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Information on EC 2.3.1.23 - 1-acylglycerophosphocholine O-acyltransferase
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EC Tree
2.3.1.23 1-acylglycerophosphocholine O-acyltransferaseIUBMB Comments
Acts preferentially with unsaturated acyl-CoA derivatives. 1-Acyl-sn-glycero-3-phosphoinositol can also act as acceptor.
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Word Map
- 2.3.1.23
- acyl-coas
- lysophospholipids
- phospholipase
-
arachidonic
-
polyunsaturated
-
lysophosphatidic
-
reacylation
- lncrnas
-
platelet-activating
- glycerophospholipids
- palmitoyl-coa
- oleoyl-coa
- arachidonoyl-coa
-
lysopcs
-
cholinephosphotransferase
-
kennedy
- lysophospholipase
-
deacylation-reacylation
- lysophosphatidylinositol
-
mboats
-
oleoyl
-
lecithin-cholesterol
-
transacylation
-
arachidonoyl
- linoleoyl-coa
-
acyl-coa-dependent
- lysophosphatidylserine
- thimerosal
-
disaturated
- glycerolphosphate
-
coa-independent
-
cholinephosphate
- lysophosphatidylglycerol
- pharmacology
- medicine
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
pcat1, lpcat3, lpcat, lysophosphatidylcholine acyltransferase, alcat1, lpcat2, lysolecithin acyltransferase, lycat, lysophospholipid acyltransferases, lyso-paf acetyltransferase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
1-acyl-sn-glycero-3-phosphocholine acyltransferase
-
-
-
-
1-acylglycerophosphocholine acyltransferase
acyl coenzyme A-monoacylphosphatidylcholine acyltransferase
-
-
-
-
acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase
-
-
-
-
acyl-CoA:lysophosphatidylcholine acyltransferase
acyltransferase, lysolecithin
-
-
-
-
AGPAT7
AYTL3
LPAT
LPC acyltransferase
LPCAT
LPCAT1
LPCAT2
LPCAT3
LPCAT4
LPEAT2
LPLAT
lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1
lyso-PAF acetyltransferase
lyso-PC acyltransferase 1
lysolecithin acyltransferase
-
-
-
-
lysoPC acyltransferase
lysophosphatide acyltransferase
-
-
-
-
lysophosphatidylcholine acyl transferase
lysophosphatidylcholine acyltransferase
lysophosphatidylcholine acyltransferase 1
lysophosphatidylcholine acyltransferase 3
lysophosphatidylcholine acyltransferase 4
lysophosphocholine acyltransferase 1
lysophosphocholine acyltransferase 2
lysophosphocholine acyltransferase 3
lysophosphocholine acyltransferase 4
lysophospholipid acyltransferase
lysophospholipid:acyl-CoA acyltransferase
mPrdx6
PGAT
YALI0E16797g
additional information
lysophosphatidylcholine acyltransferase
-
-
-
-
lysophosphatidylcholine acyltransferase 3
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
Oryctolagus cuniculus
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Acyl group transfer
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
MetaCyc
arachidonate biosynthesis I (6-desaturase, lower eukaryotes), dimorphecolate biosynthesis, docosahexaenoate biosynthesis I (lower eukaryotes), hydroxylated fatty acid biosynthesis (plants), icosapentaenoate biosynthesis I (lower eukaryotes), linoleate biosynthesis I (plants), phosphatidylcholine acyl editing, phosphatidylcholine biosynthesis VII, phospholipid remodeling (phosphatidylcholine, yeast), phospholipid remodeling (phosphatidylethanolamine, yeast), ricinoleate biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
Acts preferentially with unsaturated acyl-CoA derivatives. 1-Acyl-sn-glycero-3-phosphoinositol can also act as acceptor.
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CAS REGISTRY NUMBER
COMMENTARY
9027-64-9
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-acyl-2-lysophosphatidylethanolamine + oleoyl-CoA
1-acyl-2-oleoylphosphatidylethanolamine + CoA
-
-
-
?
1-lauroyl-2-lysophosphatidylcholine + oleoyl-CoA
CoA + 1-lauroyl-2-oleoylphosphatidylcholine
-
-
-
-
?
1-lauroyl-2-lysophosphatidylcholine + palmitoyl-CoA
CoA + 1-lauroyl-2-palmitoylphosphatidylcholine
-
-
-
-
?
1-lauroyl-2-lysophosphatidylcholine + stearoyl-CoA
CoA + 1-lauroyl-2-stearoylphosphatidylcholine
-
-
-
-
?
1-myristoyl-lysophosphatidylcholine + palmitoyl-CoA
CoA + 1-myristoyl-2-palmitoylphosphatidylcholine
-
-
-
-
?
1-oleoyl-2-lysophosphatidylcholine + oleoyl-CoA
CoA + 1,2-dioleoylphosphatidylcholine
-
-
-
-
?
1-oleoyl-2-lysophosphatidylcholine + palmitoyl-CoA
CoA + 1-oleoyl-2-palmitoylphosphatidylcholine
-
-
-
-
?
1-oleoyl-2-lysophosphatidylcholine + stearoyl-CoA
CoA + 1-oleoyl-2-stearoylphosphatidylcholine
-
-
-
-
?
1-oleoyl-lysophosphatidylcholine + palmitoyl-CoA
CoA + 1-oleoyl-2-palmitoylphosphatidylcholine
-
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + alpha-linolenoyl-CoA
1-palmitoyl-2-alpha-linolenoylphosphatidylcholine + CoA
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + arachidonoyl-CoA
1-palmitoyl-2-arachidonoylphosphatidylcholine + CoA
1-palmitoyl-2-lysophosphatidylcholine + linolenoyl-CoA
1-palmitoyl-2-alpha-linolenoylphosphatidylcholine + CoA
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + linoleoyl-CoA
1-palmitoyl-2-linoleoylphosphatidylcholine + CoA
1-palmitoyl-2-lysophosphatidylcholine + oleoyl-CoA
1-palmitoyl-2-oleoylphosphatidylcholine + CoA
1-palmitoyl-2-lysophosphatidylcholine + oleoyl-CoA
CoA + 2-oleoyl-1-palmitoylphosphatidylcholine
-
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + palmitoyl-CoA
1,2-dipalmitoylphosphatidylcholine + CoA
1-palmitoyl-2-lysophosphatidylcholine + palmitoyl-CoA
CoA + 1,2-dipalmitoylphosphatidylcholine
-
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + stearoyl-CoA
1-palmitoyl-2-stearoylphosphatidylcholine + CoA
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + stearoyl-CoA
CoA + 1-palmitoyl-2-stearoylphosphatidylcholine
-
-
-
-
?
1-palmitoyl-2-lysophosphatidylethanolamine + arachidonoyl-CoA
1-palmitoyl-2-arachidonoylphosphatidylethanolamine + CoA
-
-
-
?
1-palmitoyl-2-lysophosphatidylglycerol + palmitoyl-CoA
1,2-dipalmitoylphosphatidylglycerol + CoA
activity observed only in the presence of phosphatidylcholine (1 mg/ml)
-
-
?
1-palmitoyl-2-lysophosphatidylserine + arachidonoyl-CoA
1-palmitoyl-2-arachidonoylphosphatidylserine + CoA
1-palmitoyl-2-lysophosphatidylserine + linoleoyl-CoA
1-palmitoyl-2-linoleoylphosphatidylserine + CoA
-
-
-
?
1-palmitoyl-lysophosphatidylcholine + arachidonoyl-CoA
CoA + 1-palmitoyl-2-arachidonoylphosphatidylcholine
-
-
-
-
?
1-palmitoyl-lysophosphatidylcholine + lauroyl-CoA
CoA + 1-palmitoyl-2-lauroylphosphatidylcholine
-
-
-
-
?
1-palmitoyl-lysophosphatidylcholine + linoleoyl-CoA
CoA + 1-palmitoyl-2-linoleoylphosphatidylcholine
-
-
-
-
?
1-palmitoyl-lysophosphatidylcholine + n-octanoyl-CoA
CoA + 1-palmitoyl-2-octanoylphosphatidylcholine
-
-
-
-
?
1-palmitoyl-lysophosphatidylcholine + oleoyl-CoA
CoA + 2-oleoyl-1-palmitoylphosphatidylcholine
-
-
-
-
?
1-palmitoyl-lysophosphatidylcholine + palmitoyl-CoA
CoA + 1,2-dipalmitoylphosphatidylcholine
-
-
-
-
?
1-palmitoyl-lysophosphatidylcholine + stearoyl-CoA
CoA + 1-palmitoyl-2-stearoylphosphatidylcholine
-
-
-
-
?
1-stearoyl-2-lysophosphatidylcholine + oleoyl-CoA
CoA + 2-oleoyl-1-stearoylphosphatidylcholine
-
-
-
-
?
1-stearoyl-2-lysophosphatidylcholine + palmitoyl-CoA
CoA + 2-palmitoyl-1-stearoylphosphatidylcholine
-
-
-
-
?
1-stearoyl-2-lysophosphatidylcholine + stearoyl-CoA
CoA + 1,2-distearoylphosphatidylcholine
-
-
-
-
?
1-stearoyl-lysophosphatidylcholine + palmitoyl-CoA
CoA + 1-stearoyl-2-palmitoylphosphatidylcholine
-
-
-
-
?
acyl-CoA + 1-acyl-2-lysophosphatidylethanolamine
1,2-diacylphosphatidylethanolamine + CoA
-
-
-
?
acyl-CoA + 1-acyl-lysophosphatidylcholine
CoA + 1,2-diacyl-lysophosphatidylcholine
-
-
-
?
acyl-CoA + 1-acyl-lysophosphatidylethanolamine
CoA + 1,2-diacyl-lysophosphatidylethanolamine
-
-
-
?
acyl-CoA + 1-acyl-lysophosphatidylglycerol
CoA + 1,2-diacyl-lysophosphatidylglycerol
-
-
-
?
acyl-CoA + 1-acyl-lysophosphatidylinositol
CoA + 1,2-diacyl-lysophosphatidylinositol
-
-
-
?
acyl-CoA + 1-acyl-lysophosphatidylserine
CoA + 1,2-diacyl-lysophosphatidylserine
-
-
-
?
