Reference on EC 2.1.1.227 - 16S rRNA (cytidine1409-2'-O)-methyltransferase

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710879

Maus, C.E.; Plikaytis, B.B.; Shinnick, T.M.

Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis

Antimicrob. Agents Chemother.

571-577

2005

Mycobacterium tuberculosis

15673735

713026

Johansen, S.K.; Maus, C.E.; Plikaytis, B.B.; Douthwaite, S.

Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs

Mol. Cell

173-182

2006

Mycobacterium tuberculosis

16857584

720503

Monshupanee, T.; Johansen, S.K.; Dahlberg, A.E.; Douthwaite, S.

Capreomycin susceptibility is increased by TlyA-directed 2-O-methylation on both ribosomal subunits

Mol. Microbiol.

1194-1203

2012

Geobacillus stearothermophilus, Mycobacterium tuberculosis, no activity in Escherichia coli, Streptomyces coelicolor, Mycolicibacterium smegmatis (A0QYR0), Mycobacterium tuberculosis H37Rv, Mycolicibacterium smegmatis mc(2)155 (A0QYR0)

22779429

735991

Monshupanee, T.

Increased bacterial hemolytic activity is conferred by expression of TlyA methyltransferase but not by its 2'-O-methylation of the ribosome

Curr. Microbiol.

61-68

2013

Mycobacterium tuberculosis (P9WJ63), Mycobacterium tuberculosis H37Rv (P9WJ63)

23417025

758323

Freihofer, P.; Akbergenov, R.; Teo, Y.; Juskeviciene, R.; Andersson, D.; Boettger, E.

Nonmutational compensation of the fitness cost of antibiotic resistance in mycobacteria by overexpression of tlyA rRNA methylase

RNA

1836-1843

2016

Mycobacterium tuberculosis (P9WJ63), Mycobacterium tuberculosis H37Rv (P9WJ63)

27698071