Reference on EC 2.3.1.75 - long-chain-alcohol O-fatty-acyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wu, X.Y.; Moreau, R.A.; Stumpf, P.K.
Studies of biosynthesis of waxes by developing jojoba seed: III. Biosynthesis of wax esters from acetyl-CoA and long-chain alcohols
Lipids
16
897-902
1981
Simmondsia chinensis
-
Garver, W.S.; Kemp, J.D.; Kuehn, G.D.
A high-performance liquid chromatography-based radiometric assay for acyl-CoA:alcohol transacylase from jojoba
Anal. Biochem.
207
335-340
1992
Simmondsia chinensis
Lardizabal, K.D.; Metz, J.G.; Sakamoto, T.; Hutton, W.C.; Pollard, M.R.; Lassner, M.W.
Purification of a jojoba embryo wax synthase, cloning of its cDNA, and production of high levels of wax in seeds of transgenic Arabidopsis
Plant Physiol.
122
645-655
2000
Simmondsia chinensis (Q9XGY6), Simmondsia chinensis
Kalscheuer, R.; Luftmann, H.; Steinbuchel, A.
Synthesis of novel lipids in Saccharomyces cerevisiae by heterologous expression of an unspecific bacterial acyltransferase
Appl. Environ. Microbiol.
70
7119-7125
2004
Acinetobacter baylyi ADP1 (Q8GGG1), Acinetobacter baylyi ADP1
Uthoff, S.; Stoveken, T.; Weber, N.; Vosmann, K.; Klein, E.; Kalscheuer, R.; Steinbuchel, A.
Thio wax ester biosynthesis utilizing the unspecific bifunctional wax ester synthase/acyl coenzyme A:diacylglycerol acyltransferase of Acinetobacter sp. strain ADP1
Appl. Environ. Microbiol.
71
790-796
2005
Acinetobacter baylyi ADP1 (Q8GGG1), Acinetobacter sp., Acinetobacter sp. ADP1
Stoveken, T.; Kalscheuer, R.; Malkus, U.; Reichelt, R.; Steinbuchel, A.
The wax ester synthase/acyl coenzyme A:diacylglycerol acyltransferase from Acinetobacter sp. strain ADP1: characterization of a novel type of acyltransferase
J. Bacteriol.
187
1369-1376
2005
Acinetobacter baylyi ADP1 (Q8GGG1)
Kalscheuer, R.; Steinbuchel, A.
A novel bifunctional wax ester synthase/acyl-CoA:diacylglycerol acyltransferase mediates wax ester and triacylglycerol biosynthesis in Acinetobacter calcoaceticus ADP1
J. Biol. Chem.
278
8075-8082
2003
Acinetobacter baylyi ADP1 (Q8GGG1)
Cheng, J.B.; Russell, D.W.
Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family
J. Biol. Chem.
279
37798-37807
2004
Homo sapiens (Q6E213), Mus musculus (Q6E1M8), Mus musculus
Yen, C.L.; Brown Iv, C.H.; Monetti, M.; Farese, R.V., Jr.
A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters
J. Lipid Res.
46
2388-2397
2005
Homo sapiens, Homo sapiens (Q6E213)
Kalscheuer, R.; Stoeveken, T.; Luftmann, H.; Malkus, U.; Reichelt, R.; Steinbuechel, A.
Neutral lipid biosynthesis in engineered Escherichia coli: jojoba oil-like wax esters and fatty acid butyl esters
Appl. Environ. Microbiol.
72
1373-1379
2006
Acinetobacter baylyi
Waeltermann, M.; Stoeveken, T.; Steinbuechel, A.
Key enzymes for biosynthesis of neutral lipid storage compounds in prokaryotes: Properties, function and occurrence of wax ester synthases/acyl-CoA:diacylglycerol acyltransferases
Biochimie
89
230-242
2007
Acinetobacter baylyi, Acinetobacter baylyi ADP1 (Q8GGG1)
Holtzapple, E.; Schmidt-Dannert, C.
