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Disease on EC 2.1.1.1 - nicotinamide N-methyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Increased hepatic nicotinamide N-methyltransferase activity as a marker of cancer cachexia in mice bearing colon 26 adenocarcinoma.
Adenoma, Oxyphilic
Identification of nicotinamide N-methyltransferase as a novel tumor marker for renal clear cell carcinoma.
Alzheimer Disease
High Expression of Nicotinamide N-Methyltransferase in Patients with Sporadic Alzheimer's Disease.
Ameloblastoma
Differential expression of nicotinamide N-methyltransferase in primary and recurrent ameloblastomas and odontogenic keratocysts.
Atherosclerosis
Serum N1-Methylnicotinamide is Associated With Coronary Artery Disease in Chinese Patients.
Breast Neoplasms
Down-regulation of nicotinamide N-methyltransferase induces apoptosis in human breast cancer cells via the mitochondria-mediated pathway.
Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization.
Nicotinamide N-methyltransferase inhibits autophagy induced by oxidative stress through suppressing the AMPK pathway in breast cancer cells.
Carcinogenesis
N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291-altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis.
Nicotinamide N-methyltransferase enhances the capacity of tumorigenesis associated with the promotion of cell cycle progression in human colorectal cancer cells.
NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink.
Carcinoma
Accumulation of Nicotinamide N-Methyltransferase (NNMT) in Cancer-associated Fibroblasts: A Potential Prognostic and Predictive Biomarker for Gastric Carcinoma.
Analysis of tissue and salivary nicotinamide N-methyltransferase in oral squamous cell carcinoma: basis for the development of a noninvasive diagnostic test for early-stage disease.
Correction to: Downregulation of nicotinamide N-methyltransferase inhibits migration and epithelial-mesenchymal transition of esophageal squamous cell carcinoma via Wnt/?-catenin pathway.
Deregulation of Nicotinamide N-Methyltransferase and Gap Junction Protein Alpha-1 Causes Metastasis in Adenoid Cystic Carcinoma.
Differential expression of nicotinamide N-methyltransferase in cutaneous keratoacanthoma and squamous cell carcinoma: an immunohistochemical study.
Downregulation of nicotinamide N-methyltransferase inhibits migration and epithelial-mesenchymal transition of esophageal squamous cell carcinoma via Wnt/?-catenin pathway.
Expression and Clinical Significance of Nicotinamide N-Methyltransferase in Cervical Squamous Cell Carcinoma.
Identification of nicotinamide N-methyltransferase as a novel tumor marker for renal clear cell carcinoma.
Involvement of transforming growth factor beta 1 in the transcriptional regulation of nicotinamide N-methyltransferase in clear cell renal cell carcinoma.
N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291-altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis.
Nicotinamide N-Methyltransferase and Its Precursor Substrate Methionine Directly and Indirectly Control Malignant Metabolism During Progression of Renal Cell Carcinoma.
Nicotinamide N-methyltransferase decreases 5-fluorouracil sensitivity in human esophageal squamous cell carcinoma through metabolic reprogramming and promoting the Warburg effect.
Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization.
Nicotinamide N-methyltransferase Induces Cellular Invasion through Activating Matrix Metalloproteinase-2 Expression in Clear Cell Renal Cell Carcinoma Cells.
Nicotinamide N-Methyltransferase upregulation correlates with tumour differentiation in oral squamous cell carcinoma.
Nicotinamide N-methyltransferase upregulation inversely correlates with lymph node metastasis in oral squamous cell carcinoma.
Nicotinamide N-methyltransferase: a potential biomarker for worse prognosis in gastric carcinoma.
RNA-Mediated Gene Silencing of Nicotinamide N-Methyltransferase Is Associated with Decreased Tumorigenicity in Human Oral Carcinoma Cells.
Carcinoma, Adenoid Cystic
Deregulation of Nicotinamide N-Methyltransferase and Gap Junction Protein Alpha-1 Causes Metastasis in Adenoid Cystic Carcinoma.
Carcinoma, Hepatocellular
Elevated N-methyltransferase expression induced by hepatic stellate cells contributes to the metastasis of hepatocellular carcinoma via regulation of the CD44v3 isoform.
Expression of nicotinamide N-methyltransferase in hepatocellular carcinoma is associated with poor prognosis.
Hepatoblastomas exhibit marked NNMT downregulation driven by promoter DNA hypermethylation.
Nicotinamide methylation. Tissue distribution, developmental and neoplastic changes.
