Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Disease on EC 2.1.1.80 - protein-glutamate O-methyltransferase

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Breast Neoplasms
Prognostic value of HER2 status on circulating tumor cells in advanced-stage breast cancer patients with HER2-negative tumors.
Carcinoma
Characterization of the Enzymatic Activity of SETDB1 and Its 1:1 Complex with ATF7IP.
Evolutionary Expression of HER2 Conferred by Chromosome Aneuploidy on Circulating Gastric Cancer Cells Contributes to Developing Targeted and Chemotherapeutic Resistance.
Carcinoma, Hepatocellular
PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation.
Cholestasis
Lobe-specific heterogeneity in asymmetric dimethylarginine and matrix metalloproteinase levels in a rat model of obstructive cholestasis.
Choline Deficiency
The effects of ethionine administration and choline deficiency on protein carboxymethylase activity in mouse pancreas.
Diabetes Insipidus
High-protein carboxymethylase activity and low endogenous methyl acceptor proteins in posterior pituitary lobe of rats lacking neurophysin-vasopressin (Brattleboro rats).
Leukemia
DOT1L inhibitor EPZ-5676 displays synergistic antiproliferative activity in combination with standard of care drugs and hypomethylating agents in MLL-rearranged leukemia cells.
Mechanisms of Pinometostat (EPZ-5676) Treatment-Emergent Resistance in MLL-Rearranged Leukemia.
Lymphoma
EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity.
Lymphoma, Non-Hodgkin
Chemical cryptology of cancer's histone code.
Melanoma
Characterization of the Enzymatic Activity of SETDB1 and Its 1:1 Complex with ATF7IP.
Neoplasms
A concordant expression pattern of fatty acid synthase and membranous human epidermal growth factor receptor 2 exists in gastric cancer and is associated with a poor prognosis in gastric adenocarcinoma patients.
Biological processes and signal transduction pathways regulated by the protein methyltransferase SETD7 and their significance in cancer.
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.
Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX.
EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity.
In Situ Proteome Profiling and Bioimaging Applications of Small-Molecule Affinity-Based Probes Derived From DOT1L Inhibitors.
Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo.
Mimicking H3 Substrate Arginine in the Design of G9a Lysine Methyltransferase Inhibitors for Cancer Therapy: A Computational Study for Structure-Based Drug Design.
PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation.
Prognostic value of HER2 status on circulating tumor cells in advanced-stage breast cancer patients with HER2-negative tumors.
Protein methyltransferase inhibitors as precision cancer therapeutics: a decade of discovery.
RIZ1 is epigenetically inactivated by promoter hypermethylation in thyroid carcinoma.
Smyd3 Is a Transcriptional Potentiator of Multiple Cancer-Promoting Genes and Required for Liver and Colon Cancer Development.
Neuroblastoma
Characterization of protein carboxyl-O-methyltransferase in the spontaneous in vivo murine C-1300 neuroblastoma.
Protein carboxyl-O-methyltransferase activity in cultured C-1300 neuroblastoma cells.
Retinoblastoma
Altered expression of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukaemia.
Modulation of RIZ gene expression is associated to estradiol control of MCF-7 breast cancer cell proliferation.
Sarcoma, Avian
Selective methylation of rous sarcoma virus glycoproteins by protein methylase II.
Subacute Combined Degeneration
Correlation between inhibition of myelin basic protein (arginine) methyltransferase by sinefungin and lack of compact myelin formation in cultures of cerebral cells from embryonic mice.