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Disease on EC 2.1.1.56 - mRNA (guanine-N7)-methyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
1H, 13C, and 15N backbone chemical shift assignments of coronavirus-2 non-structural protein Nsp10.
Acute Kidney Injury
Thrombotic thrombocytopenic purpura in a 2.5-year-old boy with dengue infection: a rare complication.
Anemia
Proteins selectively killing tumor cells.
Arteritis
Arterivirus Nsp1 modulates the accumulation of minus-strand templates to control the relative abundance of viral mRNAs.
Equine arteritis virus non-structural protein 1, an essential factor for viral subgenomic mRNA synthesis, interacts with the cellular transcription co-factor p100.
Nuclear localization of non-structural protein 1 and nucleocapsid protein of equine arteritis virus.
Bluetongue
Atomic structure of the translation regulatory protein NS1 of bluetongue virus.
Bluetongue virus non-structural protein 1 is a positive regulator of viral protein synthesis.
Detection of bluetongue virus RNA in cell cultures and in the central nervous system of experimentally infected mice using in situ hybridization.
Ovine and murine T cell epitopes from the non-structural protein 1 (NS1) of bluetongue virus serotype 8 (BTV-8) are shared among viral serotypes.
Breast Neoplasms
Oncogenic PIK3CA mutations increase dependency on the mRNA cap methyltransferase, RNMT, in breast cancer cells.
Bronchitis
The cellular RNA helicase DDX1 interacts with coronavirus nonstructural protein 14 and enhances viral replication.
Coinfection
A highly conserved region between amino acids 221 and 266 of dengue virus non-structural protein 1 is a major epitope region in infected patients.
Use of whole blood over plasma enhances the detection of dengue virus RNA: possible utility in dengue vaccine trials.
Coma
Thrombotic thrombocytopenic purpura in a 2.5-year-old boy with dengue infection: a rare complication.
COVID-19
Combining SARS-CoV-2 Proofreading Exonuclease and RNA-Dependent RNA Polymerase Inhibitors as a Strategy to Combat COVID-19: A High-Throughput in silico Screening.
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase.
Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors.
Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors.
Repurposing of FDA-Approved Toremifene to Treat COVID-19 by Blocking the Spike Glycoprotein and NSP14 of SARS-CoV-2.
Structure-based virtual screening and molecular dynamics simulation of SARS-CoV-2 Guanine-N7 methyltransferase (nsp14) for identifying antiviral inhibitors against COVID-19.
Dengue
A Haemophilic Dengue Patient with Pleural Effusion and Earache.
A highly conserved region between amino acids 221 and 266 of dengue virus non-structural protein 1 is a major epitope region in infected patients.
A sensor tip based on carbon nanotube-ink printed electrode for the dengue virus NS1 protein.
A serotype-specific epitope of dengue virus 1 identified by phage displayed random peptide library.
A thiophene-modified screen printed electrode for detection of dengue virus NS1 protein.
Accuracy and efficacy of pre-dengue vaccination screening for previous dengue infection with five commercially available immunoassays: a retrospective analysis of phase 3 efficacy trials.
An outbreak of dengue fever in children in the National Capital District of Papua New Guinea in 2016.
Antigen production using heterologous expression of dengue virus-2 non-structural protein 1 (NS1) in Nicotiana tabacum (Havana) for immunodiagnostic purposes.
Antigenic cell associated dengue 2 virus proteins detected in vitro using dengue fever patients sera.
Antiplatelet autoantibodies elicited by dengue virus non-structural protein 1 cause thrombocytopenia and mortality in mice.
Applications of a Rapid and Sensitive Dengue DUO Rapid Immunochromatographic Test Kit as a Diagnostic Strategy during a Dengue Type 2 Epidemic in an Urban City.
Biochemical characterization of the (nucleoside-2'O)-methyltransferase activity of dengue virus protein NS5 using purified capped RNA oligonucleotides 7MeGpppACn and GpppACn.
Bovine serum albumin nanoparticles induce histopathological changes and inflammatory cell recruitment in the skin of treated mice.
Case Report: Cardiac Tamponade in Dengue Hemorrhagic Fever: An Unusual Manifestation of a Common Disease.
Circulation of dengue serotype 1 viruses during the 2019 outbreak in Dar es Salaam, Tanzania.
Clinical Features and Laboratory Findings of Travelers Returning to South Australia with Dengue Virus Infection.
Clinical, laboratory, and demographic determinants of hospitalization due to dengue in 7613 patients: A retrospective study based on hierarchical models.
Comparative specificity and sensitivity of NS1-based serological assays for the detection of flavivirus immune response.
Comparison between polyethylene glycol and zwitterionic polymers as antifouling coatings on wearable devices for selective antigen capture from biological tissue.
Comparison of performance of serum and plasma in panbio dengue and Japanese encephalitis virus enzyme-linked immunosorbent assays.
Could Homeopathy Become An Alternative Therapy In Dengue Fever? An example Of 10 Case Studies.
Cross-Reactivity of Rapid Salmonella Typhi IgM Immunoassay in Dengue Fever Without Co-Existing Infection.
Dataset of proteins mapped on HepG2 cells and those differentially abundant after expression of the dengue non-structural 1 protein.
Demographic, clinical and laboratory features of leptospirosis and dengue co-infection in Malaysia.
Dengue haemorrhagic fever presenting with cholestatic hepatitis: two case reports and a review of literature.
