Reference on EC 2.3.1.135 - phosphatidylcholine-retinol O-acyltransferase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Saari, J.C.; Bredberg, D.L.
Acyl-CoA:retinol acyltransferase and lecithin:retinol acyltransferase activities of bovine retinal pigment epithelial microsomes
Methods Enzymol.
190
156-163
1990
Bos taurus, Rattus norvegicus
Saari, J.C.; Bredberg, D.L.
Lecithin:retinol acyltransferase in retinal pigment epithelial microsomes
J. Biol. Chem.
264
8636-8640
1989
Bos taurus
MacDonald, P.N.; Ong, D.E.
Evidence for a lecithin-retinol acyltransferase activity in the rat small intestine
J. Biol. Chem.
263
12478-12482
1988
Rattus norvegicus
Shi, Y.Q.; Hubacek, I.; Rando, R.R.
Kinetic mechanism of lecithin retinol acyl transferase
Biochemistry
32
1257-1263
1993
Bos taurus
Herr, F.M.; Ong, D.E.
Differential interaction of lecithin-retinol acyltransferase with cellular retinol binding proteins
Biochemistry
31
6748-6755
1992
Rattus norvegicus
MacDonald, P.N.; Ong, D.E.
A lecithin:retinol acyltransferase activity in human and rat liver
Biochem. Biophys. Res. Commun.
156
157-163
1988
Homo sapiens, Rattus norvegicus
Matsuura, T.; Ross, A.C.
Regulation of hepatic lecithin:retinol acyltransferase activity by retinoic acid
Arch. Biochem. Biophys.
301
221-227
1993
Rattus norvegicus
Saari, J.C.; Bredberg, D.L.; Farrell, D.F.
Retinol esterification in bovine retinal pigment epithelium: reversibility of lecithin:retinol acyltransferase
Biochem. J.
291
697-700
1993
Bos taurus
-
Matsuura, T.; Gad, M.Z.; Harrison, E.H.; Ross, A.C.
Lecithin:retinol acyltransferase and retinyl ester hydrolase activities are differentially regulated by retinoids and have distinct distributions between hepatocyte and nonparenchymal cell fractions of rat liver
J. Nutr.
127
218-224
1997
Rattus norvegicus
Ruiz, A.; Winston, A.; Lim, Y.H.; Gilbert, B.A.; Rando, R.R.; Bok, D.
Molecular and biochemical characterization of lecithin retinol acyltransferase
J. Biol. Chem.
274
3834-3841
1999
Bos taurus, Homo sapiens (O95237), Homo sapiens
Mondal, M.S.; Ruiz, A.; Bok, D.; Rando, R.R.
Lecithin retinol acyltransferase contains cysteine residues essential for catalysis
Biochemistry
39
5215-5220
2000
Homo sapiens
Zolfaghari, R.; Ross, A.C.
Lecithin:retinol acyltransferase from mouse and rat liver: cDNA cloning and liver-specific regulation by dietary vitamin A and retinoic acid
J. Lipid Res.
41
2024-2034
2000
Mus musculus (Q9JI60), Rattus norvegicus (Q9JI61)
Ruiz, A.; Bok, D.
Molecular characterization of lecithin-retinol acyltransferase
Methods Enzymol.
316
400-413
2000
Bos taurus, Homo sapiens
Mondal, M.S.; Ruiz, A.; Hu, J.; Bok, D.; Rando, R.R.
Two histidine residues are essential for catalysis by lecithin retinol acyl transferase
FEBS Lett.
489
14-18
2001
Bos taurus, Homo sapiens
Guo, X.; Knudsen, B.S.; Peehl, D.M.; Ruiz, A.; Bok, D.; Rando, R.R.; Rhim, J.S.; Nanus, D.M.; Gudas, L.J.
Retinol metabolism and lecithin:retinol acyltransferase levels are reduced in cultured human prostate cancer cells and tissue specimens
Cancer Res.
62
1654-1661
2002
Homo sapiens
Jahng, W.J.; Cheung, E.; Rando, R.R.
Lecithin retinol acyltransferase forms functional homodimers
Biochemistry
41
6311-6319
2002
Bos taurus
Zolfaghari, R.; Wang, Y.; Chen, Q.; Sancher, A.; Ross, A.C.
