41
e108823
2022
Homo sapiens (Q712K3), Homo sapiens (Q16763)
McAlpine, J.M.R.B.; Zhu, J.; Pudjihartono, N.; Teyra, J.; Currie, M.J.; Tillett, Z.D.; Dobson, R.C.J.; Sidhu, S.S.; Day, C.L.; Middleton, A.J.
Structural and biophysical characterisation of ubiquitin variants that inhibit the ubiquitin conjugating enzyme Ube2d2
FEBS J.
291
5305-5321
2024
Homo sapiens (P62837)
Jin, B.; Li, B.; Qu, J.; Sun, Y.; Wang, M.; Yang, C.; Fan, Y.; Wang, Y.; Xu, P.; Sun, H.; Jiang, B.; Zhao, B.
Recruitment of ubiquitin E2 enzymes is determined jointly by the U-box domains and substrates of E3 ligases
FEBS Lett.
598
702-715
2024
Homo sapiens
Xu, L.; Wang, B.; Gang, Z.; Han, Z.; Wang, A.; Liu, Q.; Liu, H.; Wei, S.; Lin, Z.; Xie, C.; Hu, L.
Ubiquitin-conjugating enzyme E2S decreases the sensitivity of glioblastoma cells to temozolomide by upregulating PGAM1 via the interaction with OTUB2
Int. J. Biol. Macromol.
302
140583
2025
Homo sapiens (Q16763)
Critchley, W.R.; Smith, G.A.; Zachary, I.C.; Harrison, M.A.; Ponnambalam, S.
The E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2D2 regulate VEGFR2 dynamics and endothelial function
J. Cell Sci.
136
jcs260657
2023
Homo sapiens (P51668)
Wang, P.; Li, Y.; Ma, Y.; Zhang, X.; Li, Z.; Yu, W.; Zhu, M.; Wang, J.; Xu, Y.; Xu, A.
Comprehensive investigation into the role of ubiquitin-conjugating enzyme E2S in melanoma development
J. Invest. Dermatol.
141
374-384
2021
Homo sapiens (Q16763)
Kuang, W.; Zhuge, R.; Song, P.; Yi, L.; Zhang, S.; Zhang, Y.; Wong, Y.K.; Chen, R.; Zhang, J.; Wang, Y.; Liu, D.; Gong, Z.; Wang, P.; Ouyang, X.; Wang, J.
Eupalinolide B inhibits periodontitis development by targeting ubiquitin conjugating enzyme UBE2D3
MedComm. (2020)
6
e70034
2025
Mus musculus (P61079)
Brillada, C.; Trujillo, M.
Identification and characterization of physiological pairing of E2 ubiquitin-conjugating enzymes and E3 ubiquitin ligases
Methods Mol. Biol.
2581
13-29
2023
Embryophyta
Qi, S.; Guan, X.; Zhang, J.; Yu, D.; Yu, X.; Li, Q.; Yin, W.; Cheng, X.D.; Zhang, W.; Qin, J.J.
Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic cancer growth and metastasis
Mol. Cancer
21
70
2022
Homo sapiens (P61077)
Kiss, L.; Rhinesmith, T.; Luptak, J.; Dickson, C.F.; Weidenhausen, J.; Smyly, S.; Yang, J.C.; Maslen, S.L.; Sinning, I.; Neuhaus, D.; Clift, D.; James, L.C.
Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates
Nat. Commun.
14
2160
2023
Homo sapiens (Q96B02)
Shukla, P.K.; Bissell, J.E.; Kumar, S.; Pokhrel, S.; Palani, S.; Radmall, K.S.; Obidi, O.; Parnell, T.J.; Brasch, J.; Shrieve, D.C.; Chandrasekharan, M.B.
Structure and functional determinants of Rad6-Bre1 subunits in the histone H2B ubiquitin-conjugating complex
Nucleic Acids Res.
51
2117-2136
2023
Saccharomyces cerevisiae (P06104)
Rodriguez Tirado, C.; Wang, C.; Li, X.; Deng, S.; Gonzalez, J.; Johnson, N.A.; Xu, Y.; Metang, L.A.; Sundar Rajan, M.; Yang, Y.; Yin, Y.; Hofstad, M.; Raj, G.V.; Zhang, S.; Lemoff, A.; He, W.; Fan, J.; Wang, Y.; Wang, T.; Mu, P.
UBE2J1 is the E2 ubiquitin-conjugating enzyme regulating androgen receptor degradation and antiandrogen resistance
Oncogene
43
265-280
2024
Homo sapiens (Q9Y385)
Zheng, Y.W.; Gao, P.F.; Ma, M.Z.; Chen, Y.; Li, C.Y.
Role of ubiquitin-conjugating enzyme E2T in the carcinogenesis and progression of pancreatic cancer
Oncol. Lett.
20
1462-1468
2020
Homo sapiens (Q9NPD8)
Du, X.; Hua, R.; He, X.; Hou, W.; Li, S.; Yang, A.; Yang, G.
Echinococcus granulosus ubiquitin-conjugating enzymes (E2D2 and E2N) promote the formation of liver fibrosis in TGFbeta1-induced LX-2 cells
Parasit. Vectors
17
190
2024
Echinococcus granulosus (A0A5C1ZXC4), Echinococcus granulosus (U6JN29)
Hunt, L.C.; Curley, M.; Nyamkondiwa, K.; Stephan, A.; Jiao, J.; Kavdia, K.; Pagala, V.R.; Peng, J.; Demontis, F.
The ubiquitin-conjugating enzyme UBE2D maintains a youthful proteome and ensures protein quality control during aging by sustaining proteasome activity
PLoS Biol.
23
e3002998
2025
Drosophila melanogaster (P25867)
Jiao, A.L.; Sendinc, E.; Zee, B.M.; Wallner, F.; Shi, Y.
An E2 ubiquitin-conjugating enzyme links diubiquitinated H2B to H3K27M oncohistone function
Proc. Natl. Acad. Sci. USA
121
e2416614121
2024
Caenorhabditis elegans
Loh, Y.Y.; Anantharajan, J.; Huang, Q.; Xu, W.; Fulwood, J.; Ng, H.Q.; Ng, E.Y.; Gea, C.Y.; Choong, M.L.; Tan, Q.W.; Koh, X.; Lim, W.H.; Nacro, K.; Cherian, J.; Baburajendran, N.; Ke, Z.; Kang, C.
Identification of small-molecule binding sites of a ubiquitin-conjugating enzyme-UBE2T through fragment-based screening
Protein Sci.
33
e4904
2024
Homo sapiens (Q9NPD8)
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