Reference on EC 2.1.1.56 - mRNA (guanine-N7)-methyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Pugh, C.S.G.; Borchardt, R.T.
Effects of S-adenosylhomocysteine analogues on vaccinia viral messenger ribonucleic acid synthesis and methylation
Biochemistry
21
1535-1541
1982
Vaccinia virus
Cross, R.K.
Identification of a unique guanine-7-methyltransferase in Semliki Forest virus (SFV) infected cell extracts
Virology
130
452-463
1983
Semliki forest virus
Martin, S.A.; Paoletti, E.; Moss, B.
Purification of mRNA guanylyltransferase and mRNA (guanine-7-) methyltransferase from vaccinia virions
J. Biol. Chem.
250
9322-9329
1975
Vaccinia virus, Vaccinia virus WR
Martin, S.A.; Moss, B.
Modification of RNA by mRNA guanylyltransferase and mRNA (guanine-7-)methyltransferase from vaccinia virions
J. Biol. Chem.
250
9330-9335
1975
Vaccinia virus
Ensinger, M.J.; Martin, S.A.; Paoletti, E.; Moss, B.
Modification of the 5-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus
Proc. Natl. Acad. Sci. USA
72
2525-2529
1975
Vaccinia virus
Cong, P.; Shuman, S.
Methyltransferase and subunit association domains of vaccinia virus mRNA capping enzyme
J. Biol. Chem.
267
16424-16429
1992
Vaccinia virus
Higman, M.A.; Bourgeois, N.; Niles, E.G.
The vaccinia virus mRNA (guanine-N7-)-methyltransferase requires both subunits of the mRNA capping enzyme for activity
J. Biol. Chem.
267
16430-16437
1992
Vaccinia virus
Ensinger, M.J.; Moss, B.
Modification of the 5 terminus of mRNA by an RNA (guanine-7-)-methyltransferase from HeLa cells
J. Biol. Chem.
251
5283-5291
1976
Homo sapiens
Martin, S.A.; Moss, B.
mRNA guanylyltransferase and mRNA (guanine-7-)-methyltransferase from vaccinia virions. Donor and acceptor substrate specificites
J. Biol. Chem.
251
7313-7321
1976
Vaccinia virus, Vaccinia virus WR
Pugh, C.S.; Borchardt, R.T.; Stone, H.O.
Inhibition of Newcastle disease virion messenger RNA (guanine-7-)-methyltransferase by analogues of S-adenosylhomocysteine
Biochemistry
16
3928-3932
1977
Avian orthoavulavirus 1
Germershausen, J.; Goodman, D.; Somberg, E.W.
5 Cap methylation of homologous poly A(+) RNA by a RNA (guanine-7) methyltransferase from Neurospora crassa
Biochem. Biophys. Res. Commun.
82
871-878
1978
Neurospora crassa
Goswami, B.B.; Crea, R.; Van Boom, J.H.; Sharma, O.K.
2-5-Linked oligo(adenylic acid) and its analogs. A new class of inhibitors of mRNA methylation
J. Biol. Chem.
257
6867-6870
1982
Mus musculus, Vaccinia virus
Locht, C.; Beaudart, J.L.; Delcour, J.
Partial purification and characterization of mRNA (guanine-7-) methyltransferase from the yeast Saccharomyces cerevisiae
Eur. J. Biochem.
134
117-121
1983
Saccharomyces cerevisiae, Saccharomyces cerevisiae VY1160
Guo, P.; Moss, B.
Interaction and mutual stabilization of the two subunits of vaccinia virus mRNA capping enzyme coexpressed in Escherichia coli
Proc. Natl. Acad. Sci. USA
87
4023-4027
1990
Vaccinia virus
Monroy, G.; Spencer, E.; Hurwitz, J.
Purification of mRNA guanylyltransferase from vaccinia virions
J. Biol. Chem.
253
4481-4489
1978
Vaccinia virus, Vaccinia virus WR
Ramadevi, N.; Burroughs, N.J.; Mertens, P.P.C.; Jones, I.M.
