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EC Tree
IUBMB Comments Acts on palmitoyl-CoA and other long-chain fatty-acyl derivatives of CoA.
The enzyme appears in viruses and cellular organisms
Synonyms
acyl coa:retinol acyltransferase, retinyl-ester synthase, acyl coenzyme a:retinol acyltransferase, 11-cis-arat, retinol fatty-acyltransferase,
more
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11-cis-acyl-CoA:retinol O-acyltransferase
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acyl CoA:retinol acyltransferase
acyl CoA:retinol O-acyltransferase
-
-
acyl coenzyme A:retinol acyltransferase
-
-
acyl-CoA:retinol acyltransferase
-
-
multifunctional O-acyltransferase
-
-
retinol fatty-acyltransferase
-
-
-
-
retinyl-ester synthase
-
-
acyl CoA:retinol acyltransferase
-
-
acyl CoA:retinol acyltransferase
-
-
ArAT
-
-
additional information
-
cf. EC 2.3.1.135
additional information
-
cf. EC 2.3.1.135
additional information
-
cf. EC 2.3.1.22
additional information
-
the enzyme belongs to the acyl-CoA:diacylglycerol acyltransferase 2/acyl-CoA:monoacylglycerol acyltransferase, MGAT, gene family
additional information
-
cf. EC 2.3.1.20
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acyl-CoA + retinol = CoA + retinyl ester
acyl-CoA + retinol = CoA + retinyl ester
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-
-
-
acyl-CoA + retinol = CoA + retinyl ester
enzyme mechanism and role in the visual cycle
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Acyl group transfer
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-
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acyl-CoA:retinol O-acyltransferase
Acts on palmitoyl-CoA and other long-chain fatty-acyl derivatives of CoA.
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acyl-CoA + retinol
CoA + retinyl ester
all-trans retinol + palmitoyl-CoA
all-trans-retinyl palmitate + CoA
lauroyl-CoA + retinol
CoA + retinyllaurate
octanoyl-CoA + retinol
CoA + retinyloctanoate
oleoyl-CoA + retinol
CoA + retinyloleolate
palmitoyl-CoA + 11-cis-retinol
CoA + 11-cis-retinyl palmitate
palmitoyl-CoA + 11-cis-retinol
CoA + 11-cis-retinylpalmitate
-
-
-
-
?
palmitoyl-CoA + all-trans-retinol
CoA + all-trans-retinyl palmitate
palmitoyl-CoA + all-trans-retinol
CoA + all-trans-retinylpalmitate
-
-
-
-
?
palmitoyl-CoA + retinol
CoA + retinyl palmitate
palmitoyl-CoA + retinol
CoA + retinylpalmitate
stearoyl-CoA + retinol
CoA + retinylstearate
additional information
?
-
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
?
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
?
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
?
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
-
?
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
?
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
?
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
?
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
?
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
?
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
?
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
?
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
?
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
?
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
?
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
?
all-trans retinol + palmitoyl-CoA
all-trans-retinyl palmitate + CoA
-
-
-
-
?
all-trans retinol + palmitoyl-CoA
all-trans-retinyl palmitate + CoA
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-
-
-
?
lauroyl-CoA + retinol
CoA + retinyllaurate
-
-
-
?
lauroyl-CoA + retinol
CoA + retinyllaurate
-
-
-
?
octanoyl-CoA + retinol
CoA + retinyloctanoate
-
-
-
?
octanoyl-CoA + retinol
CoA + retinyloctanoate
-
-
-
?
oleoyl-CoA + retinol
CoA + retinyloleolate
-
-
-
?
oleoyl-CoA + retinol
CoA + retinyloleolate
-
-
-
?
oleoyl-CoA + retinol
CoA + retinyloleolate
-
-
-
?
oleoyl-CoA + retinol
CoA + retinyloleolate
-
-
-
?
oleoyl-CoA + retinol
CoA + retinyloleolate
-
-
-
?
oleoyl-CoA + retinol
CoA + retinyloleolate
-
-
-
?
palmitoyl-CoA + 11-cis-retinol
CoA + 11-cis-retinyl palmitate
-
-
-
-
r
palmitoyl-CoA + 11-cis-retinol
CoA + 11-cis-retinyl palmitate
-
-
-
-
?
