Information on EC 2.3.2.23 - E2 ubiquitin-conjugating enzyme and Organism(s) Drosophila melanogaster

for references in articles please use BRENDA:EC2.3.2.23
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Drosophila melanogaster
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
2.3.2.23
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RECOMMENDED NAME
GeneOntology No.
E2 ubiquitin-conjugating enzyme
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
protein ubiquitination
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SYSTEMATIC NAME
IUBMB Comments
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase
The E2 ubiquitin-conjugating enzyme acquires the activated ubquitin from the E1 ubiquitin-activating enzyme (EC 6.2.1.45) and binds it via a transthioesterification reaction to itself. In the human enzyme the catalytic center is located at Cys-87 where ubiquitin is bound via its C-terminal glycine in a thioester linkage.