Capping and methylation of mRNA by purified recombinant VP4 protein of bluetongue virus
Proc. Natl. Acad. Sci. USA
95
13537-13542
1998
bluetongue virus
Ahola, T.; Lampio, A.; Auvinen, P.; Kaariainen, L.
Semliki forest virus mRNA capping enzyme requires association with anionic membrane phospholipids for activity
EMBO J.
18
3164-3172
1999
Semliki forest virus
Higman, M.A.; Christen, L.A.; Niles, E.G.
The mRNA (guanine-7-)methyltransferase domain of the vaccinia virus mRNA capping enzyme. Expression in Escherichia coli and structural and kinetic comparison to the intact capping enzyme
J. Biol. Chem.
269
14974-14981
1994
Vaccinia virus
Mao, X.; Shuman, S.
Intrinsic RNA (guanine-7) methyltransferase activity of the vaccinia virus capping enzyme D1 subunit is stimulated by the D12 subunit. Identification of amino acid residues in the D1 protein required for subunit association and methyl group transfer
J. Biol. Chem.
269
24472-24479
1994
Vaccinia virus
Tsukamoto, T.; Shibagaki, Y.; Niikura, Y.; Mizumoto, K.
Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)-methyltransferase, an mRNA cap methylase
Biochem. Biophys. Res. Commun.
251
27-34
1998
Homo sapiens, Saccharomyces cerevisiae (P32783)
Yokoska, J.i.; Tsukamoto, T.; Miura, K.i.; Shiokawa, K.; Mizumoto, K.
Cloning and characterization of mRNA capping enzyme and mRNA (guanine-7-)-methyltransferase cDNAs from Xenopus laevis
Biochem. Biophys. Res. Commun.
268
617-624
2000
Xenopus laevis (Q9I8S2), Xenopus laevis (Q9IA92), Xenopus laevis (Q9IA93)
Wen, Y.; Shatkin, A.J.
Cap methyltransferase selective binding and methylation of GpppG-RNA are stimulated by importin-alpha
Genes Dev.
14
2944-2949
2000
Homo sapiens
Mao, X.; Shuman, S.
Vaccinia virus mRNA (guanine-7-)methyltransferase: mutational effects on cap methylation and AdoHcy-dependent photo-crosslinking of the cap to the methyl acceptor site
Biochemistry
35
6900-6910
1996
Vaccinia virus
Li, Y.I.; Chen, Y.J.; Hsu, Y.H.; Meng, M.
Characterization of the Adomet-dependent guanylyltransferase activity that is associated with the N terminus of bamboo mosaic virus replicase
J. Virol.
75
782-788
2001
bamboo mosaic virus
Fabrega, C.; Hausmann, S.; Shen, V.; Shuman, S.; Lima, C.D.
Structure and mechanism of mRNA cap (guanine-N7) methyltransferase
Mol. Cell
13
77-89
2004
Encephalitozoon cuniculi
Shafer, B.; Chu, C.; Shatkin, A.J.
Human mRNA cap methyltransferase: alternative nuclear localization signal motifs ensure nuclear localization required for viability
Mol. Cell. Biol.
25
2644-2649
2005
Homo sapiens
Hausmann, S.; Zheng, S.; Fabrega, C.; Schneller, S.W.; Lima, C.D.; Shuman, S.
Encephalitozoon cuniculi mRNA cap (guanine N-7) methyltransferase: methyl acceptor specificity, inhibition BY S-adenosylmethionine analogs, and structure-guided mutational analysis
J. Biol. Chem.
280
20404-20412
2005
Encephalitozoon cuniculi (Q8SR66), Encephalitozoon cuniculi
Zheng, S.; Hausmann, S.; Liu, Q.; Ghosh, A.; Schwer, B.; Lima, C.D.; Shuman, S.
Mutational analysis of Encephalitozoon cuniculi mRNA cap (guanine-N7) methyltransferase, structure of the enzyme bound to sinefungin, and evidence that cap methyltransferase is the target of sinefungins antifungal activity
J. Biol. Chem.
281
35904-35913
2006
Saccharomyces cerevisiae, Encephalitozoon cuniculi (Q8SR66), Encephalitozoon cuniculi
Peyrane, F.; Selisko, B.; Decroly, E.; Vasseur, J.J.; Benarroch, D.; Canard, B.; Alvarez, K.
