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Information on EC 2.1.1.62 - mRNA (2'-O-methyladenosine-N6-)-methyltransferase

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The enzyme appears in viruses and cellular organisms
Reaction Schemes
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a 5-(N7-methyl 5-triphosphoguanosine)-2'-O-methyladenosine-[mRNA]
=
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a 5-(N7-methyl 5-triphosphoguanosine)-N6,2'-O-dimethyladenosine-[mRNA]
Synonyms
cap-dependent 2'-O-methyltransferase, messenger ribonucleate 2'-O-methyladenosine NG-methyltransferase, mRNA cap (nucleoside-2'O)-methyltransferase, NS5MTaseDV, VP39, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + a 5-(N7-methyl 5-triphosphoguanosine)-2'-O-methyladenosine-[mRNA] = S-adenosyl-L-homocysteine + a 5-(N7-methyl 5-triphosphoguanosine)-N6,2'-O-dimethyladenosine-[mRNA]
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