Information on EC 2.3.1.181 - lipoyl(octanoyl) transferase and Organism(s) Homo sapiens

for references in articles please use BRENDA:EC2.3.1.181
Word Map on EC 2.3.1.181
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Homo sapiens


The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
2.3.1.181
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RECOMMENDED NAME
GeneOntology No.
lipoyl(octanoyl) transferase
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
lipoate biosynthesis and incorporation (yeast)
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lipoate biosynthesis and incorporation I
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lipoate biosynthesis and incorporation III (Bacillus)
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lipoate biosynthesis
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Lipoic acid metabolism
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Metabolic pathways
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SYSTEMATIC NAME
IUBMB Comments
octanoyl-[acyl-carrier protein]:protein N-octanoyltransferase
This is the first committed step in the biosynthesis of lipoyl cofactor. Lipoylation is essential for the function of several key enzymes involved in oxidative metabolism, as it converts apoprotein into the biologically active holoprotein. Examples of such lipoylated proteins include pyruvate dehydrogenase (E2 domain), 2-oxoglutarate dehydrogenase (E2 domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein) [2,3]. Lipoyl-ACP can also act as a substrate [4] although octanoyl-ACP is likely to be the true substrate [6]. The other enzyme involved in the biosynthesis of lipoyl cofactor is EC 2.8.1.8, lipoyl synthase. An alternative lipoylation pathway involves EC 6.3.1.20, lipoate---protein ligase, which can lipoylate apoproteins using exogenous lipoic acid (or its analogues).
CAS REGISTRY NUMBER
COMMENTARY hide
392687-64-8
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