Dengue Virus Glycosylation: What Do We Know?
Dengue virus infection in a French traveller to the hilly region of Nepal in 2015: a case report.
Dengue virus non-structural protein 1 activates the p38 MAPK pathway to decrease barrier integrity in primary human endothelial cells.
Dengue Virus Non-structural Protein 1 Modulates Infectious Particle Production via Interaction with the Structural Proteins.
Dengue virus non-structural protein 1: a pathogenic factor, therapeutic target, and vaccine candidate.
Dengue Virus NS1 Disrupts the Endothelial Glycocalyx, Leading to Hyperpermeability.
Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6.
Design of SERS nanotags for multiplexed lateral flow immunoassays.
Detection of dengue virus NS1 antigen in infected Aedes aegypti using a commercially available kit.
Development of a highly sensitive magneto-enzyme lateral flow immunoassay for dengue NS1 detection.
Development of a quantitative NS1-capture enzyme-linked immunosorbent assay for early detection of yellow fever virus infection.
Development of an anti-Dengue NS1 IgG ELISA to Evaluate Exposure to Dengue Virus.
Development of antibody biomarkers of long term and recent dengue virus infections.
Development of Bacteriophage Virus-Like Particle Vaccines Displaying Conserved Epitopes of Dengue Virus Non-Structural Protein 1.
Development of specific dengue virus 2'-O- and N7-methyltransferase assays for antiviral drug screening.
Diagnostic accuracy of 5 different brands of dengue virus non-structural protein 1 (NS1) antigen rapid diagnostic tests (RDT) in Indonesia.
DNA vaccine against the non-structural 1 protein (NS1) of dengue 2 virus.
Early central nervous system involvement in a young patient with dengue encephalitis.
Endocytosis of flavivirus NS1 is required for NS1-mediated endothelial hyperpermeability and is abolished by a single N-glycosylation site mutation.
Epidemiology and characteristics of the dengue outbreak in Guangdong, Southern China, in 2014.
Evaluation and use of NS1 IgM antibody detection for acute dengue virus diagnosis: report from an outbreak investigation.
Evaluation of Adamantane Derivatives as Inhibitors of Dengue Virus mRNA Cap Methyltransferase by Docking and Molecular Dynamics Simulations.
Evaluation of commercially available diagnostic tests for the detection of dengue virus NS1 antigen and anti-dengue virus IgM antibody.
Evaluation of protective efficacy and immune mechanisms of using a non-structural protein NS1 in DNA vaccine against dengue 2 virus in mice.
Evaluation of the importance of fever with respect to dengue prognosis according to the 2009 WHO classification: a retrospective study.
External quality assessment of dengue and chikungunya diagnostics in the Asia Pacific region, 2015.
Fabrication and Characterization of Simple Structure Fluidic-Based Memristor for Immunosensing of NS1 Protein Application.
Fatal Dengue, Chikungunya and Leptospirosis: The Importance of Assessing Co-infections in Febrile Patients in Tropical Areas.
Finding small molecules with pan-serotype activity to target Dengue non-structural protein 1.
First round of external quality assessment of dengue diagnostics in the WHO Western Pacific Region, 2013.
Flaviviral methyltransferase/RNA interaction: structural basis for enzyme inhibition.
Gallbladder Wall Thickening for Early Detection of Plasma Leakage in Dengue Infected Adult Patients.
Generation of human single-chain variable fragment antibodies specific to dengue virus non-structural protein 1 that interfere with the virus infectious cycle.
High-affinity five/six-letter DNA aptamers with superior specificity enabling the detection of dengue NS1 protein variants beyond the serotype identification.
High-yield production of short GpppA- and 7MeGpppA-capped RNAs and HPLC-monitoring of methyltransfer reactions at the guanine-N7 and adenosine-2'O positions.
Highly sensitive detection of dengue biomarker using streptavidin-conjugated quantum dots.
HOSPITAL- AND COMMUNITY- BASED SURVEILLANCE OF ZIKA AND DENGUE VIRUSES IN INDONESIA.
IgG1 and IgG4 antibodies against Aedes aegypti salivary proteins and risk for dengue infections.
Incidence of dengue illness in Mexican people aged 6 months to 50 years old: A prospective cohort study conducted in Jalisco.
Intravenous immunoglobulin therapy for dengue capillary leak syndrome in a renal allograft recipient.
Isolation of serotype-specific antibodies against dengue virus non-structural protein 1 using phage display and application in a multiplexed serotyping assay.
Kinetics of Dengue Non-Structural Protein 1 Antigen and IgM and IgA Antibodies in Capillary Blood Samples from Confirmed Dengue Patients.
Kinetics of non-structural protein 1, IgM and IgG antibodies in dengue type 1 primary infection.
Label-free capacitive assaying of biomarkers for molecular diagnostics.
Miller Fisher syndrome developing as a parainfectious manifestation of dengue fever: a case report and review of the literature.
Modification of S-Adenosyl-l-Homocysteine as Inhibitor of Nonstructural Protein 5 Methyltransferase Dengue Virus Through Molecular Docking and Molecular Dynamics Simulation.
Molecular mimicry between virus and host and its implications for dengue disease pathogenesis.
Mutagenesis of the dengue virus type 2 NS5 methyltransferase domain.
Neutrophil Extracellular Traps in Dengue Are Mainly Generated NOX-Independently.
Non-structural protein 1 (NS1) of dengue virus detection correlates with severity in primary but not in secondary dengue infection.