Biosynthesis of isoprenoid wax ester in Marinobacter hydrocarbonoclasticus DSM 8798: identification and characterization of isoprenoid coenzyme A synthetase and wax ester synthases
J. Bacteriol.
189
3804-3812
2007
Marinobacter nauticus
Kalscheuer, R.; Stoeveken, T.; Malkus, U.; Reichelt, R.; Golyshin, P.N.; Sabirova, J.S.; Ferrer, M.; Timmis, K.N.; Steinbuechel, A.
Analysis of storage lipid accumulation in Alcanivorax borkumensis: evidence for alternative triacylglycerol biosynthesis routes in bacteria
J. Bacteriol.
189
918-928
2007
Alcanivorax borkumensis
Turkish, A.R.; Henneberry, A.L.; Cromley, D.; Padamsee, M.; Oelkers, P.; Bazzi, H.; Christiano, A.M.; Billheimer, J.T.; Sturley, S.L.
Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily
J. Biol. Chem.
280
14755-14764
2005
Homo sapiens (Q6E213), Homo sapiens (Q6ZPD8), Homo sapiens (Q58HT5), Homo sapiens
Yen, C.L.; Monetti, M.; Burri, B.J.; Farese, R.V.
The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters
J. Lipid Res.
46
1502-1511
2005
Mus musculus
Li, F.; Wu, X.; Lam, P.; Bird, D.; Zheng, H.; Samuels, L.; Jetter, R.; Kunst, L.
Identification of the wax ester synthase/acyl-coenzyme A: diacylglycerol acyltransferase WSD1 required for stem wax ester biosynthesis in Arabidopsis
Plant Physiol.
148
97-107
2008
Arabidopsis thaliana
Holmes, R.
Comparative genomics and proteomics of vertebrate diacylglycerol acyltransferase (DGAT), acyl CoA wax alcohol acyltransferase (AWAT) and monoacylglycerol acyltransferase (MGAT)
Comp. Biochem. Physiol. D
5
45-54
2010
Homo sapiens (Q6E213), Homo sapiens (Q58HT5), Homo sapiens, Monodelphis domestica, Mus musculus (Q6E1M8), Mus musculus (A2ADU9), Mus musculus
Stveken, T.; Kalscheuer, R.; Steinbchel, A.
Both histidine residues of the conserved HHXXXDG motif are essential for wax ester synthase/acyl-CoA:diacylglycerol acyltransferase catalysis
Eur. J. Lipid Sci. Technol.
111
112-119
2009
Acinetobacter baylyi
-
Klypina, N.; Hanson, S.
Arabidopsis thaliana wax synthase gene homologues show diverse expression patterns that suggest a specialized role for these genes in reproductive organs
Plant Sci.
175
312-320
2008
Arabidopsis thaliana (Q9FJ74), Arabidopsis thaliana (Q9FJ73), Arabidopsis thaliana (Q9FJ72), Arabidopsis thaliana (Q9FGN1), Arabidopsis thaliana (Q3ED15), Arabidopsis thaliana (Q4PT07), Arabidopsis thaliana (Q9LNL1), Arabidopsis thaliana (Q9FJ78), Arabidopsis thaliana (Q9FJ77), Arabidopsis thaliana (Q9FJ76), Arabidopsis thaliana (Q9FJ75)
-
Barney, B.M.; Wahlen, B.D.; Garner, E.; Wei, J.; Seefeldt, L.C.
Differences in substrate specificities of five bacterial wax ester synthases
Appl. Environ. Microbiol.
78
5734-5745
2012
Acinetobacter baylyi, Marinobacter nauticus, Psychrobacter cryohalolentis, Psychrobacter cryohalolentis K5, Rhodococcus jostii
Teerawanichpan, P.; Qiu, X.
Fatty acyl-CoA reductase and wax synthase from Euglena gracilis in the biosynthesis of medium-chain wax esters
Lipids
45
263-273
2010
Euglena gracilis (D7PN09), Euglena gracilis
Miklaszewska, M.; Kawinski, A.; Banas, A.
Detailed characterization of the substrate specificity of mouse wax synthase
Acta Biochim. Pol.
60
209-215
2013
Mus musculus (Q6E1M8), Mus musculus
Barney, B.; Mann, R.; Ohlert, J.
Identification of a residue affecting fatty alcohol selectivity in wax ester synthase
Appl. Environ. Microbiol.