High-yield production of short GpppA- and 7MeGpppA-capped RNAs and HPLC-monitoring of methyltransfer reactions at the guanine-N7 and adenosine-2O positions
Nucleic Acids Res.
35
e26
2007
Homo sapiens
Hall, M.P.; Ho, C.K.
Characterization of a Trypanosoma brucei RNA cap (guanine N-7) methyltransferase
RNA
12
488-497
2006
Trypanosoma brucei
Schwer, B.; Shuman, S.
Genetic analysis of poxvirus mRNA cap methyltransferase: suppression of conditional mutations in the stimulatory D12 subunit by second-site mutations in the catalytic D1 subunit
Virology
352
145-156
2006
Vaccinia virus
Zheng, S.; Shuman, S.
Mutational analysis of vaccinia virus mRNA cap (guanine-N7) methyltransferase reveals essential contributions of the N-terminal peptide that closes over the active site
RNA
14
2297-2304
2008
Vaccinia virus
Milani, M.; Mastrangelo, E.; Bollati, M.; Selisko, B.; Decroly, E.; Bouvet, M.; Canard, B.; Bolognesi, M.
Flaviviral methyltransferase/RNA interaction: structural basis for enzyme inhibition
Antiviral Res.
83
28-34
2009
Dengue virus, Wesselsbron virus
Selisko, B.; Peyrane, F.F.; Canard, B.; Alvarez, K.; Decroly, E.
Biochemical characterization of the (nucleoside-2'O)-methyltransferase activity of dengue virus protein NS5 using purified capped RNA oligonucleotides (7Me)GpppAC(n) and GpppAC(n)
J. Gen. Virol.
91
112-121
2010
Dengue virus
Dong, H.; Ren, S.; Zhang, B.; Zhou, Y.; Puig-Basagoiti, F.; Li, H.; Shi, P.Y.
West Nile virus methyltransferase catalyzes two methylations of the viral RNA cap through a substrate-repositioning mechanism
J. Virol.
82
4295-4307
2008
West Nile virus
Cowling, V.H.
Enhanced mRNA cap methylation increases cyclin D1 expression and promotes cell transformation
Oncogene
29
930-936
2009
Homo sapiens
Chen, Y.; Cai, H.; Pan, J.; Xiang, N.; Tien, P.; Ahola, T.; Guo, D.
Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase
Proc. Natl. Acad. Sci. USA
106
3484-3489
2009
Severe acute respiratory syndrome-related coronavirus
Zheng, S.; Shuman, S.
Structure-function analysis of vaccinia virus mRNA cap (guanine-N7) methyltransferase
RNA
14
696-705
2008
Vaccinia virus
Chung, K.Y.; Dong, H.; Chao, A.T.; Shi, P.Y.; Lescar, J.; Lim, S.P.
Higher catalytic efficiency of N-7-methylation is responsible for processive N-7 and 2-O methyltransferase activity in dengue virus
Virology
402
52-60
2010
Dengue virus
Dong, H.; Chang, D.C.; Xie, X.; Toh, Y.X.; Chung, K.Y.; Zou, G.; Lescar, J.; Lim, S.P.; Shi, P.Y.
Biochemical and genetic characterization of dengue virus methyltransferase
Virology
405
568-578
2010
Dengue virus
Zhang, X.; Wei, Y.; Ma, Y.; Hu, S.; Li, J.
Identification of aromatic amino acid residues in conserved region VI of the large polymerase of vesicular stomatitis virus is essential for both guanine-N-7 and ribose 2-O methyltransferases
Virology
408
241-252
2010
vesicular stomatitis virus
Sun, Y.; Wang, Z.; Tao, J.; Wang, Y; Wu, A; Yang, Z.; Wang, K.; Shi, L.; Chen, Y.; Guo, D.