NS1-based tests with diagnostic utility for confirming dengue infection: a meta-analysis.
Outbreak of severe dengue associated with DENV-3 in the city of Manado, North Sulawesi, Indonesia.
Piezoelectric immunochip coated with thin films of bacterial cellulose nanocrystals for dengue detection.
Platelet activation and aggregation response to dengue virus nonstructural protein 1 and domains.
Precisão e confiabilidade de um teste imuno-cromatográfico rápido NS1 para diagnóstico DENV-1 no ponto de atendimento e no laboratório.
Preparation and Application of Yellow Fever Virus NS1 protein-specific Monoclonal Antibodies.
Production of recombinant dengue non-structural 1 (NS1) proteins from clinical virus isolates.
Protective efficacy of the recombinant, live-attenuated, CYD tetravalent dengue vaccine in Thai schoolchildren: a randomised, controlled phase 2b trial.
Protein refolding based on high hydrostatic pressure and alkaline pH: Application on a recombinant dengue virus NS1 protein.
Rational selection of hidden epitopes for a molecularly imprinted electrochemical sensor in the recognition of heat-denatured dengue NS1 protein.
Retooling phage display with electrohydrodynamic nanomixing and nanopore sequencing.
Serological point-of-care and label-free capacitive diagnosis of dengue virus infection.
Simultaneous Detection of Dengue NS1 Antigen, IgM plus IgG and Platelet Enumeration during an Outbreak.
Spontaneous splenic rupture in dengue fever with non-fatal outcome in an adult.
Suboptimal diagnostic performance of dengue non-structural protein 1 antigen rapid test during non-endemic periods in southern Taiwan.
Super induction of dengue virus NS1 protein in E. coli.
Surface plasmon resonance analysis for detecting non-structural protein 1 of dengue virus in Indonesia.
Susceptibility of mouse macrophage J774 to dengue virus infection.
Targeting the non-structural protein 1 from dengue virus to a dendritic cell population confers protective immunity to lethal virus challenge.
The dengue virus non-structural protein 1 (NS1) is secreted efficiently from infected mosquito cells.
The dengue virus non-structural protein 1 (NS1) is secreted from infected mosquito cells via a non-classical caveolin-1-dependent pathway.
The diagnostic sensitivity of dengue rapid test assays is significantly enhanced by using a combined antigen and antibody testing approach.
The effect of the dengue non-structural 1 protein expression over the HepG2 cell proteins in a proteomic approach.
The establishment and clinical evaluation of a novel, rapid, no-wash one-step immunoassay for the detection of dengue virus non-structural protein 1.
Thrombotic thrombocytopenic purpura in a 2.5-year-old boy with dengue infection: a rare complication.
Toward the identification of viral cap-methyltransferase inhibitors by fluorescence screening assay.
Transient Expression of Dengue Virus NS1 Antigen in Nicotiana benthamiana for Use as a Diagnostic Antigen.
Two Cases of False-Positive Dengue Non-Structural Protein 1 (NS1) Antigen in Patients with Hematological Malignancies and a Review of the Literature on the Use of NS1 for the Detection of Dengue Infection.
Utility of a multiplex real-time polymerase chain reaction for combined detection and serotyping of dengue virus in paediatric patients hospitalised with severe dengue: A report from Chennai.
Utility of a Multiplex Real-Time Polymerase Chain Reaction for Combined Detection and Serotyping of Dengue Virus in Paediatric Patients Hospitalised with Severe Dengue: A Report from Chennai.
Vimentin interacts with heterogeneous nuclear ribonucleoproteins and dengue nonstructural protein 1 and is important for viral replication and release.
[Perinatal Dengue: A case Report].
Encephalitis
Comparison of performance of serum and plasma in panbio dengue and Japanese encephalitis virus enzyme-linked immunosorbent assays.
Early central nervous system involvement in a young patient with dengue encephalitis.
Encephalitis, Japanese
Comprehensive Mapping Antigenic Epitopes of NS1 Protein of Japanese Encephalitis Virus with Monoclonal Antibodies.
Comprehensive mapping of West Nile virus (WNV)- and Japanese encephalitis virus serocomplex-specific linear B-cell epitopes from WNV non-structural protein 1.
Non-structural protein 1 (NS1) antibody-based assays to differentiate West Nile (WN) virus from Japanese encephalitis virus infections in horses: Effects of WN virus NS1 antibodies induced by inactivated WN vaccine.
Non-structural protein 1 from Japanese encephalitis virus expressed in E. coli retains its molecular weight and immunogenicity.
Encephalitis, Tick-Borne
Antibody responses to tick-borne encephalitis virus non-structural protein 1 and whole virus antigen-a new tool in the assessment of suspected vaccine failure patients.
Comparative specificity and sensitivity of NS1-based serological assays for the detection of flavivirus immune response.
Tick-Borne Encephalitis Virus Vaccines Contain Non-Structural Protein 1 Antigen and may Elicit NS1-Specific Antibody Responses in Vaccinated Individuals.
Enteritis
Cellular microRNA miR-181b inhibits replication of mink enteritis virus by repression of non-structural protein 1 translation.
Exanthema
Cytokine gene polymorphisms associated with symptomatic parvovirus B19 infection.
Flavivirus Infections
A high-throughput and multiplex microsphere immunoassay based on non-structural protein 1 can discriminate three flavivirus infections.