Cloning and molecular expression analysis of large and small lecithin:retinol acyltransferase mRNAs in the liver and other tissues of adult rats
Biochem. J.
368
621-631
2002
Rattus norvegicus (Q9JI61)
Rando, R.R.
Membrane-bound lecithin-retinol acyltransferase
Biochem. Biophys. Res. Commun.
292
1243-1250
2002
Bos taurus, Homo sapiens, Rattus norvegicus
Jahng, W.J.; Xue, L.; Rando, R.R.
Lecithin retinol acyltransferase is a founder member of a novel family of enzymes
Biochemistry
42
12805-12812
2003
Homo sapiens (O95237)
Bok, D.; Ruiz, A.; Yaron, O.; Jahng, W.J.; Ray, A.; Xue, L.; Rando, R.R.
Purification and characterization of a transmembrane domain-deleted form of lecithin retinol acyltransferase
Biochemistry
42
6090-6098
2003
Homo sapiens
Xue, L.; Rando, R.R.
Roles of cysteine 161 and tyrosine 154 in the lecithin-retinol acyltransferase mechanism
Biochemistry
43
6120-6126
2004
Homo sapiens (O95237)
Hoegberg, P.; Schmidt, C.K.; Nau, H.; Catharine Ross, A.; Zolfaghari, R.; Fletcher, N.; Trossvik, C.; Nilsson, C.B.; Hakansson, H.
2,3,7,8-Tetrachlorodibenzo-p-dioxin induces lecithin: retinol acyltransferase transcription in the rat kidney
Chem. Biol. Interact.
145
1-16
2003
Rattus norvegicus
Zhan, H.C.; Gudas, L.J.; Bok, D.; Rando, R.; Nanus, D.M.; Tickoo, S.K.
Differential expression of the enzyme that esterifies retinol, lecithin:retinol acyltransferase, in subtypes of human renal cancer and normal kidney
Clin. Cancer Res.
9
4897-4905
2003
Homo sapiens
Trevino, S.G.; Schuschereba, S.T.; Bowman, P.D.; Tsin, A.
Lecithin:retinol acyltransferase in ARPE-19
Exp. Eye Res.
80
897-900
2005
Homo sapiens, no activity in Gallus gallus
Kaschula, C.H.; Jin, M.H.; Desmond-Smith, N.S.; Travis, G.H.
Acyl CoA:retinol acyltransferase (ARAT) activity is present in bovine retinal pigment epithelium
Exp. Eye Res.
82
111-121
2005
Bos taurus
Zolfaghari, R.; Ross, A.C.
Cloning, gene organization and identification of an alternative splicing process in lecithin:retinol acyltransferase cDNA from human liver
Gene
341
181-188
2004
Homo sapiens (O95237)
Batten, M.L.; Imanishi, Y.; Maeda, T.; Tu, D.C.; Moise, A.R.; Bronson, D.; Possin, D.; Van Gelder, R.N.; Baehr, W.; Palczewski, K.
Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver
J. Biol. Chem.
279
10422-10432
2004
Mus musculus
Muniz, A.; Villazana-Espinoza, E.T.; Thackeray, B.; Tsin, A.T.
11-cis-Acyl-CoA:retinol O-acyltransferase activity in the primary culture of chicken Muller cells
Biochemistry
45
12265-12273
2006
Gallus gallus
Sheren-Manoff, M.; Shin, S.J.; Su, D.; Bok, D.; Rando, R.R.; Gudas, L.J.
Reduced lecithin:retinol acyltransferase expression in human breast cancer
Int. J. Oncol.
29
1193-1199
2006
Homo sapiens
Piantedosi, R.; Ghyselinck, N.; Blaner, W.S.; Vogel, S.
Cellular retinol-binding protein type III is needed for retinoid incorporation into milk
J. Biol. Chem.
280
24286-24292
2005
Mus musculus, Mus musculus C57/BL6J
O'Byrne, S.M.; Wongsiriroj, N.; Libien, J.; Vogel, S.; Goldberg, I.J.; Baehr, W.; Palczewski, K.; Blaner, W.S.
Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT)
J. Biol. Chem.
280
35647-35657
2005
Mus musculus
Golczak, M.; Imanishi, Y.; Kuksa, V.; Maeda, T.; Kubota, R.; Palczewski, K.
Lecithin:retinol acyltransferase is responsible for amidation of retinylamine, a potent inhibitor of the retinoid cycle
J. Biol. Chem.
280
42263-42273
2005
Bos taurus, Mus musculus
Moise, A.R.; Golczak, M.; Imanishi, Y.; Palczewski, K.
Topology and membrane association of lecithin: retinol acyltransferase
J. Biol. Chem.
282
2081-2090
2007
Mus musculus
Jin, M.; Yuan, Q.; Li, S.; Travis, G.H.
Role of LRAT on the retinoid isomerase activity and membrane association of Rpe65
J. Biol. Chem.
282
20915-20924
2007
Bos taurus, Mus musculus, Mus musculus 129S2/Sv
Sweeney, M.O.; McGee, T.L.; Berson, E.L.; Dryja, T.P.
Low prevalence of lecithin retinol acyltransferase mutations in patients with Leber congenital amaurosis and autosomal recessive retinitis pigmentosa
Mol. Vis.
13
588-593
2007
Homo sapiens
Liu, L.; Tang, X.H.; Gudas, L.J.
Homeostasis of retinol in lecithin: retinol acyltransferase gene knockout mice fed a high retinol diet
Biochem. Pharmacol.
75
2316-2324
2008
Mus musculus (Q9JI60)
Bussieres, S.; Buffeteau, T.; Desbat, B.; Breton, R.; Salesse, C.
Secondary structure of a truncated form of lecithin retinol acyltransferase in solution and evidence for its binding and hydrolytic action in monolayers
Biochim. Biophys. Acta
1778
1324-1334
2008
Escherichia coli BL21
Cai, K.; Gudas, L.J.
Retinoic acid receptors and GATA transcription factors activate the transcription of the human lecithin:retinol acyltransferase gene
Int. J. Biochem. Cell Biol.
41
546-553
2009
Homo sapiens
Kim, Y.K.; Wassef, L.; Hamberger, L.; Piantedosi, R.; Palczewski, K.; Blaner, W.S.; Quadro, L.
Retinyl ester formation by lecithin: retinol acyltransferase is a key regulator of retinoid homeostasis in mouse embryogenesis
J. Biol. Chem.
283
5611-5621
2008
Mus musculus
Nagatsuma, K.; Hayashi, Y.; Hano, H.; Sagara, H.; Murakami, K.; Saito, M.; Masaki, T.; Lu, T.; Tanaka, M.; Enzan, H.; Aizawa, Y.; Tajiri, H.; Matsuura, T.
Lecithin: retinol acyltransferase protein is distributed in both hepatic stellate cells and endothelial cells of normal rodent and human liver
Liver Int.
29
47-54
2009
Mus musculus, Homo sapiens (O95237), Homo sapiens
Tang, X.H.; Su, D.; Albert, M.; Scognamiglio, T.; Gudas, L.J.
Overexpression of lecithin:retinol acyltransferase in the epithelial basal layer makes mice more sensitive to oral cavity carcinogenesis induced by a carcinogen
Cancer Biol. Ther.
8
1212-1213
2009
Homo sapiens
Amann, P.M.; Luo, C.; Owen, R.W.; Hofmann, C.; Freudenberger, M.; Schadendorf, D.; Eichmueller, S.B.; Bazhin, A.V.
Vitamin A metabolism in benign and malignant melanocytic skin cells: importance of lecithin/retinol acyltransferase and RPE65
J. Cell. Physiol.
227
718-728
2012
Homo sapiens
Jiang, W.; Napoli, J.L.
Reorganization of cellular retinol-binding protein type 1 and lecithin:retinol acyltransferase during retinyl ester biosynthesis
Biochim. Biophys. Acta
1820
859-869
2012
Homo sapiens
Ruiz, A.; Bok, D.
Focus on molecules: lecithin retinol acyltransferase
Exp. Eye Res.
90
186-187
2010
Homo sapiens, Mus musculus
Bussieres, S.; Cantin, L.; Salesse, C.
