Disease on EC 2.3.1.87 - aralkylamine N-acetyltransferase and Organism(s) Homo sapiens
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Acidosis
Acidosis-sensing glutamine pump SNAT2 determines amino acid levels and mammalian target of rapamycin signalling to protein synthesis in L6 muscle cells.
Acidosis
Inhibition of SNAT2 by metabolic acidosis enhances proteolysis in skeletal muscle.
Acquired Immunodeficiency Syndrome
Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.
aralkylamine n-acetyltransferase deficiency
Inhibition of the glutamine transporter SNAT1 confers neuroprotection in mice by modulating the mTOR-autophagy system.
aralkylamine n-acetyltransferase deficiency
Prolonged swim-test immobility of serotonin N-acetyltransferase (AANAT)-mutant mice.
Astrocytoma
Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas.
Brain Injuries
Up-regulation of miR-325-3p suppresses pineal aralkylamine N-acetyltransferase (Aanat) after neonatal hypoxia-ischemia brain injury in rats.
Brain Neoplasms
Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas.
Breast Neoplasms
Activation of SNAT1/SLC38A1 in human breast cancer: correlation with p-Akt overexpression.
Breast Neoplasms
Altered Umbilical Cord Blood Nutrient Levels, Placental Cell Turnover and Transporter Expression in Human Term Pregnancies Conceived by Intracytoplasmic Sperm Injection (ICSI).
Breast Neoplasms
Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer.
Breast Neoplasms
Polymorphisms in circadian genes, night work and breast cancer: results from the GENICA study.
Breast Neoplasms
SNAT2 transceptor signalling via mTOR: a role in cell growth and proliferation?
Carcinogenesis
Activation of SNAT1/SLC38A1 in human breast cancer: correlation with p-Akt overexpression.
Carcinogenesis
O-GlcNAcylation of YY1 stimulates tumorigenesis in colorectal cancer cells by targeting SLC22A15 and AANAT.
Carcinoma, Hepatocellular
Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene.
Carcinoma, Hepatocellular
Despite Increased ATF4 Binding at the C/EBP-ATF Composite Site following Activation of the Unfolded Protein Response, System A Transporter 2 (SNAT2) Transcription Activity Is Repressed in HepG2 Cells.
Choriocarcinoma
Human placental trophoblasts synthesize melatonin and express its receptors.
Chronobiology Disorders
The flavonoid myricetin reduces nocturnal melatonin levels in the blood through the inhibition of serotonin N-acetyltransferase.
Colorectal Neoplasms
AA-NAT, MT1 and MT2 Correlates with Cancer Stem-Like Cell Markers in Colorectal Cancer: Study of the Influence of Stage and p53 Status of Tumors.
Colorectal Neoplasms
Melatonin reduces endothelin-1 expression and secretion in colon cancer cells through the inactivation of FoxO-1 and NF-??
Colorectal Neoplasms
O-GlcNAcylation of YY1 stimulates tumorigenesis in colorectal cancer cells by targeting SLC22A15 and AANAT.
Endometrial Neoplasms
ASCT2 regulates glutamine uptake and cell growth in endometrial carcinoma.
Epilepsy
Modulation of epileptiform activity by glutamine and system A transport in a model of post-traumatic epilepsy.
Glioma
Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas.
Infections
Attacking the Supply Lines: HIV-1 Restricts Alanine Uptake to Prevent T Cell Activation.
Infections
Expression of Melatonin Synthesizing Enzymes in Helicobacter pylori Infected Gastric Mucosa.
Infections
The Amino Acid-mTORC1 Pathway Mediates APEC TW-XM-Induced Inflammation in bEnd.3 Cells.
Insulin Resistance
Chronic treatment with dexamethasone alters clock gene expression and melatonin synthesis in rat pineal gland at night.
Insulin Resistance
Inhibition of SNAT2 by metabolic acidosis enhances proteolysis in skeletal muscle.
Intestinal Volvulus
Characterization of the arylalkylamine N-acetyltransferase in Onchocerca volvulus.
Ischemic Attack, Transient
Arylalkylamine N-acetyltransferase (AANAT) is expressed in astrocytes and melatonin treatment maintains AANAT in the gerbil hippocampus induced by transient cerebral ischemia.
Klatskin Tumor
Overexpression of Prdx1 in hilar cholangiocarcinoma: a predictor for recurrence and prognosis.
Liver Cirrhosis
Pinealectomy or light exposure exacerbates biliary damage and liver fibrosis in cholestatic rats through decreased melatonin synthesis.
Liver Cirrhosis
Prolonged exposure of cholestatic rats to complete dark inhibits biliary hyperplasia and liver fibrosis.
Melanoma
Gender-specific associations between polymorphisms of the circadian gene RORA and cutaneous melanoma susceptibility.
Melanosis
A New Arylalkylamine N-Acetyltransferase in Silkworm (Bombyx mori) Affects Integument Pigmentation.
Melanosis
Mutations of an arylalkylamine-n-acetyl transferase, BM-IAANAT, are responsible for the silkworm melanism mutant.