palmitoyl-CoA + 11-cis-retinol
CoA + 11-cis-retinyl palmitate
-
esterification of 11-cis-retinol is four times greater than esterification of all-trans-retinol in Muller cells
-
-
?
palmitoyl-CoA + all-trans-retinol
CoA + all-trans-retinyl palmitate
-
-
-
-
r
palmitoyl-CoA + all-trans-retinol
CoA + all-trans-retinyl palmitate
-
-
-
-
?
palmitoyl-CoA + all-trans-retinol
CoA + all-trans-retinyl palmitate
-
esterification of 11-cis-retinol is four times greater than esterification of all-trans-retinol in Muller cells
-
-
?
palmitoyl-CoA + retinol
CoA + retinyl palmitate
-
-
-
-
?
palmitoyl-CoA + retinol
CoA + retinyl palmitate
-
-
-
-
?
palmitoyl-CoA + retinol
CoA + retinylpalmitate
-
-
-
?
palmitoyl-CoA + retinol
CoA + retinylpalmitate
-
-
-
?
palmitoyl-CoA + retinol
CoA + retinylpalmitate
-
-
-
?
palmitoyl-CoA + retinol
CoA + retinylpalmitate
-
-
-
-
?
palmitoyl-CoA + retinol
CoA + retinylpalmitate
-
-
-
?
palmitoyl-CoA + retinol
CoA + retinylpalmitate
-
-
-
?
palmitoyl-CoA + retinol
CoA + retinylpalmitate
-
-
-
?
palmitoyl-CoA + retinol
CoA + retinylpalmitate
-
-
-
?
palmitoyl-CoA + retinol
CoA + retinylpalmitate
-
polyunsaturated derivatives are poor substrates
-
?
palmitoyl-CoA + retinol
CoA + retinylpalmitate
-
predominant fatty acid among tissue retinyl esters
-
?
palmitoyl-CoA + retinol
CoA + retinylpalmitate
-
better effect with long chain fatty acids
-
?
palmitoyl-CoA + retinol
CoA + retinylpalmitate
-
better effect with long chain fatty acids
-
?
palmitoyl-CoA + retinol
CoA + retinylpalmitate
-
-
-
?
palmitoyl-CoA + retinol
CoA + retinylpalmitate
-
-
-
?
palmitoyl-CoA + retinol
CoA + retinylpalmitate
-
-
-
?
palmitoyl-CoA + retinol
CoA + retinylpalmitate
-
-
-
?
stearoyl-CoA + retinol
CoA + retinylstearate
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-
-
?
stearoyl-CoA + retinol
CoA + retinylstearate
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-
-
?
stearoyl-CoA + retinol
CoA + retinylstearate
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-
-
?
stearoyl-CoA + retinol
CoA + retinylstearate
-
-
-
?
additional information
?
-
-
ARAT may complement LRAT, EC 2.3.1.135, to provide additional retinyl-ester synthase activity under conditions of high all-trans-retinol
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-
?
additional information
?
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-
the multifunctional O-acyltransferase likely plays an important role in lipid metabolism in human skin
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-
?
additional information
?
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the multifunctional enzyme plays an important role in lipid metabolism in human skin
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-
?
additional information
?
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acyl coenzyme A:diacylglycerol acyltransferase, DGAT, EC 2.3.1.20, and acyl coenzyme A:monoacylglycerolol acyltransferase, MGAT, EC 2.3.1.22, also show activity with retinol, overview
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-
?
additional information
?
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the multifunctional O-acetyltransferase is catalyzing the reactions of the acyl-CoA:retinol acyltransferase, of the monoacylglycerol transferase, EC 2.3.1.22, of the diacylglycerol transferase, EC 2.3.1.20, and of the wax synthase, EC 2.3.1.75, overview
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-
?
additional information
?
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the reaction is also catalyzed by the acyl coenzyme A:diacylglycerol acyltransferase, DGAT, EC 2.3.1.22
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-
?
additional information
?
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ARAT plays a role in retinol metabolism in tissues with low levels of cytosolic retinol binding protein or when cellular retinol concentrations are relatively high, thereby protecting cells from toxicity resulting from excess unesterified retinol
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-
?
additional information
?
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cells and tissues from DGAT1-deficient mice exhibit reduced ARAT activity, and the mice have increased levels of unesterified retinol in their livers on a high-retinol diet
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-
?
additional information
?
