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EC unknown
Reaction Schemes
+
a [corrinoid protein]
=
a [methyl-corrinoid protein]
+
Synonyms C7955_113110 , MtyB,
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C7955_113110
A0A317RJG9
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gamma-butyrobetaine + a [corrinoid protein] = a [methyl-corrinoid protein] + 4-(dimethylamino)butanoic acid
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-
-
-
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gamma-butyrobetaine:[corrinoid-binding protein] Co-methyltransferase
-
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choline + [corrinoid-binding protein Co(I)-MtqC]
[methyl-corrinoid-protein Co(I)-MtqC] + 2-(dimethylamino)ethan-1-ol
A0A317RJG9
Substrates: -
?
gamma-butyrobetaine + [corrinoid-binding protein Co(I)-MtqC]
[methyl-corrinoid-protein Co(I)-MtqC] + 4-(dimethylamino)butanoate
A0A317RJG9
Substrates: -
?
glycine betaine + [corrinoid-binding protein Co(I)-MtqC]
[methyl-corrinoid-protein Co(I)-MtqC] + N-dimethylglycine
A0A317RJG9
Substrates: -
?
L-carnitine + [corrinoid-binding protein Co(I)-MtqC]
[methyl-corrinoid-protein Co(I)-MtqC] + L-norcarnitine
A0A317RJG9
Substrates: -
?
proline betaine + [corrinoid-binding protein Co(I)-MtqC]
[methyl-corrinoid-protein Co(I)-MtqC] + N-methylproline
A0A317RJG9
Substrates: -
?
additional information
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A0A317RJG9
Substrates: demethylation of other methylated amines occurs at much lower rates than observed with gamma-butyrobetaine or L-carnitine as a substrate
?
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3.5
gamma-butyrobetaine
A0A317RJG9
pH 7.2, 37°C
4
L-carnitine
A0A317RJG9
pH 7.2, 37°C
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3
gamma-butyrobetaine
A0A317RJG9
pH 7.2, 37°C
6.8
L-carnitine
A0A317RJG9
pH 7.2, 37°C
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-
A0A317RJG9
UniProt
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Highest Expressing Human Cell Lines
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Cell Line Links
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physiological function
A0A317RJG9
proteins MtyB, MtqC (a corrinoid-binding protein), and MtqA (a corrinoid:tetrahydrofolate methyltransferase) are significantly elevated in gamma-butyrobetaine-grown cells. Together, they act as a gamma-butyrobetaine:tetrahydrofolate methyltransferase system, forming a key intermediate of acetogenesis. Recombinant MtyB acts as a gamma-butyrobetaine:MtqC methyltransferase but cannot methylate free cobalamin cofactor
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MtyB constitutes 0.9 mol% from gamma-butyrobetaine-grown cells but is not detectable in the proteome of cells grown on lactate
A0A317RJG9
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Ellenbogen, J.; Jiang, R.; Kountz, D.; Zhang, L.; Krzycki, J.
The MttB superfamily member MtyB from the human gut symbiont Eubacterium limosum is a cobalamin-dependent gamma-butyrobetaine methyltransferase
J. Biol. Chem.
297
101327
2021
Eubacterium limosum (A0A317RJG9)
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