show all | hide all No of entries

Information on EC - polyprenyldihydroxybenzoate methyltransferase

for references in articles please use BRENDA:EC2.1.1.114
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
This enzyme is involved in ubiquinone biosynthesis. Ubiquinones from different organisms have a different number of prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone-9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units. For example, the human COQ3 enzyme can restore biosynthesis of ubiquinone-6 in coq3 deletion mutants of yeast . The enzymes from yeast and rat also catalyse the methylation of 3-demethylubiquinol-6 and 3-demethylubiquinol-9, respectively (this activity is classified as EC, 3-demethylubiquinol 3-O-methyltransferase).
Specify your search results
Select one or more organisms in this record: ?
Word Map
  • nonfermentable
  • elegans
  • co-migrate
  • peripherally
  • multi-subunit
  • q-deficient
  • p-hydroxybenzoic
  • digitonin-solubilized
  • worms
  • native-page
  • isoprenoid
  • medicine
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase, AtCOQ3, COQ-3, COQ3, Coq3 O-methyltransferase, Coq3p, DHHB methyltransferase, DHHB-MTase, dihydroxyhexaprenylbenzoate methyltransferase, UbiG, more
S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate
show the reaction diagram
Select items on the left to see more content.