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IUBMB Comments A number of acyl-CoAs can act as acyl donor; maximum activity is obtained with linoleoyl-CoA. Not identical with EC 2.3.1.20 diacylglycerol O- acyltransferase.
The expected taxonomic range for this enzyme is: Homo sapiens
Synonyms 1-hexadecyl-2-acetylglycerol acyltransferase, acyltransferase, 1-hexadecyl-2-acetylglycerol, more
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1-hexadecyl-2-acetylglycerol acyltransferase
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acyltransferase, 1-hexadecyl-2-acetylglycerol
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acyl-CoA + 1-O-alkyl-2-acetyl-sn-glycerol = CoA + 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol
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Acyl group transfer
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acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol O-acyltransferase
A number of acyl-CoAs can act as acyl donor; maximum activity is obtained with linoleoyl-CoA. Not identical with EC 2.3.1.20 diacylglycerol O-acyltransferase.
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linoleoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol
CoA + 1-O-hexadecyl-2-acetyl-3-linoleoyl-sn-glycerol
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Substrates: best substrate, not acetyl-CoA Products: -
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additional information
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Substrates: related to platelet-activating factor metabolism Products: -
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additional information
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Substrates: related to platelet-activating factor metabolism Products: -
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additional information
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no metal ion requirement
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1-O-Hexadecyl-2-oleoyl-sn-glycerol
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competitive inhibitor of 1-hexadecyl-2-acetyl-3-acyl-sn-glycerol synthesis
1-oleoyl-2-acetyl-sn-glycerol
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mixed-type inhibition
Ca2+
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6% inhibition at 2 mM
Cu2+
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96% inhibition at 2 mM
Mn2+
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35% inhibition at 2 mM
Zn2+
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93% inhibition at 2 mM
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bovine serum albumin
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activation, molar ratio substrate linoleoyl-CoA/albumin: 2:4:1
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0.032
1-O-Hexadecyl-2-oleoyl-sn-glycerol
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brenda
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brenda
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brenda
Highest Expressing Human Cell Lines
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58
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50% activity after 15 min
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Kawasaki, T.; Snyder, F.
Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells [published erratum appears in J Biol Chem 1988 Jul 25;263(21):10539]
J. Biol. Chem.
263
2593-2596
1988
Homo sapiens
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