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Information on EC - tryptophan 2-C-methyltransferase

for references in articles please use BRENDA:EC2.1.1.106
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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
       tryptophan 2-C-methyltransferase
IUBMB Comments
The enzyme, characterized from the bacterium Streptomyces laurentii, is involved in thiostrepton biosynthesis. It is a radical SAM enzyme that contains a [4Fe-4S] center and a cobalamin cofactor. The enzyme first transfers the methyl group from SAM to the bound cobalamin, followed by transfer from methylcobalamin to L-tryptophan, resulting in retention of the original methyl group configuration. The second transfer is likely to involve a CH3 radical species formed from methylcobalamin by the concerted action of a partially ligated radical SAM [4Fe-4S]2+/1+ center.
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The enzyme appears in viruses and cellular organisms
S-adenosylmethionine:tryptophan 2-methyltransferase, thiostrepton A tryptophan methyltransferase, thiostrepton tryptophan methyltransferase, tryptophan 2-methyltransferase, TsrM, TsrT, more
S-adenosyl-L-methionine + L-tryptophan = S-adenosyl-L-homocysteine + L-2-methyltryptophan
show the reaction diagram
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