Development of a quantitative NS1-capture enzyme-linked immunosorbent assay for early detection of yellow fever virus infection.
Gastroenteritis
MUTAGENESIS OF CORONAVIRUS NSP14 REVEALS ITS POTENTIAL ROLE IN MODULATION OF THE INNATE IMMUNE RESPONSE.
Hematologic Neoplasms
Two Cases of False-Positive Dengue Non-Structural Protein 1 (NS1) Antigen in Patients with Hematological Malignancies and a Review of the Literature on the Use of NS1 for the Detection of Dengue Infection.
Hepatitis
Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity.
Effects of mutagenesis of murine hepatitis virus nsp1 and nsp14 on replication in culture.
High Fidelity of Murine Hepatitis Virus Replication Is Decreased in nsp14 Exoribonuclease Mutants.
Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing.
Murine coronaviruses encoding nsp2 at different genomic loci have altered replication, protein expression, and localization.
Murine Hepatitis Virus nsp14 Exoribonuclease Activity Is Required for Resistance to Innate Immunity.
Mutagenesis of S-Adenosyl-l-Methionine-Binding Residues in Coronavirus nsp14 N7-Methyltransferase Demonstrates Differing Requirements for Genome Translation and Resistance to Innate Immunity.
Hepatitis B
Influenza vaccine: progress in a vaccine that elicits a broad immune response.
Hepatitis C
Secretion and purification of hepatitis C virus NS1 glycoprotein produced by recombinant baculovirus-infected insect cells.
Herpes Simplex
RING-Domain E3 Ligase-Mediated Host-Virus Interactions: Orchestrating Immune Responses by the Host and Antagonizing Immune Defense by Viruses.
Infections
A highly conserved region between amino acids 221 and 266 of dengue virus non-structural protein 1 is a major epitope region in infected patients.
An Attempt Towards Lab And Clinical Combine Appraised, Including Future Concerns Regarding Dengue Infection.
Antibody responses to tick-borne encephalitis virus non-structural protein 1 and whole virus antigen-a new tool in the assessment of suspected vaccine failure patients.
Aspects of T Cell-Mediated Immunity Induced in Mice by a DNA Vaccine Based on the Dengue-NS1 Antigen after Challenge by the Intracerebral Route.
Cellular microRNA miR-181b inhibits replication of mink enteritis virus by repression of non-structural protein 1 translation.
Comprehensive Mapping Antigenic Epitopes of NS1 Protein of Japanese Encephalitis Virus with Monoclonal Antibodies.
Comprehensive mapping of West Nile virus (WNV)- and Japanese encephalitis virus serocomplex-specific linear B-cell epitopes from WNV non-structural protein 1.
Conformational plasticity of the influenza A virus NS1 protein.
Cytokine gene polymorphisms associated with symptomatic parvovirus B19 infection.
Dengue haemorrhagic fever presenting with cholestatic hepatitis: two case reports and a review of literature.
Development of a quantitative NS1-capture enzyme-linked immunosorbent assay for early detection of yellow fever virus infection.
Development of an anti-Dengue NS1 IgG ELISA to Evaluate Exposure to Dengue Virus.
Development of antibody biomarkers of long term and recent dengue virus infections.
Diagnostic accuracy of 5 different brands of dengue virus non-structural protein 1 (NS1) antigen rapid diagnostic tests (RDT) in Indonesia.
Differentiation of West Nile Virus-Infected Animals from Vaccinated Animals by Competitive ELISA Using Monoclonal Antibodies Against Non-Structural Protein 1.
Disruption of Src homology 3-binding motif within non-structural protein 1 of influenza B virus unexpectedly enhances viral replication in human cells.
Distinction between serological responses following tick-borne encephalitis virus (TBEV) infection vs vaccination, Sweden 2017.
DNA vaccination with the Aleutian mink disease virus NS1 gene confers partial protection against disease.
Establishment of functional B cell memory against parvovirus B19 capsid proteins may be associated with resolution of persistent infection.
Ethanolic Extract of Melia Fructus Has Anti-influenza A Virus Activity by Affecting Viral Entry and Viral RNA Polymerase.
Evaluation of protective efficacy and immune mechanisms of using a non-structural protein NS1 in DNA vaccine against dengue 2 virus in mice.
Highly sensitive detection of dengue biomarker using streptavidin-conjugated quantum dots.
IgG1 and IgG4 antibodies against Aedes aegypti salivary proteins and risk for dengue infections.
In-silico search of virus-specific host microRNAs regulating avian influenza virus NS1 expression.
Influenza A virus non-structural protein 1 (NS1) interacts with cellular multifunctional protein nucleolin during infection.
Influenza virus non-structural protein 1 (NS1) disrupts interferon signaling.
Inhibition of autophagy promotes human RSV NS1-induced inflammation and apoptosis in vitro.
Isolation of serotype-specific antibodies against dengue virus non-structural protein 1 using phage display and application in a multiplexed serotyping assay.
Kinetics of non-structural protein 1, IgM and IgG antibodies in dengue type 1 primary infection.
Miller Fisher syndrome developing as a parainfectious manifestation of dengue fever: a case report and review of the literature.
Molecular characteristics of the human pandemic influenza A virus (H1N1).
MUTAGENESIS OF CORONAVIRUS NSP14 REVEALS ITS POTENTIAL ROLE IN MODULATION OF THE INNATE IMMUNE RESPONSE.