Yeast-based assays for the high-throughput screening of inhibitors of coronavirus RNA cap guanine-N7-methyltransferase
Antiviral Res.
104
156-164
2014
Severe acute respiratory syndrome-related coronavirus (P0C6X7), Severe acute respiratory syndrome-related coronavirus
Chen, Y.; Tao, J.; Sun, Y.; Wu, A.; Su, C.; Gao, G.; Cai, H.; Qiu, S., Wu, Y.; Ahola, T., Guo, D.
Structure-function analysis of severe acute respiratory syndrome coronavirus RNA cap guanine-N7-methyltransferase
J. Virol.
87
6296-6305
2013
Severe acute respiratory syndrome-related coronavirus (P0C6X7), Severe acute respiratory syndrome-related coronavirus
Thillier, Y.; Decroly, E.; Morvan, F.; Canard, B.; Vasseur, J.J.; Debart, F.
Synthesis of 5' cap-0 and cap-1 RNAs using solid-phase chemistry coupled with enzymatic methylation by human (guanine-N7)-methyl transferase
RNA
18
856-868
2012
Homo sapiens (O43148)
Jin, X.; Chen, Y.; Sun, Y.; Zeng, C.; Wang, Y.; Tao, J.; Wu, A.; Yu, X.; Zhang, Z.; Tian, J.; Guo, D.
Characterization of the guanine-N7 methyltransferase activity of coronavirus nsp14 on nucleotide GTP
Virus Res.
176
45-52
2013
Severe acute respiratory syndrome-related coronavirus (P0C6X7), Severe acute respiratory syndrome-related coronavirus
Aouadi, W.; Eydoux, C.; Coutard, B.; Martin, B.; Debart, F.; Vasseur, J.J.; Contreras, J.M.; Morice, C.; Querat, G.; Jung, M.L.; Canard, B.; Guillemot, J.C.; Decroly, E.
Toward the identification of viral cap-methyltransferase inhibitors by fluorescence screening assay
Antiviral Res.
144
330-339
2017
Homo sapiens, Severe acute respiratory syndrome-related coronavirus
Varshney, D.; Lombardi, O.; Schweikert, G.; Dunn, S.; Suska, O.; Cowling, V.H.
mRNA cap methyltransferase, RNMT-RAM, promotes RNA Pol II-dependent transcription
Cell Rep.
23
1530-1542
2018
Homo sapiens
Case, J.B.; Ashbrook, A.W.; Dermody, T.S.; Denison, M.R.
Mutagenesis of S-adenosyl-L-methionine-binding residues in coronavirus nsp14 N7-methyltransferase demonstrates differing requirements for genome translation and resistance to innate immunity
J. Virol.
90
7248-7256
2016
Murine hepatitis virus
Trotman, J.B.; Giltmier, A.J.; Mukherjee, C.; Schoenberg, D.R.
RNA guanine-7 methyltransferase catalyzes the methylation of cytoplasmically recapped RNAs
Nucleic Acids Res.
45
10726-10739
2017
Homo sapiens
Martin, B.; Coutard, B.; Guez, T.; Paesen, G.C.; Canard, B.; Debart, F.; Vasseur, J.J.; Grimes, J.M.; Decroly, E.
The methyltransferase domain of the Sudan ebolavirus L protein specifically targets internal adenosines of RNA substrates, in addition to the cap structure
Nucleic Acids Res.
46
7902-7912
2018
Sudan ebolavirus
Bueren-Calabuig, J.A.; G Bage, M.; Cowling, V.H.; Pisliakov, A.V.
Mechanism of allosteric activation of human mRNA cap methyltransferase (RNMT) by RAM insights from accelerated molecular dynamics simulations
Nucleic Acids Res.
47
8675-8692
2019
Homo sapiens (O43148), Homo sapiens
Dunn, S.; Lombardi, O.; Lukoszek, R.; Cowling, V.H.
Oncogenic PIK3CA mutations increase dependency on the mRNA cap methyltransferase, RNMT, in breast cancer cells
Open Biology
9
190052
2019
Homo sapiens
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