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
acyl-CoA + 1-acyl-sn-glycero-3-phosphoethanolamine
CoA + 1,2-diacyl-sn-glycero-3-phosphoethanolamine
-
-
-
?
acyl-CoA + 1-acyl-sn-glycero-3-phosphoryldimethylethanolamine
CoA + 1,2-diacyl-sn-glycero-3-phosphoryldimethylethanolamine
-
preferred acyl acceptors in descending order: 1-acyl-sn-glycero-3-phosphocholine, 1-acyl-sn-glycero-3-phosphoryldimethylethanolamine, 1-acyl-sn-glycero-3-phosphorylmonomethylethanolamine, 1-acyl-sn-glycero-3-phosphorylethanolamine
-
?
acyl-CoA + 1-acyl-sn-glycero-3-phosphorylethanolamine
CoA + 1,2-diacyl-sn-glycero-3-phosphorylethanolamine
-
-
-
?
acyl-CoA + 1-acyl-sn-glycero-3-phosphorylmonomethylethanolamine
CoA + 1,2-diacyl-sn-glycero-3-phosphorylmonomethylethanolamine
-
-
-
?
acyl-CoA + 1-decanoyl-sn-glycero-3-phosphocholine
CoA + 1-decanoyl-2-acyl-sn-glycero-3-phosphocholine
-
-
-
?
acyl-CoA + 1-lauroyl-sn-glycero-3-phosphocholine
CoA + 1-lauroyl-2-acyl-sn-glycero-3-phosphocholine
-
-
-
?
acyl-CoA + 1-myristoyl-sn-glycero-3-phosphocholine
CoA + 1-myristoyl-2-acyl-sn-glycero-3-phosphocholine
-
preferred acyl acceptors: 1-myristyl-sn-glycero-3-phosphocholine, 1-stearyl-sn-glycero-3-phosphocholine, 1-oleoyl-sn-glycero-3-phosphocholine and 1-linoleoyl-sn-glycero-3-phosphocholine, very little activity with 1-decanoyl-sn-glycero-3-phosphocholine
-
?
acyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine
CoA + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine
-
-
-
?
acyl-CoA + 1-oleoyl-sn-glycero-3-phosphocholine
CoA + 1-oleoyl-2-acyl-sn-glycero-3-phosphocholine
acyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine
acyl-CoA + 1-stearoyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-acyl-sn-glycero-3-phosphocholine
-
no activity with 1-myristoyl-sn-glycero-3-phosphocholine
-
r
acyl-CoA + 2-acyl-sn-lysophosphatidylglycerol
CoA + 1,2-diacyl-sn-lysophosphatidylglycerol
-
-
-
?
acyl-CoA + lysophosphatidylcholine
CoA + phosphatidylcholine
-
-
-
?
alpha-linolenoyl-CoA + 1-oleoyl-lysophosphatidylcholine
CoA + 1-oleoyl-2-alpha-linolenoyl-lysophosphatidylcholine
-
-
-
-
r
alpha-linolenoyl-CoA + 1-oleoyl-sn-glycero-3-phosphocholine
CoA + 1-oleoyl-2-alpha-linolenoyl-sn-glycero-3-phosphocholine
-
-
-
-
r
arachidonoyl-CoA + 1-acyl-lysophosphatidylcholine
CoA + 1-acyl-2-arachidonoyl-lysophosphatidylcholine
preferred substrate
-
-
?
arachidonoyl-CoA + 1-acyl-lysophosphatidylethanolamine
CoA + 1-acyl-2-arachidonoyl-lysophosphatidylethanolamine
-
-
-
?
arachidonoyl-CoA + 1-acyl-lysophosphatidylserine
CoA + 1-acyl-2-arachidonoyl-lysophosphatidylserine
-
-
-
?
arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine
arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphoethanolamine
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine
arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphoinositol
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphoinositol
arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphoserine
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphoserine
arachidonoyl-CoA + 1-arachidoyl-2-lysophosphatidylcholine
CoA + 2-arachidonoyl-1-arachidoylphosphatidylcholine
-
-
-
?
arachidonoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine
CoA + 2-arachidonoyl-1-O-hexadecyl-sn-glycero-3-phosphocholine
LPCAT3 acylates 1-O-alkyl-sn-glycero-3-phosphocholine with arachidonyl-CoA but not with acetyl-CoA
-
-
?
arachidonoyl-CoA + 1-palmitoyl-2-lysophosphatidylcholine
CoA + 2-arachidonoyl-1-palmitoylphosphatidylcholine
-
-
-
?
arachidonoyl-CoA + 1-palmitoyl-2-lysophosphatidylethanolamine
CoA + 2-arachidonoyl-1-palmitoylphosphatidylethanolamine
lysophosphatidylethanolamine acylation is evident. But no significant activity of acylation is detected when 16:0-lysophosphatidylglycerol is used as substrate
-
-
?
arachidonoyl-CoA + 1-stearoyl-2-lysophosphatidylcholine
CoA + 2-arachidonoyl-1-stearoylphosphatidylcholine
-
-
-
?
arachidonoyl-CoA + 1-stearoyl-lysophosphatidylcholine
CoA + 1-stearoyl-2-arachidonoyl-lysophosphatidylcholine
preferred reaction
-
-
?
arachidonoyl-CoA + 2-stearoyl-lysophosphatidylcholine
CoA + 1-arachidonoyl-2-stearoyl-lysophosphatidylcholine
low activity, cf. EC 2.3.1.62
-
-
?
arachidonoyl-CoA + NBD-labelled lysophosphatidylcholine
CoA + NBD-2-arachidonoyl-phosphatidylcholine
-
-
-
-
arachidonoyl-CoA + palmitoyl-lysophosphatidylcholine
CoA + 2-arachidonoyl-1-palmitoylphosphatidylcholine
-
-
-
?
cis-11-eicosaenoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-cis-11-eicosaenoyl-sn-glycero-3-phosphocholine
-
13% of activity with arachidonoyl-CoA
-
r
decanoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-decanoyl-sn-glycero-3-phosphocholine
-
58% of activity with arachidonoyl-CoA
-
r
decanoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-decanoyl-sn-glycero-3-phosphocholine
-
highest activity with 1-palmitoyl-sn-glycero-3-phosphocholine as acceptor, preferred acyl donors in descending order: decanoyl-CoA, oleoyl-CoA, arachidonoyl-CoA, stearoyl-CoA, linolenoyl-CoA, dodecanoyl-CoA, palmitoyl-CoA
-
?
docosahexaenoyl-CoA + 1-acyl-sn-glycero-3-phosphoethanolamine
CoA + 1-acyl-2-docosahexaenoyl-sn-glycero-3-phosphoethanolamine
-
-
-
?
docosahexaenoyl-CoA + 1-arachidonoyl-sn-glycero-3-phosphoethanolamine
CoA + 1-arachidonoyl-2-docosahexaenoyl-sn-glycero-3-phosphoethanolamine
-
-
-
?
docosahexaenoyl-CoA + 1-oleoyl-sn-glycero-3-phosphoethanolamine
CoA + 1-oleoyl-2-docosahexaenoyl-sn-glycero-3-phosphoethanolamine
-
-
-
?
docosahexaenoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphoethanolamine
CoA + 1-palmitoyl-2-docosahexaenoyl-sn-glycero-3-phosphoethanolamine
-
-
-
?
docosahexanoyl-CoA + 1-octadecenyl-sn-glycero-3-phosphoethanolamine
CoA + 1-octadecenyl-2-docosahexanoyl-sn-glycero-3-phosphoethanolamine
reaction of EC 2.3.1.25
-
-
?
eicosatrienoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-eicosatrienoyl-sn-glycero-3-phosphocholine
-
20% of activity with arachidonoyl-CoA
-
r
linolenoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-linolenoyl-sn-glycero-3-phosphocholine
-
8% of activity with arachidonoyl-CoA
-
r
linolenoyl-CoA + 1-linolenoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dilinolenoyl-sn-glycero-3-phosphocholine
-
-
-
-
?
linoleoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine
linoleoyl-CoA + 1-linoleoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dilinoleoyl-sn-glycero-3-phosphocholine
-
-
-
-
?
linoleoyl-CoA + 1-oleoyl-lysophosphatidylcholine
CoA + 1-oleoyl-2-linoleoyl-lysophosphatidylcholine
-
-
-
-
r
linoleoyl-CoA + 1-oleoyl-sn-glycero-3-phosphocholine
CoA + 1-oleoyl-2-linoleoyl-sn-glycero-3-phosphocholine
-
-
-
-
r
linoleoyl-CoA + 1-palmitoyl-2-lysophosphatidylcholine
CoA + 1-palmitoyl-2-linoleoylphosphatidylcholine
-
-
-
?
linoleoyl-CoA + 1-palmitoyl-2-lysophosphatidylcholine
CoA + 2-linoleoyl-1-palmitoylphosphatidylcholine
-
-
-
?
lyso-platelet-activating factor + acetyl-CoA
platelet-activating factor + CoA
activity observed only in the presence of phosphatidylcholine (1 mg/ml)
-
-
?
myristoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-myristoyl-sn-glycero-3-phosphocholine
oleoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine
oleoyl-CoA + 1-acyl-sn-glycero-3-phosphoethanolamine
CoA + 1-acyl-2-oleoyl-sn-glycero-3-phosphoethanolamine
-
-
-
?
oleoyl-CoA + 1-acyl-sn-glycero-3-phosphoinositol
CoA + 1-acyl-2-oleoyl-sn-glycero-3-phosphoinositol
oleoyl-CoA + 1-azido-oleoyl-sn-lysophosphatidyl-(N-methyl)-choline
CoA + 1-azido-oleoyl-2-oleoyl-sn-lysophosphatidyl-(N-methyl)-choline
-
-
-
?
oleoyl-CoA + 1-oleoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dioleoyl-lysophosphatidylcholine
-
-
-
-
r
oleoyl-CoA + 1-oleoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dioleoyl-sn-glycero-3-phosphocholine
oleoyl-CoA + 1-oleoyl-sn-lysophosphatidylcholine
CoA + 1,2-dioleoyl-sn-lysophosphatidylcholine
oleoyl-CoA + 1-oleoyl-sn-lysophosphatidylethanolamine
CoA + 1,2-dioleoyl-sn-lysophosphatidylethanolamine
oleoyl-CoA + 1-palmitoyl-2-lysophosphatidylcholine
CoA + 2-oleoyl-1-palmitoylphosphatidylcholine
-
-
-
?
oleoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine
-
-
-
-
?
oleoyl-CoA + lyso-platelet-activating factor
CoA + platelet-activating factor
-
-
-
-
?
oleoyl-CoA + palmitoyl-lysophosphatidylcholine
CoA + 2-oleoyl-1-palmitoylphosphatidylcholine
-
-
-
?
oleoyl-CoA + sn-1-myristoyl-lysophosphatidylcholine
CoA + 1-myristoyl-2-oleoylphosphatidylcholine
-
-
-
-
?
oleoyl-CoA + sn-1-stearoyl-lysophosphatidylcholine
CoA + 2-oleoyl-1-stearoylphosphatidylcholine
-
-
-
-
?
oleyl-CoA + sn-1-oleoyl-lysophosphatidylcholine
CoA + 1,2-dioleoylphosphatidylcholine
-
-
-
-
?
palmitoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-palmitoyl-sn-glycero-3-phosphocholine
palmitoyl-CoA + 1-oleoyl-lysophosphatidylcholine
CoA + 1-oleoyl-2-palmitoyl-lysophosphatidylcholine
-
low activity
-
-
r
palmitoyl-CoA + 1-palmitoyl-2-lysophosphatidylcholine
CoA + 1,2-dipalmitoylphosphatidylcholine
palmitoyl-CoA + 1-palmitoyl-lysophosphatidylcholine
CoA + 1,2-dipalmitoyl-lysophosphatidylcholine
palmitoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
palmitoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoylphosphatidylcholine
-
-
-
-
?
palmitoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + dipalmitoylphosphatidylcholine
i.e. 1-palmitoyl-lysophosphatidylcholine
-
-
?
palmitoyl-CoA + 1-palmitoyl-sn-lysophosphatidylcholine
CoA + 1,2-dipalmitoyl-sn-lysophosphatidylcholine
palmitoyl-CoA + 2-palmitoyl-lysophosphatidylcholine
CoA + 1,2-dipalmitoyl-sn-lysophosphatidylcholine
reaction of EC 2.3.1.62
-
-
?
palmitoyl-CoA + 2-palmitoyl-sn-lysophosphatidylcholine
CoA + 1,2-dipalmitoyl-sn-lysophosphatidylcholine
reaction of EC 2.3.1.62
-
-
?
palmitoyl-CoA + sn-1-myristoyl-lysophosphatidylcholine
CoA + 1-myristoyl-2-palmitoylphosphatidylcholine
-
-
-
-
?
palmitoyl-CoA + sn-1-oleoyl-lysophosphatidylcholine
CoA + 1-oleoyl-2-palmitoylphosphatidylcholine
-
-
-
-
?
palmitoyl-CoA + sn-1-stearoyl-lysophosphatidylcholine
CoA + 1-stearoyl-2-palmitoylphosphatidylcholine
-
-
-
-
?
stearoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-stearoyl-sn-glycero-3-phosphocholine
stearoyl-CoA + 1-oleoyl-lysophosphatidylcholine
CoA + 1-oleoyl-2-stearoyl-lysophosphatidylcholine
-
low activity
-
-
r
stearoyl-CoA + 1-oleoyl-sn-lysophosphatidylglycerol
CoA + 1-oleoyl-2-stearoyl-sn-lysophosphatidylglycerol
LYCAT introduces stearic acid predominantly at the sn-1 position of lysophosphatidylglycerol (LPG), cf. EC 2.3.1.62
-
-
?
stearoyl-CoA + 1-palmitoyl-2-lysophosphatidylcholine
CoA + 2-stearoyl-1-palmitoylphosphatidylcholine
-
-
-
?
stearoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-stearoyl-sn-glycero-3-phosphocholine
-
-
-
-
?
stearoyl-CoA + 1-stearoyl-sn-glycero-3-phosphocholine
CoA + 1,2-distearoyl-sn-glycero-3-phosphocholine
-
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + arachidonoyl-CoA
1-palmitoyl-2-arachidonoylphosphatidylcholine + CoA
-
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + arachidonoyl-CoA
1-palmitoyl-2-arachidonoylphosphatidylcholine + CoA
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + arachidonoyl-CoA
1-palmitoyl-2-arachidonoylphosphatidylcholine + CoA
-
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + arachidonoyl-CoA
1-palmitoyl-2-arachidonoylphosphatidylcholine + CoA
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + linoleoyl-CoA
1-palmitoyl-2-linoleoylphosphatidylcholine + CoA
-
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + linoleoyl-CoA
1-palmitoyl-2-linoleoylphosphatidylcholine + CoA
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + linoleoyl-CoA
1-palmitoyl-2-linoleoylphosphatidylcholine + CoA
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + oleoyl-CoA
1-palmitoyl-2-oleoylphosphatidylcholine + CoA
-
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + oleoyl-CoA
1-palmitoyl-2-oleoylphosphatidylcholine + CoA
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + oleoyl-CoA
1-palmitoyl-2-oleoylphosphatidylcholine + CoA
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + palmitoyl-CoA
1,2-dipalmitoylphosphatidylcholine + CoA
-
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + palmitoyl-CoA
1,2-dipalmitoylphosphatidylcholine + CoA
activity observed only in the presence of phosphatidylcholine (1 mg/ml)
-
-
?
1-palmitoyl-2-lysophosphatidylserine + arachidonoyl-CoA
1-palmitoyl-2-arachidonoylphosphatidylserine + CoA
-
-
-
?
1-palmitoyl-2-lysophosphatidylserine + arachidonoyl-CoA
1-palmitoyl-2-arachidonoylphosphatidylserine + CoA
-
-
-
?
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
participates in deacylation/reacylation cycle of cell membranes
-
?
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
determines composition of phosphocholine in myocardium
-
?
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
-
?
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
microsomal enzyme is more active toward unsaturated acyl-CoAs, the mitochondrial enzyme has a very high specificity toward linoleoyl-CoA
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
highest activity with polyunsaturated acyl-CoAs e.g. arachidonoyl-CoA, eicosatrienoyl-CoA and linoleoyl-CoA
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
?
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
phosphatidylcholine is the major site for polyunsaturated fatty acid synthesis
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
the reverse reaction of enzyme LPCAT uses phosphatidylcholine as substrate and forms acyl-CoA and lysophosphatidylcholine
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
?
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
specificity of enzyme LPCAT1 for lyso-PC as an acyl acceptor
-
-
?
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
Mus musculus BALB/c
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
Mus musculus C57BL/10J
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
Mus musculus FVB/N
-
-
-
?
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
Mus musculus FVB/N
specificity of enzyme LPCAT1 for lyso-PC as an acyl acceptor
-
-
?
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
2 isoenzymes differing in their selectivity toward saturated and unsaturated fatty acids
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
-
?
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
specificity for acyl-CoA with unsaturated acyl groups, 1-palmitoyl-sn-glycero-3-phosphocholine is a better acceptor than 1-stearyl-sn-glycero-3-phosphocholine
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
highest activity with polyunsaturated acyl-CoAs e.g. arachidonoyl-CoA, eicosatrienoyl-CoA and linoleoyl-CoA
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
selectivity for polyunsaturated fatty acids, preferred acyl donors in descending order: arachidonyl-CoA, eicosapentaenoyl-CoA, docosahexaenoyl-CoA, in platelets, 1-acyl-sn-glycero-3-phosphocholine is a better acceptor than 1-acyl-sn-glycero-3-phosphorylethanolamine
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
participates in deacylation/reacylation cycle of cell membranes
-
?
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
r
acyl-CoA + 1-acyl-sn-lysophosphatidylcholine
CoA + 1,2-diacyl-sn-lysophosphatidylcholine
-
-
-
?
acyl-CoA + 1-acyl-sn-lysophosphatidylcholine
CoA + 1,2-diacyl-sn-lysophosphatidylcholine
-
-
-
?
acyl-CoA + 1-oleoyl-sn-glycero-3-phosphocholine
CoA + 1-oleoyl-2-acyl-sn-glycero-3-phosphocholine
-
preferred acyl acceptors in descending order: 1-oleoyl-sn-glycero-3-phosphocholine, 1-myristoyl-sn-glycero-3-phosphocholine, 1-lauroyl-sn-glycero-3-phosphocholine, 1-stearoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-sn-glycero-3-phosphocholine, 1-decanoyl-sn-glycero-3-phosphocholine and 1-arachidonoyl-sn-glycero-3-phosphocholine
-
?
acyl-CoA + 1-oleoyl-sn-glycero-3-phosphocholine
CoA + 1-oleoyl-2-acyl-sn-glycero-3-phosphocholine
-
integral membrane enzyme, preferred acyl acceptors in descending order: 1-oleoyl-sn-glycero-3-phosphocholine, 1-stearoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-sn-glycero-3-phosphocholine, 1-myristoyl-sn-glycero-3-phosphocholine, 1-lauroyl-sn-glycero-3-phosphocholine and 1-decanoyl-sn-glycero-3-phosphocholine
-
?
acyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine
-
no activity with 1-myristoyl-sn-glycero-3-phosphocholine
-
r
acyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine
-
at 0.16 mM 1-palmitoyl-sn-glycero-3-phosphocholine is preferred 3.5fold over 1-stearoyl-sn-glycero-3-phosphocholine
-
r
arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine
-
preferred acyl donor
-
r
arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine
-
preferred acyl donors in descending order: arachidonoyl-CoA, oleoyl-CoA and palmitoyl-CoA
-
?
arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine
-
-
-
?
arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine
-
-
-
?
arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine
-
arachidonoyl-CoA is the preferred acyl donor at 0.1 mM lysophosphatidylcholine concentrations in neuronal nuclei, 1-palmitoyl-sn-glycero-3-phosphocholine is preferred over 1-oleoyl-sn-glycero-3-phosphocholine as acyl acceptor
-
r
arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine
-
preferred acyl donors in descending order: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA, very little activity with palmitoyl-CoA, lauroyl-CoA, myristoyl-CoA, palmitolenoyl-CoA and stearoyl-CoA
-
r
arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine
-
preferred acyl donor
-
r
arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine
-
preferred acyl donors in descending order: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA, palmitoyl-CoA, stearoyl-CoA, 1-palmitoyl-sn-glycero-3-phosphocholine is preferred over 1-stearoyl-sn-glycero-3-phosphocholine as acceptor
-
?
arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine
-
peripheral and integral acyltransferase, specific for arachidonoyl-CoA and oleoyl-CoA
-
-
r
arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphoethanolamine
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine
-
-
-
?
arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphoethanolamine
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine
-
57% and 6% of activity with 1-acyl-sn-glycero-3-phosphocholine in microsomes and phosphatidylcholine vesicles respectively
-
?
arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphoinositol
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphoinositol
-
preferred acyl donor arachidonoyl-CoA, other acyl donors: cis,cis-11,14-eicosadienoyl-CoA, cis-11-eicosaenoyl-CoA, linolenoyl-coA, linoleoyl-CoA, oleoyl-CoA, stearoyl-CoA, palmitoleoyl-CoA, palmitoyl-CoA, dodecanoyl-CoA and decanoyl-coA, no activity with 1-acyl-sn-glycero-3-phosphocholine
-
?
arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphoinositol
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphoinositol
-
-
-
?
arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphoinositol
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphoinositol
-
35% and 8% of activity with 1-acyl-sn-glycero-3-phosphocholine in microsomes and phosphatidylcholine vesicles respectively
-
?
arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphoserine
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphoserine
-
-
-
-
?
arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphoserine
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphoserine
-
99% and 22% of activity with 1-acyl-sn-glycero-3-phosphocholine in microsomes and phosphatidylcholine vesicles respectively
-
?
linoleoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine
-
-
-
r
linoleoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine
-
-
-
r
linoleoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine
-
-
-
r
linoleoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine
-
only acyl donor of the mitochondrial enzyme, 1-acyl-sn-glycero-3-phosphocholine and 1-alkenyl-sn-glycero-3-phosphocholine can act as acyl acceptors
-
r
linoleoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine
-
-
-
?
linoleoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine
-
-
-
-
?
linoleoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine
-
-
-
r
linoleoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine
-
-
-
r
myristoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-myristoyl-sn-glycero-3-phosphocholine
-
-
-
r
myristoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-myristoyl-sn-glycero-3-phosphocholine
-
41% of activity with arachidonoyl-CoA
-
r
myristoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-myristoyl-sn-glycero-3-phosphocholine
-
-
-
r
myristoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-myristoyl-sn-glycero-3-phosphocholine
-
-
-
r
myristoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-myristoyl-sn-glycero-3-phosphocholine
-
-
-
r
oleoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine
-
-
-
r
oleoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine
-
-
-
r
oleoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine
-
best acyl donor
-
r
oleoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine
-
-
-
r
oleoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine
-
-
-
r
oleoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine
-
-
-
r
oleoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine
Mus musculus C57BL/10J
-
-
-
r
oleoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine
-
-
-
-
?
oleoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine
-
-
-
-
?
oleoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine
-
-
-
r
oleoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine
-
-
-
r
oleoyl-CoA + 1-acyl-sn-glycero-3-phosphoinositol
CoA + 1-acyl-2-oleoyl-sn-glycero-3-phosphoinositol
-
preferred acyl donors in descending order: oleoyl-CoA, palmitoyl-CoA and arachidonoyl-CoA
-
?
oleoyl-CoA + 1-acyl-sn-glycero-3-phosphoinositol
CoA + 1-acyl-2-oleoyl-sn-glycero-3-phosphoinositol
-
-
-
?
oleoyl-CoA + 1-acyl-sn-glycero-3-phosphoinositol
CoA + 1-acyl-2-oleoyl-sn-glycero-3-phosphoinositol
Mus musculus C57BL/10J
-
-
-
?
oleoyl-CoA + 1-oleoyl-lysophosphatidic acid
CoA + 1,2-dioleoyl-sn-lysophosphatidic acid
-
-
-
r
oleoyl-CoA + 1-oleoyl-lysophosphatidic acid
CoA + 1,2-dioleoyl-sn-lysophosphatidic acid
very low activity, cf. EC 2.3.1.51
-
-
r
oleoyl-CoA + 1-oleoyl-lysophosphatidic acid
CoA + 1,2-dioleoyl-sn-lysophosphatidic acid
low activity, cf. EC 2.3.1.51
-
-
r
oleoyl-CoA + 1-oleoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dioleoyl-sn-glycero-3-phosphocholine
-
-
-
-
?
oleoyl-CoA + 1-oleoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dioleoyl-sn-glycero-3-phosphocholine
-
-
-
-
r
oleoyl-CoA + 1-oleoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dioleoyl-sn-glycero-3-phosphocholine
-
-
-
-
?
oleoyl-CoA + 1-oleoyl-sn-lysophosphatidylcholine
CoA + 1,2-dioleoyl-sn-lysophosphatidylcholine
-
-
-
r
oleoyl-CoA + 1-oleoyl-sn-lysophosphatidylcholine
CoA + 1,2-dioleoyl-sn-lysophosphatidylcholine
preferred substrate, high activity
-
-
r
oleoyl-CoA + 1-oleoyl-sn-lysophosphatidylcholine
CoA + 1,2-dioleoyl-sn-lysophosphatidylcholine
-
-
-
r
oleoyl-CoA + 1-oleoyl-sn-lysophosphatidylcholine
CoA + 1,2-dioleoyl-sn-lysophosphatidylcholine
preferred substrate, high activity
-
-
r
oleoyl-CoA + 1-oleoyl-sn-lysophosphatidylethanolamine
CoA + 1,2-dioleoyl-sn-lysophosphatidylethanolamine
-
-
-
r
oleoyl-CoA + 1-oleoyl-sn-lysophosphatidylethanolamine
CoA + 1,2-dioleoyl-sn-lysophosphatidylethanolamine
very low activity, cf. EC 2.3.1.121
-
-
r
oleoyl-CoA + 1-oleoyl-sn-lysophosphatidylethanolamine
CoA + 1,2-dioleoyl-sn-lysophosphatidylethanolamine
-
-
-
r
oleoyl-CoA + 1-oleoyl-sn-lysophosphatidylethanolamine
CoA + 1,2-dioleoyl-sn-lysophosphatidylethanolamine
low activity, cf. EC 2.3.1.121
-
-
r
palmitoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-palmitoyl-sn-glycero-3-phosphocholine
-
-
-
r
palmitoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-palmitoyl-sn-glycero-3-phosphocholine
-
-
-
r
palmitoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-palmitoyl-sn-glycero-3-phosphocholine
-
-
-
r
palmitoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-palmitoyl-sn-glycero-3-phosphocholine
-
-
-
-
?
palmitoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-palmitoyl-sn-glycero-3-phosphocholine
-
-
-
r
palmitoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-palmitoyl-sn-glycero-3-phosphocholine
-
-
-
r
palmitoyl-CoA + 1-palmitoyl-2-lysophosphatidylcholine
CoA + 1,2-dipalmitoylphosphatidylcholine
-
-
-
?
palmitoyl-CoA + 1-palmitoyl-2-lysophosphatidylcholine
CoA + 1,2-dipalmitoylphosphatidylcholine
-
-
-
?
palmitoyl-CoA + 1-palmitoyl-lysophosphatidylcholine
CoA + 1,2-dipalmitoyl-lysophosphatidylcholine
quantification of palmitic acid by gas chromatography
-
-
?
palmitoyl-CoA + 1-palmitoyl-lysophosphatidylcholine
CoA + 1,2-dipalmitoyl-lysophosphatidylcholine
quantification of palmitic acid by gas chromatography
-
-
?
palmitoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
-
-
-
-
?
palmitoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
-
preferred substrate
-
-
?
palmitoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
-
-
-
?
palmitoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
quantification of palmitic acid by gas chromatography
-
-
?
palmitoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
-
-
-
?
palmitoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
quantification of palmitic acid by gas chromatography
-
-
?
palmitoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
Mus musculus C57BL/6J
-
-
-
?
palmitoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
Mus musculus C57BL/6J
quantification of palmitic acid by gas chromatography
-
-
?
palmitoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
-
-
-
?
palmitoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
quantification of palmitic acid by gas chromatography
-
-
?
palmitoyl-CoA + 1-palmitoyl-sn-lysophosphatidylcholine
CoA + 1,2-dipalmitoyl-sn-lysophosphatidylcholine
-
-
-
?
palmitoyl-CoA + 1-palmitoyl-sn-lysophosphatidylcholine
CoA + 1,2-dipalmitoyl-sn-lysophosphatidylcholine
-
-
-
?
palmitoyl-CoA + 1-palmitoyl-sn-lysophosphatidylcholine
CoA + 1,2-dipalmitoyl-sn-lysophosphatidylcholine
-
-
-
?
palmitoyl-CoA + 1-palmitoyl-sn-lysophosphatidylcholine
CoA + 1,2-dipalmitoyl-sn-lysophosphatidylcholine
dipalmitoyl-PC is biosynthesized by LPCAT1 in the Lands' cycle
-
-
?
stearoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-stearoyl-sn-glycero-3-phosphocholine
-
-
-
-
r
stearoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-stearoyl-sn-glycero-3-phosphocholine
-
-
-
-
r
stearoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-stearoyl-sn-glycero-3-phosphocholine
-
-
-
r
stearoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-stearoyl-sn-glycero-3-phosphocholine
-
-
-
-
r
stearoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-stearoyl-sn-glycero-3-phosphocholine
-
-
-
-
r
additional information
?
-
Arabidopsis thaliana lysophospholipid acyltransferase utilizes both mono- and dilysocardiolipin as an acyl acceptor. The enzyme robustly acylates 1-acyl-lysophosphatidylethanolamine (PE), 1-acyl-lysophosphatidylglycerol (PG), 1-acyl lysophosphatidylserine (PS), and 1-acyl-phosphatidylinositol (PI) using acyl-CoA as the acyl donor to produce PE, PG, PS, and PI, respectively. Di-linoleoylphosphatidylcholine is used as the acyl donor and mono-lysocardiolipin is used as the acyl acceptor in a reaction. No transfer of the linoleoyl chains is detected in an At1g78690-dependent manner suggesting that, despite the strong homology, the cardiolipin remodeling enzyme tafazzin and the lysophospholipid acyltransferase catalyze unique reactions. No 18:2 acyl chains are detected in other phospholipid pools in an At1g78690-dependent manner. Enzyme At1g78690 does not function as a transacylase using phosphatidyylcholine as an acyl donor. Mass spectrometric identification of in vitro products
-
-
-
additional information
?
-
-
Arabidopsis thaliana lysophospholipid acyltransferase utilizes both mono- and dilysocardiolipin as an acyl acceptor. The enzyme robustly acylates 1-acyl-lysophosphatidylethanolamine (PE), 1-acyl-lysophosphatidylglycerol (PG), 1-acyl lysophosphatidylserine (PS), and 1-acyl-phosphatidylinositol (PI) using acyl-CoA as the acyl donor to produce PE, PG, PS, and PI, respectively. Di-linoleoylphosphatidylcholine is used as the acyl donor and mono-lysocardiolipin is used as the acyl acceptor in a reaction. No transfer of the linoleoyl chains is detected in an At1g78690-dependent manner suggesting that, despite the strong homology, the cardiolipin remodeling enzyme tafazzin and the lysophospholipid acyltransferase catalyze unique reactions. No 18:2 acyl chains are detected in other phospholipid pools in an At1g78690-dependent manner. Enzyme At1g78690 does not function as a transacylase using phosphatidyylcholine as an acyl donor. Mass spectrometric identification of in vitro products
-
-
-
additional information
?
-
substrate specificity (towards different acyl acceptors) of the lysophospholipid:acyl-CoA acyltransferase in the forward reactions with [14C]oleoyl-CoA, assay optimization. Lysophosphatidylcholine is by far the best substrate for AtLPCAT2. Ratio between reverse and forward activities for different LPLATs for different phospholipids, overview. Highest amounts in PtdCho with AtLPCAT2
-
-
-
additional information
?
-
-
the specificity of the enzyme may respresent a barrier to the incorporation of medium-chain fatty acids at the sn-2 position of triacylglycerol
-
-
?
additional information
?