Non-structural protein 1 (NS1) antibody-based assays to differentiate West Nile (WN) virus from Japanese encephalitis virus infections in horses: Effects of WN virus NS1 antibodies induced by inactivated WN vaccine.
Non-structural protein 1 (NS1) of dengue virus detection correlates with severity in primary but not in secondary dengue infection.
Non-structural protein 1 from Japanese encephalitis virus expressed in E. coli retains its molecular weight and immunogenicity.
Non-structural protein 1 from Zika virus: Heterologous expression, purification, and potential for diagnosis of Zika infections.
Nuclear localization of non-structural protein 1 and nucleocapsid protein of equine arteritis virus.
Platelet activation and aggregation response to dengue virus nonstructural protein 1 and domains.
Preparation and Application of Yellow Fever Virus NS1 protein-specific Monoclonal Antibodies.
Respiratory syncytial virus non-structural protein 1 facilitates virus replication through miR-29a-mediated inhibition of interferon-? receptor.
Role of mitochondria in parvovirus pathology.
Salivary Detection of Dengue Virus NS1 Protein with a Label-Free Immunosensor for Early Dengue Diagnosis.
Screening pipeline for Flavivirus based Inhibitors for Zika Virus NS1.
Serologic diagnosis of West Nile and St. Louis encephalitis virus infections in domestic chickens.
Structural Basis for a Novel Interaction between the NS1 Protein Derived from the 1918 Influenza Virus and RIG-I.
Structure of the Dengue Virus Glycoprotein NS1 by Electron Microscopy and Single Particle Analysis.
SUMO1 modification of the non-structural protein 1 of influenza A virus.
Super induction of dengue virus NS1 protein in E. coli.
Susceptibility of mouse macrophage J774 to dengue virus infection.
The Central Role of Non-Structural Protein 1 (NS1) in Influenza Biology and Infection.
The Influenza NS1 Protein: What Do We Know in Equine Influenza Virus Pathogenesis?
The viral non-structural protein 1 alpha (Nsp1?) inhibits p53 apoptosis activity by increasing murine double minute 2 (mdm2) expression in porcine reproductive and respiratory syndrome virus (PRRSV) early-infected cells.
Tick-borne encephalitis virus (TBEV): non-structural protein (NS1) IgG ELISA differentiating infection vs. vaccination antibody responses.
Two Cases of False-Positive Dengue Non-Structural Protein 1 (NS1) Antigen in Patients with Hematological Malignancies and a Review of the Literature on the Use of NS1 for the Detection of Dengue Infection.
Zika virus as an oncolytic treatment of human neuroblastoma cells requires CD24.
Influenza in Birds
Alleles A and B of non-structural protein 1 of avian influenza A viruses differentially inhibit beta interferon production in human and mink lung cells.
Annexin A2 (ANXA2) interacts with nonstructural protein 1 and promotes the replication of highly pathogenic H5N1 avian influenza virus.
Changes in the NS1 gene of avian influenza viruses isolated in Thailand affect expression of type I interferon in primary chicken embryonic fibroblast cells.
Construction of a human scFv antibody library with VH regions randomized and its application
Construction of a human scFv antibody library with VH regions randomized and its application.
Detection of highly pathogenic avian influenza virus infection in vaccinated chicken flocks by monitoring antibodies against non-structural protein 1 (NS1).
Double-stranded RNA-induced activation of activating protein-1 promoter is differentially regulated by the non-structural protein 1 of avian influenza A viruses.
Effective inhibition of mRNA accumulation and protein expression of H5N1 avian influenza virus NS1 gene in vitro by small interfering RNAs.
Effects of NS1 variants of H5N1 influenza virus on interferon induction, TNFalpha response and p53 activity.
Highly pathogenic avian influenza A virus H5N1 non-structural protein 1 is associated with apoptotic activation of the intrinsic mitochondrial pathway.
Identification of a Highly Conserved Epitope on Avian Influenza Virus Non-Structural Protein 1 Using a Peptide Microarray.
Mechanism of a Mutation in Non-Structural Protein 1 Inducing High Pathogenicity of Avian Influenza Virus H5N1.
MicroRNA expression profiles from HEK293 cells expressing H5N1 avian influenza virus non-structural protein 1.
Non-structural protein 1 from avian influenza virus H9N2 is an efficient RNA silencing suppressor with characteristics that differ from those of Tomato bushy stunt virus p19.
Non-structural protein 1 of avian influenza A viruses differentially inhibit NF-?B promoter activation.
Preferential Selection and Contribution of Non-Structural Protein 1 (NS1) to the Efficient Transmission of Panzootic Avian Influenza H5N8 Virus Clades 2.3.4.4A and B in Chickens and Ducks.
The C-terminus of non-structural protein 1 (NS1) in H5N8 clade 2.3.4.4 avian influenza virus affects virus fitness in human cells and virulence in mice.
Viral-Host Interactome Analysis Reveals Chicken STAU2 Interacts With Non-structural Protein 1 and Promotes the Replication of H5N1 Avian Influenza Virus.
Influenza, Human
A novel RNA-binding motif in influenza A virus non-structural protein 1.
A NS1-binding monoclonal antibody interacts with two residues that are highly conserved in seasonal as well as newly emerged influenza A virus.
A Promising IFN-Deficient System to Manufacture IFN-Sensitive Influenza Vaccine Virus.
A single point mutation (Y89F) within the non-structural protein 1 of influenza A viruses limits epithelial cell tropism and virulence in mice.
