Reference on EC 2.3.1.85 - fatty-acid synthase system and Organism(s) Homo sapiens
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wakil, S.J.; Stoops, J.K.; Joshi, V.C.
Fatty acid synthesis and its regulation
Annu. Rev. Biochem.
52
537-579
1983
Anser sp., Bos taurus, Canis lupus familiaris, Gallus gallus, Columba sp., Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus
Jayakumar, A.; Huang, W.Y.; Raetz, B.; Chirala, S.S.; Wakil, S.J.
Cloning and expression of the multifunctional human fatty acid synthase and its subdomains in Escherichia coli
Proc. Natl. Acad. Sci. USA
93
14509-14514
1996
Homo sapiens
Jayakumar, A.; Tai, M.H.; Huang, W.Y.; Al-Feel, W.; Hsu, M.; Abu-Elheiga, L.; Chirala, S.S.; Wakil, S.J.
Human fatty acid synthase: properties and molecular cloning
Proc. Natl. Acad. Sci. USA
92
8695-8699
1995
Homo sapiens
Wagle, S.; Bui, A.; Ballard, P.L.; Shuman, H.; Gonzales, J.; Gonzales, L.W.
Hormonal regulation and cellular localization of fatty acid synthase in human fetal lung
Am. J. Physiol.
277
L381-L390
1999
Homo sapiens
Swinnen, J.V.; Van Veldhoven, P.P.; Timmermans, L.; De Schrijver, E.; Brusselmans, K.; Vanderhoydonc, F.; Van de Sande, T.; Heemers, H.; Heyns, W.; Verhoeven, G.
Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains
Biochem. Biophys. Res. Commun.
302
898-903
2003
Homo sapiens
Agostini, M.; Silva, S.D.; Zecchin, K.G.; Coletta, R.D.; Jorge, J.; Loda, M.; Graner, E.
Fatty acid synthase is required for the proliferation of human oral squamous carcinoma cells
Oral Oncol.
40
728-735
2004
Homo sapiens
Chakravarty, B.; Gu, Z.; Chirala, S.S.; Wakil, S.J.; Quiocho, F.A.
Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain
Proc. Natl. Acad. Sci. USA
101
15567-15572
2004
Homo sapiens (P49327)
Carlisle-Moore, L.; Gordon, C.R.; Machutta, C.A.; Miller, W.T.; Tonge, P.J.
Substrate recognition by the human fatty-acid synthase
J. Biol. Chem.
280
42612-42618
2005
Homo sapiens
Asturias, F.J.
Mammalian fatty acid synthase: X-ray structure of a molecular assembly line
ACS Chem. Biol.
1
135-138
2006
Homo sapiens
Consolazio, A.; Alo, P.L.; Rivera, M.; Iacopini, F.; Paoluzi, O.A.; Crispino, P.; Pica, R.; Paoluzi, P.
Overexpression of fatty acid synthase in ulcerative colitis
Am. J. Clin. Pathol.
126
113-118
2006
Homo sapiens
Lupu, R.; Menendez, J.A.
Pharmacological inhibitors of fatty acid synthase (FASN)-catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?
Curr. Pharm. Biotechnol.
7
483-494
2006
Homo sapiens
van de Sande, T.; Roskams, T.; Lerut, E.; Joniau, S.; Van Poppel, H.; Verhoeven, G.; Swinnen, J.V.
High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB
J. Pathol.
206
214-219
2005
Homo sapiens
Wang, H.Q.; Altomare, D.A.; Skele, K.L.; Poulikakos, P.I.; Kuhajda, F.P.; Di Cristofano, A.; Testa, J.R.
Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells
Oncogene
24
3574-3582
2005
Homo sapiens
Schmidt, L.J.; Ballman, K.V.; Tindall, D.J.
Inhibition of fatty acid synthase activity in prostate cancer cells by dutasteride
Prostate
67
1111-1120
2007
Homo sapiens
Grunt, T.W.; Wagner, R.; Grusch, M.; Berger, W.; Singer, C.F.; Marian, B.; Zielinski, C.C.; Lupu, R.
Interaction between fatty acid synthase- and ErbB-systems in ovarian cancer cells
Biochem. Biophys. Res. Commun.
385
454-459
2009
Homo sapiens
Kim, K.J.; Kim, H.Y.; Cho, H.K.; Kim, K.H.; Cheong, J.