-
-
with the different seed microsomal fractions, substrate specificity, overview. Gondoyl-CoA and erucoyl-CoA, which are not accepted by CsLPCATs. The most preferred acyl donor in the assays with the microsomal fraction of the 24 and 31 days-after-flowering (DAF) seeds is linoleoyl-CoA, at 17 DAF alpha-linolenoyl-CoA is preferred. The activity of the backward reactions of the CsLPCATs in seed microsomal fractions is generally the highest at 17 DAF. Low activity with sn-2-O-glycero-3-phosphocholines (cf. EC 2.3.1.62)
-
-
-
additional information
?
-
-
5 nmol of exogenous sn-1-oleoyl-lysophosphatidylcholine and 5 nmol of [14C]acyl-CoA are used as in vitro substrates, assay method optimization, overview
-
-
-
additional information
?
-
-
priming of Mono-Mac 6 cells by IFNgamma appears to involve LPCAT
-
-
?
additional information
?
-
-
the enzyme may mediate the priming reactions of monocytes to the cytokine interferon-gamma. The enzyme might also effect the responses of monocytes to the bacterial agent lipopolysaccharide that may be important in the development of sepsis
-
-
?
additional information
?
-
-
low activity with lauroyl-CoA, linoleoyl-CoA and arachidonyl-CoA
-
-
?
additional information
?
-
-
inhibition of Golgi complex-associated LPAT activity by the drug CI-976 stimulates Golgi tubule formation and subsequent redistribution of resident Golgi proteins to the endoplasmic reticulum, affecting secretory and endocytic membrane trafficking pathways, overview
-
-
?
additional information
?
-
reduced activity with lysophosphatidylethanolamine and lysophosphatidylserine
-
-
?
additional information
?
-
-
reduced activity with lysophosphatidylethanolamine and lysophosphatidylserine
-
-
?
additional information
?
-
a linear incorporation of labeled fatty acyl CoA into dipalmitoyl phosphatidylcholine (PC) indicates that lysophosphatidylcholine generated by Prdx6 PLA2 activity remains bound to the enzyme for the reacylation reaction
-
-
-
additional information
?
-
development and evaluation of an accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases, overview. Positional specificity of the hydroxyl group of the glycerol backbone (sn-2 or sn-1) at which LPLATs introduce a fatty acid. LPCAT1 introduces palmitic acid both at the sn-1 and sn-2 positions of palmitoyl-lysophosphatidylcholine (LPC). sn-1-Palmitoyl LPC appears to have a slightly higher affinity for LPCAT1 than sn-2-palmitoyl LPC, while sn-2-palmitoyl LPC has a higher turnover rate
-
-
-
additional information
?
-
the enzyme is highly specific for substrates palmitoyl-CoA and lysophosphatidylcholine. Lysophosphatidylethanolamine, lysophosphatidylglycerol, lysophosphatidylinositol, and lysophosphatidylserine are poor substrates, as well as stearoyl-CoA, acetyl-CoA, oleoyl-CA, and arachidonoyl-CoA
-
-
-
additional information
?
-
the enzyme is involved in dipalmitoylphosphatidylcholine synthesis
-
-
?
additional information
?
-
-
the enzyme is involved in dipalmitoylphosphatidylcholine synthesis
-
-
?
additional information
?
-
the enzyme synthesizes phosphatidylcholine in pulmonary surfactant and plays a pivotal role in respiratory physiology and in membrane biogenesis
-
-
?
additional information
?
-
-
the enzyme synthesizes phosphatidylcholine in pulmonary surfactant and plays a pivotal role in respiratory physiology and in membrane biogenesis
-
-
?
additional information
?
-
LPCAT1 shows a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl- or 1-palmitoyl-LPC as acyl donors and acceptors, respectively
-
-
?
additional information
?
-
-
LPCAT1 shows a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl- or 1-palmitoyl-LPC as acyl donors and acceptors, respectively
-
-
?
additional information
?
-
substrate specificity, LPCAT prefers lysophosphatidylcholine as a substrate over lysophosphatidic acid, lysophosphatidylinositol, lysophosphatidylserine, lysophosphatidylethanolamine, or lysophosphatidylglycerol, and prefers palmitoyl-CoA to oleoyl-CoA as the acyl donor, the enzyme is involved in synthesis of membrane surfactant proteins and regulation of surfactant phospholipid biosynthesis
-
-
?
additional information
?
-
-
substrate specificity, LPCAT prefers lysophosphatidylcholine as a substrate over lysophosphatidic acid, lysophosphatidylinositol, lysophosphatidylserine, lysophosphatidylethanolamine, or lysophosphatidylglycerol, and prefers palmitoyl-CoA to oleoyl-CoA as the acyl donor, the enzyme is involved in synthesis of membrane surfactant proteins and regulation of surfactant phospholipid biosynthesis
-
-
?
additional information
?
-
-
histone H4 protein is subject to palmitoylation catalyzed by Lpcat1 in a calcium-regulated manner. Cytosolic Lpcat1 shifts into the nucleus in lung epithelia in response to exogenous Ca2+. Nuclear Lpcat1 colocalizes with and binds to histone H4, where it catalyzes histone H4 palmitoylation. Residue Ser47 within histone H4 serves as a putative acceptor site, indicative of Lpcat1-mediated O-palmitoylation. Lpcat1 knock-down or expression of a histone H4 Ser47A mutant protein in cells decreases cellular mRNA synthesis
-
-
?
additional information
?
-
enzyme LPCAT1 directly interacts with StarD10 protein, amino acids 79-271 of LPCAT1 and the steroidogenic acute regulatory protein-related lipid transfer (START) domain of START domain-containing protein 10 (StarD10) are sufficient for this interaction. The enzyme also interacts with StarD7-I but not StarD7-II or StarD2/PCTP transfer protein
-
-
?
additional information
?
-
a linear incorporation of labeled fatty acyl CoA into dipalmitoyl phosphatidylcholine (PC) indicated that lysophosphatidylcholine generated by Prdx6 PLA2 activity remains bound to the enzyme for the reacylation reaction
-
-
-
additional information
?
-
-
a linear incorporation of labeled fatty acyl CoA into dipalmitoyl phosphatidylcholine (PC) indicated that lysophosphatidylcholine generated by Prdx6 PLA2 activity remains bound to the enzyme for the reacylation reaction
-
-
-
additional information
?
-
LPCAT3 is critical for introduction of polyunsaturated fatty acids (PUFAs), especially arachidonic acid (20:4) at the sn-2 position of various LPLs, generating various types of arachidonoyl phospholipids
-
-
-
additional information
?
-
LPCAT3 is critical for introduction of polyunsaturated fatty acids (PUFAs), especially arachidonic acid (20:4) at the sn-2 position of various LPLs, generating various types of arachidonoyl phospholipids
-
-
-
additional information
?
-
LPCAT3 is critical for introduction of polyunsaturated fatty acids (PUFAs), especially arachidonic acid (20:4) at the sn-2 position of various LPLs, generating various types of arachidonoyl phospholipids
-
-
-
additional information
?
-
LPCAT4 has lysophosphatidylethanolamine acyltransferase as well as LPCAT activity. LPCAT uses lysophosphatidylcholine (LPC) as a substrate to generate phosphatidylcholine. Preference of LPCAT4 for oleoyl-CoA during chondrogenic differentiation. LPCAT4 does not prefer linoleoyl-, (5Z,8Z,11Z,14Z)-eicosatetraenoyl-, or docosahexaenoyl-CoA. Analysis of the fatty acid composition of whole cell lysates
-
-
-
additional information
?
-
LYCAT introduces stearic acid (18:0) selectively at the sn-1 position of lysophosphatidylinositol (LPI). The enzyme also catalyzes the reacylation of lysocardiolipin to cardiolipin
-
-
-
additional information
?
-
LYCAT introduces stearic acid (18:0) selectively at the sn-1 position of lysophosphatidylinositol (LPI). The enzyme also catalyzes the reacylation of lysocardiolipin to cardiolipin
-
-
-
additional information
?
-
LYCAT introduces stearic acid (18:0) selectively at the sn-1 position of lysophosphatidylinositol (LPI). The enzyme also catalyzes the reacylation of lysocardiolipin to cardiolipin
-
-
-
additional information
?
-
development and evaluation of an accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases, overview. Positional specificity of the hydroxyl group of the glycerol backbone (sn-2 or sn-1) at which LPLATs introduce a fatty acid. LPCAT1 introduces palmitic acid both at the sn-1 and sn-2 positions of palmitoyl-LPC
-
-
-
additional information
?
-
development and evaluation of an accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases, overview. Positional specificity of the hydroxyl group of the glycerol backbone (sn-2 or sn-1) at which LPLATs introduce a fatty acid. LPCAT1 introduces palmitic acid both at the sn-1 and sn-2 positions of palmitoyl-LPC
-
-
-
additional information
?
-
development and evaluation of an accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases, overview. Positional specificity of the hydroxyl group of the glycerol backbone (sn-2 or sn-1) at which LPLATs introduce a fatty acid. LPCAT1 introduces palmitic acid both at the sn-1 and sn-2 positions of palmitoyl-LPC
-
-
-
additional information
?
-
development and evaluation of an accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases, overview. Positional specificity of the hydroxyl group of the glycerol backbone (sn-2 or sn-1) at which LPLATs introduce a fatty acid. LPCAT3 introduces arachidonic acid predominantly at the sn-2 position of lysophosphatidylcholine (LPC)
-
-
-
additional information
?
-
development and evaluation of an accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases, overview. Positional specificity of the hydroxyl group of the glycerol backbone (sn-2 or sn-1) at which LPLATs introduce a fatty acid. LPCAT3 introduces arachidonic acid predominantly at the sn-2 position of lysophosphatidylcholine (LPC)
-
-
-
additional information
?
-
development and evaluation of an accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases, overview. Positional specificity of the hydroxyl group of the glycerol backbone (sn-2 or sn-1) at which LPLATs introduce a fatty acid. LPCAT3 introduces arachidonic acid predominantly at the sn-2 position of lysophosphatidylcholine (LPC)
-
-
-
additional information
?
-
development and evaluation of an accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases, overview. Positional specificity of the hydroxyl group of the glycerol backbone (sn-2 or sn-1) at which LPLATs introduce a fatty acid. LYCAT introduces stearic acid predominantly at the sn-1 position of LPG. The enzyme also catalyzes the reacylation of lysocardiolipin to cardiolipin
-
-
-
additional information
?
-
development and evaluation of an accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases, overview. Positional specificity of the hydroxyl group of the glycerol backbone (sn-2 or sn-1) at which LPLATs introduce a fatty acid. LYCAT introduces stearic acid predominantly at the sn-1 position of LPG. The enzyme also catalyzes the reacylation of lysocardiolipin to cardiolipin
-
-
-
additional information
?
