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Information on EC 2.3.1.277 - phosphorylated butenolide synthase

for references in articles please use BRENDA:EC2.3.1.277

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IUBMB Comments

The enzyme catalyses the first committed step in the biosynthesis of γ-butyrolactone, as well as 2-alkyl-4-hydroxymethylfuran-3-carboxylate (methylenomycin furan) autoregulators that control secondary metabolism and morphological development in Streptomyces bacteria.

The expected taxonomic range for this enzyme is: Streptomyces
Reaction Schemes
hide(Overall reactions are displayed. Show all >>)
a 3-oxoacyl-[acyl-carrier protein]
+
glycerone phosphate
=
a (4-alkanoyl-5-oxo-2H-furan-3-yl)methyl phosphate
+
H2O
+
a holo-[acyl-carrier protein]
+
=
a (4-alkanoyl-5-oxo-2H-furan-3-yl)methyl phosphate
+
+

Synonyms
2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate synthase, afsA, barX, mmfL, scbA, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a 2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate = a (4-alkanoyl-5-oxo-2H-furan-3-yl)methyl phosphate + H2O
show the reaction diagram
(1b), spontaneous
-
-
-
a 3-oxoacyl-[acyl-carrier protein] + glycerone phosphate = a (4-alkanoyl-5-oxo-2H-furan-3-yl)methyl phosphate + H2O + a holo-[acyl-carrier protein]
show the reaction diagram
overall reaction
-
-
-
a 3-oxoacyl-[acyl-carrier protein] + glycerone phosphate = a 2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate + a holo-[acyl-carrier protein]
show the reaction diagram
(1a)
-
-
-
PATHWAY SOURCE
PATHWAYS
MetaCyc
A-factor gamma-butyrolactone biosynthesis, IM-2 type gamma-butyrolactones biosynthesis, virginiae butanolide type gamma-butyrolactones biosynthesis
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