Lecithin retinol acyltransferase and its S175R mutant have a similar secondary structure content and maximum insertion pressure but different enzyme activities
Exp. Eye Res.
93
778-781
2011
Homo sapiens
Amengual, J.; Golczak, M.; Palczewski, K.; von Lintig, J.
Lecithin:retinol acyltransferase is critical for cellular uptake of vitamin A from serum retinol-binding protein
J. Biol. Chem.
287
24216-24227
2012
Mus musculus, Mus musculus C57/BL6J / 129 Sv
Bussieres, S.; Cantin, L.; Desbat, B.; Salesse, C.
Binding of a truncated form of lecithin:retinol acyltransferase and its N- and C-terminal peptides to lipid monolayers
Langmuir
28
3516-3523
2012
Homo sapiens
Kida, Y.; Xia, Z.; Zheng, S.; Mordwinkin, N.M.; Louie, S.G.; Zheng, S.G.; Feng, M.; Shi, H.; Duan, Z.; Han, Y.P.
Interleukin-1 as an injury signal mobilizes retinyl esters in hepatic stellate cells through down regulation of lecithin retinol acyltransferase
PLoS ONE
6
e26644
2011
Rattus norvegicus
Horchani, H.; Bussires, S.; Cantin, L.; Lhor, M.; Lalibert-Gemme, J.S.; Breton, R.; Salesse C.
Enzymatic activity of lecithin:retinol acyltransferase: a thermostable and highly active enzyme with a likely mode of interfacial activation
Biochim. Biophys. Acta
1844
1128-1836
2014
Homo sapiens (O95237)
Hassel, J.C.; Amann, P.M.; Schadendorf, D.; Eichmueller, S.B.; Nagler, M.; Bazhin, A.V.
Lecithin retinol acyltransferase as a potential prognostic marker for malignant melanoma
Exp. Dermatol.
22
757-759
2013
Homo sapiens
Golczak, M.; Sears, A.E.; Kiser, P.D.; Palczewski, K.
LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3
Nat. Chem. Biol.
11
26-32
2015
Mus musculus (Q9JI60)
Prukova, D.; Ileninova, Z.; Antosova, B.; Kasparek, P.; Gregor, M.; Sedlacek, R.
Transgenic reporter mice with promoter region of murine LRAT specifically marks lens and meiosis spermatocytes
Physiol. Res.
64
247-254
2015
Mus musculus
Gauthier, M.E.; Roy, S.; Cantin, L.; Salesse, C.
Comparison between the enzymatic activity, structure and substrate binding of mouse and human lecithin retinol acyltransferase
Biochem. Biophys. Res. Commun.
519
832-837
2019
Homo sapiens (O95237), Homo sapiens, Mus musculus (Q9JI60), Mus musculus
Chelstowska, S.; Widjaja-Adhi, M.A.K.; Silvaroli, J.A.; Golczak, M.
Impact of LCA-associated E14L LRAT mutation on protein stability and retinoid homeostasis
Biochemistry
56
4489-4499
2017
Homo sapiens (O95237)
Ajat, M.; Molenaar, M.; Brouwers, J.F.H.M.; Vaandrager, A.B.; Houweling, M.; Helms, J.B.
Hepatic stellate cells retain the capacity to synthesize retinyl esters and to store neutral lipids in small lipid droplets in the absence of LRAT
Biochim. Biophys. Acta
1862
176-187
2017
Homo sapiens (O95237), Mus musculus (Q9JI60)
Liang, X.; He, Y.; Chen, M.; Ping, Q.; Chen, J.
The association of lecithin retinol acyltransferase and the 25(OH)D receptor with pediatric overweight and obesity
Eur. J. Clin. Nutr.
73
1626-1629
2019
Homo sapiens (O95237), Homo sapiens
Mezaki, Y.; Nagatsuma, K.; Yokoyama, H.; Park, J.; Nakamura, M.; Masaki, T.; Blomhoff, R.; Senoo, H.; Matsuura, T.
Biochemical and histochemical analyses of lecithin retinol acyltransferase from polar bear (Ursus maritimus) livers
Polar Biol.
41
805-815
2018
Ursus maritimus (A0A384BN88)
-
html completed