-
development and evaluation of an accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases, overview. Positional specificity of the hydroxyl group of the glycerol backbone (sn-2 or sn-1) at which LPLATs introduce a fatty acid. LYCAT introduces stearic acid predominantly at the sn-1 position of LPG. The enzyme also catalyzes the reacylation of lysocardiolipin to cardiolipin
-
-
-
additional information
?
-
LPCAT3 biosynthesizes phosphatidylcholine with arachidonic acid. LPCAT3 can also produce phosphatidylethanolamine and phosphatidylserine with arachidonic acid
-
-
-
additional information
?
-
LPCAT3 biosynthesizes phosphatidylcholine with arachidonic acid. LPCAT3 can also produce phosphatidylethanolamine and phosphatidylserine with arachidonic acid
-
-
-
additional information
?
-
LPCAT3 biosynthesizes phosphatidylcholine with arachidonic acid. LPCAT3 can also produce phosphatidylethanolamine and phosphatidylserine with arachidonic acid
-
-
-
additional information
?
-
mouse LPEAT2 (mLPEAT2) has LPEAT, LPCAT, and LPGAT activities using 22:6-CoA as a donor. mLPEAT2 shows significant activities for both acyl and alkenyl species
-
-
-
additional information
?
-
the enzyme Lpcat1 also shows lyso-PAF acetyltransferase activity, EC 2.3.1.67
-
-
-
additional information
?
-
the enzyme Lpcat1 also shows lyso-PAF acetyltransferase activity, EC 2.3.1.67
-
-
-
additional information
?
-
the enzyme Lpcat1 also shows lyso-PAF acetyltransferase activity, EC 2.3.1.67
-
-
-
additional information
?
-
the enzyme Lpcat2 also shows lyso-PAF acetyltransferase activity, EC 2.3.1.67
-
-
-
additional information
?
-
the enzyme Lpcat2 also shows lyso-PAF acetyltransferase activity, EC 2.3.1.67
-
-
-
additional information
?
-
the enzyme Lpcat2 also shows lyso-PAF acetyltransferase activity, EC 2.3.1.67
-
-
-
additional information
?
-
Mus musculus C57BL/6J
a linear incorporation of labeled fatty acyl CoA into dipalmitoyl phosphatidylcholine (PC) indicated that lysophosphatidylcholine generated by Prdx6 PLA2 activity remains bound to the enzyme for the reacylation reaction
-
-
-
additional information
?
-
Mus musculus FVB/N
enzyme LPCAT1 directly interacts with StarD10 protein, amino acids 79-271 of LPCAT1 and the steroidogenic acute regulatory protein-related lipid transfer (START) domain of START domain-containing protein 10 (StarD10) are sufficient for this interaction. The enzyme also interacts with StarD7-I but not StarD7-II or StarD2/PCTP transfer protein
-
-
?
additional information
?
-
-
Golgi membrane tubule formation can result from increasing the content of lysophospholipids in membranes, either by stimulation of a phospholipase A2 or by inhibition of an lysophosphatidylcholine acyltransferase. The two opposing enzyme activities may help to coordinately regulate Golgi membrane shape and tubule formation
-
-
?
additional information
?
-
-
inhibition of Golgi complex-associated LPAT activity by the drug CI-976 stimulates Golgi tubule formation and subsequent redistribution of resident Golgi proteins to the endoplasmic reticulum, affecting secretory and endocytic membrane trafficking pathways, overview
-
-
?
additional information
?
-
the enzyme is involved in dipalmitoylphosphatidylcholine synthesis
-
-
?
additional information
?
-
substrate specificity, LPCAT prefers lysophosphatidylcholine as a substrate over lysophosphatidic acid, lysophosphatidylinositol, lysophosphatidylserine, lysophosphatidylethanolamine, or lysophosphatidylglycerol, and prefers palmitoyl-CoA to oleoyl-CoA as the acyl donor, the enzyme is involved in synthesis of membrane surfactant proteins and regulation of surfactant phospholipid biosynthesis
-
-
?
additional information
?
-
a linear incorporation of labeled fatty acyl CoA into dipalmitoyl phosphatidylcholine (PC) indicates that lysophosphatidylcholine generated by Prdx6 PLA2 activity remains bound to the enzyme for the reacylation reaction
-
-
-
additional information
?
-
substrate specificity (towards different acyl acceptors) of the lysophospholipid:acyl-CoA acyltransferase in the forward reactions with [14C]oleoyl-CoA, assay optimization. Ratio between reverse and forward activities for different LPLATs for different phospholipids, overview. Very high activity in the forward reaction by the Ale1, while its ability to operate reversibly on all tested lipids is very low, highest amounts in PtdCho
-
-
-
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-palmitoyl-2-lysophosphatidylcholine + arachidonoyl-CoA
1-palmitoyl-2-arachidonoylphosphatidylcholine + CoA
-
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + linoleoyl-CoA
1-palmitoyl-2-linoleoylphosphatidylcholine + CoA
-
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + oleoyl-CoA
1-palmitoyl-2-oleoylphosphatidylcholine + CoA
-
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + palmitoyl-CoA
1,2-dipalmitoylphosphatidylcholine + CoA
-
-
-
-
?
acyl-CoA + 1-acyl-lysophosphatidylcholine
CoA + 1,2-diacyl-lysophosphatidylcholine
-
-
-
?
acyl-CoA + 1-acyl-lysophosphatidylethanolamine
CoA + 1,2-diacyl-lysophosphatidylethanolamine
-
-
-
?
acyl-CoA + 1-acyl-lysophosphatidylglycerol
CoA + 1,2-diacyl-lysophosphatidylglycerol
-
-
-
?
acyl-CoA + 1-acyl-lysophosphatidylinositol
CoA + 1,2-diacyl-lysophosphatidylinositol
-
-
-
?
acyl-CoA + 1-acyl-lysophosphatidylserine
CoA + 1,2-diacyl-lysophosphatidylserine
-
-
-
?
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
acyl-CoA + 1-acyl-sn-glycero-3-phosphoethanolamine
CoA + 1,2-diacyl-sn-glycero-3-phosphoethanolamine
-
-
-
?
acyl-CoA + 2-acyl-sn-lysophosphatidylglycerol
CoA + 1,2-diacyl-sn-lysophosphatidylglycerol
-
-
-
?
alpha-linolenoyl-CoA + 1-oleoyl-lysophosphatidylcholine
CoA + 1-oleoyl-2-alpha-linolenoyl-lysophosphatidylcholine
-
-
-
-
r
alpha-linolenoyl-CoA + 1-oleoyl-sn-glycero-3-phosphocholine
CoA + 1-oleoyl-2-alpha-linolenoyl-sn-glycero-3-phosphocholine
-
-
-
-
r
arachidonoyl-CoA + 1-acyl-lysophosphatidylcholine
CoA + 1-acyl-2-arachidonoyl-lysophosphatidylcholine
preferred substrate
-
-
?
arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine
docosahexaenoyl-CoA + 1-acyl-sn-glycero-3-phosphoethanolamine
CoA + 1-acyl-2-docosahexaenoyl-sn-glycero-3-phosphoethanolamine
-
-
-
?
linoleoyl-CoA + 1-oleoyl-lysophosphatidylcholine
CoA + 1-oleoyl-2-linoleoyl-lysophosphatidylcholine
-
-
-
-
r
linoleoyl-CoA + 1-oleoyl-sn-glycero-3-phosphocholine
CoA + 1-oleoyl-2-linoleoyl-sn-glycero-3-phosphocholine
-
-
-
-
r
oleoyl-CoA + 1-acyl-sn-glycero-3-phosphoethanolamine
CoA + 1-acyl-2-oleoyl-sn-glycero-3-phosphoethanolamine
-
-
-
?
oleoyl-CoA + 1-oleoyl-lysophosphatidic acid
CoA + 1,2-dioleoyl-sn-lysophosphatidic acid
-
-
-
r
oleoyl-CoA + 1-oleoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dioleoyl-lysophosphatidylcholine
-
-
-
-
r
oleoyl-CoA + 1-oleoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dioleoyl-sn-glycero-3-phosphocholine
-
-
-
-
r
oleoyl-CoA + 1-oleoyl-sn-lysophosphatidylcholine
CoA + 1,2-dioleoyl-sn-lysophosphatidylcholine
oleoyl-CoA + 1-oleoyl-sn-lysophosphatidylethanolamine
CoA + 1,2-dioleoyl-sn-lysophosphatidylethanolamine
palmitoyl-CoA + 1-oleoyl-lysophosphatidylcholine
CoA + 1-oleoyl-2-palmitoyl-lysophosphatidylcholine
-
low activity
-
-
r
palmitoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
palmitoyl-CoA + 1-palmitoyl-sn-lysophosphatidylcholine
CoA + 1,2-dipalmitoyl-sn-lysophosphatidylcholine
dipalmitoyl-PC is biosynthesized by LPCAT1 in the Lands' cycle
-
-
?
stearoyl-CoA + 1-oleoyl-lysophosphatidylcholine
CoA + 1-oleoyl-2-stearoyl-lysophosphatidylcholine
-
low activity
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
participates in deacylation/reacylation cycle of cell membranes
-
?
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
determines composition of phosphocholine in myocardium
-
?
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
-
?
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
?
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
phosphatidylcholine is the major site for polyunsaturated fatty acid synthesis
-
-
r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
?
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
Mus musculus FVB/N
-
-
-
?
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
-
-
-
?
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
participates in deacylation/reacylation cycle of cell membranes
-
?
acyl-CoA + 1-acyl-sn-lysophosphatidylcholine
CoA + 1,2-diacyl-sn-lysophosphatidylcholine
-
-
-
?
acyl-CoA + 1-acyl-sn-lysophosphatidylcholine
CoA + 1,2-diacyl-sn-lysophosphatidylcholine
-
-
-
?
arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine
-
-
-
?
arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine
-
-
-
?
oleoyl-CoA + 1-oleoyl-sn-lysophosphatidylcholine
CoA + 1,2-dioleoyl-sn-lysophosphatidylcholine
-
-
-
r
oleoyl-CoA + 1-oleoyl-sn-lysophosphatidylcholine
CoA + 1,2-dioleoyl-sn-lysophosphatidylcholine
-
-
-
r
oleoyl-CoA + 1-oleoyl-sn-lysophosphatidylethanolamine
CoA + 1,2-dioleoyl-sn-lysophosphatidylethanolamine
-
-
-
r
oleoyl-CoA + 1-oleoyl-sn-lysophosphatidylethanolamine
CoA + 1,2-dioleoyl-sn-lysophosphatidylethanolamine
-
-
-
r
palmitoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
-
-
-
?
palmitoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
-
-
-
?
palmitoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
Mus musculus C57BL/6J
-
-
-
?
palmitoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
-
-
-
?
additional information
?
-
-
the specificity of the enzyme may respresent a barrier to the incorporation of medium-chain fatty acids at the sn-2 position of triacylglycerol
-
-
?
additional information
?
