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Information on EC 2.3.1.41 - beta-ketoacyl-[acyl-carrier-protein] synthase I

for references in articles please use BRENDA:EC2.3.1.41

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IUBMB Comments

This enzyme is responsible for the chain-elongation step of dissociated (type II) fatty-acid biosynthesis, i.e. the addition of two C atoms to the fatty-acid chain. Escherichia coli mutants that lack this enzyme are deficient in unsaturated fatty acids. The enzyme can use fatty acyl thioesters of ACP (C2 to C16) as substrates, as well as fatty acyl thioesters of Co-A (C4 to C16) . The substrate specificity is very similar to that of EC 2.3.1.179, β-ketoacyl-ACP synthase II, with the exception that the latter enzyme is far more active with palmitoleoyl-ACP (C16Δ9) as substrate, allowing the organism to regulate its fatty-acid composition with changes in temperature [4,5].

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

Synonyms
condensing enzyme, beta-ketoacyl synthase, kas i, beta-ketoacyl-acp synthase, beta-ketoacyl synthetase, 3-ketoacyl-acyl carrier protein synthase, 3-ketoacyl-acp synthase, beta-ketoacyl-acp synthase i, beta-ketoacyl-acyl carrier protein synthase i, fatty acid condensing enzyme, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
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PATHWAY SOURCE
PATHWAYS
MetaCyc
(5Z)-dodecenoate biosynthesis I, (5Z)-dodecenoate biosynthesis II, 8-amino-7-oxononanoate biosynthesis I, fatty acid biosynthesis initiation (mitochondria), fatty acid elongation -- saturated, gondoate biosynthesis (anaerobic), mycolate biosynthesis, octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast), oleate biosynthesis IV (anaerobic), palmitate biosynthesis II (type II fatty acid synthase), palmitate biosynthesis III, palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate), stearate biosynthesis II (bacteria and plants), stearate biosynthesis IV, streptorubin B biosynthesis, superpathway of fatty acid biosynthesis initiation, tetradecanoate biosynthesis (mitochondria)
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