We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Old data from external sources may still be available.
Please check here for current data:
EC unknown
Reaction Schemes
+
guanine1370 in 16S rRNA
=
2'-O-methylguanine1370 in 16S rRNA
+
+
Synonyms
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine + guanine1370 in 16S rRNA = 2'-O-methylguanine1370 in 16S rRNA + H+ + S-adenosyl-L-homocysteine
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine:16S rRNA (guanine1370-2'-O-)-methyltransferase
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine + guanine1370 in 16S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanine1370 in 16S rRNA
Substrates: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine + guanine1370 in 16S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanine1370 in 16S rRNA
Substrates: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Neoplasms
The ATF/CREB site is the key element for transcription of the human RNA methyltransferase like 1(RNMTL1) gene, a newly discovered 17p13.3 gene.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
UniProt
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
brenda
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
brenda
-
-
brenda
Highest Expressing Human Cell Lines
Filter by:
Cell Line Links
Gene Links
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
physiological function
MRM2 and MRM3 are responsible for modification of nucleotides of the 16S rRNA A-loop, an essential component of the peptidyl transxadferase center. Inactivation of MRM2 or MRM3 in human cells by RNA interference results in respiratory incompetence as a consequence of diminished mitochondrial translation. Ineffective translation in MRM2- and MRM3-depleted cells results from aberxadrant assembly of the large subunit of the mitochondrial ribosome
physiological function
knockdown of MRM3 significantly increases accessibility of 16 S rRNA to DNAzyme cleavage at residue G1370
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
MRM3_HUMAN
420
0
47020
Swiss-Prot
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Lee, K.W.; Bogenhagen, D.F.
Assignment of 2'-O-methyltransferases to modification sites on the mammalian mitochondrial large subunit 16 S ribosomal RNA (rRNA)
J. Biol. Chem.
289
24936-24942
2014
Homo sapiens (Q9HC36), Homo sapiens
brenda
Rorbach, J.; Boesch, P.; Gammage, P.A.; Nicholls, T.J.J.; Pearce, S.F.; Patel, D.; Hauser, A.; Perocchi, F.; Minczuk, M.
MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome
Mol. Biol. Cell
25
2542-2555 /
2014
Homo sapiens (Q9HC36), Homo sapiens
brenda
html completed
show
top
