Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Disease on EC 2.1.2.3 - phosphoribosylaminoimidazolecarboxamide formyltransferase

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism.
Arthritis
5-Aminoimidazole-4-carboxamide ribonucleotide-transformylase and inosine-triphosphate-pyrophosphatase genes variants predict remission rate during methotrexate therapy in patients with juvenile idiopathic arthritis.
Association of the 5-aminoimidazole-4-carboxamide ribonucleotide transformylase gene with response to methotrexate in juvenile idiopathic arthritis.
Arthritis, Juvenile
5-Aminoimidazole-4-carboxamide ribonucleotide-transformylase and inosine-triphosphate-pyrophosphatase genes variants predict remission rate during methotrexate therapy in patients with juvenile idiopathic arthritis.
Association of the 5-aminoimidazole-4-carboxamide ribonucleotide transformylase gene with response to methotrexate in juvenile idiopathic arthritis.
Arthritis, Rheumatoid
Association of the ATIC 347 C/G polymorphism with responsiveness to and toxicity of methotrexate in rheumatoid arthritis: a meta-analysis.
Effects of methotrexate on nucleotide pools in normal human T cells and the CEM T cell line.
Evidence for the hypothesis that 10-formyldihydrofolate is the in vivo substrate for aminoimidazolecarboxamide ribotide transformylase.
Metabolism-blocked antifolates as potential anti-rheumatoid arthritis agents: 4-amino-4-deoxy-5,8,10-trideazapteroyl-d,l-4'-methyleneglutamic acid (CH-1504) and its analogs.
Ataxia Telangiectasia
DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy.
Breast Neoplasms
Proteomic analysis of human macrophages exposed to hypochlorite-oxidized low-density lipoprotein.
Targeting tumour proliferation with a small-molecule inhibitor of AICAR transformylase homodimerization.
Carcinogenesis
The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Inhibits Hepatosteatosis and Liver Tumorigenesis in a High-Fat Diet Murine Model Treated with Diethylnitrosamine (DEN).
Carcinoma
Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Selection.
Carcinoma, Hepatocellular
The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Inhibits Hepatosteatosis and Liver Tumorigenesis in a High-Fat Diet Murine Model Treated with Diethylnitrosamine (DEN).
Diabetes, Gestational
AMP-Activated Protein (AMPK) in Pathophysiology of Pregnancy Complications.
Fetal Growth Retardation
AMP-Activated Protein (AMPK) in Pathophysiology of Pregnancy Complications.
Graft vs Host Disease
Cyclosporine and methotrexate-related pharmacogenomic predictors of acute graft-versus-host disease.
Huntington Disease
AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease.
AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3.
Infections
The Mesorhizobium loti purB gene is involved in infection thread formation and nodule development in Lotus japonicus.
Insulin Resistance
Serum Is Not Necessary for Prior Pharmacological Activation of AMPK to Increase Insulin Sensitivity of Mouse Skeletal Muscle.
Kidney Failure, Chronic
Podocytes maintain high basal levels of autophagy independent of mtor signaling.
Leukemia
5-Aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase from human CCRF-CEM leukemia cells: purification, pH dependence, and inhibitors.
Dual effects of pyrazofurin and 3-deazauridine upon pyrimidine and purine biosynthesis in mouse L1210 leukemia.
Lung Injury
AICAR decreases acute lung injury by phosphorylating AMPK and upregulating heme oxygenase-1.
Neoplasms
AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3.
Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models.
Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening.
Differential effects of AMPK agonists on cell growth and metabolism.
Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors.
Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model.
DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy.
Peptide YY (PYY) Is Expressed in Human Skeletal Muscle Tissue and Expanding Human Muscle Progenitor Cells.
STYK1 promotes autophagy through enhancing the assembly of autophagy-specific class III phosphatidylinositol 3-kinase complex I.
Targeting tumour proliferation with a small-molecule inhibitor of AICAR transformylase homodimerization.
Nephrosis
Podocytes maintain high basal levels of autophagy independent of mtor signaling.
Ovarian Neoplasms
Activation of AMP-activated Protein Kinase by Metformin Induces Protein Acetylation in Prostate and Ovarian Cancer Cells.
Pre-Eclampsia
AMP-Activated Protein (AMPK) in Pathophysiology of Pregnancy Complications.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Novel pyrrolo[2,3-d]pyrimidine antifolate TNP-351: cytotoxic effect on methotrexate-resistant CCRF-CEM cells and inhibition of transformylases of de novo purine biosynthesis.
Pregnancy Complications
AMP-Activated Protein (AMPK) in Pathophysiology of Pregnancy Complications.
Premature Birth
AMP-Activated Protein (AMPK) in Pathophysiology of Pregnancy Complications.
Psoriasis
Outcomes of methotrexate therapy for psoriasis and relationship to genetic polymorphisms.
Sepsis
Activation of AMP-activated protein kinase during sepsis/inflammation improves survival by preserving cellular metabolic fitness.
Starvation
Metabolomics profiling of metformin-mediated metabolic reprogramming bypassing AMPK?.
Tuberculosis
Structural analyses of a purine biosynthetic enzyme from Mycobacterium tuberculosis reveal a novel bound nucleotide.
Tuberous Sclerosis
Podocytes maintain high basal levels of autophagy independent of mtor signaling.
Venous Thrombosis
Associations of common polymorphisms in the thymidylate synthase, reduced folate carrier and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase genes with folate and homocysteine levels and venous thrombosis risk.