Neoplasm Metastasis
Increased SNAT1 is a marker of human osteosarcoma and potential therapeutic target.
Neoplasms
AA-NAT, MT1 and MT2 Correlates with Cancer Stem-Like Cell Markers in Colorectal Cancer: Study of the Influence of Stage and p53 Status of Tumors.
Neoplasms
Activation of SNAT1/SLC38A1 in human breast cancer: correlation with p-Akt overexpression.
Neoplasms
Adiponectin Inhibits Nutrient Transporters and Promotes Apoptosis in Human Villous Cytotrophoblasts: Involvement in the Control of Fetal Growth.
Neoplasms
Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells.
Neoplasms
Effect of TNF-alpha on the melatonin synthetic pathway in the rat pineal gland: basis for a 'feedback' of the immune response on circadian timing.
Neoplasms
Histological features and expression of enzymes implicated in melatonin synthesis in pineal parenchymal tumours and in cultured tumoural pineal cells.
Neoplasms
STAT1-NF?B crosstalk triggered by interferon gamma regulates noradrenaline-induced pineal hormonal production.
Nervous System Diseases
Selective tonicity-induced expression of the neutral amino-acid transporter SNAT2 in oligodendrocytes in rat brain following systemic hypertonicity.
Obesity
Design, synthesis and in vitro evaluation of novel benzo[b]thiophene derivatives as serotonin N-acetyltransferase (AANAT) inhibitors.
Osteosarcoma
Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells.
Osteosarcoma
Increased SNAT1 is a marker of human osteosarcoma and potential therapeutic target.
Paraproteinemias
Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target.
Peritonitis
Pineal arylalkylamine N-acetyl-transferase (Aanat) gene expression as a target of inflammatory mediators in the chicken.
Pulmonary Edema
Sodium coupled neutral amino acid transporter SNAT2 counteracts cardiogenic pulmonary edema by driving alveolar fluid clearance.
Retinoblastoma
Regulation of AA-NAT and HIOMT gene expression by butyrate and cyclic AMP in Y79 human retinoblastoma cells.
Retinoblastoma
The human serotonin N-acetyltransferase (EC 2.3.1.87) gene (AANAT): structure, chromosomal localization, and tissue expression.
Rett Syndrome
Dysregulation of Glutamine Transporter SNAT1 in Rett Syndrome Microglia: A Mechanism for Mitochondrial Dysfunction and Neurotoxicity.
Sarcopenia
Skeletal muscle: from birth to old age, routes to mechanical and metabolic failure.
Scoliosis
Association study of tryptophan hydroxylase 1 and arylalkylamine N-acetyltransferase polymorphisms with adolescent idiopathic scoliosis in Han Chinese.
Seizures
Modulation of epileptiform activity by glutamine and system A transport in a model of post-traumatic epilepsy.
Sepsis
Sepsis-induced changes in amino acid transporters and leucine signaling via mTOR in skeletal muscle.
Sleep Disorders, Circadian Rhythm
Arylalkylamine N-acetyltransferase (AANAT) genotype as a personal trait in melatonin synthesis.
Sleep Disorders, Circadian Rhythm
Significant association of the arylalkylamine N-acetyltransferase ( AA-NAT) gene with delayed sleep phase syndrome.
Sleep Disorders, Circadian Rhythm
The G619A Aa-nat gene polymorphism does not contribute to sleep time variation in the Brazilian population.
Sleep Wake Disorders
Computational Analysis of N-acetyl transferase in Tribolium castaneum.
Sleep Wake Disorders
Crystal structure of the dopamine N-acetyltransferase-acetyl-CoA complex provides insights into the catalytic mechanism.
Squamous Cell Carcinoma of Head and Neck
ASCT2 (SLC1A5)-dependent glutamine uptake is involved in the progression of head and neck squamous cell carcinoma.
Starvation
Amino acid starvation induces the SNAT2 neutral amino acid transporter by a mechanism that involves eukaryotic initiation factor 2alpha phosphorylation and cap-independent translation.
Starvation
Characterization and Regulation of the Amino Acid Transporter SNAT2 in the Small Intestine of Piglets.
Starvation
Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells.
Starvation
Effects of starvation, re-feeding and timing of food supply on daily rhythm features of gut melatonin in carp (Catla catla).
Starvation
Enhanced small neutral but not branched chain amino acid transport after epigenetic sodium coupled neutral amino acid transporter-2 (SNAT2) cDNA expression in myoblasts.
Starvation
Proteasomal modulation of cellular SNAT2 (SLC38A2) abundance and function by unsaturated fatty acid availability.
Starvation
Specificity of amino acid regulated gene expression: analysis of genes subjected to either complete or single amino acid deprivation.
Starvation
The synthesis of SNAT2 transporters is required for the hypertonic stimulation of system A transport activity.
Stroke
Inhibition of the glutamine transporter SNAT1 confers neuroprotection in mice by modulating the mTOR-autophagy system.
Uterine Cervical Neoplasms
Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells.
Vitamin A Deficiency
Regulation of the expression of serotonin N-acetyltransferase gene in Japanese quail (Coturnix japonica): II. Effect of vitamin A deficiency.