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Information on EC 2.1.1.139 - 3'-demethylstaurosporine O-methyltransferase for references in articles please use BRENDA:EC2.1.1.139
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IUBMB Comments Catalyses the final step in the biosynthesis of staurosporine, an alkaloidal antibiotic that is a potent inhibitor of protein kinases, especially protein kinase C.
The enzyme appears in viruses and cellular organisms
Synonyms
3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase, staurosporine synthase,
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3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase
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staurosporine synthase
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S-adenosyl-L-methionine + 3'-demethylstaurosporine = S-adenosyl-L-homocysteine + staurosporine
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transfer of methyl group
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S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase
Catalyses the final step in the biosynthesis of staurosporine, an alkaloidal antibiotic that is a potent inhibitor of protein kinases, especially protein kinase C.
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S-adenosyl-L-methionine + 3'-demethylstaurosporine
S-adenosyl-L-homocysteine + staurosporine
S-adenosyl-L-methionine + 3'-demethylstaurosporine
S-adenosyl-L-homocysteine + staurosporine
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S-adenosyl-L-methionine + 3'-demethylstaurosporine
S-adenosyl-L-homocysteine + staurosporine
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S-adenosyl-L-methionine + 3'-demethylstaurosporine
S-adenosyl-L-homocysteine + staurosporine
S-adenosyl-L-methionine + 3'-demethylstaurosporine
S-adenosyl-L-homocysteine + staurosporine
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S-adenosyl-L-methionine + 3'-demethylstaurosporine
S-adenosyl-L-homocysteine + staurosporine
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1H-indole
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62% activity left at 1.1 mM
3'-demethylstaurosporine
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69% activity at 1.1 mM
anthranilate
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75% activity left at 1.1 mM
Indole-3-pyruvate
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44% activity left at 1.1 mM
S-(5'-adenosyl)-L-homocysteine
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strong inhibition, 8% activity left at 1.1 mM, probably competitive inhibition
sinefungin
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antiprotozoal antibiotic from Streptomyces griseolus, efficient inhibition with concentrations higher than 1 mg/100 ml
tryptophan
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64% activity left at 1.1 mM
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tryptophan
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2fold increase at 0.2 mM
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brenda
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brenda
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anion exchange chromatography, partial purification
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Yang, S.W.; Lin, L.J.; Cordell, G.A.; Wang, P.; Corley, D.G.
O- and N-methylation in the biosynthesis of staurosporine
J. Nat. Prod.
62
1551-1553
1999
Lentzea albida
brenda
Weidner, S.; Kittelmann, M.; Goeke, K.; Ghisalba, O.; Zähner, H.
3'-Demethoxy-3'hydroxystaurosporine O-methyltransferase from Streptomyces longisporoflavus catalyzing the last step in the biosynthesis of staurosporine
J. Antibiot.
51
697-682
1998
Streptomyces longisporoflavus
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brenda
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