Carcinoma, Non-Small-Cell Lung
Nicotinamide N-methyltransferase in Non-small Cell Lung Cancer: Promising Results for Targeted Anti-cancer Therapy.
Role of nicotinamide N-methyltransferase in non-small cell lung cancer: in vitro effect of shRNA-mediated gene silencing on tumourigenicity.
Carcinoma, Renal Cell
Identification of nicotinamide N-methyltransferase as a novel tumor marker for renal clear cell carcinoma.
Involvement of transforming growth factor beta 1 in the transcriptional regulation of nicotinamide N-methyltransferase in clear cell renal cell carcinoma.
Nicotinamide N-Methyltransferase and Its Precursor Substrate Methionine Directly and Indirectly Control Malignant Metabolism During Progression of Renal Cell Carcinoma.
Nicotinamide N-methyltransferase Induces Cellular Invasion through Activating Matrix Metalloproteinase-2 Expression in Clear Cell Renal Cell Carcinoma Cells.
Nicotinamide N-methyltransferase protein expression in renal cell cancer.
Carcinoma, Squamous Cell
Differential expression of nicotinamide N-methyltransferase in cutaneous keratoacanthoma and squamous cell carcinoma: an immunohistochemical study.
Expression and Clinical Significance of Nicotinamide N-Methyltransferase in Cervical Squamous Cell Carcinoma.
Colorectal Neoplasms
Accumulation of Nicotinamide N-Methyltransferase (NNMT) in Cancer-associated Fibroblasts: A Potential Prognostic and Predictive Biomarker for Gastric Carcinoma.
High stromal nicotinamide N-methyltransferase (NNMT) indicates poor prognosis in colorectal cancer.
Identification of nicotinamide N-methyltransferase as a novel serum tumor marker for colorectal cancer.
Identification of PSME3 as a novel serum tumor marker for colorectal cancer by combining two-dimensional polyacrylamide gel electrophoresis with a strictly mass spectrometry-based approach for data analysis.
Nicotinamide N-methyltransferase enhances resistance to 5-fluorouracil in colorectal cancer cells through inhibition of the ASK1-p38 MAPK pathway.
Nicotinamide N-methyltransferase enhances the capacity of tumorigenesis associated with the promotion of cell cycle progression in human colorectal cancer cells.
Overexpression of Nicotinamide N-methyltransferase mainly covers stroma of colorectal cancer and correlates with unfavorable survival by its product 1-MNA.
Coronary Artery Disease
Serum N1-methylnicotinamide is Associated with Left Ventricular Systolic Dysfunction in Chinese.
Diabetes Mellitus, Type 2
Roles of Nicotinamide N-Methyltransferase in Obesity and Type 2 Diabetes.
Endometrial Neoplasms
Nicotinamide N-methyltransferase expression and its association with phospho-Akt, p53 expression, and survival in high-grade endometrial cancer
Esophageal Squamous Cell Carcinoma
Correction to: Downregulation of nicotinamide N-methyltransferase inhibits migration and epithelial-mesenchymal transition of esophageal squamous cell carcinoma via Wnt/?-catenin pathway.
Downregulation of nicotinamide N-methyltransferase inhibits migration and epithelial-mesenchymal transition of esophageal squamous cell carcinoma via Wnt/?-catenin pathway.
Nicotinamide N-methyltransferase decreases 5-fluorouracil sensitivity in human esophageal squamous cell carcinoma through metabolic reprogramming and promoting the Warburg effect.
Glioblastoma
Nicotinamide metabolism regulates glioblastoma stem cell maintenance.
Glioma
Interferon-gamma elevates nicotinamide N-methyltransferase activity and nicotinamide level in human glioma cells.
Heart Defects, Congenital
Eight-fold increased risk for congenital heart defects in children carrying the nicotinamide N-methyltransferase polymorphism and exposed to medicines and low nicotinamide.
Heart Diseases
Association of MTHFR A1298C polymorphism with conotruncal heart disease.
Hepatitis
Nicotinamide N-methyltransferase (NNMT) and 1-methylnicotinamide (MNA) in experimental hepatitis induced by concanavalin A in the mouse.
Hepatoblastoma
Hepatoblastomas exhibit marked NNMT downregulation driven by promoter DNA hypermethylation.
Hyperhomocysteinemia
Hyperhomocysteinemia does not affect global DNA methylation and nicotinamide N-methyltransferase expression in mice.
Hyperlipidemias
Physiological Study on Association between Nicotinamide N-Methyltransferase Gene Polymorphisms and Hyperlipidemia.
