Reference on EC 2.3.1.255 - N-terminal amino-acid Nalpha-acetyltransferase NatA
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Polevoda, B.; Sherman, F.
Composition and function of the eukaryotic N-terminal acetyltransferase subunits
Biochem. Biophys. Res. Commun.
308
1-11
2003
Saccharomyces cerevisiae
Sugiura, N.; Adams, S.M.; Corriveau, R.A.
An evolutionarily conserved N-terminal acetyltransferase complex associated with neuronal development
J. Biol. Chem.
278
40113-40120
2003
Mus musculus
Gautschi, M.; Just, S.; Mun, A.; Ross, S.; Rcknagel, P.; Dubaquie, Y.; Ehrenhofer-Murray, A.; Rospert, S.
The yeast Nalpha-acetyltransferase NatA is quantitatively anchored to the ribosome and interacts with nascent polypeptides
Mol. Cell. Biol.
23
7403-7414
2003
Saccharomyces cerevisiae, Saccharomyces cerevisiae MH272-3f a/alpha
Geissenhoener, A.; Weise, C.; Ehrenhofer-Murray, A.E.
Dependence of ORC silencing function on NatA-mediated Na acetylation in Saccharomyces cerevisiae
Mol. Cell. Biol.
24
10300-10312
2004
Saccharomyces cerevisiae
Arnesen, T.; Gromyko, D.; Kagabo, D.; Betts, M.; Starheim, K.; Varhaug, J.; Anderson, D.; Lillehaug, J.
A novel human NatA N-terminal acetyltransferase complex: HNaa16p-hNaa10p (hNat2-hArd1)
BMC Biochem.
10
15
2009
Homo sapiens
Ohkawa, N.; Sugisaki, S.; Tokunaga, E.; Fujitani, K.; Hayasaka, T.; Setou, M.; Inokuchi, K.
N-acetyltransferase ARD1-NAT1 regulates neuronal dendritic development
Genes Cells
13
1171-1183
2008
Mus musculus (Q9QY36)
Pezza, J.A.; Langseth, S.X.; Raupp Yamamoto, R.; Doris, S.M.; Ulin, S.P.; Salomon, A.R.; Serio, T.R.
The NatA acetyltransferase couples Sup35 prion complexes to the [PSI+] phenotype
Mol. Biol. Cell
20
1068-1080
2009
Saccharomyces cerevisiae
Perrot, M.; Massoni, A.; Boucherie, H.
Sequence requirements for Nalpha-terminal acetylation of yeast proteins by NatA
Yeast
25
513-527
2008
Saccharomyces cerevisiae
Wang, Y.; Mijares, M.; Gall, M.; Turan, T.; Javier, A.; Bornemann, D.; Manage, K.; Warrior, R.
Drosophila variable nurse cells encodes arrest defective 1 (ARD1), the catalytic subunit of the major N-terminal acetyltransferase complex
Dev. Dyn.
239
2813-2827
2010
Drosophila melanogaster (Q9VT75)
Arnesen, T.; Starheim, K.K.; Van Damme, P.; Evjenth, R.; Dinh, H.; Betts, M.J.; Ryningen, A.; Vandekerckhove, J.; Gevaert, K.; Anderson, D.
The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation
Mol. Cell. Biol.
30
1898-1909
2010
Homo sapiens
Chang, Y.Y.; Hsu, C.H.
Structural basis for substrate-specific acetylation of Nalpha-acetyltransferase Ard1 from Sulfolobus solfataricus
Sci. Rep.
5
8673
2015
Saccharolobus solfataricus (Q980R9)
Ree, R.; Myklebust, L.; Thiel, P.; Foyn, H.; Fladmark, K.; Arnesen, T.
The N-terminal acetyltransferase Naa10 is essential for zebrafish development
Biosci. Rep.
35
e00249
2015
Danio rerio (Q7T3B8), Danio rerio
Seo, J.H.; Park, J.H.; Lee, E.J.; Kim, K.W.
Different subcellular localizations and functions of human ARD1 variants
Int. J. Oncol.
46
701-707
2015
Homo sapiens (Q6P4J0)
Eiyama, A.; Okamoto, K.
Protein N-terminal acetylation by the NatA complex is critical for selective mitochondrial degradation
J. Biol. Chem.
290
25034-25044
2015
Saccharomyces cerevisiae
Magin, R.S.; March, Z.M.; Marmorstein, R.
The N-terminal acetyltransferase Naa10/ARD1 does not acetylate lysine residues
J. Biol. Chem.
291
5270-5277
2016
Homo sapiens
Liszczak, G.; Goldberg, J.M.; Foyn, H.; Petersson, E.J.; Arnesen, T.; Marmorstein, R.
Molecular basis for N-terminal acetylation by the heterodimeric NatA complex
Nat. Struct. Mol. Biol.