Acetylation at K108 of the NS1 protein is important for the replication and virulence of influenza virus.
Alanine substitutions within a linker region of the influenza A virus non-structural protein 1 alter its subcellular localization and attenuate virus replication.
Alleles A and B of non-structural protein 1 of avian influenza A viruses differentially inhibit beta interferon production in human and mink lung cells.
Altering Intracellular Localization of the RNA Interference Factors by Influenza A Virus Non-structural Protein 1.
Amino acid substitution K186E in the canine influenza virus H3N8 NS1 protein restores its ability to inhibit host gene expression.
Analysis of influenza A virus NS1 dimer interfaces in solution by pulse EPR distance measurements.
Analysis of the PDZ binding specificities of Influenza A virus NS1 proteins.
Avian influenza viruses inhibit the major cellular signalling integrator c-Abl.
Biochemical and structural characterization of the interface mediating interaction between the influenza A virus non-structural protein-1 and a monoclonal antibody.
Conformational plasticity of the influenza A virus NS1 protein.
Conserved surface features form the double-stranded RNA binding site of non-structural protein 1 (NS1) from influenza A and B viruses.
Critical Role of an Antiviral Stress Granule Containing RIG-I and PKR in Viral Detection and Innate Immunity.
CRK adaptor protein expression is required for efficient replication of avian influenza A viruses and controls JNK-mediated apoptotic responses.
Definition of a human T cell epitope from influenza A non-structural protein 1 using HLA-A2.1 transgenic mice.
Design, synthesis, and evaluation of novel small molecule inhibitors of the influenza virus protein NS1.
Dimer Interface of the Effector Domain of Non-structural Protein 1 from Influenza A Virus: AN INTERFACE WITH MULTIPLE FUNCTIONS.
Discovery of novel influenza inhibitors targeting the interaction of dsRNA with the NS1 protein by structure-based virtual screening.
Disruption of Src homology 3-binding motif within non-structural protein 1 of influenza B virus unexpectedly enhances viral replication in human cells.
Double-stranded RNA-induced activation of activating protein-1 promoter is differentially regulated by the non-structural protein 1 of avian influenza A viruses.
Effects of the S42 residue of the H1N1 swine influenza virus NS1 protein on interferon responses and virus replication.
Exploring naphthyl-carbohydrazides as inhibitors of influenza A viruses.
Functional Characterization and Direct Comparison of Influenza A, B, C, and D NS1 Proteins in vitro and in vivo.
Generation and characterization of a new panel of broadly reactive anti-NS1 mAbs for detection of influenza A virus.
Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection.
Genomic and protein structural maps of adaptive evolution of human influenza A virus to increased virulence in the mouse.
Heterologous interactions between NS1 proteins from different influenza A virus subtypes/strains.
Identification of NS1 domains of avian H5N1 influenza virus which influence the interaction with the NOLC1 protein.
Impairment of the Staufen1-NS1 interaction reduces influenza viral replication.
Induction of protective class I MHC-restricted CTL in mice by a recombinant influenza vaccine in aluminium hydroxide adjuvant.
Influenza A H3N2 subtype virus NS1 protein targets into the nucleus and binds primarily via its C-terminal NLS2/NoLS to nucleolin and fibrillarin.
Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression.
Influenza A virus non-structural protein 1 (NS1) interacts with cellular multifunctional protein nucleolin during infection.
Influenza A virus NS1 optimises virus infectivity by enhancing genome packaging in a dsRNA-binding dependent manner.
Influenza A virus protein NS1 exhibits strain-independent conformational plasticity.
Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins.
Influenza vaccine: progress in a vaccine that elicits a broad immune response.
Influenza virus non-structural protein 1 (NS1) disrupts interferon signaling.
Influenza virus NS1- C/EBP? gene regulatory complex inhibits RIG-I transcription.
Large-scale analysis of Influenza A virus sequences reveals potential drug-target sites of NS proteins.
Messenger RNA translation enhancement by immune evasion proteins: a comparative study between EKB (vaccinia virus) and NS1 (influenza A virus).
Molecular characteristics of the human pandemic influenza A virus (H1N1).
Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.
Mutations associated with severity of the pandemic influenza A(H1N1)pdm09 in humans: a systematic review and meta-analysis of epidemiological evidence.
Non-linear enhancement of mRNA delivery efficiencies by influenza A derived NS1 protein engendering host gene inhibition property.
Non-structural protein 1 from avian influenza virus H9N2 is an efficient RNA silencing suppressor with characteristics that differ from those of Tomato bushy stunt virus p19.
Non-structural protein 1 of H3N2 influenza A virus induces nucleolar stress via interaction with nucleolin.
Non-structural protein 1 of influenza viruses inhibits rapid mRNA degradation mediated by double-stranded RNA-binding protein, staufen1.
NS1-binding protein abrogates the elevation of cell viability by the influenza A virus NS1 protein in association with CRKL.
Phosphorylation of Influenza A virus NS1 protein at threonine 49 suppresses its interferon antagonistic activity.
Polymorphism of the NS1 proteins of type A influenza virus.
Prophylactic protection against respiratory viruses conferred by a prototype live attenuated influenza virus vaccine.
Prophylactic Protection Against Respiratory Viruses Conferred by a Prototype Live Attenuated Influenza Virus Vaccine.
Protein clustering and RNA phylogenetic reconstruction of the influenza a virus NS1 protein allow an update in classification and identification of motif conservation.