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DGAT1 is catalyzing the reactions of the monoacylglycerol transferase, EC 2.3.1.22, of the diacylglycerol transferase, EC 2.3.1.20, of the wax synthase, EC 2.3.1.75, and of the acyl-CoA:retinol acyltransferase, EC 2.3.1.76, overview
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-
?
additional information
?
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the triacylglycerol synthesis enzyme DGAT1, EC 2.3.1.20, also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters, overview
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-
?
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acyl-CoA + retinol
CoA + retinyl ester
all-trans retinol + palmitoyl-CoA
all-trans-retinyl palmitate + CoA
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-
-
-
?
palmitoyl-CoA + 11-cis-retinol
CoA + 11-cis-retinyl palmitate
palmitoyl-CoA + all-trans-retinol
CoA + all-trans-retinyl palmitate
palmitoyl-CoA + retinol
CoA + retinyl palmitate
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-
-
-
?
additional information
?
-
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
?
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
?
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
?
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
-
?
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
?
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
?
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
?
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
?
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
?
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
?
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
?
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
?
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
?
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
?
acyl-CoA + retinol
CoA + retinyl ester
-
-
-
?
palmitoyl-CoA + 11-cis-retinol
CoA + 11-cis-retinyl palmitate
-
-
-
-
r
palmitoyl-CoA + 11-cis-retinol
CoA + 11-cis-retinyl palmitate
-
esterification of 11-cis-retinol is four times greater than esterification of all-trans-retinol in Muller cells
-
-
?
palmitoyl-CoA + all-trans-retinol
CoA + all-trans-retinyl palmitate
-
-
-
-
r
palmitoyl-CoA + all-trans-retinol
CoA + all-trans-retinyl palmitate
-
esterification of 11-cis-retinol is four times greater than esterification of all-trans-retinol in Muller cells
-
-
?
additional information
?
-
-
ARAT may complement LRAT, EC 2.3.1.135, to provide additional retinyl-ester synthase activity under conditions of high all-trans-retinol
-
-
?
additional information
?
-
-
the multifunctional O-acyltransferase likely plays an important role in lipid metabolism in human skin
-
-
?
additional information
?
-
-
the multifunctional enzyme plays an important role in lipid metabolism in human skin
-
-
?
additional information
?
-
-
ARAT plays a role in retinol metabolism in tissues with low levels of cytosolic retinol binding protein or when cellular retinol concentrations are relatively high, thereby protecting cells from toxicity resulting from excess unesterified retinol
-
-
?
additional information
?
-
-
cells and tissues from DGAT1-deficient mice exhibit reduced ARAT activity, and the mice have increased levels of unesterified retinol in their livers on a high-retinol diet
-
-
?
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(6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate
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activity inhibited at 0.5%
2,3,7,8-tetrachlorodibenzo-p-dioxin
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decreased activity
5,5'-dithiobis(2-nitrobenzoic acid)
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activity inhibited above 2 mM
all-trans-retinylbromoacetate
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cellular retinol-binding protein
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specific inhibition of retinol fatty-acyltransferase by capturing substrate
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p-chloromercuribenzoate
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activity abolished at 5 mM
p-chloromercuriphenylsulfonic acid
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activity abolished at 6 mM
p-hydroxymercuribenzoate
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activity inhibited at 2 and 6 mM
sodium deoxycholate
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activity inhibited at 0.5%
sodium taurocholate
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activity abolished at 8 mM
progesterone
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progesterone
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activity inhibited above 0.05 mM
XP620
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selective isozyme DGAT1 inhibitor, inhibits the diacylglycerol acyltransferase and the retinol acyltransferase activities at the retinol recognition site, inhibition of 85% of retinyl ester production in intact differentiated Caco-2 cells, IC50: 88.7 nM
XP620
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inhibits the ARAT activity of acyl coenzyme A:diacylglycerol acyltransferase isozyme 1 dependent on the retinol concentration in vivo and in vitro, IC50: 110 nM, no inhibition of isozyme 2 and acyl coenzyme A:monoacylglycerol acyltransferase isozyme 3, overview
additional information
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not inhibited by cholesterol
-
additional information
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not inhibited by PMSF
-
additional information
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not inhibited by EDTA 2 mM
-
additional information
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not inhibited by PMSF
-
additional information
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not inhibited by 3,3',4,4'-tetrachlorobiphenyl
-
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bovine serum albumin
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bovine serum albumin
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0.02 mM enhances activity
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dithiothreitol
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dithiothreitol
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5 mM enhances activity
additional information
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in presence of palmitoyl-CoA and CRALBP, Muller cell membranes synthesize 11-cis-retinyl ester from 11-cis-retinol at a rate which is 20-fold higher than that of all-trans-retinyl ester, in absence of CRALBP, 11-cis-retinyl ester synthesis is greatly reduced by 7-fold, in absence of palmitoyl-CoA, retinyl ester synthesis is not observed
-
additional information
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not enhanced by retinoic acids
-
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Neoplasms
Enhancement of acyl coenzyme A:retinol acyltransferase in rat liver and mammary tumor tissue by retinyl acetate and its competitive inhibition by N-(4-hydroxyphenyl) retinamide.
