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Information on EC 2.3.1.9 - acetyl-CoA C-acetyltransferase and Organism(s) Pseudomonas aeruginosa

for references in articles please use BRENDA:EC2.3.1.9

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IUBMB Comments

The enzyme, found in both eukaryotes and prokaryotes, catalyses the Claisen condensation of an acetyl-CoA and an acyl-CoA (often another acetyl-CoA), leading to the formation of an acyl-CoA that is longer by two carbon atoms. The reaction starts with the acylation of a nucleophilic cysteine at the active site, usually by acetyl-CoA but potentially by a different acyl-CoA, with concomitant release of CoA. In the second step the acyl group is transferred to an acetyl-CoA molecule. cf. EC 2.3.1.16, acetyl-CoA C-acyltransferase.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
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2
acetyl-CoA
=
CoA
+
acetoacetyl-CoA
2
=
+

Synonyms
acetoacetyl-coa thiolase, acetyl-coa acetyltransferase, erg10, acoat, acetyl-coa c-acetyltransferase, cytosolic acetoacetyl-coa thiolase, 2-methylacetoacetyl-coa thiolase, osat1, acetoacetyl coa thiolase, aact2, more

SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2-methylacetoacetyl-CoA thiolase
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3-oxothiolase
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acetoacetyl CoA thiolase
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acetoacetyl-CoA thiolase
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acetyl coenzyme A thiolase
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acetyl-CoA acetyltransferase
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acetyl-CoA:N-acetyltransferase
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acetyltransferase, acetyl coenzyme A
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beta-acetoacetyl coenzyme A thiolase
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thiolase II
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
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condensation
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thiolytic cleavage
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PATHWAY SOURCE
PATHWAYS
MetaCyc
(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered), 2-deoxy-D-ribose degradation II, 2-methylpropene degradation, 3-hydroxypropanoate/4-hydroxybutanate cycle, 4-oxopentanoate degradation, acetoacetate degradation (to acetyl CoA), acetyl-CoA fermentation to butanoate, crotonate fermentation (to acetate and cyclohexane carboxylate), ethylmalonyl-CoA pathway, glutaryl-CoA degradation, isoprene biosynthesis II (engineered), isopropanol biosynthesis (engineered), ketogenesis, ketolysis, L-glutamate degradation V (via hydroxyglutarate), L-lysine fermentation to acetate and butanoate, methyl tert-butyl ether degradation, mevalonate pathway I (eukaryotes and bacteria), mevalonate pathway II (haloarchaea), mevalonate pathway III (Thermoplasma), mevalonate pathway IV (archaea), oleate beta-oxidation, polyhydroxybutanoate biosynthesis, pyruvate fermentation to acetone, pyruvate fermentation to butanoate, pyruvate fermentation to butanol I, pyruvate fermentation to butanol II (engineered), pyruvate fermentation to hexanol (engineered), valproate beta-oxidation
SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:acetyl-CoA C-acetyltransferase
The enzyme, found in both eukaryotes and prokaryotes, catalyses the Claisen condensation of an acetyl-CoA and an acyl-CoA (often another acetyl-CoA), leading to the formation of an acyl-CoA that is longer by two carbon atoms. The reaction starts with the acylation of a nucleophilic cysteine at the active site, usually by acetyl-CoA but potentially by a different acyl-CoA, with concomitant release of CoA. In the second step the acyl group is transferred to an acetyl-CoA molecule. cf. EC 2.3.1.16, acetyl-CoA C-acyltransferase.
CAS REGISTRY NUMBER
COMMENTARY hide
9027-46-7
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Highest Expressing Human Cell Lines
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