Recovery of TRIM25-Mediated RIG-I Ubiquitination through Suppression of NS1 by RNA Aptamers.
Replication-Competent ?NS1 Influenza A Viruses Expressing Reporter Genes.
Residues F103 and M106 within the influenza A virus NS1 CPSF4-binding region regulate interferon-stimulated gene translation initiation.
Role of c-Jun terminal kinase (JNK) activation in influenza A virus-induced autophagy and replication.
Single-stranded DNA aptamer that specifically binds to the influenza virus NS1 protein suppresses interferon antagonism.
Structural Basis for a Novel Interaction between the NS1 Protein Derived from the 1918 Influenza Virus and RIG-I.
Structural basis for influenza virus NS1 protein block of mRNA nuclear export.
Structure and Function of the Influenza A Virus Non-Structural Protein 1.
Study on the Mechanisms of Active Compounds in Traditional Chinese Medicine for the Treatment of Influenza Virus by Virtual Screening.
SUMO1 modification of the non-structural protein 1 of influenza A virus.
Suppression of the antiviral response by an influenza histone mimic.
Synthesis and evaluation of quinoxaline derivatives as potential influenza NS1A protein inhibitors.
The C-Terminal Effector Domain of Non-Structural Protein 1 of Influenza A Virus Blocks IFN-? Production by Targeting TNF Receptor-Associated Factor 3.
The C-terminus of non-structural protein 1 (NS1) in H5N8 clade 2.3.4.4 avian influenza virus affects virus fitness in human cells and virulence in mice.
The Central Role of Non-Structural Protein 1 (NS1) in Influenza Biology and Infection.
The functional impairment of natural killer cells during influenza virus infection.
The Influenza NS1 Protein: What Do We Know in Equine Influenza Virus Pathogenesis?
The NS1 Protein: A Multitasking Virulence Factor.
Threonine 80 phosphorylation of non-structural protein 1 regulates the replication of influenza A virus by reducing the binding affinity with RIG-I.
TRIM25 and DEAD-Box RNA Helicase DDX3X Cooperate to Regulate RIG-I-Mediated Antiviral Immunity.
Virtual screening of potential inhibitors from TCM for the CPSF30 binding site on the NS1A protein of influenza A virus.
Kidney Failure, Chronic
Thrombotic thrombocytopenic purpura in a 2.5-year-old boy with dengue infection: a rare complication.
Leukopenia
Miller Fisher syndrome developing as a parainfectious manifestation of dengue fever: a case report and review of the literature.
Melanoma
Proteins selectively killing tumor cells.
Mumps
Development of Improved Mumps Vaccine Candidates by Mutating Viral mRNA Cap Methyltransferase Sites in the Large Polymerase Protein.
Neoplasms
Detection and a possible link between parvovirus B19 and thyroid cancer.
Molecular characteristics of the human pandemic influenza A virus (H1N1).
Non-Structural protein 1 (NS1) gene of Canine Parvovirus-2 regresses chemically induced skin tumors in Wistar rats.
Porcine reproductive and respiratory syndrome virus non-structural protein 1 suppresses tumor necrosis factor-alpha promoter activation by inhibiting NF-?B and Sp1.
Proteins selectively killing tumor cells.
Parasitemia
The mRNA cap methyltransferase gene TbCMT1 is not essential in vitro but is a virulence factor in vivo for bloodstream form Trypanosoma brucei.
Persistent Infection
Caspase-mediated cleavage of murine norovirus NS1/2 potentiates apoptosis and is required for persistent infection of intestinal epithelial cells.
Porcine Reproductive and Respiratory Syndrome
Amino acid residues in the non-structural protein 1 of porcine reproductive and respiratory syndrome virus involved in down-regulation of TNF-? expression in vitro and attenuation in vivo.
Identification of amino acid residues important for anti-IFN activity of porcine reproductive and respiratory syndrome virus non-structural protein 1.
Modulation of type I interferon induction by porcine reproductive and respiratory syndrome virus and degradation of CREB-binding protein by non-structural protein 1 in MARC-145 and HeLa cells.
Porcine reproductive and respiratory syndrome virus non-structural protein 1 suppresses tumor necrosis factor-alpha promoter activation by inhibiting NF-?B and Sp1.
The viral non-structural protein 1 alpha (Nsp1?) inhibits p53 apoptosis activity by increasing murine double minute 2 (mdm2) expression in porcine reproductive and respiratory syndrome virus (PRRSV) early-infected cells.
Transcriptome analysis of pig macrophages expressing porcine reproductive and respiratory syndrome virus non-structural protein 1.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Establishment of functional B cell memory against parvovirus B19 capsid proteins may be associated with resolution of persistent infection.
Purpura, Thrombotic Thrombocytopenic
Thrombotic thrombocytopenic purpura in a 2.5-year-old boy with dengue infection: a rare complication.
Severe Acute Respiratory Syndrome
Biochemical characterization of exoribonuclease encoded by SARS coronavirus.
Characterization of the guanine-N7 methyltransferase activity of coronavirus nsp14 on nucleotide GTP.
Expression, purification and characterization of recombinant severe acute respiratory syndrome coronavirus non-structural protein 1.
Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase.
High Fidelity of Murine Hepatitis Virus Replication Is Decreased in nsp14 Exoribonuclease Mutants.
Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA.
Structural basis and functional analysis of the SARS coronavirus nsp14-nsp10 complex.
