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Disease on EC 2.1.1.228 - tRNA (guanine37-N1)-methyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Mature methyl-deficient tRNA isolated from a mammary adenocarcinoma.
Methyl-accepting RNA in 13762 mammary adenocarcinoma correlated with low adenine methyltransferase levels.
Carcinogenesis
Chromosome 8 BAC array comparative genomic hybridization and expression analysis identify amplification and overexpression of TRMT12 in breast cancer.
Carcinoma
A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-?.
Carcinoma, Hepatocellular
Composition, associated tissue methyltransferase activity, and catabolic end products of transfer RNA from carcinogen-induced hepatoma and normal monkey livers.
Diabetes Mellitus
tRNA methyltransferase homologue gene TRMT10A mutation in young adult-onset diabetes with intellectual disability, microcephaly and epilepsy.
Epilepsy
tRNA methyltransferase 10 homologue A (TRMT10A) mutation in a Chinese patient with diabetes, insulin resistance, intellectual deficiency and microcephaly.
tRNA methyltransferase homologue gene TRMT10A mutation in young adult-onset diabetes with intellectual disability, microcephaly and epilepsy.
Infections
Alteration in tRNA methyltransferase activity in mengovirus infection: host range specificity.
Insulin Resistance
tRNA methyltransferase 10 homologue A (TRMT10A) mutation in a Chinese patient with diabetes, insulin resistance, intellectual deficiency and microcephaly.
Intellectual Disability
Expanding the Phenotype of TRMT10A Mutations: Case Report and a Review of the Existing Cases.
Mutations in the tRNA methyltransferase 1 gene TRMT1 cause congenital microcephaly, isolated inferior vermian hypoplasia and cystic leukomalacia in addition to intellectual disability.
TRMT1-catalyzed tRNA modifications are required for redox homeostasis to ensure proper cellular proliferation and oxidative stress survival.
TRMT10A mutation in a child with diabetes, short stature, microcephaly and hypoplastic kidneys.
tRNA methyltransferase 10 homologue A (TRMT10A) mutation in a Chinese patient with diabetes, insulin resistance, intellectual deficiency and microcephaly.
tRNA Methyltransferase Defects and Intellectual Disability.
tRNA methyltransferase homologue gene TRMT10A mutation in young adult-onset diabetes with intellectual disability, microcephaly and epilepsy.
Leukemia
Differences in activity of N2-guanine tRNA methyltransferase II among several inbred strains of mice.
Microcephaly
Expanding the Phenotype of TRMT10A Mutations: Case Report and a Review of the Existing Cases.
Mutations in the tRNA methyltransferase 1 gene TRMT1 cause congenital microcephaly, isolated inferior vermian hypoplasia and cystic leukomalacia in addition to intellectual disability.
Pancreatic ?-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes.
TRMT10A mutation in a child with diabetes, short stature, microcephaly and hypoplastic kidneys.
tRNA methyltransferase 10 homologue A (TRMT10A) mutation in a Chinese patient with diabetes, insulin resistance, intellectual deficiency and microcephaly.
tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humans.
tRNA methyltransferase homologue gene TRMT10A mutation in young adult-onset diabetes with intellectual disability, microcephaly and epilepsy.
Neoplasms
A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-?.
A system of RNA modifications and biased codon use controls cellular stress response at the level of translation.
Methyl-accepting RNA in 13762 mammary adenocarcinoma correlated with low adenine methyltransferase levels.
Somatic cancer mutations in the DNMT2 tRNA methyltransferase alter its catalytic properties.
tRNA Methyltransferase Defects and Intellectual Disability.
Nervous System Diseases
tRNA Methyltransferase Defects and Intellectual Disability.
Ovarian Neoplasms
Association of tRNA methyltransferase NSUN2/IGF-II molecular signature with ovarian cancer survival.
Ovarian cancer proliferation and apoptosis are regulated by human transfer RNA methyltransferase 9-likevia LIN9.
Retinoblastoma
Ovarian cancer proliferation and apoptosis are regulated by human transfer RNA methyltransferase 9-likevia LIN9.
Starvation
Retrograde nuclear import of tRNA precursors is required for modified base biogenesis in yeast.
Vitamin A Deficiency
The effect of vitamin A deficiency on testicular transfer RNA methyltransferase activity.