Reference on EC 2.1.1.204 - tRNA (cytosine38-C5)-methyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rai, K.; Chidester, S.; Zavala, C.V.; Manos, E.J.; James, S.R.; Karpf, A.R.; Jones, D.A.; Cairns, B.R.
Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafish
Genes Dev.
21
261-266
2007
Danio rerio
Schaefer, M.; Pollex, T.; Hanna, K.; Tuorto, F.; Meusburger, M.; Helmm M.; Lyko, F.
RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage
Genes Dev.
24
1590-1595
2010
Drosophila melanogaster (Q9U6H7)
Schaefer, M.; Steringer, J.P.; Lyko, F.
The Drosophila cytosine-5 methyltransferase Dnmt2 is associated with the nuclear matrix and can access DNA during mitosis
PLoS One
3
e1414
2008
Drosophila melanogaster
Jurkowski, T.P.; Meusburger, M.; Phalke, S.; Helm, M.; Nellen, W.; Reuter, G.; Jeltsch, A.
Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism
RNA
14
1663-1670
2008
Drosophila melanogaster, Homo sapiens
Goll, M.G.; Kirpekar, F.; Maggert, K.A.; Yoder, J.A.; Hsieh, C.L.; Zhang, X.; Golic, K.G.; Jacobsen, S.E.; Bestor, T.H.
Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2
Science
311
395-398
2006
Homo sapiens (O14717), Homo sapiens
Jurkowski, T.P.; Shanmugam, R.; Helm, M.; Jeltsch, A.
Mapping the tRNA binding site on the surface of human DNMT2 methyltransferase
Biochemistry
51
4438-4444
2012
Homo sapiens
Elhardt, W.; Shanmugam, R.; Jurkowski, T.P.; Jeltsch, A.
Somatic cancer mutations in the DNMT2 tRNA methyltransferase alter its catalytic properties
Biochimie
112
66-72
2015
Homo sapiens
Uysal, F.; Akkoyunlu, G.; Ozturk, S.
Dynamic expression of DNA methyltransferases (DNMTs) in oocytes and early embryos
Biochimie
116
103-113
2015
Bos taurus, Homo sapiens, Mus musculus (O55055)
Burgess, A.; David, R.; Searle, I.
Conservation of tRNA and rRNA 5-methylcytosine in the kingdom Plantae
BMC Plant Biol.
15
199
2015
Arabidopsis thaliana
Tuorto, F.; Herbst, F.; Alerasool, N.; Bender, S.; Popp, O.; Federico, G.; Reitter, S.; Liebers, R.; Stoecklin, G.; Groene, H.J.; Dittmar, G.; Glimm, H.; Lyko, F.
The tRNA methyltransferase Dnmt2 is required for accurate polypeptide synthesis during haematopoiesis
EMBO J.
34
2350-2362
2015
Mus musculus (O55055), Mus musculus C57BL/6 (O55055)
Militello, K.T.; Chen, L.M.; Ackerman, S.E.; Mandarano, A.H.; Valentine, E.L.
A map of 5-methylcytosine residues in Trypanosoma brucei tRNA revealed by sodium bisulfite sequencing
Mol. Biochem. Parasitol.
193
122-126
2014
no activity in Trypanosoma brucei
Khoddami, V.; Cairns, B.R.
Identification of direct targets and modified bases of RNA cytosine methyltransferases
Nat. Biotechnol.
31
458-464
2013
Homo sapiens
Mueller, M.; Hartmann, M.; Schuster, I.; Bender, S.; Thuering, K.L.; Helm, M.; Katze, J.R.; Nellen, W.; Lyko, F.; Ehrenhofer-Murray, A.E.
Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuine
Nucleic Acids Res.
43
10952-10962
2015
Dictyostelium discoideum, Schizosaccharomyces pombe
Govindaraju, G.; Jabeena, C.A.; Sethumadhavan, D.V.; Rajaram, N.; Rajavelu, A.
DNA methyltransferase homologue TRDMT1 in Plasmodium falciparum specifically methylates endogenous aspartic acid tRNA
Biochim. Biophys. Acta
1860
1047-1057
2017
Plasmodium falciparum (Q8IBI4)
Ehrenhofer-Murray, A.E.
Cross-talk between Dnmt2-dependent tRNA methylation and queuosine modification
Biomolecules
7
14
2017
no activity in Saccharomyces cerevisiae, Mus musculus (O55055), Schizosaccharomyces pombe (P40999), Drosophila melanogaster (Q9VKB3), Schizosaccharomyces pombe ATCC 24843 (P40999), Schizosaccharomyces pombe 972 (P40999)
Shanmugam, R.; Fierer, J.; Kaiser, S.; Helm, M.; Jurkowski, T.P.; Jeltsch, A.
Cytosine methylation of tRNA-Asp by DNMT2 has a role in translation of proteins containing poly-Asp sequences
Cell Discov.
1
15010
2015
Homo sapiens (O14717), Homo sapiens, Mus musculus (O55055), Mus musculus
Genenncher, B.; Durdevic, Z.; Hanna, K.; Zinkl, D.; Mobin, M.B.; Senturk, N.; Da Silva, B.; Legrand, C.; Carre, C.; Lyko, F.; Schaefer, M.
Mutations in cytosine-5 tRNA methyltransferases impact mobile element expression and genome stability at specific DNA repeats
Cell Rep.
22
1861-1874
2018
Drosophila melanogaster (Q9U6H7)
Mueller, M.; Hartmann, M.; Schuster, I.; Bender, S.; Thuering, K.L.; Helm, M.; Katze, J.R.; Nellen, W.; Lyko, F.; Ehrenhofer-Murray, A.E.
Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuine
Nucleic Acids Res.
43
10952-10962
2015
Schizosaccharomyces pombe (P40999)
Uysal, F.; Akkoyunlu, G.; Ozturk, S.
DNA methyltransferases exhibit dynamic expression during spermatogenesis
Reprod. Biomed. Online
33
690-702
2016
Homo sapiens (O14717), Mus musculus (O55055)
Johannsson, S.; Neumann, P.; Wulf, A.; Welp, L.M.; Gerber, H.D.; Krull, M.; Diederichsen, U.; Urlaub, H.; Ficner, R.
Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiency by the tRNA nucleoside queuosine
Sci. Rep.
8
8880
2018
Schizosaccharomyces pombe (P40999), Schizosaccharomyces pombe ATCC 24843 (P40999), Schizosaccharomyces pombe 972 (P40999)
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