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0.0041 - 0.0048
all-trans-retinol
additional information
additional information
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0.0087
11-cis-retinol
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-
0.0087
11-cis-retinol
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pH 7.5, 37°C, retinal pigment epithelium microsomes
0.0041
all-trans-retinol
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pH 7.5, 37°C, retinal pigment epithelium microsomes
0.0041 - 0.0048
all-trans-retinol
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depending on assay method
0.0139
palmitoyl-CoA
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pH 7.4, 37°C, recombinant enzyme
0.0139
palmitoyl-CoA
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ARAT activity of recombinant acyl coenzyme A:diacylglycerol acyltransferase isozyme 1, pH 7.4, 37°C
0.016
retinol
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0.0259
retinol
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pH 7.4, 37°C, recombinant enzyme
0.0259
retinol
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ARAT activity of recombinant acyl coenzyme A:diacylglycerol acyltransferase isozyme 1, pH 7.4, 37°C
additional information
additional information
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kinetics
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additional information
additional information
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kinetics
-
additional information
additional information
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kinetics, recombinant enzyme
-
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additional information
additional information
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inhibition kinetics depend highly on retinol concentration, overview, recombinant enzyme
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0.000045
XP620
-
pH 7.4, 37°C, recombinant enzyme
0.00045
XP620
-
ARAT activity of acyl coenzyme A:diacylglycerol acyltransferase isozyme 1, pH 7.4, 37°C
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0.0000887 - 0.00011
XP620
0.0000887
XP620
Homo sapiens
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selective isozyme DGAT1 inhibitor, inhibits the diacylglycerol acyltransferase and the retinol acyltransferase activities at the retinol recognition site, inhibition of 85% of retinyl ester production in intact differentiated Caco-2 cells, IC50: 88.7 nM
0.00011
XP620
Homo sapiens
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inhibits the ARAT activity of acyl coenzyme A:diacylglycerol acyltransferase isozyme 1 dependent on the retinol concentration in vivo and in vitro, IC50: 110 nM, no inhibition of isozyme 2 and acyl coenzyme A:monoacylglycerol acyltransferase isozyme 3, ov
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0.000023
-
11-cis-retinyl ester synthesis in absence of cellular retinol-binding protein
0.00045
-
ARAT activity of recombinant acyl coenzyme A:diacylglycerol acyltransferase isozyme 2 in SF9 cell membrane preparation
0.00084
-
ARAT activity of recombinant acyl coenzyme A:monoacylglycerol acyltransferase isozyme 3 in SF9 cell membrane preparation
additional information
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activity determined from microsomes
additional information
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activity determined from microsomes
additional information
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-
additional information
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activity determined from microsomes
additional information
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measurements of retinol and retinyl esters in liver
additional information
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activity determined from microsomes
additional information
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activity determined from microsomes
additional information
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activity determined from microsomes
additional information
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activity determined from microsomes
additional information
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activity determined from microsomes
additional information
-
activity determined from microsomes
additional information
-
activity determined from microsomes
additional information
-
description of assay method
additional information
-
activity determined from microsomes
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7 - 8
-
maximum esterification
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3 - 11
-
decreasing activity below pH 5
6 - 10
-
maximum esterification between pH 7-8
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22
-
asay at room temperature
37
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assay at
37
-
in vivo and in vitro assay at
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cat
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brenda
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brenda
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brenda
Sprague-Dawley
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brenda
fish, brook trout
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brenda
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brenda
bovine calf or adult
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brenda
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brenda
cell cultures
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brenda
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brenda
Sprague-Dawley
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brenda
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brenda
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squamous SCC12b and SCC13b lines are common type of skin cancer that has reduced capacity to esterify retinol relative to normal keratinocytes
brenda
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brenda
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D033 line
brenda
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brenda
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primary cell culture
brenda
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brenda
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very low expression level
brenda
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brenda
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brenda