20
1098-1105
2013
Schizosaccharomyces pombe (O74985)
Han, S.H.; Ha, J.Y.; Kim, K.H.; Oh, S.J.; Kim, D.J.; Kang, J.Y.; Yoon, H.J.; Kim, S.H.; Seo, J.H.; Kim, K.W.; Suh, S.W.
Expression, crystallization and preliminary X-ray crystallographic analyses of two N-terminal acetyltransferase-related proteins from Thermoplasma acidophilum
Acta Crystallogr. Sect. F
62
1127-1130
2006
Thermoplasma acidophilum (Q9HJ33), Thermoplasma acidophilum (Q9HM13), Thermoplasma acidophilum
Kim, S.H.; Park, J.A.; Kim, J.H.; Lee, J.W.; Seo, J.H.; Jung, B.K.; Chun, K.H.; Jeong, J.W.; Bae, M.K.; Kim, K.W.
Characterization of ARD1 variants in mammalian cells
Biochem. Biophys. Res. Commun.
340
422-427
2006
Homo sapiens (P41227), Mus musculus (Q9QY36)
Wan, K.; Tsuchihashi, K.; Kanda, K.; Shimoji, K.; Mizuta, K.
Nalpha-acetyltransferase NatA is involved in ribosome synthesis in Saccharomyces cerevisiae
Biosci. Biotechnol. Biochem.
77
631-638
2013
Saccharomyces cerevisiae
Arnesen, T.; Thompson, P.R.; Varhaug, J.E.; Lillehaug, J.R.
The protein acetyltransferase ARD1: a novel cancer drug target?
Curr. Cancer Drug Targets
8
545-553
2008
Homo sapiens
Park, E.C.; Szostak, J.W.
ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity
EMBO J.
11
2087-2093
1992
Saccharomyces cerevisiae
Mullen, J.R.; Kayne, P.S.; Moerschell, R.P.; Tsunasawa, S.; Gribskov, M.; Colavito-Shepanski, M.; Grunstein, M.; Sherman, F.; Sternglanz, R.
Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast
EMBO J.
8
2067-2075
1989
Saccharomyces cerevisiae
Doerfel, M.J.; Lyon, G.J.
The biological functions of Naa10 - From amino-terminal acetylation to human disease
Gene
567
103-131
2015
Homo sapiens (P41227)
Ingram, A.K.; Cross, G.A.; Horn, D.
Genetic manipulation indicates that ARD1 is an essential Nalpha-acetyltransferase in Trypanosoma brucei
Mol. Biochem. Parasitol.
111
309-317
2000
Trypanosoma brucei (Q9NFL8), Trypanosoma brucei MiTat 427 (Q9NFL8)
Yoon, H.; Kim, H.L.; Chun, Y.S.; Shin, D.H.; Lee, K.H.; Shin, C.S.; Lee, D.Y.; Kim, H.H.; Lee, Z.H.; Ryoo, H.M.; Lee, M.N.; Oh, G.T.; Park, J.W.
NAA10 controls osteoblast differentiation and bone formation as a feedback regulator of Runx2
Nat. Commun.
5
5176
2014
Mus musculus (Q9QY36)
Myklebust, L.; Stove, S.; Arnesen, T.
Naa10 in development and disease
Oncotarget
6
34041-34042
2015
Homo sapiens (P41227)
DePaolo, J.S.; Wang, Z.; Guo, J.; Zhang, G.; Qian, C.; Zhang, H.; Zabaleta, J.; Liu, W.
Acetylation of androgen receptor by ARD1 promotes dissociation from HSP90 complex and prostate tumorigenesis
Oncotarget
7
71417-71428
2016
Mus musculus
Xu, F.; Huang, Y.; Li, L.; Gannon, P.; Linster, E.; Huber, M.; Kapos, P.; Bienvenut, W.; Polevoda, B.; Meinnel, T.; Hell, R.; Giglione, C.; Zhang, Y.; Wirtz, M.; Chen, S.; Li, X.
Two N-terminal acetyltransferases antagonistically regulate the stability of a nod-like receptor in Arabidopsis
Plant Cell
27
1547-1562
2015
Arabidopsis thaliana
Hou, M.; Zhuang, J.; Fan, S.; Wang, H.; Guo, C.; Yao, H.; Lin, D.; Liao, X.
Biophysical and functional characterizations of recombinant RimI acetyltransferase from Mycobacterium tuberculosis
Acta Biochim. Biophys. Sin. (Shanghai)
51
960-968
2019
Mycobacterium tuberculosis (I6YG32), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (I6YG32), Mycobacterium tuberculosis ATCC 25618 (I6YG32)
McTiernan, N.; Stoeve, S.I.; Aukrust, I.; Marli, M.T.; Myklebust, L.M.; Houge, G.; Arnesen, T.
NAA10 dysfunction with normal NatA-complex activity in a girl with non-syndromic ID and a de novo NAA10 p.(V111G) variant - a case report
BMC Med. genet.
19
47
2018
Homo sapiens (P41227 AND Q9BXJ9), Homo sapiens
Ree, R.; Geithus, A.S.; Toerring, P.M.; Soerensen, K.P.; Damkjaer, M.; Damkjaer, M.; Lynch, S.A.; Arnesen, T.