-
-
with the different seed microsomal fractions, substrate specificity, overview. Gondoyl-CoA and erucoyl-CoA, which are not accepted by CsLPCATs. The most preferred acyl donor in the assays with the microsomal fraction of the 24 and 31 days-after-flowering (DAF) seeds is linoleoyl-CoA, at 17 DAF alpha-linolenoyl-CoA is preferred. The activity of the backward reactions of the CsLPCATs in seed microsomal fractions is generally the highest at 17 DAF. Low activity with sn-2-O-glycero-3-phosphocholines (cf. EC 2.3.1.62)
-
-
-
additional information
?
-
-
priming of Mono-Mac 6 cells by IFNgamma appears to involve LPCAT
-
-
?
additional information
?
-
-
the enzyme may mediate the priming reactions of monocytes to the cytokine interferon-gamma. The enzyme might also effect the responses of monocytes to the bacterial agent lipopolysaccharide that may be important in the development of sepsis
-
-
?
additional information
?
-
-
inhibition of Golgi complex-associated LPAT activity by the drug CI-976 stimulates Golgi tubule formation and subsequent redistribution of resident Golgi proteins to the endoplasmic reticulum, affecting secretory and endocytic membrane trafficking pathways, overview
-
-
?
additional information
?
-
a linear incorporation of labeled fatty acyl CoA into dipalmitoyl phosphatidylcholine (PC) indicates that lysophosphatidylcholine generated by Prdx6 PLA2 activity remains bound to the enzyme for the reacylation reaction
-
-
-
additional information
?
-
the enzyme is involved in dipalmitoylphosphatidylcholine synthesis
-
-
?
additional information
?
-
-
the enzyme is involved in dipalmitoylphosphatidylcholine synthesis
-
-
?
additional information
?
-
the enzyme synthesizes phosphatidylcholine in pulmonary surfactant and plays a pivotal role in respiratory physiology and in membrane biogenesis
-
-
?
additional information
?
-
-
the enzyme synthesizes phosphatidylcholine in pulmonary surfactant and plays a pivotal role in respiratory physiology and in membrane biogenesis
-
-
?
additional information
?
-
-
histone H4 protein is subject to palmitoylation catalyzed by Lpcat1 in a calcium-regulated manner. Cytosolic Lpcat1 shifts into the nucleus in lung epithelia in response to exogenous Ca2+. Nuclear Lpcat1 colocalizes with and binds to histone H4, where it catalyzes histone H4 palmitoylation. Residue Ser47 within histone H4 serves as a putative acceptor site, indicative of Lpcat1-mediated O-palmitoylation. Lpcat1 knock-down or expression of a histone H4 Ser47A mutant protein in cells decreases cellular mRNA synthesis
-
-
?
additional information
?
-
enzyme LPCAT1 directly interacts with StarD10 protein, amino acids 79-271 of LPCAT1 and the steroidogenic acute regulatory protein-related lipid transfer (START) domain of START domain-containing protein 10 (StarD10) are sufficient for this interaction. The enzyme also interacts with StarD7-I but not StarD7-II or StarD2/PCTP transfer protein
-
-
?
additional information
?
-
a linear incorporation of labeled fatty acyl CoA into dipalmitoyl phosphatidylcholine (PC) indicated that lysophosphatidylcholine generated by Prdx6 PLA2 activity remains bound to the enzyme for the reacylation reaction
-
-
-
additional information
?
-
-
a linear incorporation of labeled fatty acyl CoA into dipalmitoyl phosphatidylcholine (PC) indicated that lysophosphatidylcholine generated by Prdx6 PLA2 activity remains bound to the enzyme for the reacylation reaction
-
-
-
additional information
?
-
LPCAT3 is critical for introduction of polyunsaturated fatty acids (PUFAs), especially arachidonic acid (20:4) at the sn-2 position of various LPLs, generating various types of arachidonoyl phospholipids
-
-
-
additional information
?
-
LPCAT3 is critical for introduction of polyunsaturated fatty acids (PUFAs), especially arachidonic acid (20:4) at the sn-2 position of various LPLs, generating various types of arachidonoyl phospholipids
-
-
-
additional information
?
-
LPCAT3 is critical for introduction of polyunsaturated fatty acids (PUFAs), especially arachidonic acid (20:4) at the sn-2 position of various LPLs, generating various types of arachidonoyl phospholipids
-
-
-
additional information
?
-
LPCAT4 has lysophosphatidylethanolamine acyltransferase as well as LPCAT activity. LPCAT uses lysophosphatidylcholine (LPC) as a substrate to generate phosphatidylcholine. Preference of LPCAT4 for oleoyl-CoA during chondrogenic differentiation. LPCAT4 does not prefer linoleoyl-, (5Z,8Z,11Z,14Z)-eicosatetraenoyl-, or docosahexaenoyl-CoA. Analysis of the fatty acid composition of whole cell lysates
-
-
-
additional information
?
-
LYCAT introduces stearic acid (18:0) selectively at the sn-1 position of lysophosphatidylinositol (LPI). The enzyme also catalyzes the reacylation of lysocardiolipin to cardiolipin
-
-
-
additional information
?
-
LYCAT introduces stearic acid (18:0) selectively at the sn-1 position of lysophosphatidylinositol (LPI). The enzyme also catalyzes the reacylation of lysocardiolipin to cardiolipin
-
-
-
additional information
?
-
LYCAT introduces stearic acid (18:0) selectively at the sn-1 position of lysophosphatidylinositol (LPI). The enzyme also catalyzes the reacylation of lysocardiolipin to cardiolipin
-
-
-
additional information
?
-
Mus musculus C57BL/6J
a linear incorporation of labeled fatty acyl CoA into dipalmitoyl phosphatidylcholine (PC) indicated that lysophosphatidylcholine generated by Prdx6 PLA2 activity remains bound to the enzyme for the reacylation reaction
-
-
-
additional information
?
-
Mus musculus FVB/N
enzyme LPCAT1 directly interacts with StarD10 protein, amino acids 79-271 of LPCAT1 and the steroidogenic acute regulatory protein-related lipid transfer (START) domain of START domain-containing protein 10 (StarD10) are sufficient for this interaction. The enzyme also interacts with StarD7-I but not StarD7-II or StarD2/PCTP transfer protein
-
-
?
additional information
?
-
-
Golgi membrane tubule formation can result from increasing the content of lysophospholipids in membranes, either by stimulation of a phospholipase A2 or by inhibition of an lysophosphatidylcholine acyltransferase. The two opposing enzyme activities may help to coordinately regulate Golgi membrane shape and tubule formation
-
-
?
additional information
?
-
-
inhibition of Golgi complex-associated LPAT activity by the drug CI-976 stimulates Golgi tubule formation and subsequent redistribution of resident Golgi proteins to the endoplasmic reticulum, affecting secretory and endocytic membrane trafficking pathways, overview
-
-
?
additional information
?
-
the enzyme is involved in dipalmitoylphosphatidylcholine synthesis
-
-
?
additional information
?
-
a linear incorporation of labeled fatty acyl CoA into dipalmitoyl phosphatidylcholine (PC) indicates that lysophosphatidylcholine generated by Prdx6 PLA2 activity remains bound to the enzyme for the reacylation reaction
-
-
-
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
1-azido-oleoyl-sn-lysophosphatidylcholine
-
0.2 mM, 50% inactivation after photolysis
18-(4'-azido-2'-hydroxybenzoylamino)-oleic acid
-
0.4 mM; 73% inhibition, reversible inhibition in the dark, irreversible inactivation after photolysis, used as photoaffinity label
Ag+
-
0.000005 mM, almost complete inhibition, noncompetitive, irreversible, probably due to formation of a thiolate
Cu2+
-
0.00001 mM, 50% inhibition, noncompetitive, irreversible, probably due to formation of a thiolate
DTNB
complete inhibition of LPCAT in wild-type and in recombinant heterologous yeast microsomes
Hg2+
-
0.00001 mM, 50% inhibition, noncompetitive, irreversible, probably due to formation of a thiolate
lipopolysaccharide
suppresses the enzyme activity of isozyme LPCAT3 toward linoleoyl-CoA and arachidonoyl-CoA in phorbol 12-myristate 13-acetate-treated U-937 cells
Pb2+
-
0.00002 mM, 50% inhibition, noncompetitive, irreversible, probably due to formation of a thiolate
photooxidized phospholipids
-
0.0001-0.01 mM photoxoidized phospholipids preincubated with 0.1 mg microsomal membranes, approx. 45% loss of initial activity
-
CI-976
-
inhibition of Golgi complex-associated LPAT activity by the drug CI-976 stimulates Golgi tubule formation and subsequent redistribution of resident Golgi proteins to the endoplasmic reticulum, it prevents recycling of transferrin receptors, but does not inhibit transferrin uptake, overview
CI-976
-
complete inhibition at 0.05 mM, IC50: 0.015 mM, inhibition of Golgi complex-associated LPAT activity by the drug CI-976 stimulates Golgi tubule formation and subsequent redistribution of resident Golgi proteins to the endoplasmic reticulum, overview
Cyclic nucleotide phosphodiesterase inhibitors
-
gastric mucosa microsomes
-
N-ethylmaleimide
15 min preincubation on ice with 40 mM: activity completely abolished
N-ethylmaleimide
-
1 mM, 30% inhibition after 5 min, 95% inhibition after 45 min
p-chloromercuriphenyl sulfonic acid
-
partially restorable by dithitothreitol
palmitoyl-CoA
inhibition at higher concentrations of palmitoyl-CoA, possibly due to a detergent effect
additional information
enzyme activity can be inhibited by high levels of acyl acceptors
-
additional information
-
enzyme activity can be inhibited by high levels of acyl acceptors
-
additional information
in wild-type lamellar bodies, markedly decreased incorporation of labeled palmitate into phosphatidylcholine is observed in the presence of MJ33, an inhibitor of the PLA2 activity of Prdx6 and, therefore, an inhibitor of LPC generation. This decreased incorporation of palmitate into PC in the presence of MJ33 is reversed by the addition of exogenous LPC to the LB incubation medium. Presence of CI-976 also markedly inhibits the incorporation of palmitoyl CoA into PC, but, unlike the results with MJ33, there is no change in the inhibition with addition of LPC
-
additional information
-
in wild-type lamellar bodies, markedly decreased incorporation of labeled palmitate into phosphatidylcholine is observed in the presence of MJ33, an inhibitor of the PLA2 activity of Prdx6 and, therefore, an inhibitor of LPC generation. This decreased incorporation of palmitate into PC in the presence of MJ33 is reversed by the addition of exogenous LPC to the LB incubation medium. Presence of CI-976 also markedly inhibits the incorporation of palmitoyl CoA into PC, but, unlike the results with MJ33, there is no change in the inhibition with addition of LPC
