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The enzyme catalyses the methylation of guanosine2251, a modification conserved in the peptidyltransferase domain of 23S rRNA.
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The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
guanosine2251 in 23S rRNA
2'-O-methylguanosine2251 in 23S rRNA
23S rRNA methyltransferase, rlmB
, rRNA Gm2251 methyltransferase, yifH
S-adenosyl-L-methionine + guanosine2251 in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine2251 in 23S rRNA
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