Hypertension, Pulmonary
Activation of the nicotinamide N-methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension.
Insulin Resistance
Genetic Nicotinamide N-Methyltransferase (Nnmt) Deficiency in Male Mice Improves Insulin Sensitivity in Diet-Induced Obesity but Does Not Affect Glucose Tolerance.
Iron Overload
Nicotinamide N-methyltransferase expression decreases in iron overload, exacerbating toxicity in mouse hepatocytes.
Ischemic Stroke
Homocyst(e)ine and stroke.
Keratoacanthoma
Differential expression of nicotinamide N-methyltransferase in cutaneous keratoacanthoma and squamous cell carcinoma: an immunohistochemical study.
Leukemia
Stat3 up-regulates expression of nicotinamide N-methyltransferase in human cancer cells.
Liver Diseases
Thiamethoxam induces nonalcoholic fatty liver disease in mice via methionine metabolism disturb via nicotinamide N-methyltransferase overexpression.
Liver Neoplasms
Hepatoblastomas exhibit marked NNMT downregulation driven by promoter DNA hypermethylation.
Lung Neoplasms
Nicotinamide N-methyltransferase in Non-small Cell Lung Cancer: Promising Results for Targeted Anti-cancer Therapy.
Role of nicotinamide N-methyltransferase in non-small cell lung cancer: in vitro effect of shRNA-mediated gene silencing on tumourigenicity.
Serum levels of nicotinamide N-methyltransferase in patients with lung cancer.
Targeting Nicotinamide N-Methyltransferase and miR-449a in EGFR-TKI-Resistant Non-Small-Cell Lung Cancer Cells.
Lymphatic Metastasis
Nicotinamide N-methyltransferase upregulation inversely correlates with lymph node metastasis in oral squamous cell carcinoma.
Melanoma
Analysis of nicotinamide N-methyltransferase in oral malignant melanoma and potential prognostic significance.
Nicotinamide N-methyltransferase gene silencing enhances chemosensitivity of melanoma cell lines.
Nicotinamide N-methyltransferase: potential involvement in cutaneous malignant melanoma.
Metabolic Syndrome
Potential Involvement of Nicotinamide N-Methyltransferase in the Pathogenesis of Metabolic Syndrome.
Muscular Dystrophies
NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation.
Nasopharyngeal Carcinoma
Nicotinamide N-methyltransferase overexpression is associated with Akt phosphorylation and indicates worse prognosis in patients with nasopharyngeal carcinoma.
Neoplasm Metastasis
Deregulation of Nicotinamide N-Methyltransferase and Gap Junction Protein Alpha-1 Causes Metastasis in Adenoid Cystic Carcinoma.
Nicotinamide N-methyltransferase upregulation inversely correlates with lymph node metastasis in oral squamous cell carcinoma.
Neoplasms
1-Methylnicotinamide is an immune regulatory metabolite in human ovarian cancer.
Accumulation of Nicotinamide N-Methyltransferase (NNMT) in Cancer-associated Fibroblasts: A Potential Prognostic and Predictive Biomarker for Gastric Carcinoma.
Cancer stem cell enrichment is associated with enhancement of nicotinamide N-methyltransferase expression.
Cancer stem cell overexpression of nicotinamide N-methyltransferase enhances cellular radiation resistance.
Chemical Proteomic Profiling of Human Methyltransferases.
Composite three-marker assay for early detection of kidney cancer.
Differential proteomic analysis of renal cell carcinoma tissue interstitial fluid.
Down-regulation of nicotinamide N-methyltransferase induces apoptosis in human breast cancer cells via the mitochondria-mediated pathway.
Effect of orally administered phenethyl isothiocyanate on hepatic gene expression in rats.
Enhanced expression of nicotinamide N-methyltransferase in human papillary thyroid carcinoma cells.
Expression and Clinical Significance of Nicotinamide N-Methyltransferase in Cervical Squamous Cell Carcinoma.
Hepatoblastomas exhibit marked NNMT downregulation driven by promoter DNA hypermethylation.
High stromal nicotinamide N-methyltransferase (NNMT) indicates poor prognosis in colorectal cancer.
Identification and characterization of cancer stem cells from head and neck squamous cell carcinoma cell lines.
Identification of nicotinamide N-methyltransferase as a novel serum tumor marker for colorectal cancer.
Identification of nicotinamide N-methyltransferase as a novel tumor marker for renal clear cell carcinoma.