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brenda
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colon cancer cell line
brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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very low expression level
brenda
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brenda
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brenda
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brenda
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brenda
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highly expressed in
brenda
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high expression level
brenda
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neutral lipid synthesis enzyme acyl-CoA:diacylglycerol acyltransferase 1 functions as the major acyl-CoA:retinol acyltransferase
brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
additional information
-
cells and tissues from DGAT1-deficient mice exhibit reduced ARAT activity
brenda
additional information
-
DGAT1 exhibits ARAT activity in in vitro assays and accounts for a large portion of ARAT activity in the liver, testis, and kidney of mice
brenda
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brenda
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brenda
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brenda
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the enzyme is is very hydrophobic and has multiple predicted membrane-spanning domains
brenda
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brenda
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membrane fraction
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brenda
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membrane fraction
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brenda
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brenda
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membrane fraction
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brenda
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membrane fraction
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brenda
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membrane fraction
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-
brenda
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membrane fraction
-
brenda
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physiological function
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neutral lipid synthesis enzyme acyl-CoA:diacylglycerol acyltransferase DGAT1 functions as the major acyl-CoA:retinol acyltransferase. When dietary retinol is abundant, DGAT1 deficiency results in elevated levels of retinoic acid in skin and cyclical hair loss, both are prevented by dietary retinol deprivation. DGAT1-deficient skin exhibits enhanced sensitivity to topically administered retinol. Deletion of the enzyme specifically in the epidermis causes alopecia
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additional information
-
cells and tissues from DGAT1-deficient mice exhibit reduced ARAT activity, and the mice have increased levels of unesterified retinol in their livers on a high-retinol diet
additional information
-
DGAT1 deficiency also perturbs retinol metabolism in the livers of Dgat-/- mice, hepatic levels of unesterified retinol are increased in Dgat-/- mice challenged with high-retinol diets
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6 - 11
-
activity is decreased below
487497
7.2
-
phosphate buffer
487494
7.8
-
Tris-HCl buffer
487497
7.4
-
phosphate buffer
487488
7.4
-
phosphate buffer
487488, 487489, 487490, 487492, 487495
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70
-
activity abolished in 20 min
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-70ºC, phosphate buffer, pH 7.2, DTT, 12 months
-
-70ºC, phosphate buffer, pH 7.4, DTT, 2 months
-
-80ºC, Tris-acetate, pH 7, DTT, 6 months
-
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native enzyme partially by membrane preparation
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partial purification by differential centrifugation
partial purification by differential centrifugation
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partial purification by differential centrifugation
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partial purification by differential centrifugation
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partial purification by differential centrifugation
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partial purification by differential centrifugation
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chromosomal location, expression of the FLAG-tagged enzyme in Spodoptera frugiperda Sf9 cells and in COS-7 cells
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expression in HEK-293T cells
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expression in insect cells or in COS-7 cells
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expression in Spodoptera frugiperda Sf9 cell membranes using the baculovrisu transfection system
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expression in Spodoptera frugiperda Sf9 cells
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FLAG-tagged enzyme expression in COS-7 cells, the cells expressing DGAT1 show ARAT and WAX synthase, EC 2.3.1.75, activities
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medicine
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retinyl esterification: storage of vitamin A
medicine
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retinyl esterification: storage of vitamin A
medicine
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retinyl esterification: storage of vitamin A
medicine
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keratinocyte growth and differentiation
medicine
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neutral lipid synthesis enzyme acyl-CoA:diacylglycerol acyltransferase DGAT1 functions as the major acyl-CoA:retinol acyltransferase. When dietary retinol is abundant, DGAT1 deficiency results in elevated levels of retinoic acid in skin and cyclical hair loss, both are prevented by dietary retinol deprivation. DGAT1-deficient skin exhibits enhanced sensitivity to topically administered retinol. Deletion of the enzyme specifically in the epidermis causes alopecia
medicine
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retinyl esterification: storage of vitamin A
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Ross, A.C.
