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Information on EC 2.1.1.86 - tetrahydromethanopterin S-methyltransferase

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IUBMB Comments
Involved in the formation of methane from CO2 in methanogenic archaea. The reaction involves the export of one or two sodium ions. The enzyme from the archaeon Methanobacterium thermoautotrophicum is a membrane-associated multienzyme complex composed of eight different subunits, and contains a 5'-hydroxybenzimidazolyl-cobamide prosthetic group, to which the methyl group is attached during the transfer. A soluble enzyme that is induced by the presence of CO has been reported as well .
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Word Map
The expected taxonomic range for this enzyme is: Euryarchaeota
Synonyms
h4mpt, n5-methyltetrahydromethanopterin:coenzyme m methyltransferase, mtra-h, ma4384, tetrahydromethanopterin methyltransferase, methyl-tetrahydromethanopterin:coenzyme-m methyltransferase, n5-methyltetrahydromethanopterin coenzyme m methyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
5-methyl-5,6,7,8-tetrahydromethanopterin + CoM + 2 Na+/in = 5,6,7,8-tetrahydromethanopterin + 2-(methylsulfanyl)ethane-1-sulfonate + 2 Na+/out
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