Identification of PSME3 as a novel serum tumor marker for colorectal cancer by combining two-dimensional polyacrylamide gel electrophoresis with a strictly mass spectrometry-based approach for data analysis.
Increased hepatic nicotinamide N-methyltransferase activity as a marker of cancer cachexia in mice bearing colon 26 adenocarcinoma.
Inhibiting proliferation in KB cancer cells by RNA interference-mediated knockdown of nicotinamide N-methyltransferase expression.
Long Non-coding RNA ST8SIA6-AS1 Promotes Lung Adenocarcinoma Progression Through Sponging miR-125a-3p.
Maternal nicotinamide supplementation causes global DNA hypomethylation, uracil hypo-incorporation and gene expression changes in fetal rats.
Nicotinamide methylation. Tissue distribution, developmental and neoplastic changes.
Nicotinamide N-methyltransferase as a potential marker for cancer.
Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization.
Nicotinamide N-methyltransferase enhances resistance to 5-fluorouracil in colorectal cancer cells through inhibition of the ASK1-p38 MAPK pathway.
Nicotinamide N-methyltransferase enhances the capacity of tumorigenesis associated with the promotion of cell cycle progression in human colorectal cancer cells.
Nicotinamide N-methyltransferase expression and its association with phospho-Akt, p53 expression, and survival in high-grade endometrial cancer
Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer.
Nicotinamide N-methyltransferase in endothelium protects against oxidant stress-induced endothelial injury.
Nicotinamide N-methyltransferase in nonmelanoma skin cancers.
Nicotinamide N-methyltransferase inhibits autophagy induced by oxidative stress through suppressing the AMPK pathway in breast cancer cells.
Nicotinamide N-Methyltransferase Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Gastric Cancer.
Nicotinamide N-methyltransferase overexpression is associated with Akt phosphorylation and indicates worse prognosis in patients with nasopharyngeal carcinoma.
Nicotinamide N-methyltransferase overexpression may be associated with poor prognosis in ovarian cancer.
Nicotinamide N-methyltransferase promotes epithelial-mesenchymal transition in gastric cancer cells by activating transforming growth factor-?1 expression.
Nicotinamide N-methyltransferase protein expression in renal cell cancer.
Nicotinamide N-Methyltransferase Suppression Participates in Nickel-Induced Histone H3 Lysine9 Dimethylation in BEAS-2B Cells.
Nicotinamide N-Methyltransferase upregulation correlates with tumour differentiation in oral squamous cell carcinoma.
Nicotinamide N-Methyltransferase: Genomic Connection to Disease.
NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink.
Overexpression of Nicotinamide N-methyltransferase mainly covers stroma of colorectal cancer and correlates with unfavorable survival by its product 1-MNA.
Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration.
Prognostic Value of Nicotinamide N-Methyltransferase Expression in Patients With Solid Tumors: A Systematic Review and Meta-Analysis.
Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts.
Radioproteomics in patients with ovarian cancer.
Role of nicotinamide N-methyltransferase in non-small cell lung cancer: in vitro effect of shRNA-mediated gene silencing on tumourigenicity.
Scale-Up Evaluation of a Composite Tumor Marker Assay for the Early Detection of Renal Cell Carcinoma.
Stat3 up-regulates expression of nicotinamide N-methyltransferase in human cancer cells.
Targeting Nicotinamide N-Methyltransferase and miR-449a in EGFR-TKI-Resistant Non-Small-Cell Lung Cancer Cells.
Neuroblastoma
Nicotinamide N-methyltransferase expression in SH-SY5Y human neuroblastoma cells decreases oxidative stress.
Nicotinamide N-methyltransferase expression in SH-SY5Y neuroblastoma and N27 mesencephalic neurones induces changes in cell morphology via ephrin-B2 and Akt signalling.
Non-alcoholic Fatty Liver Disease
Thiamethoxam induces nonalcoholic fatty liver disease in mice via methionine metabolism disturb via nicotinamide N-methyltransferase overexpression.
Obesity
Antisense oligonucleotide and thyroid hormone conjugates for obesity treatment.
Association between Nicotinamide N-Methyltransferase Gene Polymorphisms and Obesity in Chinese Han Male College Students.
Genetic Nicotinamide N-Methyltransferase (Nnmt) Deficiency in Male Mice Improves Insulin Sensitivity in Diet-Induced Obesity but Does Not Affect Glucose Tolerance.
Identification of rare variants in CADM1 in patients with anorexia nervosa.
Loss of the RNA polymerase III repressor MAF1 confers obesity resistance.
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.
Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase.
