Disease on EC 2.3.2.12 - peptidyltransferase
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Gram-Negative Bacterial Infections
Septal Class A Penicillin-Binding Protein Activity and ld-Transpeptidases Mediate Selection of Colistin-Resistant Lipooligosaccharide-Deficient Acinetobacter baumannii.
Hypersensitivity
Hypersensitivity of Rhodobacter sphaeroides ribosomes to protein synthesis inhibitors: structural and functional implications.
Hypersensitivity
Stm1p alters the ribosome association of eukaryotic elongation factor 3 and affects translation elongation.
Infections
In situ assays demonstrate that interferon-gamma suppresses infection-stimulated hepatic fibrin deposition by promoting fibrinolysis.
Infertility
Independent evolution of a new allele of F(1) pollen sterility gene S27 encoding mitochondrial ribosomal protein L27 in Oryza nivara.
Neoplasms
Protein synthesis in tumor host. II. Increased activity of peptide elongation factor 1 in experimental rat tumors and in host liver.
peptidyltransferase deficiency
Non-Stressful Death of 23S rRNA Mutant G2061C Defective in Puromycin Reaction.
Starvation
Changes in ribosomal activity of Escherichia coli cells during prolonged culture in sea salts medium.
Tuberculosis
A Fluorescence-based Assay for Screening ?-Lactams Targeting the Mycobacterium tuberculosis Transpeptidase LdtMt2.
Tuberculosis
Atypically Modified Carbapenem Antibiotics Display Improved Antimycobacterial Activity in the Absence of ?-Lactamase Inhibitors.
Tuberculosis
Building a Full-Atom Model of L,Dtranspeptidase 2 from Mycobacterium tuberculosis for Screening New Inhibitors.
Tuberculosis
Catalytic mechanism of L,D-transpeptidase 2 from Mycobacterium tuberculosis described by a computational approach: insights for the design of new antibiotics drugs.
Tuberculosis
Crystal structure of L,D-transpeptidase LdtMt2 in complex with meropenem reveals the mechanism of carbapenem against Mycobacterium tuberculosis.
Tuberculosis
Isolation, Purification and Characterization of L,D-transpeptidase 2 from Mycobacterium tuberculosis.
Tuberculosis
Loss of a Functionally and Structurally Distinct ld-Transpeptidase, LdtMt5, Compromises Cell Wall Integrity in Mycobacterium tuberculosis.
Tuberculosis
Molecular insight on the non-covalent interactions between carbapenems and L,D-transpeptidase 2 from Mycobacterium tuberculosis: ONIOM study.
Tuberculosis
Simulating the inhibition reaction of Mycobacterium tuberculosis L,D-transpeptidase 2 by carbapenems.
Tuberculosis
Structural and biochemical analyses of the LdtMt2-panipenem adduct provide new insights into the effect of the 1-?-methyl group on carbapenems.
Tuberculosis
Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase LdtMt2 by biapenem and tebipenem.
Tuberculosis
Structures of free and inhibited forms of the L,D-transpeptidase LdtMt1 from Mycobacterium tuberculosis.
Tuberculosis
Targeting the cell wall of Mycobacterium tuberculosis: A molecular modelling investigation of the interaction of imipenem and meropenem with L,D-transpeptidase 2.
Tuberculosis
Targeting the cell wall of Mycobacterium tuberculosis: structure and mechanism of L,D-transpeptidase 2.
Tuberculosis
Targeting the Mycobacterium tuberculosis transpeptidase LdtMt2 with cysteine-reactive inhibitors including ebselen.
Tuberculosis
The 1-?-methyl group confers a lower affinity of l,d-transpeptidase LdtMt2 for ertapenem than for imipenem.
Tuberculosis
The Mycobacterium tuberculosis protein LdtMt2 is a nonclassical transpeptidase required for virulence and resistance to amoxicillin.
Typhoid Fever
Peptidoglycan editing by a specific LD-transpeptidase controls the muramidase-dependent secretion of typhoid toxin.
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