-
additional information
-
activity is reduced in rigid membranes obtained by incorporation of sphingomyelin and dipalmitoylphosphatidylcholine
-
additional information
-
not inhibited by 2-methoxy-5-methyl-1,3,4-triacetoxybenzene and 1,4-diacetoxy-2-methoxy-5-methyl-3-tetradecanoyloxybenzene
-
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Ca2+-ionophore A23187
-
0.3 units/ml, approx. 5fold activation in endothelial cells in the presence of low-density lipoprotein
dioleoylphosphatidylcholine
-
incorporation in membrane elevates acyltransferase activity
egg yolk phosphatidylcholine
-
incorporation in membrane elevates acyltransferase activity
-
low-density lipoprotein
-
1 mg/ml, approx. 10fold activation in endothelial cells, 7fold activation in the presence of both ionomycin and 1-oleoyl-2-acetyl glycerol
-
phosphatidylethanolamine
-
incorporation in membrane elevates acyltransferase activity
phosphatidylserine
-
incorporation in membrane elevates acyltransferase activity
thrombin
-
0.3 units/ml, approx. 5fold activation in endothelial cells in the presence of low-density lipoprotein
-
phosphatidylinositol
-
incorporation in membrane elevates acyltransferase activity
additional information
glucocorticoids and fibroblast growth factor induce the enzyme
-
additional information
-
glucocorticoids and fibroblast growth factor induce the enzyme
-
additional information
lipopolysaccharide-induced phosphorylation at residue S34 leads to activation of enzyme. Phosphorylation is triggered through lipopolysaccharide-Toll like receptor 4 signalling and may directly depend on MAPK-activated protein kinase2
-
additional information
in macrophages, extracellular stimuli such as ATP, PAF, and lipopolysaccharides phosphorylate and activate LPCAT2, but not LPCAT1
-
additional information
in macrophages, extracellular stimuli such as ATP, PAF, and lipopolysaccharides phosphorylate and activate LPCAT2, but not LPCAT1
-
additional information
in macrophages, extracellular stimuli such as ATP, PAF, and lipopolysaccharides phosphorylate and activate LPCAT2, but not LPCAT1
-
additional information
glucocorticoids and fibroblast growth factor induce the enzyme
-
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.2668
NBD-labelled lysophosphatidylcholine
pH 6.0, 30°C, recombinant enzyme
-
0.0023
1-palmitoyl-lysophosphatidylcholine
pH 7.4, 30°C, recombinant enzyme
0.005
Arachidonoyl-CoA
Vmax: 12.4 pmol/min/microgram protein for arachidonoyl-CoA
0.0132
docosahexanoyl-CoA
with 1-palmitoyl-sn-glycero-3-phosphoethanolamine, pH and temperature not specified in the publication
0.00314
docosahexanoyl-CoA
with 1-octadecenyl-sn-glycero-3-phosphoethanolamine, pH and temperature not specified in the publication
additional information
additional information
-
kinetic data of soluble and liposome-bound enzyme
-
additional information
additional information
Km of NBD-lyso-PC and arachidonoyl CoA by the model of Bi-Bi reaction under optimal conditions. The theoretical Km values calculated by Bi-Bi kinetic equations are more accurate than that calculated by the Michaelis-Menten equation because the apparent Km of one substrate calculated by the Michaelis-Menten equation may be influenced by the concentration of another, whereas Bi-Bi kinetic equations could overcome this disadvantage. From the Lineweaver-Burk plots, a sequential kinetic mechanism can be proposed, but only a sequential Bi-Bi kinetic mechanism can be infered
-
additional information
additional information
-
Km of NBD-lyso-PC and arachidonoyl CoA by the model of Bi-Bi reaction under optimal conditions. The theoretical Km values calculated by Bi-Bi kinetic equations are more accurate than that calculated by the Michaelis-Menten equation because the apparent Km of one substrate calculated by the Michaelis-Menten equation may be influenced by the concentration of another, whereas Bi-Bi kinetic equations could overcome this disadvantage. From the Lineweaver-Burk plots, a sequential kinetic mechanism can be proposed, but only a sequential Bi-Bi kinetic mechanism can be infered
-
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.0132
docosahexanoyl-CoA
with 1-palmitoyl-sn-glycero-3-phosphoethanolamine, pH and temperature not specified in the publication
0.00314
docosahexanoyl-CoA
with 1-octadecenyl-sn-glycero-3-phosphoethanolamine, pH and temperature not specified in the publication
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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.02
2-methoxy-5-methyl-3-tetradecanoyloxy-1,4-benzoquinone
Rattus norvegicus
-
at pH 6.9 and 37°C
0.003
3-decanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone
Rattus norvegicus
-
at pH 6.9 and 37°C
0.139
3-hexanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone
Rattus norvegicus
-
at pH 6.9 and 37°C
0.015
CI-976
Rattus norvegicus
-
complete inhibition at 0.05 mM, IC50: 0.015 mM, inhibition of Golgi complex-associated LPAT activity by the drug CI-976 stimulates Golgi tubule formation and subsequent redistribution of resident Golgi proteins to the endoplasmic reticulum, overview
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
0.0001
-
activity in freshly prepared erythrocyte membranes with palmitoyl-CoA as acyl donor
0.0004
purified unphosphorylated recombinant mutant D31A enzyme, pH 4.0, 30°C, substrates LPC and palmitoyl CoA
0.0006
-
activity in stored erythrocyte membranes with palmitoyl-CoA as acyl donor
0.0007
-
activity in freshly prepared erythrocyte membranes with oleoyl-CoA as acyl donor
0.01
-
partially purified enzyme, 1-palmitoyl-glycero-3-phosphocholine as substrate
0.024
purified unphosphorylated recombinant enzyme, pH 7.0, 30°C, substrates LPC and palmitoyl CoA
0.028
0.042
-
integral membrane enzyme, 1-palmitoyl-glycero-3-phosphocholine as substrate
0.059
purified unphosphorylated recombinant mutant C47S enzyme, pH 4.0, 30°C, substrates LPC and palmitoyl CoA
0.064
purified unphosphorylated recombinant mutant S32A enzyme, pH 4.0, 30°C, substrates LPC and palmitoyl CoA
0.065
0.066
purified unphosphorylated recombinant mutant D140A enzyme, pH 4.0, 30°C, substrates LPC and palmitoyl CoA
0.068
purified unphosphorylated recombinant enzyme, pH 4.0, 30°C, substrates LPC and palmitoyl CoA
0.268
substrate: alpha-linolenoyl-CoA, 28°C, no cooperativity: Hill number 1.0
0.652
purified phosphorylated recombinant enzyme, pH 4.0, 30°C, substrates LPC and palmitoyl CoA
0.661
purified phosphorylated recombinant enzyme, pH 7.0, 30°C, substrates LPC and palmitoyl CoA
0.662
additional information
0.028
purified unphosphorylated recombinant enzyme, pH 7.0, 30°C, substrates LPC and palmitoyl CoA
0.065
purified unphosphorylated recombinant enzyme, pH 4.0, 30°C, substrates LPC and palmitoyl CoA
0.065
purified unphosphorylated recombinant mutant H26A enzyme, pH 4.0, 30°C, substrates LPC and palmitoyl CoA
0.065
purified unphosphorylated recombinant wild-type enzyme, pH 4.0, 30°C, substrates LPC and palmitoyl CoA
0.662
purified phosphorylated recombinant enzyme, pH 7.0, 30°C, substrates LPC and palmitoyl CoA
0.662
purified phosphorylated recombinant enzyme, pH 4.0, 30°C, substrates LPC and palmitoyl CoA
additional information
-
among all the different substrates examined, 1-myristoyl-LPC (14:0) and 1-palmitoyl-LPC (16:0) has the most robust activity, whereas no detectable activity is observed using 1-hexanoyl (6:0) and 1-arachidoyl (20:0) LPC as substrates
additional information
-
among the saturated fatty acyl-CoAs, only lauroyl-CoA has comparable activity compared with unsaturated fatty acyl-CoAs. Oleoyl-CoA (18:1), linoleoyl-CoA (18:2), and arachidonoyl-CoA (20:4) all demonstrate robust LPCAT activity
additional information
LPCAT3 exhibits the highest activity with lysophosphatidylcholine. LPCAT3 exhibits substrate preferences in the order of 1-stearoyl-2-lysophosphatidylcholine > 1-arachidoyl-2-lysophosphatidylcholine > 1-O-hexadecyl-sn-glycero-3-phosphocholine > 1-palmitoyl-2-lysophosphatidylcholine
additional information
-
LPCAT3 exhibits the highest activity with lysophosphatidylcholine. LPCAT3 exhibits substrate preferences in the order of 1-stearoyl-2-lysophosphatidylcholine > 1-arachidoyl-2-lysophosphatidylcholine > 1-O-hexadecyl-sn-glycero-3-phosphocholine > 1-palmitoyl-2-lysophosphatidylcholine
additional information
LPCAT3 is most active in utilizing linoleoyl-CoA as acyl donor. Order range: linoleoyl-CoA > palmitoyl-CoA > arachidonoyl-CoA > oleoyl-CoA > stearoyl-CoA
additional information
-
LPCAT3 is most active in utilizing linoleoyl-CoA as acyl donor. Order range: linoleoyl-CoA > palmitoyl-CoA > arachidonoyl-CoA > oleoyl-CoA > stearoyl-CoA
additional information
LPCAT activities of wild-type and mutant recombinant Prdx6, lungs isolated from wild-type and mutant mice, and lentiviral vector-infected mouse pulmonary microvascular endothelial cells (MPMVECs), overview
additional information
-
LPCAT activities of wild-type and mutant recombinant Prdx6, lungs isolated from wild-type and mutant mice, and lentiviral vector-infected mouse pulmonary microvascular endothelial cells (MPMVECs), overview
additional information
-
activity is different in either its microsomal environment or vesicles and is affected by the phospholipid molecular species environment
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6.8
7 - 8
7.2
7.4
7
-
1-acyl-sn-glycero-3-phosphocholine and 1-alkenyl-sn-glycero-3-phosphocholine acyltransferase activities
7
-
transfer of arachidonoyl-CoA is more rapid at a higher pH, liver enzyme
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6 - 10
-
pH 6.0: about 55% of maximal activity, pH 10.0: about 80% of maximal activity, Golgi-associated enzyme
6 - 12
-
activity range, 64% of maximal activity at pH 11.0, 34% at pH 12.0, and 10% at pH 6.0
6 - 9
6.5 - 8
-
pH 6.5: about 80% of maximal activity, pH 8.0: about 70% of maximal activity
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
20
25
30
37
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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
10 - 60
-
activity range, about 30% of maximal activity at 10°C, very low activity at 60°C, high activity at 20-40°C
20 - 50
-
20°C: about 55% of maximal activity, 50°C: 65% of maximal activity
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