Retinol esterification by rat liver microsomes. Evidence for a fatty acyl coenzyme A: retinol acyltransferase
J. Biol. Chem.
257
2453-2459
1982
Felis silvestris, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
Ball, M.D.
Acyl coenzyme A-dependent retinol esterification
Methods Enzymol.
189
446-449
1990
Rattus norvegicus
brenda
Ross, A.C.
Measurement of acyl coenzyme A-dependent esterification of retinol
Methods Enzymol.
189
442-445
1990
Rattus norvegicus
brenda
Saari, J.C.; Bredberg, D.L.
Acyl-CoA:retinol acyltransferase and lecithin:retinol acyltransferase activities of bovine retinal pigment epithelial microsomes
Methods Enzymol.
190
156-163
1990
Bos taurus
brenda
Chaudhary, L.R.; Nelson, E.C.
Some properties and subcellular distribution of acyl-coenzyme A: retinol acyltransferase activity in rat testes
Biochim. Biophys. Acta
917
24-32
1987
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
MacDonald, P.N.; Ong, D.E.
Assay of lecithin-retinol acyltransferase
Methods Enzymol.
189
450-459
1990
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
Nilsson, C.B.; Hanber, A.; Trossvik, C.; Haekansson, H.
2,3,7,8-Tetrachlorodibenzo-p-dioxin affects retinol esterification in rat hepatic stellate cells and kidney
Environ. Toxicol. Pharmacol.
2
17-23
1996
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
Ross, A.C.; Kempner, E.S.
Radiation inactivation analysis of acyl-CoA:retinol acyltransferase and lecithin:retinol acyltransferase in rat liver
J. Lipid Res.
34
1201-1207
1993
Rattus norvegicus
brenda
Jurukovski, V.; Simon, M.
Reduced lecithin:retinol acyl transferase activity in cultured squamous cell carcinoma lines results in increased substrate-driven retinoic acid synthesis
Biochim. Biophys. Acta
1436
479-490
1999
Homo sapiens
brenda
Ndayibagira, A.; Spear, P.A.
Esterification and hydrolysis of vitamin A in the liver of brook trout (Salvelinus fontinalis) and the influence of a coplanar polychlorinated biphenyl
Comp. Biochem. Physiol. C
122C
317-325
1999
Salvelinus fontinalis
-
brenda
Kaschula, C.H.; Jin, M.H.; Desmond-Smith, N.S.; Travis, G.H.
Acyl CoA:retinol acyltransferase (ARAT) activity is present in bovine retinal pigment epithelium
Exp. Eye Res.
82
111-121
2005
Bos taurus, Homo sapiens
brenda
Yen, C.L.; Brown Iv, C.H.; Monetti, M.; Farese, R.V., Jr.
A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters
J. Lipid Res.
46
2388-2397
2005
Homo sapiens
brenda
Muniz, A.; Villazana-Espinoza, E.T.; Thackeray, B.; Tsin, A.T.
11-cis-Acyl-CoA:retinol O-acyltransferase activity in the primary culture of chicken Muller cells
Biochemistry
45
12265-12273
2006
Gallus gallus
brenda
Orland, M.D.; Anwar, K.; Cromley, D.; Chu, C.; Chen, L.; Billheimer, J.T.; Hussain, M.M.; Cheng, D.
Acyl coenzyme A dependent retinol esterification by acyl coenzyme A:diacylglycerol acyltransferase 1
Biochim. Biophys. Acta
1737
76-82
2005
Homo sapiens
brenda
Yen, C.L.; Monetti, M.; Burri, B.J.; Farese, R.V.
The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters
J. Lipid Res.
46
1502-1511
2005
Mus musculus
brenda
Shih, M.Y.; Kane, M.A.; Zhou, P.; Yen, C.L.; Streeper, R.S.; Napoli, J.L.; Farese, R.V.
Retinol esterification by DGAT1 is essential for retinoid homeostasis in murine skin
J. Biol. Chem.
284
4292-4299
2009
Mus musculus
brenda
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Transporter Classification Database (TCDB):
2.A.50.4.1
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