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Information on EC 2.3.1.114 - 3,4-dichloroaniline N-malonyltransferase
for references in articles please use BRENDA:EC2.3.1.114
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EC Tree 2 Transferases
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.114 3,4-dichloroaniline N-malonyltransferase
The enzyme appears in viruses and cellular organisms
showSynonyms
DCA-N-MT, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
DCA-N-MT
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
malonyl-CoA + 3,4-dichloroaniline = CoA + N-(3,4-dichlorophenyl)-malonamate
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Acyl group transfer
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-
-
-
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SYSTEMATIC NAME
IUBMB Comments
malonyl-CoA:3,4-dichloroaniline N-malonyltransferase
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CAS REGISTRY NUMBER
COMMENTARY
94489-99-3
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
malonyl-CoA + 2,3,4,5-tetrachloroaniline
CoA + N-(2,3,4,5-tetrachlorophenyl)-malonamate
-
Substrates: 29% of activity with 3,4-dichloroaniline
Products: -
Products: -
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malonyl-CoA + 2,3,4-trichloroaniline
CoA + N-(2,3,4-trichlorophenyl)-malonamate
-
Substrates: 50% of activity with 3,4-dichloroaniline
Products: -
Products: -
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malonyl-CoA + 2,4,5-trichloroaniline
CoA + N-(2,4,5-trichlorophenyl)-malonamate
-
Substrates: 22% of activity with 3,4-dichloroaniline
Products: -
Products: -
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malonyl-CoA + 2,4-dichloroaniline
CoA + N-(2,4-dichlorophenyl)-malonamate
-
Substrates: 53% of activity with 3,4-dichloroaniline
Products: -
Products: -
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malonyl-CoA + 2,5-dichloroaniline
CoA + N-(2,5-dichlorophenyl)-malonamate
-
Substrates: 53% of activity with 3,4-dichloroaniline
Products: -
Products: -
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malonyl-CoA + 2-chloroaniline
CoA + N-(2-chlorophenyl)-malonamate
-
Substrates: 61% of activity with 3,4-dichloroaniline
Products: -
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malonyl-CoA + 3,4,5-trichloroaniline
CoA + N-(3,4,5-trichloro-phenyl)-malonamate
-
Substrates: 30% of activity with 3,4-dichloroaniline
Products: -
Products: -
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malonyl-CoA + 3,4,5-trichloroaniline
CoA + N-(3,4,5-trichlorophenyl)-malonamate
-
Substrates: 72% of activity with 3,4-dichloroaniline
Products: -
Products: -
?
malonyl-CoA + 3,5-dichloroaniline
CoA + N-(3,5-dichlorophenyl)-malonamate
-
Substrates: 48% of activity with 3,4-dichloroaniline
Products: -
Products: -
?
malonyl-CoA + 3-chloroaniline
CoA + N-(3-chlorophenyl)-malonamate
-
Substrates: 67% of activity with 3,4-dichloroaniline
Products: -
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?
malonyl-CoA + 4-aminophenol
CoA + N-(phenyl)-malonamate
-
Substrates: 20% of activity with 3,4-dichloroaniline
Products: -
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malonyl-CoA + 4-bromoaniline
CoA + N-(4-bromophenyl)-malonamate
-
Substrates: 75% of activity with 3,4-dichloroaniline
Products: -
Products: -
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malonyl-CoA + 4-chloroaniline
CoA + N-(4-chlorophenyl)-malonamate
-
Substrates: 87% of activity with 3,4-dichloroaniline
Products: -
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malonyl-CoA + 4-nitroaniline
CoA + N-(4-nitrophenyl)-malonamate
-
Substrates: 43% of activity with 3,4-dichloroaniline
Products: -
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malonyl-CoA + 7-amino-4-methylcoumarin
N-(4-methylcoumaryl)-7-malonamate
-
Substrates: 70% of activity with 3,4-dichloroaniline
Products: -
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malonyl-CoA + 3,4-dichloroaniline
CoA + N-(3,4-dichlorophenyl)-malonamate
-
Substrates: -
Products: -
Products: -
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malonyl-CoA + 3,4-dichloroaniline
CoA + N-(3,4-dichlorophenyl)-malonamate
-
Substrates: enzyme is involved in detoxification of 3,4-dichloroaniline
Products: -
Products: -
?
malonyl-CoA + 3,4-dichloroaniline
CoA + N-(3,4-dichlorophenyl)-malonamate
Arachis hypogaea ssp. fastigiata
-
Substrates: -
Products: -
Products: -
?
malonyl-CoA + 3,4-dichloroaniline
CoA + N-(3,4-dichlorophenyl)-malonamate
-
Substrates: -
Products: -
Products: -
?
malonyl-CoA + 3,4-dichloroaniline
CoA + N-(3,4-dichlorophenyl)-malonamate
-
Substrates: preferred substrate
Products: -
Products: -
?
malonyl-CoA + 3,4-dichloroaniline
CoA + N-(3,4-dichlorophenyl)-malonamate
-
Substrates: enzyme is involved in detoxification of 3,4-dichloroaniline
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
malonyl-CoA + 3,4-dichloroaniline
CoA + N-(3,4-dichlorophenyl)-malonamate
-
Substrates: enzyme is involved in detoxification of 3,4-dichloroaniline
Products: -
Products: -
?
malonyl-CoA + 3,4-dichloroaniline
CoA + N-(3,4-dichlorophenyl)-malonamate
-
Substrates: enzyme is involved in detoxification of 3,4-dichloroaniline
Products: -
Products: -
?
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
4-chloromercuribenzoate
-
0.1 mM, complete inhibition, activity can be restored by incubation with 2 mM dithiothreitol for 30 min at 0°C
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
ammonium sulfate, DEAE-cellulose, Blue Sepharose, Acrylex P-100, Matrix gel green
Arachis hypogaea ssp. fastigiata
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ammonium sulfate, ion-exchange, Sephadex G-100, hydrophobic interaction, gel filtration
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Matern, U.; Feser, C.; Heller, W.
N-Malonyltransferases from peanut
Arch. Biochem. Biophys.
235
218-227
1984
Arachis hypogaea ssp. fastigiata
brenda
Sandermann, Jr.H.; Schmitt, r.; Eckey, H.; Bauknecht, T.
Plant biochemistry of xenobiotics: isolation and properties of soybean O- and N-glucosyl and O- and N-malonyltransferases for chlorinated phenols and anilines
Arch. Biochem. Biophys.
287
341-350
1991
Glycine max
brenda
Schmidt, B.; Rivero, C.; Thiede, B.
3,4-Dichloroaniline N-glucosyl- and N-malonyltransferase activities in cell cultures and plants of soybean and wheat
Phytochemistry
39
81-84
1995
Glycine max, no activity in Triticum aestivum
-
brenda
Lao, S.H.; Loutre, C.; Brazier, M.; Coleman, J.O.D.; Cole, D.J.; Edwards, R.; Theodoulou, F.L.
3,4-Dichloroaniline is detoxified and exported via different pathways in Arabidopsis and soybean
Phytochemistry
63
653-661
2003
Arabidopsis thaliana, Glycine max
brenda
EXTERNAL LINKS (specific for EC-Number 2.3.1.114)
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Release 2023.1 (January 2023)
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