Synthesis in Escherichia coli cells and characterization of the active exoribonuclease of severe acute respiratory syndrome coronavirus.
The cellular RNA helicase DDX1 interacts with coronavirus nonstructural protein 14 and enhances viral replication.
[Synthesis in Escherichia coli cells and characterization of the active exoribonuclease of severe acute respiratory syndrome coronavirus]
Severe Dengue
Avian anti-NS1 IgY antibodies neutralize dengue virus infection and protect against lethal dengue virus challenge.
Case Report: Cardiac Tamponade in Dengue Hemorrhagic Fever: An Unusual Manifestation of a Common Disease.
Pathogenesis of Dengue: Dawn of a New Era.
Platelet activation and aggregation response to dengue virus nonstructural protein 1 and domains.
Recent advances in understanding dengue.
Thrombocytopenia
Antiplatelet autoantibodies elicited by dengue virus non-structural protein 1 cause thrombocytopenia and mortality in mice.
Miller Fisher syndrome developing as a parainfectious manifestation of dengue fever: a case report and review of the literature.
Platelet activation and aggregation response to dengue virus nonstructural protein 1 and domains.
Thrombotic Microangiopathies
Thrombotic thrombocytopenic purpura in a 2.5-year-old boy with dengue infection: a rare complication.
Vaccinia
Definition of a human T cell epitope from influenza A non-structural protein 1 using HLA-A2.1 transgenic mice.
Effects of alanine cluster mutations in the D12 subunit of vaccinia virus mRNA (guanine-N7) methyltransferase.
Genetic analysis of poxvirus mRNA cap methyltransferase: suppression of conditional mutations in the stimulatory D12 subunit by second-site mutations in the catalytic D1 subunit.
Messenger RNA translation enhancement by immune evasion proteins: a comparative study between EKB (vaccinia virus) and NS1 (influenza A virus).
Mutational analysis of vaccinia virus mRNA cap (guanine-N7) methyltransferase reveals essential contributions of the N-terminal peptide that closes over the active site.
Poxvirus mRNA cap methyltransferase. Bypass of the requirement for the stimulatory subunit by mutations in the catalytic subunit and evidence for intersubunit allostery.
Structure-function analysis of vaccinia virus mRNA cap (guanine-N7) methyltransferase.
Synthesis of mRNA guanylyltransferase and mRNA methyltransferases in cells infected with vaccinia virus.
Yeast mRNA cap methyltransferase is a 50-kilodalton protein encoded by an essential gene.
Vesicular Stomatitis
Amino acid residues within conserved domain VI of the vesicular stomatitis virus large polymerase protein essential for mRNA cap methyltransferase activity.
Identification of a new region in the vesicular stomatitis virus L polymerase protein which is essential for mRNA cap methylation.
Influenza vaccine: progress in a vaccine that elicits a broad immune response.
Viremia
Dengue in travelers: kinetics of viremia and NS1 antigenemia and their associations with clinical parameters.
Virological and Immunological Outcomes in Rhesus Monkeys after Exposure to Dengue Virus-Infected Aedes aegypti Mosquitoes.
Virus Diseases
Added value of IgA antibodies against Zika virus non-structural protein 1 in the diagnosis of acute Zika virus infections.
Classification of salivary based NS1 from Raman Spectroscopy with support vector machine.
Detection of highly pathogenic avian influenza virus infection in vaccinated chicken flocks by monitoring antibodies against non-structural protein 1 (NS1).
Development of an anti-Dengue NS1 IgG ELISA to Evaluate Exposure to Dengue Virus.
Emetine, a potent alkaloid for the treatment of SARS-CoV-2 targeting papain-like protease and non-structural proteins: pharmacokinetics, molecular docking and dynamic studies.
Evaluation and use of NS1 IgM antibody detection for acute dengue virus diagnosis: report from an outbreak investigation.
Impairment of the Staufen1-NS1 interaction reduces influenza viral replication.
Mutagenesis of S-Adenosyl-l-Methionine-Binding Residues in Coronavirus nsp14 N7-Methyltransferase Demonstrates Differing Requirements for Genome Translation and Resistance to Innate Immunity.
Non-structural protein 1 (NS1) antibody-based assays to differentiate West Nile (WN) virus from Japanese encephalitis virus infections in horses: Effects of WN virus NS1 antibodies induced by inactivated WN vaccine.
Phosphorylation of Influenza A virus NS1 protein at threonine 49 suppresses its interferon antagonistic activity.
Prophylactic protection against respiratory viruses conferred by a prototype live attenuated influenza virus vaccine.
Prophylactic Protection Against Respiratory Viruses Conferred by a Prototype Live Attenuated Influenza Virus Vaccine.
The Central Role of Non-Structural Protein 1 (NS1) in Influenza Biology and Infection.
West Nile Fever
Non-structural protein 1 (NS1) antibody-based assays to differentiate West Nile (WN) virus from Japanese encephalitis virus infections in horses: Effects of WN virus NS1 antibodies induced by inactivated WN vaccine.
Serologic diagnosis of West Nile and St. Louis encephalitis virus infections in domestic chickens.
Yellow Fever
Development and Clinical Evaluation of a Rapid Diagnostic Test for Yellow Fever Non-Structural Protein 1.
Zika Virus Infection
Added value of IgA antibodies against Zika virus non-structural protein 1 in the diagnosis of acute Zika virus infections.
Zika Virus Antibody Titers Three Years after Confirmed Infection.