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Homo sapiens
Q6IN84
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Information on EC 2.1.1.B125 - 16S rRNA (guanine1145-2'-O)-methyltransferase
for references in articles please use BRENDA:EC2.1.1.B125
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EC unknown
preliminary BRENDA-supplied EC number
EC Tree
2 Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.B125 16S rRNA (guanine1145-2'-O)-methyltransferase
The expected taxonomic range for this enzyme is: Homo sapiens
Reaction Schemes
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guanine1145 in 16S rRNA
+
S-adenosyl-L-methionine
=
2'-O-methylguanine1145 in 16S rRNA
+
S-adenosyl-L-homocysteine
guanine1145 in 16S rRNA
+
=
2'-O-methylguanine1145 in 16S rRNA
+
Synonyms
MRM1,
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SYNONYM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
MRM1
Homo sapiens
Q6IN84
-
757147
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Go to Reaction Search
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
guanine1145 in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanine1145 in 16S rRNA + S-adenosyl-L-homocysteine
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Go to Systematic Name Search
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:16S rRNA (guanine1145-2'-O-)-methyltransferase
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
guanine1145 in 16S rRNA + S-adenosyl-L-methionine
2'-O-methylguanine1145 in 16S rRNA + S-adenosyl-L-homocysteine
Homo sapiens
Q6IN84
757147
Substrates: -
Products: -
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
guanine1145 in 16S rRNA + S-adenosyl-L-methionine
2'-O-methylguanine1145 in 16S rRNA + S-adenosyl-L-homocysteine
Homo sapiens
Q6IN84
757147
Substrates: -
Products: -
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only manually annotated data
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AMENDA
enzyme occurrence in organism, localization and source tissue with reliability ranks
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enzyme occurrence in organism, localization and source tissue with reliability ranks
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FRENDA
co-occurrence of enzyme names and organism names (less precise)
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Homo sapiens
-
757147
Q6IN84
UniProt
brenda
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enzyme occurrence in organism, localization and source tissue with reliability ranks
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
HEK-293 cell
Homo sapiens
Q6IN84
-
757147
brenda
HeLa cell
Homo sapiens
Q6IN84
-
757147
brenda
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Go to Localization Search
only manually annotated data
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enzyme occurrence in organism, localization and source tissue with reliability ranks
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
mitochondrion
Homo sapiens
Q6IN84
-
5739
757147
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Go to General Information Search
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
Homo sapiens
Q6IN84
knockdown of MRM1 significantly increases accessibility of 16 S rRNA to DNAzyme cleavage at residue G1145
757147
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Go to AA Sequence and Transmembrane Helices Search
Go to Localization Prediction
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
Q6IN84
pBLAST
MRM1_HUMAN
Homo sapiens
353
0
38638
Swiss-Prot
Show Sequence
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References Search
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
757147
Lee, K.W.; Bogenhagen, D.F.
Assignment of 2'-O-methyltransferases to modification sites on the mammalian mitochondrial large subunit 16 S ribosomal RNA (rRNA)
J. Biol. Chem.
289
24936-24942
2014
Homo sapiens (Q6IN84)
25074936
brenda
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EXTERNAL LINKS (specific for EC-Number 2.1.1.B125)
ExplorEnz (official portal for IUBMB Enzyme Nomenclature)
Expasy Enzyme Nomenclature Database
KEGG
SABIO-RK
NCBI:
PubMed
,
Protein
,
Nucleotide
,
Structure
,
Gene
,
OMIM
Enzyme Nomenclature (alternative site)
UniProt
PDB
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)
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