The SDF-1alpha/CXCR4 axis induces the expression of fatty acid synthase via sterol regulatory element binding protein-1 activation in cancer cells
Carcinogenesis
31
679-686
2010
Homo sapiens
Lu, S.; Archer, M.C.
Sp1 coordinately regulates de novo lipogenesis and proliferation in cancer cells
Int. J. Cancer
126
416-425
2010
Homo sapiens
Lau, D.S.; Archer, M.C.
The 10t,12c isomer of conjugated linoleic acid inhibits fatty acid synthase expression and enzyme activity in human breast, colon, and prostate cancer cells
Nutr. Cancer
62
116-121
2010
Homo sapiens
Chen, Q.; Reimer, R.A.
Dairy protein and leucine alter GLP-1 release and mRNA of genes involved in intestinal lipid metabolism in vitro
Nutrition
25
340-349
2009
Homo sapiens
Zeng, X.F.; Li, W.W.; Fan, H.J.; Wang, X.Y.; Ji, P.; Wang, Z.R.; Ma, S.; Li, L.L.; Ma, X.F.; Yang, S.Y.
Discovery of novel fatty acid synthase (FAS) inhibitors based on the structure of ketoaceyl synthase (KS) domain
Bioorg. Med. Chem. Lett.
21
4742-4744
2011
Homo sapiens (P49327)
Oh, J.; Hwang, I.H.; Hong, C.E.; Lyu, S.Y.; Na, M.
Inhibition of fatty acid synthase by ginkgolic acids from the leaves of Ginkgo biloba and their cytotoxic activity
J. Enzyme Inhib. Med. Chem.
28
565-568
2013
Gallus gallus, Homo sapiens
Pappenberger, G.; Benz, J.; Gsell, B.; Hennig, M.; Ruf, A.; Stihle, M.; Thoma, R.; Rudolph, M.G.
Structure of the human fatty acid synthase KS-MAT didomain as a framework for inhibitor design
J. Mol. Biol.
397
508-519
2010
Homo sapiens (P49327)
Zhao, W.; Wang, Y.; Hao, W.; Zhao, M.; Peng, S.
In vitro inhibition of fatty acid synthase by 1,2,3,4,6-penta-O-galloyl-beta-D-glucose plays a vital role in anti-tumour activity
Biochem. Biophys. Res. Commun.
445
346-351
2014
Homo sapiens
Cui, W.; Liang, Y.; Tian, W.; Ji, M.; Ma, X.
Regulating effect of beta-ketoacyl synthase domain of fatty acid synthase on fatty acyl chain length in de novo fatty acid synthesis
Biochim. Biophys. Acta
1861
149-155
2016
Homo sapiens
Hopperton, K.E.; Duncan, R.E.; Bazinet, R.P.; Archer, M.C.
Fatty acid synthase plays a role in cancer metabolism beyond providing fatty acids for phospholipid synthesis or sustaining elevations in glycolytic activity
Exp. Cell Res.
320
302-310
2014
Homo sapiens
Hopcroft, P.; Fisher, D.
Development of a medium-throughput targeted LCMS assay to detect endogenous cellular levels of malonyl-CoA to screen fatty acid synthase inhibitors
J. Biomol. Screen.
21
111-116
2016
Homo sapiens
Liu, H.; Wu, X.; Dong, Z.; Luo, Z.; Zhao, Z.; Xu, Y.; Zhang, J.T.
Fatty acid synthase causes drug resistance by inhibiting TNF-alpha and ceramide production
J. Lipid Res.
54
776-785
2013
Homo sapiens
Bollu, L.R.; Katreddy, R.R.; Blessing, A.M.; Pham, N.; Zheng, B.; Wu, X.; Weihua, Z.
Intracellular activation of EGFR by fatty acid synthase dependent palmitoylation
Oncotarget
6
34992-35003
2015
Homo sapiens
Wang, Y.; Nie, F.; Ouyang, J.; Wang, X.; Ma, X.
Inhibitory effects of sea buckthorn procyanidins on fatty acid synthase and MDA-MB-231 cells
Tumour Biol.
35
9563-9569
2014
Homo sapiens
Crous-Maso, J.; Palomeras, S.; Relat, J.; Camo, C.; Martinez-Garza, U.; Planas, M.; Feliu, L.; Puig, T.
(-)-Epigallocatechin 3-gallate synthetic analogues inhibit fatty acid synthase and show anticancer activity in triple negative breast cancer
Molecules
23
1160
2018
Homo sapiens (P49327)