79
396-399
2013
Acinetobacter baylyi (Q8GGG1), Acinetobacter baylyi, Marinobacter nauticus (A1TX06), Marinobacter nauticus DSM 11845 (A1TX06)
Barney, B.M.; Ohlert, J.M.; Timler, J.G.; Lijewski, A.M.
Altering small and medium alcohol selectivity in the wax ester synthase
Appl. Microbiol. Biotechnol.
99
9675-9684
2015
Marinobacter nauticus (A1TX06), Marinobacter nauticus DSM 11845 (A1TX06)
Shi, S.; Valle-Rodriguez, J.O.; Siewers, V.; Nielsen, J.
Engineering of chromosomal wax ester synthase integrated Saccharomyces cerevisiae mutants for improved biosynthesis of fatty acid ethyl esters
Biotechnol. Bioeng.
111
1740-1747
2014
Marinobacter nauticus (A3RE51)
Kawelke, S.; Feussner, I.
Two predicted transmembrane domains exclude very long chain fatty acyl-CoAs from the active site of mouse wax synthase
PLoS ONE
10
e0145797
2015
Mus musculus (Q6E1M8), Mus musculus
Aslan, S.; Hofvander, P.; Dutta, P.; Sun, C.; Sitbon, F.
Increased production of wax esters in transgenic tobacco plants by expression of a fatty acid reductase:wax synthase gene fusion
Transgenic Res.
24
945-953
2015
Marinobacter nauticus
Miklaszewska, M.; Banas, A.
Biochemical characterization and substrate specificity of jojoba fatty acyl-CoA reductase and jojoba wax synthase
Plant Sci.
249
84-92
2016
Simmondsia chinensis
Roettig, A.; Strittmatter, C.S.; Schauer, J.; Hiessl, S.; Poehlein, A.; Daniel, R.; Steinbuechel, A.
Role of wax ester synthase/acyl coenzyme A diacylglycerol acyltransferase in oleaginous Streptomyces sp. strain G25
Appl. Environ. Microbiol.
82
5969-5981
2016
Streptomyces sp. G25
Miklaszewska, M.; Dittrich-Domergue, F.; Banas, A.; Domergue, F.
Wax synthase MhWS2 from Marinobacter hydrocarbonoclasticus substrate specificity and biotechnological potential for wax ester production
Appl. Microbiol. Biotechnol.
102
4063-4074
2018
Marinobacter nauticus (A3RE51)
Zhang, N.; Mao, Z.; Luo, L.; Wan, X.; Huang, F.; Gong, Y.
Two bifunctional enzymes from the marine protist Thraustochytrium roseum biochemical characterization of wax ester synthase/acyl-CoA diacylglycerol acyltransferase activity catalyzing wax ester and triacylglycerol synthesis
Biotechnol. Biofuels
10
185
2017
Thraustochytrium roseum (A0A1Z2RWY4), Thraustochytrium roseum (A0A3G1ICG7), Thraustochytrium roseum, Thraustochytrium roseum ATCC28210 (A0A3G1ICG7), Thraustochytrium roseum ATCC28210 (A0A1Z2RWY4)
Yu, D.; Hornung, E.; Iven, T.; Feussner, I.
High-level accumulation of oleyl oleate in plant seed oil by abundant supply of oleic acid substrates to efficient wax ester synthesis enzymes
Biotechnol. Biofuels
11
53
2018
Acinetobacter baylyi (Q8GGG1), Marinobacter nauticus, Acinetobacter baylyi ATCC 3305 (Q8GGG1)
Lanfranconi, M.; Alvarez, H.
Rewiring neutral lipids production for the de novo synthesis of wax esters in Rhodococcus opacus PD630
J. Biotechnol.
260
67-73
2017
Rhodococcus opacus, Rhodococcus opacus PD630
Blaner, W.
Acyl-CoA wax alcohol acyltransferase 2 Its regulation and actions in support of color vision
J. Lipid Res.
58
633-635
2017
Homo sapiens
Arne, J.M.; Widjaja-Adhi, M.A.; Hughes, T.; Huynh, K.W.; Silvaroli, J.A.; Chelstowska, S.; Moiseenkova-Bell, V.Y.; Golczak, M.