OS 33-03 SERUM N1-METHYLNICOTINAMIDE IS ASSOCIATED WITH OBESITY AND DIABETES IN CHINESE.
Roles of Nicotinamide N-Methyltransferase in Obesity and Type 2 Diabetes.
Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice.
Serum N(1)-Methylnicotinamide Is Associated With Obesity and Diabetes in Chinese.
Serum N1-methylnicotinamide is Associated with Left Ventricular Systolic Dysfunction in Chinese.
Odontogenic Cysts
Differential expression of nicotinamide N-methyltransferase in primary and recurrent ameloblastomas and odontogenic keratocysts.
Osteoporosis
Long non-coding RNA XIST promotes osteoporosis by inhibiting the differentiation of bone marrow mesenchymal stem cell by sponging miR-29b-3p that suppresses nicotinamide N-methyltransferase.
Ovarian Neoplasms
Nicotinamide N-methyltransferase overexpression may be associated with poor prognosis in ovarian cancer.
Patients with low nicotinamide N-methyltransferase expression benefit significantly from bevacizumab treatment in ovarian cancer.
Radioproteomics in patients with ovarian cancer.
Pancreatic Neoplasms
Effects of Nicotinamide N -Methyltransferase on PANC-1 Cells Proliferation, Metastatic Potential and Survival Under Metabolic Stress.
Expression profile and prognostic value of NNMT in patients with pancreatic cancer.
Parkinson Disease
Expression of nicotinamide N-methyltransferase (E.C. 2.1.1.1) in the Parkinsonian brain.
High expression of nicotinamide N-methyltransferase in patients with idiopathic Parkinson's disease.
High Expression of Nicotinamide N-Methyltransferase in Patients with Sporadic Alzheimer's Disease.
The effect of heavy metals on nicotinamideN-methyltransferase activityin vitro relating to Parkinson's disease.
Prostatic Neoplasms
Nicotinamide N-methyltransferase enhances the progression of prostate cancer by stabilizing sirtuin 1.
Nicotinamide N-methyltransferase is overexpressed in prostate cancer and correlates with prolonged progression-free and overall survival times.
Pulmonary Disease, Chronic Obstructive
Expression and functional significance of nicotinamide N-methyl transferase in skeletal muscles of patients with chronic obstructive pulmonary disease.
Skin Neoplasms
Nicotinamide N-methyltransferase in nonmelanoma skin cancers.
Spinal Dysraphism
Nicotinamide N-methyl transferase (NNMT) gene polymorphisms and risk for spina bifida.
Squamous Cell Carcinoma of Head and Neck
Analysis of tissue and salivary nicotinamide N-methyltransferase in oral squamous cell carcinoma: basis for the development of a noninvasive diagnostic test for early-stage disease.
Nicotinamide N-Methyltransferase upregulation correlates with tumour differentiation in oral squamous cell carcinoma.
Nicotinamide N-methyltransferase upregulation inversely correlates with lymph node metastasis in oral squamous cell carcinoma.
Stomach Neoplasms
Nicotinamide N-Methyltransferase Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Gastric Cancer.
Nicotinamide N-methyltransferase promotes epithelial-mesenchymal transition in gastric cancer cells by activating transforming growth factor-?1 expression.
Overexpression of nicotinamide N-methyltransferase in gastric cancer tissues and its potential post-translational modification.
The differential proteome profile of stomach cancer: identification of the biomarker candidates.
Thyroid Cancer, Papillary
Activation of nicotinamide N-methyltransferase gene promoter by hepatocyte nuclear factor-1beta in human papillary thyroid cancer cells.
Enhanced expression of nicotinamide N-methyltransferase in human papillary thyroid carcinoma cells.
Histone deacetylase inhibitor depsipeptide represses nicotinamide N-methyltransferase and hepatocyte nuclear factor-1beta gene expression in human papillary thyroid cancer cells.
Tuberculosis
Triggering the expression of a silent gene cluster from genetically intractable bacteria results in scleric acid discovery.
Urinary Bladder Neoplasms
A potential role of heat shock proteins and nicotinamide N-methyl transferase in predicting response to radiation in bladder cancer.
Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration.
Upregulation of tissue and urinary nicotinamide N-methyltransferase in bladder cancer: potential for the development of a urine-based diagnostic test.
Urologic Neoplasms
The Utility of Nicotinamide N-Methyltransferase as a Potential Biomarker to Predict the Oncological Outcomes for Urological Cancers: An Update.
Uterine Cervical Neoplasms
Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in HeLa cells.