A novel NAA10 p.(R83H) variant with impaired acetyltransferase activity identified in two boys with ID and microcephaly
BMC Med. Genet.
20
101
2019
Homo sapiens (P41227 AND Q9BXJ9), Homo sapiens
Chien, M.H.; Lee, W.J.; Yang, Y.C.; Tan, P.; Pan, K.F.; Liu, Y.C.; Tsai, H.C.; Hsu, C.H.; Wen, Y.C.; Hsiao, M.; Hua, K.T.
N-alpha-acetyltransferase 10 protein promotes metastasis by stabilizing matrix metalloproteinase-2 protein in human osteosarcomas
Cancer Lett.
433
86-98
2018
Homo sapiens (P41227)
Stoeve, S.I.; Blenski, M.; Stray-Pedersen, A.; Wierenga, K.J.; Jhangiani, S.N.; Akdemir, Z.C.; Crawford, D.; McTiernan, N.; Myklebust, L.M.; Purcarin, G.; McNall-Knapp, R.; Wadley, A.; Belmont, J.W.; Kim, J.J.; Lupski, J.R.; Arnesen, T.
A novel NAA10 variant with impaired acetyltransferase activity causes developmental delay, intellectual disability, and hypertrophic cardiomyopathy
Eur. J. Hum. Genet.
26
1294-1305
2018
Homo sapiens (P41227), Homo sapiens
Lee, M.N.; Kweon, H.Y.; Oh, G.T.
N-alpha-acetyltransferase 10 (NAA10) in development the role of NAA10
Exp. Mol. Med.
50
1-11
2018
Caenorhabditis elegans (O61219), Saccharomyces cerevisiae (P07347 AND P12945), Homo sapiens (P41227), Mus musculus (Q3UX61), Mus musculus (Q9QY36), Danio rerio (Q7T3B8), Arabidopsis thaliana (Q9FKI4), Trypanosoma brucei (Q9NFL8), Drosophila melanogaster (Q9VT75), Mus musculus C57Bl6/J (Q3UX61), Mus musculus C57Bl6/J (Q9QY36), Saccharomyces cerevisiae ATCC 204508 (P07347 AND P12945), Caenorhabditis elegans DAF-31 (O61219)
Ochaya, S.; Franzen, O.; Buhwa, D.A.; Foyn, H.; Butler, C.E.; Stove, S.I.; Tyler, K.M.; Arnesen, T.; Matovu, E.; Aslund, L.; Andersson, B.
Characterization of evolutionarily conserved Trypanosoma cruzi NatC and NatA-N-terminal acetyltransferase complexes
J. Parasitol. Res.
2019
6594212
2019
Trypanosoma cruzi (Q4DSU6 AND Q4D0P4), Trypanosoma cruzi CL Brener (Q4DSU6 AND Q4D0P4)
Vo, T.T.L.; Park, J.H.; Lee, E.J.; Nguyen, Y.T.K.; Han, B.W.; Nguyen, H.T.T.; Mun, K.C.; Ha, E.; Kwon, T.K.; Kim, K.W.; Jeong, C.H.; Seo, J.H.
Characterization of lysine acetyltransferase activity of recombinant human ARD1/NAA10
Molecules
25
588
2020
Homo sapiens (P41227)
Deng, S.; McTiernan, N.; Wei, X.; Arnesen, T.; Marmorstein, R.
Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK
Nat. Commun.
11
818
2020
Homo sapiens (P41227 AND Q9BXJ9), Homo sapiens
Pathak, D.; Bhat, A.; Sapehia, V.; Rai, J.; Rao, A.
Biochemical evidence for relaxed substrate specificity of Nalpha-acetyltransferase (Rv3420c/rimI) of Mycobacterium tuberculosis
Sci. Rep.
6
28892
2016
Mycobacterium tuberculosis (I6YG32), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 (I6YG32), Mycobacterium tuberculosis H37Rv (I6YG32)
Xu, H.; Han, Y.; Liu, B.; Li, R.
Unc-5 homolog B (UNC5B) is one of the key downstream targets of N-alpha-acetyltransferase 10 (Naa10)
Sci. Rep.
6
38508
2016
Homo sapiens (P41227), Mus musculus (Q9QY36), Mus musculus C57 (Q9QY36)
Lyon, G.
From molecular understanding to organismal biology of N-terminal acetyltransferases
Structure
27
1053-1055
2019
Saccharomyces cerevisiae (P07347 AND P12945), Saccharomyces cerevisiae, Homo sapiens (P41227 AND Q9BXJ9), Schizosaccharomyces pombe (Q9UTI3 AND O74985), Schizosaccharomyces pombe ATCC 24843 (Q9UTI3 AND O74985), Schizosaccharomyces pombe 972 (Q9UTI3 AND O74985), Saccharomyces cerevisiae ATCC 204508 (P07347 AND P12945)
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