Allosteric modulation of the substrate specificity of acyl-CoA wax alcohol acyltransferase 2
J. Lipid Res.
58
719-730
2017
Mus musculus (Q6E1M8)
Iven, T.; Hornung, E.; Heilmann, M.; Feussner, I.
Synthesis of oleyl oleate wax esters in Arabidopsis thaliana and Camelina sativa seed oil
Plant Biotechnol. J.
14
252-259
2016
Simmondsia chinensis
Tomiyama, T.; Kurihara, K.; Ogawa, T.; Maruta, T.; Ogawa, T.; Ohta, D.; Sawa, Y.; Ishikawa, T.
Wax ester synthase/diacylglycerol acyltransferase isoenzymes play a pivotal role in wax ester biosynthesis in Euglena gracilis
Sci. Rep.
7
13504
2017
Euglena gracilis (A0A1E1GJC5), Euglena gracilis (A0A1E1GJD2), Euglena gracilis
Mancipe, N.C.; Mulliner, K.M.; Plunkett, M.H.; Barney, B.M.
Canvasing the substrate-binding pockets of the wax ester synthase
Biochemistry
61
922-932
2022
Marinobacter nauticus (A1TX06)
Widjaja-Adhi, M.A.K.; Kolesnikov, A.V.; Vasudevan, S.; Park, P.S.; Kefalov, V.J.; Golczak, M.
Acyl-CoA wax alcohol acyltransferase 2 modulates the cone visual cycle in mouse retina
FASEB J.
36
e22390
2022
Mus musculus (Q6E1M8)
Ma, H.; Zheng, J.; Li, Y.; Zhao, L.; Zou, S.; Hu, Q.; Han, D.
A novel bifunctional wax ester synthase involved in early triacylglycerol accumulation in unicellular green microalga Haematococcus pluvialis under high light stress
Front. Bioeng. Biotechnol.
9
794714
2022
Haematococcus lacustris, Haematococcus lacustris NIES144
Yang, S.; Tang, H.; Wei, X.; Zhao, Y.; Wang, Z.; Su, H.; Niu, L.; Yuan, Y.; Zhang, X.
BrWAX3, encoding a beta-ketoacyl-CoA synthase, plays an essential role in cuticular wax biosynthesis in Chinese cabbage
Int. J. Mol. Sci.
23
10938
2022
Brassica rapa
Yang, Y.; Zhou, Z.; Li, Y.; Lv, Y.; Yang, D.; Yang, S.; Wu, J.; Li, X.; Gu, Z.; Sun, X.; Yang, Y.
Uncovering the role of a positive selection site of wax ester synthase/diacylglycerol acyltransferase in two closely related Stipa species in wax ester synthesis under drought stress
J. Exp. Bot.
71
4159-4170
2020
Stipa purpurea (A0A6B9MQP2), Stipa capillacea (A0A6B9MRS2)
Xu, Y.; Pan, X.; Lu, J.; Wang, J.; Shan, Q.; Stout, J.; Chen, G.
Evolutionary and biochemical characterization of a Chromochloris zofingiensis MBOAT with wax synthase and diacylglycerol acyltransferase activity
J. Exp. Bot.
72
5584-5598
2021
Chromochloris zofingiensis
Shalini, T.; Martin, A.
Identification, isolation, and heterologous expression of sunflower wax synthase for the synthesis of tailored wax esters
J. Food Biochem.
44
e13433
2020
Helianthus annuus (A0A8E3SFF7)
Cheng, D.; Li, L.; Rizhsky, L.; Bhandary, P.; Nikolau, B.J.
Heterologous expression and characterization of plant wax ester producing enzymes
Metabolites
12
577
2022
Arabidopsis thaliana (Q9FJ72), Arabidopsis thaliana (Q9FJ76)
Yang, T.; Li, Y.; Liu, Y.; He, L.; Liu, A.; Wen, J.; Mysore, K.S.; Tadege, M.; Chen, J.
The 3-ketoacyl-CoA synthase WFL is involved in lateral organ development and cuticular wax synthesis in Medicago truncatula
Plant Mol. Biol.
105
193-204
2021
Medicago truncatula
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